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| 1 | Role of regulatory T cell in the pathogenesis of inflammatorybowel disease显示文摘Regulatory T(Treg) cells play key roles in various immune responses. For example, Treg cells contribute to the complex pathogenesis of inflammatory bowel disease(IBD), which includes Crohn's disease and ulcerative colitis during onset or development of that disease. Many animal models of IBD have been used to investigate factors such as pathogenic cytokines, pathogenic bacteria, and T-cell functions, including those of Treg cells. In addition, analyses of patients with IBD facilitate our understanding of the precise mechanism of IBD. This review article focuses on the role of Treg cells and outlines the pathogenesis and therapeutic strategies of IBD based on previous reports. | akiko yamada rieko arakaki masako saito takaaki tsunematsu yasusei kudo naozumi ishimaru | 2016 | World Journal of Gastroenterology2016，22，7： | 24 |
| 2 | Cerebral lipiodol embolism related to a vascular lake during chemoembolization in hepatocellular carcinoma:A case report and review of the literature显示文摘A male patient underwent conventional transcatheter chemoembolization for advanced recurrent hepatocellular carcinoma(HCC). Even after the injection of 7 m L of lipiodol followed by gelatin sponge particles, the flow of feeding arteries did not slow down. A repeat angiography revealed a newly developed vascular lake draining into systemic veins; however, embolization was continued without taking noticing of the vascular lake. The patient's level of consciousness deteriorated immediately after the procedure, and non-contrast computed tomography revealed pulmonary and cerebral lipiodol embolisms. The patient's level of consciousness gradually improved after 8 wk in intensive care. In this case, a vascular lake emerged during chemoembolization and drained into systemic veins, offering a pathway carrying lipiodol to pulmonary vessels, the most likely cause of this serious complication. We should be aware that vascular lakes in HCC may drain into systemic veins and can cause intratumoral arteriovenous shunts. | Hideki Ishimaru Minoru Morikawa Takayuki Sakugawa Ichiro Sakamoto Yasuhide Motoyoshi Yohei Ikebe Masataka Uetani | 2018 | World Journal of Gastroenterology2018，24，37： | 9 |
| 3 | Myb-related genes of the Kyoho grape (Vitis labruscana) regulate anthocyanin biosynthesis显示文摘 | S. Kobayashi M. Ishimaru K. Hiraoka C. Honda | 2002 | Planta2002，，6： | 4 |
| 4 | Rice-Specific Mitochondrial Iron-Regulated Gene (MIR) Plays an Important Role in Iron Homeostasis显示文摘线粒体利用铁(Fe ) ,但是涉及 mitochondrial Fe 规定的蛋白质没在植物被描绘。我们克隆并且描绘 mitochondrial 调整铁(米尔) 在米饭的基因在 Fe 包含了动态平衡。当在烟草 BY-2 房间表示了时,米尔对线粒体局部性。米尔抄本极大地在根和射击织物响应 Fe 缺乏被增加。当相当或相同的事物没为另外的有机体在米饭或 Arabidopsis 染色体数据库,或在 EST 数据库被发现,米尔不对任何已知的蛋白质相应。在 MIR T-DNA 猛烈米饭异种(米尔) 的生长显著地被损害与相比野类型(WT ) 当在 Fe 缺乏或足够的条件下面成长时,种。而且,多于当在 Fe 足够或缺乏的条件下面成长时,两次在与 WT 相比的射击和根织物的 Fe 的数量种,米尔植物积累了。尽管有在根和射击的 Fe 的高累积,米尔植物触发了 Fe-deficiency-inducible 基因的表达式,显示那米尔不能利用为生理的函数的 Fe。这些结果清楚地建议那米尔是大米特定的 mitochondrial 蛋白质,最近演变,并且在 Fe 动态平衡起一个重要作用。 | Yasuhiro Ishimaru Khurram Bashir Masaru Fujimoto Gynheung An Reiko Nakanishi Itai Nobuhiro Tsutsumi Hiromi Nakanishi Naoko K Nishizawa | 2009 | Molecular Plant2009，2，5： | 3 |
| 5 | Characterization of QTL for unique agronomic traits of new-plant-type rice varieties using introgression lines of IR64显示文摘To enhance the yield potential of an elite indica rice cultivar,an introgression(BC_3-derived) line of IR64,YTH288,was developed using a new-plant-type cultivar,IR66215-44-2-3,as a donor parent.YTH288 has agronomically valuable characteristics such as large panicles,few unproductive tillers,and large leaves inherited from NPT.To identify the genetic basis of these traits,we used 167 F_2 plants derived from a cross between IR64 and YTH288 to conduct QTL analysis for five agronomic traits:days to heading(DTH),culm length(CL),flag leaf length(FLL),flag leaf width(FLW),and filled spikelet number per panicle(FSN).Six putative QTL were detected:four on chromosome4(for CL,FLL,FLW,and FSN) and two on chromosome 2(for DTH and FLL).All QTL with the IR66215-44-2-3 allele,except that for FLL on chromosome 2,had positive effects on each trait.To confirm the effects of these putative QTL,we developed NILs with the IR64 genetic background by marker-assisted selection.We observed significant differences in several agronomic traits between IR64 and NILs that carried these QTL on chromosomes2 and 4.Additionally,four IR64-NILs carrying chromosomal segments derived from different NPT varieties on the