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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | 妊娠前心血管功能与先兆子痫及胎儿生长受限的关系显示文摘妊娠期间的子痫前期和胎儿生长受限与后期母亲心血管病风险增加有关。目前尚不清楚这种关联是因果关系还是由类似的事先存在的风险因素导致。澄清这种关联需要在受孕前征募研究对象,但在方法上是困难的。 | Foo FL Mahendru AA Masini G Fraser A Cacciatore S MacIntyre DA McEniery CM Wilkinson IB Bennett PR Lees CC 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，8： | 3 |
| 3 | Association of C-reactive protein and hyperuricemia with diabetic nephropathy in Chinese type 2 diabetic patients显示文摘 | Fu CC Wu DA Wang JH | 2009 | Acta Diabetol2009，46，2： | 1 |
| 4 | Ctyptosporidium and Giardia recoveries in natural waters by using environmental protection agency method 1623 显示文摘 | DiGiorgio CL Gonzalez DA Huitt CC | 2002 | Appl Environ Microbiol2002，68，12： | 1 |
| 5 | Treatment of facial wounds with botulinum toxin a improves cosmetic outcome in primates显示文摘 | Gassner HG Sherris DA Otley CC | 2000 | Plast Reconstr Surg2000，105，6： | 1 |
| 6 | Ablation in mice of the mTORC components raptor, rietor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1 显示文摘 | Guertin DA Stevens DM Thoreen CC | 2006 | Cell2006，11，6： | 1 |
| 7 | Stern cell survival and functional outcome after n'aumatic brain injury is dependent on transplant timing and locatian显示文摘 | Shear DA Tate CC Tate MC | 2011 | Restor Neurol Neurosci2011，29，4： | 1 |
| 8 | The effect of plasm a-treated polyethylene fiber on the fracture strength of polym ethylm ethacrylate显示文摘 | Ramols VJ Runyan DA Christensen CC | 2001 | J Prosthet Dent2001，81，1： | 1 |
| 9 | Genes preferential y induced by depolarization after concussive brain injury:effects of age and injury severity显示文摘 | Giza CC Prins ML Hovda DA | | 0，，04： | 1 |
| 10 | Early mortality risk score:i- dentification of poor outcomes following upfront surgery for reseetable pancreatic cancer显示文摘 | Hsu CC Wolfgang CL Laheru DA | 2012 | J Gastrointest Surg2012，16，4： | 1 |
| 11 | The accumulation of whole body sketetal mass in third and fourth-grade children: affects of age, gender, ethnicity, and body composition显示文摘 | Nelson DA Simpson PM Johnson CC | 1997 | Bone1997，20，1： | 1 |
| 12 | Resistant Hypertension and Hyperaldosteronism显示文摘 | Gonzaga CC Calhoun DA | 2008 | Curr Hyperten Rep2008，10，6： | 1 |
| 13 | The effect of plasma-treated polyethylene fiber on the fracture strength of polymethyl methacrylate显示文摘 | Ramols VJ Runyan DA Christenaen CC | | 0，，01： | 1 |
| 14 | Early mortality risk score : i- dentification of poor outcomes following upfront surgery for resectable pancreatic cancer显示文摘 | Hsu CC Wolfgang CL Laheru DA | 2012 | J Gastrointest Surg2012，16，4： | 1 |
| 15 | Apoptotic features of selective neuronal death in ischemia,ePilePsy and gPl20 txicity显示文摘 | Zouaoui DA Represa A | 1996 | TINS1996，19，： | 1 |
| 16 | Association of C-reactive protein and hyperuricemia with diabetic nephropathy in Chinese type 2 di- abetic patients 显示文摘 | Fu CC Wu DA Wang JH | 2009 | Acta Diabetol2009，46，2： | 1 |
| 17 | The assessment of cellular proliferation by immunohistochemistry: a review of currently available methods and their applications显示文摘 | Yu CC Woods AL Levision DA | | 0，，： | 1 |
| 18 | A reevaluation of the role of crystalloid preload in the prevention of hypotention associated with spinal anesthesia for elective cesarean section 显示文摘 | Rout CC Rocke DA Levin | 1999 | Anesthesiology1999，79，： | 1 |
| 19 | Markov chain Monte Carlo methods and the label switching problem in Bayesian mixture modeling显示文摘 | Jasra A Holmes CC Stephens DA | | 0，，01： | 1 |
| 20 | A reevaluation of the role of crystalloid preload in the prevention of hypotension associated with spinal anesthesia for elective cesarean section显示文摘 | Rout CC Rocke DA Levin J | 1993 | Anesthesiology1993，79，2： | 1 |
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