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| 1 | Effect of Clostridium butyricum on fecal flora in Helicobacter pylori eradication therapy显示文摘AIM: To investigate the effect of probiotic bacterium,Clostridium butyricum MIYAIRI 588 strain (CBM) on the changes of the fecal flora in Helicobacter pylori(H pylori)treatment.METHODS: Thirty-five patients with gastric or duodenal ulcers positive for Hpylori were randomized either to 1 wk amoxicillin, clarithromycin, lansoprazole (Group 1) or to the same regimen supplemented with CBM 7 dahead of the triple therapy (Group 2). Stool samples were collected before and 2, 4, 7, 15, and 22 d after the starting eradication therapy, and were examined intestinal flora. Patients were required to keep a diary record of their condition. RESULTS: Obligate anaerobes decreased significantly on d 2, 4, 8 and 15 in Group 1. On the other hand, they did not decrease significantly in Group 2. The Escherichiacoli was dominant bacterium in Enterobacteriaceae, butthat was replaced by other species such as Klebsiella and Enterobacter after eradication in Group 1. The change was suppressed in Group 2. Abdominal symptoms were less frequent in Group 2 than in Group 1.CONCLUSION: The combined use of CBM reduced the changes in the intestinal flora and decreased the incidence of gastrointestinal side effects. | Izumi Shimbo Taketo Yamaguchi Takeo Odaka Kenichi Nakajima Akinori Koide Hidehiko Koyama Hiromitsu Saisho | 2005 | World Journal of Gastroenterology2005，11，47： | 18 |
| 2 | Peroral endoscopic myotomy (POEM) for esophageal achalasia*显示文摘 | H. Inoue H. Minami Y. Kobayashi Y. Sato M. Kaga M. Suzuki H. Satodate N. Odaka H. Itoh S. Kudo | 2010 | Endoscopy2010，，04： | 8 |
| 3 | Significance of a novel sucrose permeability test using serum in the diagnosis of early gastric cancer显示文摘AIM: To investigate the usefulness of sucrose permeability test using serum in the diagnosis of gastric diseases, with special reference to early gastric cancer (EGC).METHODS: A total of 63 subjects, including 11patients with gastric ulcer, 20 patients with gastric cancer (13, early; 7, advanced) and 32 healthy controls,were studied. Blood and urine samples were collected repeatedly for 5 h before and after the sucrose loading.Sucrose levels were measured by a newly developed enzymatic method.RESULTS: Serum sucrose levels started to increase15 min after loading, and peaked at 60 min in the gastric disease groups. The levels for gastric ulcer, EGC and advanced gastric cancer (AGC) at 60 min were significantly higher than that in the healthy controls(26.9±2.4, 34.4±5.0, and 71.8±15.6 vs 7.9±0.7 mol/L,respectively, P<0.01). The cut-off level set at 15.4 mol/L(60 min) offered the best distinction between EGC patients and healthy controls; and the sensitivity and specificity were 92.3% and 93.8%, respectively, while those of the urine method were 76.9% and 93.8%,respectively.CONCLUSIONS: The gastric permeability test using serum is reliable for the detection of EGC, and this test can provide results much earlier than the conventional urine method. This test may offer a useful alternative to more invasive tests for EGC. | Tadayuki Shishido Taketo Yamaguchi Takeo Odaka Masanori Seimiya Hiromitsu Saisho Fumio Nomura | 2005 | World Journal of Gastroenterology2005，11，44： | 5 |
| 4 | Impact of glucocorticoid on neurogenesis显示文摘Neurogenesis is currently an area of great interest in neuroscience.It is closely linked to brain diseases,including mental disorders and neurodevelopmental disease.Both embryonic and adult neurogeneses are influenced by glucocorticoids secreted from the adrenal glands in response to a variety of stressors.Moreover,proliferation/differentiation of the neural stem/progenitor cells(NSPCs)is affected by glucocorticoids through intracellular signaling pathways such as phosphoinositide 3-kinase(PI3K)/Akt,hedgehog,and Wnt.Our review presents recent evidence of the impact of glucocorticoids on NSPC behaviors and the underlying molecular mechanisms;this provides important information for understanding the pathological role of glucocorticoids on neurogenesis-associated brain diseases. | Haruki Odaka Naoki Adachi Tadahiro Numakawa | 2017 | Neural Regeneration Research2017，12，7： | 4 |
