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| 1 | Hypofractionated stereotactic rad iotherapy alone without whole-brain irradiation for patien ts with solitary and oligo brain metastasis using noninvasive fixation of the skull显示文摘To evaluate the efficacy and toxicity of hypofractionated stereotactic radiotherapy(HSRT)using noninvasive fixation of the sk ull on solitary or oligo brain metastatic p atients as an alternative to stereotactic radiosurgery(SRS)using invasive fixation.The subjects were 87patients who had 4or fewer brain meta stases(50solitary,37oligometastases).Treatment was conducted on 159meta stases by using a linac-based stereotactic system.T he median isocentric dose was 35Gy in4fractions.Whole-brain irradiati on was not applied as an initial treatment.For the salvage treatmen t of metachronous brain metastases,repeat HSRT or whole-brain irradiation was applied.The actuarial1-year local tumor control rate was 81%.Treatment-related complicatio ns were observed in 4patients in the e arly period(<3months)and in 2patients in the late period.T he median survival period was 8.7mon ths.Metachronous brain metastases occurred in 30patients,and none of the 18patients who were eligible for salvage HSRT refused to re ceive it again.Hypofractionated stereotactic radiotherapy achieved tumor control and survival equivalent to those of SRS reported i n the literature.The results suggested that HSRT could be an alternative for solitary or oligo br ain metastatic patients with less to xicity and less invasiveness compared to | Aoyama H Shirato H Onimaru R Kagei K Ikeda J Ishii N Sawamura Y Miyasaka K | 2003 | 癌症2003，22，7： | 12 |
| 2 | Long-term prognostic impact of circulating tumour cells in gastric cancer patients显示文摘AIM To analyse the long-term prognostic impact of circulating tumour cells(CTCs) in gastric cancer patients who underwent surgery. METHODS A 7.5-m L peripheral vein blood sample was obtained from each patient with treatment-negative gastric adenocarcinoma before surgery. OBP-401, a telomerasespecific, replication-selective, oncolytic adenoviral agent carrying the green fluorescent protein gene, was used to label CTCs. Correlations between the number of CTCs and clinical end points were evaluated. RESULTS The median follow-up period of the surviving patients with gastric cancer was 60 mo. The CTC number tended to increase concomitantly with disease progression. The overall survival of patients with more than five CTCs in 7.5-m L of peripheral blood was lower than that of patients with five or less CTCs, although the difference was not significant(P = 0.183). A significant difference in relapse-free survival was found between patients with more than five and those with five or less CTCs(P = 0.034).CONCLUSION A lower number of CTCs was correlated with higher relapse-free survival rates in patients. Detection of CTCs using OBP-401 may be useful for predicting prognosis in gastric cancer. | Hiroaki Ito Jun Sato Yukio Tsujino Noriko Yamaguchi Satoshi Kimura Keigo Gohda Katsuhiro Murakami Manabu Onimaru Tohru Ohmori Fumihiro Ishikawa Haruhiro Inoue | 2016 | World Journal of Gastroenterology2016，22，46： | 8 |
| 3 | Submucosal tunnel endoscopy:Peroral endoscopicmyotomy and peroral endoscopic tumor resection显示文摘Peroral endoscopic myotomy(POEM) is an innovative,minimally invasive, endoscopic treatment for esophageal achalasia and other esophageal motility disorders, emerged from the natural orifice transluminal endoscopic surgery procedures, and since the first human case performed by Inoue in 2008, showed exciting results in international level, with more than 4000 cases globally up to now. POEM showed superior characteristics than the standard 100-year-old surgical or laparoscopic Heller myotomy(LHM), not only for all types of esophageal achalasia [classical(Ⅰ), vigorous(Ⅱ), spastic(Ⅲ), Chicago Classification], but also for advanced sigmoid type achalasia(S1 and S2), failed LHM, or other esophageal motility