long arm of chromosome 4 exhibited similar pleiotropic To enhance the yield potential of an elite indica rice cultivar, an introgression(BC3-derived) line of IR64, YTH288, was developed using a new-plant-type cultivar,IR66215-44-2-3, as a donor parent. YTH288 has agronomically valuable characteristics such as large panicles, few unproductive tillers, and large leaves inherited from NPT.To identify the genetic basis of these traits, we used 167 F2 plants derived from a cross between IR64 and YTH288 to conduct QTL analysis for five agronomic traits: days to heading(DTH), culm length(CL), flag leaf length(FLL), flag leaf width(FLW), and filled spikelet number per panicle(FSN). Six putative QTL were detected: four on chromosome4(for CL, FLL, FLW, and FSN) and two on chromosome 2(for DTH and FLL). All QTL with the IR66215-44-2-3 allele, except that for FLL on chromosome 2, had positive effects on each trait. To confirm the effects of these putative QTL, we developed NILs with the IR64 genetic background by marker-assisted selection. We observed significant differences in several agronomic traits between IR64 and NILs that carried these QTL on chromosomes2 and 4. Additionally, four IR64-NILs carrying chromosomal segments derived from different NPT varieties on the long arm of chromosome 4 exhibited similar pleiotropiceffects for unique agronomic traits. These NILs can be used as research materials for studying each trait and as breeding materials for yield improvement of indica rice cultivars. | Analiza G.Tagle Daisuke Fujita Leodegario A.Ebron Mary Jeanie Telebanco-Yanoria Kazuhiro Sasaki Tsutomu Ishimaru Yoshimichi Fukuta Nobuya Kobayashi | 2016 | The Crop Journal2016，4，1： | 2 |
| 6 | Two flavone 2'-glucosides from Scutellaria baicalensis显示文摘 | Ishimaru K Nishikawa K Omoto T | 1995 | Phytochemistry1995，40，1： | 2 |
| 7 | Changes in presynaptic proteins,SNAP-25 and synaptophysin,in the hippocampal CAI area in ischemic gerbils显示文摘 | Ishimaru H Casamenti F Ueda K | 2001 | Brain Res2001，903，12： | 1 |
| 8 | Two flavone 2' -glucosides from Scutellaria baicalensis显示文摘 | KANJI ISHIMARU KAZUTAKA NISHIKAWA TOSHITO OMOTO | 1995 | Phytochemistry1995，40，1： | 1 |
| 9 | Outbreaks of hand-foot-and-mouth disease by enterovirus 71 显示文摘 | Ishimaru Y | 1980 | Arch Dis Child1980，55，8： | 1 |
| 10 | Artificial molec- Mar clamp: A novel device for synthetic polymerases显示文摘 | Takashima Y Osaki M Ishimaru Y | 2011 | An- gewandte Chemie International Edition2011，50，33： | 1 |
| 11 | Accuracy of pre- and postcontrast 3D time-of-flight MR angiography in pa- tients with acute ischemic stroke~ correlation with catheter angiography显示文摘 | Ishimaru H Ochi M Morikawa M | 2007 | AJNR2007，28，： | 1 |
| 12 | An Imaging Technique Us- ing Confocal Circular Synthetic Aperture Radar 显示文摘 | Ishimaru A Chan T K Kuga Y | 1998 | IEEE Transactions on Geoscience and Remote Sensing1998，36，5： | 1 |
| 13 | Rapid and sensitive detection of heat-labile Ⅰ and heat-stable Ⅰ enterotoxin genes of enterotoxigenic Escherichia coli by loop-mediated isothermal amplification显示文摘 | Yano A Ishimaru R Hujikata R | 2007 | Microbiol Methods2007，68，2： | 1 |
| 14 | Rapidly progressive T-cell angiocentric lymphoma with CD56+ phenotype involving bilateral orbits and skin in a patient with anti-HTLV-I antibody 显示文摘 | Kato K Matsuguchi T Ishimaru T | 1996 | Rinsho Ketsueki1996，37，2： | 1 |
| 15 | Expression of a xyloglucan endotransglycosylase gene is closely related to grape berry softening 显示文摘 | ISHIMARU M KOBAYASHI S | 2002 | Plant Science2002，162，4： | 1 |
| 16 | Comparison ofUDP-glucose:flavonoid 3-O-glucosyltransferase(UFGT)gene sequences between white grapes(Vitis vinifera)andtheir sports with red skin显示文摘 | Kobayashi S Ishimaru M Ding C K et al | 2001 | Plant Sci2001，160，： | 1 |
| 17 | NGF delays rather than prevents the cholinergic terminal damage and delayed neuronal death in the hippocampus after ischermia显示文摘 | Ishimaru H Takahashi A Ikarashi Y | 1998 | Brain Res1998，789，： | 1 |
| 18 | Salusins:newly identified bioactive peptides with hemodynamic and mitogenic activities显示文摘 | Shichiri M Ishimaru S Ota T | 2003 | Nat Med2003，9，9： | 1 |
| 19 | Diffuse ref-lectance from a finite blood medium: applications to the modeling of fiber optical catheters显示文摘 | Reynolds L Johnson C Ishimaru A | 1976 | Appl Opt1976，15，： | 1 |
| 20 | Influence of Dietary Bacillus subtilis C-3102 Spores on Live Performance of Broiler Chickens in Four Controlled Pen Trials显示文摘 | D M Hooge H Ishimaru M D Sims | 2004 | Journal of Applied Poultry Research2004，13，： | 1 |
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