| 5 | 均匀充量柴油燃烧的优化控制方法的研究显示文摘作为降低柴油机废气排放的一种方法,对均匀充量柴油燃烧技术(HCDC)进行了试验,将一部分燃油喷入进气道以形成均匀预混合气,这样,在直接喷入气缸的柴油着火之前,这种均匀预混合气从进气道进入气缸。试验结果显示,能显著降低NO_x和排烟。如果柴油预先与空气混合,预混合气会过早地自燃,从而难以保持在上止点附近着火定时,从而限制了柴油机的运行工况。虽然,降低排放的主要目标是实现高负荷工况下的稳定低排放燃烧,但是柴油机实际运行大多包括部分负荷工况。因此,即使在部分负荷运行范围内,如果HCDC能够实现低排放燃烧,则能够大大降低柴油机废气排放。因此在本研究中,在低负荷和中等负荷运行范围内,试图通过直喷燃油喷油定时的控制和EGR来改善燃烧和降低排放。对于全负荷工况,力求通过燃用高抗爆震性能的含氧化合物的柴油来优化HCDC。试验结果表明,在油门半开和低预混合燃油比的条件下,通过延迟(优化)直喷燃油喷油定时,能大大降低NO_x,而不增加排烟。这与在高预混合燃油比条件下所获得的效果是相同的。还发现通过优化预混合燃油比和EGR率,能降低NO_x排放,而不增加排烟。此外,能够确认,经在柴油中混入MTBE(甲基特丁基醚),当HCDC在柴油机整个运行范围起作用时,NO_x和排烟都能得到降低。通过延迟直喷燃油喷油定时,NO_x和排烟还能得到进一步降低。 | Matsuo Odaka Hisakazu Suzuki Noriyuki Koike 马玲 | 2001 | 国外内燃机2001，33，5： | 4 |
| 6 | 单侧外展神经麻痹作为吉兰-巴雷综合征的局部变异 | Tatsumoto M. Odaka M. Hirata K. Yuki N. 潘佳鸿 | 2006 | 世界核心医学期刊文摘(眼科学分册)2006，0，8： | 2 |
| 7 | Pulmonary vein analysis using three- dimensional computed tomography angiography for thoracic surgery显示文摘 | Akiba T Marushima H Odaka M | 2010 | Gen Thorac Cardiovasc Surg2010，58，7： | 1 |
| 8 | Relationship of bacterial strains to clinical syndromes of Campylobacter - associated neuropathies 显示文摘 | Kimoto K Koga M Odaka M | 2006 | Neurology2006，67，10： | 1 |
| 9 | TMP-153, a novel ACAT inhibitor, lowers plasma cholesterol through its hepatic action in golden hamsters显示文摘 | Sugiyama Y Odaka H Itokawa S | 1995 | Atherosclerosis1995，，118： | 1 |
| 10 | Longitudinal changes of antigangioside antiboclies before and after Guillaln-Barr6 syndrome on-set subsequent to Campylobacter jejuni enteritis显示文摘 | Koga M Yuki N | 2003 | J Neurol Sei2003，210，12： | 1 |
| 11 | Usefulness of anti-GQ1b IgG antibody testing in Fisher syndrome compared with cerebrospinal fluid examination显示文摘 | Nishimoto Y Odaka M Hirata K | 2004 | J Neuroimmunol2004，148，12： | 1 |
| 12 | Indentification of antimicrobial and antioxidant constitutens from licorice of Russian and Xinjiang origin显示文摘 | Odaka K Tamura Y Yamamoto M | 1987 | Chem Parm bull1987，37，9： | 1 |
| 13 | Anti-GQlb IgG antibody syndrome:clinical and immunological range显示文摘 | Odaka M Yuki N Hirata K | 2001 | J Neurol Neurosurg Psychiatry2001，70，1： | 1 |
| 14 | Bickerstaff's brainstem encephalitis: clinical features of 62 cases and a subgroup associated with Guillain-Barr6 syndrome 显示文摘 | Odaka M Yuki N Yamada M | 2003 | Brain2003，126，10： | 1 |
| 15 | Transforming growth factor- beta stimulates the expression of eotaxin/CC chemokine ligand 11 and its promoter activity through binging site for nuclear factor-kappaB in airway smooth muscle cells显示文摘 | Matsukura S Odaka M Kurokawa M | 2010 | Clin Exp Allergy2010，40，： | 1 |
| 16 | Pioglitazone time-dependently reduces tumor necrosis factor-α level in muscle and improves metabolic abnormalities in Wistar fatty rats 显示文摘 | Odaka H Suzuki M | 1998 | Diabetologia1998，41，： | 1 |
| 17 | PhotocatalyticTi02 Thin Film Deposited onto Glass by DC MagnetronSputtering显示文摘 | TAKEDA S SUZUKI S ODAKA H | 2001 | Thin Solid Films2001，392，2： | 1 |
| 18 | Colonic transit time and rectoanal videomanometry in Parkinson’s disease显示文摘 | Sakakibara R Odaka T Uchiyama T | 2003 | J Neurol Neurosurg Psychia2003，74，2： | 1 |
| 19 | A new method of quickly estimating epicentral distance and magnitude from a single seismic record 显示文摘 | Odaka T Ashiya K Tsukada S | 2003 | Bulletin of seismological society of America2003，93，1： | 1 |
| 20 | Anti-GQ1b Ig G antibody syndrome:clinical and immunological rang显示文摘 | Odaka M Yuki N Hirata K | 2001 | J Neurol Neurosurg Psychiatry2001，70，1： | 1 |
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