disorders(diffuse esophageal spasm, nutcracker esophagus or Jackhammer esophagus). POEM starts with a mucosal incision, followed by submucosal tunnel creation crossing the esophagogastric junction(EGJ) and myotomy. Finally the mucosal entry is closed with endoscopic clip placement. POEM permitted relatively free choice of myotomy length and localization. Although it is technically demanding procedure, POEM can be performed safely and achieves very good control of dysphagia and chest pain. Gastroesophageal reflux is the most common troublesome side effect, and is well controllable with proton pump inhibitors. Furthermore, POEM opened the era of submucosal tunnel endoscopy, with many other applications. Based on the same principles with POEM, in combination with new technological developments, such as endoscopic suturing, peroral endoscopic tumor resection(POET), is safely and effectively applied for challenging submucosal esophageal, EGJ and gastric cardia tumors(submucosal tumors), emerged from muscularis propria. POET showed up to know promising results, however, it is restricted to specialized centers. The present article reviews the recent data of POEM and POET and discussed controversial issues that need further study and future perspectives. | Nikolas Eleftheriadis Haruhiro Inoue Haruo Ikeda Manabu Onimaru Roberta Maselli Grace Santi | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，2： | 7 |
| 4 | Endoscopic Mucosal Resection, Endoscopic Submucosal Dissection, and Beyond: Full-Layer Resection for Gastric Cancer with Nonexposure Technique (CLEAN-NET)显示文摘 | Haruhiro Inoue Haruo Ikeda Toshihisa Hosoya Akira Yoshida Manabu Onimaru Michitaka Suzuki Shin-ei Kudo | 2012 | Surgical Oncology Clinics of North America2012，，1： | 2 |
| 5 | Endocytoscopic visualization of squamous cell islands within Barrett's epithelium显示文摘AIM: To study the endocytoscopic visualization of squamous cell islands within Barrett's epithelium. METHODS: Endocytoscopy (ECS) has been studied in the surveillance of Barrett's esophagus, with controversial results. In initial studies, however, a soft catheter type endocytoscope was used, while only methylene blue dye was used for the staining of Barrett's mucosa. Integrated type endocytoscopes (GIF-Q260 EC, Olympus Corp, Tokyo, Japan) have been recently developed, with the incorporation of a high-power magnifying endocytoscope into a standard endoscope together with narrow-band imaging (NBI). Moreover, double staining with a mixture of 0.05% crystal violet and 0.1% of methylene blue (CM) during ECS enables higher quality images comparable to conventional hematoxylin eosin histopathological images.RESULTS: In vivo endocytoscopic visualization of papillary squamous cell islands within glandular Barrett's epithelium in a patient with long-segment Barrett's esophagus is reported. Conventional white light endoscopy showed typical long-segment Barrett's esophagus, with small squamous cell islands within normal Barrett's mucosa, which were better visualized by NBI endoscopy. ECS after double CM staining showed regular Barrett's esophagus, while higher magnification (×480) revealed the orifices of glandular structures better. Furthermore, typical squamous cell papillary protrusion, classified as endocytoscopic atypia classification (ECA) 2 according to ECA, was identified within regular glandular Barrett's mucosa. Histological examination of biopsies taken from the same area showed squamous epithelium within glandular Barrett's mucosa, corresponding well to endocytoscopic findings. CONCLUSION: To our knowledge, this is the first report of in vivo visualization of esophageal papillary squamous cell islands surrounded by glandular Barrett's epithelium. | Nicholas Eleftheriadis Haruhiro Inoue Haruo Ikeda Manabu Onimaru Akira Yoshida Toshihisa Hosoya Roberta Maselli Shin-ei Kudo | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，4： | 2 |
