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| 1 | Long-term outcomes of hepatocellular carcinoma that underwent chemoembolization for bridging or downstaging显示文摘BACKGROUND Prospective study of 200 patients with hepatocellular carcinoma(HCC)that underwent liver transplant(LT)after drug-eluting beads transarterial chemoembolization(DEB-TACE)for downstaging versus bridging.Overall survival and tumor recurrence rates were calculated,eligibility for LT,time on the waiting list and radiological response were compared.After TACE,only patients within Milan Criteria(MC)were transplanted.More patients underwent LT in bridging group.Five-year post-transplant overall survival,recurrence-free survival has no difference between the groups.Complete response was observed more frequently in bridging group.Patients in DS group can achieve posttransplant survival and HCC recurrence-free probability,at five years,just like patients within MC in patients undergoing DEB-TACE.AIM To determine long-term outcomes of patients with HCC that underwent LT after DEB-TACE for downstaging vs bridging.METHODS Prospective cohort study of 200 patients included from April 2011 through June 2014.Bridging group included patients within MC.Downstaging group(out of MC)was divided in 5 subgroups(G1 to G5).Total tumor diameter was≤8 cm for G1,2,3,4(n=42)and was>8 cm for G5(n=22).Downstaging(n=64)and bridging(n=136)populations were not significantly different.Overall survival and tumor recurrence rates were calculated by the Kaplan-Meier method.Additionally,eligibility for LT,time on the waiting list until LT and radiological response were compared.RESULTS After TACE,only patients within MC were transplanted.More patients underwent LT in bridging group 65.9%(P=0.001).Downstaging population presented:higher number of nodules 2.81(P=0.001);larger total tumor diameter 8.09(P=0.001);multifocal HCC 78%(P=0.001);more post-transplantation recurrence 25%(P=0.02).Patients with maximal tumor diameter up to 7.05 cm were more likely to receive LT(P=0.005).Median time on the waiting list was significantly longer in downstaging group 10.6 mo(P=0.028).Five-year posttransplant overall survival was 73.5%in downstaging and 72.3%bridging groups(P=0.31),and recurrence-free survival was 62.1%in downstaging and 74.8%bridging groups(P=0.93).Radiological response:complete response was observed more frequently in bridging group(P=0.004).CONCLUSION Tumors initially exceeding the MC down-staged after DEB-TACE,can achieve post-transplant survival and HCC recurrence-free probability,at five years,just like patients within MC in patients undergoing DEB-TACE. | Breno Boueri Affonso Francisco Leonardo Galastri Joaquim Mauricio da Motta Leal Filho Felipe Nasser Priscila Mina Falsarella Rafael Noronha Cavalcante Marcio Dias de Almeida Guilherme Eduardo Goncalves Felga Leonardo Guedes Moreira Valle Nelson Wolosker | 2019 | World Journal of Gastroenterology2019，25，37： | 21 |
| 2 | Reduced retinal blood flow velocity in diabetic retinopathy 显示文摘 | Burgansky-Eliash Z Nelson DA Bar-Tal OP | 2010 | Retina2010，30，5： | 1 |
| 3 | RAKE and LNA- ISH reveal microRNA expression and localization in archival human brain 显示文摘 | Nelson PT Baldwin DA Kloosterman WP | 2006 | RNA2006，12，： | 1 |
| 4 | Microarray based, high-throughput gene expression profiling of microRNAs显示文摘 | Nelson PT Baldwin DA Scearce LM | 2004 | Nat Methods2004，1，2： | 1 |
| 5 | Aversive parenting in china:Associations with child physical and relational aggression显示文摘 | NELSON DA HART CH JIN S | 2006 | Child Dev2006，77，3： | 1 |
| 6 | The accumulation of whole body sketetal mass in third and fourth-grade children: affects of age, gender, ethnicity, and body composition显示文摘 | Nelson DA Simpson PM Johnson CC | 1997 | Bone1997，20，1： | 1 |
| 7 | Allopurinol improves myocardial efficiency in patients with idiopathic dilated cardiomyopathy显示文摘 | Cappola TP Kass DA Nelson GS | 2001 | Circulation2001，104，20： | 1 |
| 8 | Effects of triethyl lead administration on the expression of glutathione S-transferase isoenzymes andquinone reduetase in rat kidney and liver显示文摘 | Daggett DA Nuwaysir EF Nelson SA | 1997 | Toxicology1997，117，1： | 1 |
| 9 | Um estudo comparativo do desempenho dos protocolos iSCSI e fibre channel显示文摘 | Antonio J R Neto Nelson L S da Fonseca | 2007 | IEEE Latin America Transactions2007，5，3： | 1 |
| 10 | Effects of leadon rat kidney and liver: GSTexpression and oxidative stress 显示文摘 | Daggett DA Oberley TD Nelson SA | 1998 | Toxicology1998，128，3： | 1 |
| 11 | Perceived Usefulness,Ease of Use and Usage of Information Technology:A Replication显示文摘 | Adams DA Nelson RR Todd PA | 1992 | MIS Quarterly1992，16，2： | 1 |
| 12 | Microarray- based, high-throughput gene expression profiling of mi- croRNAs 显示文摘 | Nelson PT Baldwin DA Scearee LM | 2004 | Nat Methods2004，1，2： | 1 |
| 13 | Acute muscle stretching inhibits muscle strength endurance performance显示文摘 | Nelson AG Kokkonen J Arnall DA | | 0，，： | 1 |
| 14 | Reduced retinal blood flow velocity in diabetic retinopothy显示文摘 | Burgansky-Eliash Z Nelson DA Bar-Tal OP | | 0，，： | 1 |
| 15 | RAKE and LNA--ISH reveal microRNA expression and localiza--tion in archival human brain 显示文摘 | NELSON PT BALDWIN DA KLOOSTERMAN WP | 2006 | RNA2006，12，2： | 1 |
| 16 | Periarticular osteoporosis in osteoarthritis of the knee 显示文摘 | Karvonen RL Miller PR Nelson DA | 1998 | J Rheumatol1998，25，11： | 1 |
| 17 | Incidence and risk factors for agranulocytosis in Latin American countries—the Latin Study显示文摘 | Nelson Hamerschlak Eliane Maluf Alexandre Biasi Cavalcanti álvaro Avezum Júnior José Eluf-Neto Roberto Passeto Falc?o Irene Gyongyvér Heidemarie Lorand-Metze Daniel Goldenberg Cézar Leite Santana Daniela de Oliveira Werneck Rodrigues Leny Nascimento da Mo | 2008 | European Journal of Clinical Pharmacology2008，，9： | 1 |
| 18 | Arondomized trial of sodium fluoride as a treatment for postmenopausal osteoporosis显示文摘 | Kleerekoper M Peterson EL Nelson DA | | 0，，01： | 1 |
| 19 | Clq differentially modulates phagocytosis and cytokine responses during ingestion of apoptotic cells by human monocytes,macrophages,and dendritic cells显示文摘 | Fraser DA Laust AK Nelson EL | 2009 | J Immunol2009，183，10： | 1 |
| 20 | The accumulation of whole body skeletal mass in third-and fourth-grade children:affects of age,gender,ethnicity,and body composition显示文摘 | Nelson DA Simpson PM Johnson CC | 1997 | Bone1997，20，1： | 1 |
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