| 6 | Per-oral Endoscopic Myotomy is a Viable Option for Failed Surgical Esophagocardiomyotomy Instead of Re-Do Surgical Heller Myotomy: A Single Center Prospective Study显示文摘 | Manabu Onimaru Haruhiro Inoue Haruo Ikeda Akira Yoshida Esperanza Grace Santi Hiroki Sato Hiroaki Ito Roberta Maselli Shin-ei Kudo | 2013 | Journal of the American College of Surgeons2013，，： | 2 |
| 7 | 54 Clinical Results in 300 Cases of POEM for Esophageal Achalasia a Single Institute Registered Prospective Study显示文摘 | Haruhiro Inoue Haruo Ikeda Manabu Onimaru Akira Yoshida Hiroki Sato Esperanza Grace R. Santi Roberta Maselli Nicholas Eleftheriadis Shin-Ei Kudo | 2013 | Gastrointestinal Endoscopy2013，，5： | 2 |
| 8 | Acetic acid spray enhances accuracy of narrow-band imaging magnifying endoscopy for endoscopic tissue characterization of early gastric cancer显示文摘 | Nikolas Eleftheriadis Haruhiro Inoue Haruo Ikeda Manabu Onimaru Akira Yoshida Roberta Maselli Grace Santi Shin-ei Kudo | 2013 | Gastrointestinal Endoscopy2013，，： | 2 |
| 9 | Submucosal endoscopic tumor resection for subepithelial tumors in the esophagus and cardia显示文摘 | H. Inoue H. Ikeda T. Hosoya M. Onimaru A. Yoshida N. Eleftheriadis R. Maselli S. Kudo | 2012 | Endoscopy2012，，03： | 2 |
| 10 | Predicting the chemosensitivity of pancreatic cancer cells by quantifyingthe expression levels of genes associated with the metabolism of gemcitabine and5-fluorouracil显示文摘 | Nobuaki Kurata Hayato Fujita Kenoki Ohuchida Kazuhiro Mizumoto Prawej Mahawithitwong Hiroshi Sakai Manabu Onimaru Tatsuya Manabe Takao Ohtsuka Masao Tanaka | 2011 | International Journal of Oncology2011，，2： | 2 |
| 11 | Magnification narrow-band imaging for the diagnosis of early gastric cancer: a review of the Japanese literature for the Western endoscopist显示文摘 | Bu’Hussain Hayee Haruhiro Inoue Hiroki Sato Esperanza Grace Santi Akira Yoshida Manabu Onimaru Haruo Ikeda Shin-ei Kudo | 2013 | Gastrointestinal Endoscopy2013，，： | 2 |
| 12 | Characterization and distribution of a new enterotoxin related superantigen produced by Staphylococcus aureus显示文摘 | Abe J Ito Y Onimaru M | 2000 | Microbiol Immunol2000，44，2： | 1 |
| 13 | Combination with low-dose gemcitabine and hTERT-promoter-dependent condi- tionally replicative adenovirus enhances cytotoxicity through their crosstalk mechanisms in pancreatic cancer显示文摘 | Onimaru M Ohuchida K Nagai E | 2010 | Cancer Lett2010，294，2： | 1 |
| 14 | Training in peroral endoscopic myotomy (POEM) for esophageal achalasia显示文摘 | Nicholas Eleftheriadis Haruhiro Inoue Shin-ei Kudo Roberta Maselli Toshihisa Hosoya Akira Yoshida Manabu Onimaru Haruo Ikeda | 2012 | Therapeutics and Clinical Risk Management (default)2012，，： | 1 |
| 15 | Determination of tetrabromo- bisphenol A in human serum by liquid chromatography-electrospray ionization tandem mass spectrometry 显示文摘 | Hayama T Yoshida H Onimaru S | 2004 | Journal of Chromatography B2004，809，： | 1 |
| 16 | Tolerance of organs at risk in small volume, hypofractionated, image - guided radiother- apy for primary and metastatic lung cancers显示文摘 | Onimaru R Shirato H Shimizu S | 2003 | Int J Radiat On- col Biol Phys2003，56，： | 1 |
| 17 | Tolerance of organs at risk in small-volume,hypofractionated,image-guided radiotherapy for primary and metastatic lung cancers显示文摘 | Onimaru R Shirato H Shimizu S | 2003 | Int J Radiat Oncol Biol Phys2003，56，1： | 1 |
| 18 | Characterization and distribution of a new enterotoxin-related super antigen produced by Staphylococcus aureus显示文摘 | ABE J ITO Y ONIMARU M | 2000 | Microbiol Immunol2000，44，： | 1 |
| 19 | FGF-2 gene transfercan stimulate HGF expression,irrespective of hypoxia-mediated down regulation in ischemic limbs显示文摘 | Onimaru M Yonemitsu Y Tanii M | 2002 | Circ Res2002，91，： | 1 |
| 20 | Peroral endoscopic myotomy is a viable option for failed surgical esophagocardiomyotomy instead of redo surgical Heller myotomy: a single center prospective study显示文摘 | Onimaru M Inoue H Ikeda H | 2013 | J Am Coil Surg2013，217，4： | 1 |
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