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| 1 | Epigenetic profiles of pre-diabetes transitioning to type 2 diabetes and nephropathy显示文摘AIM: To examine DNA methylation profiles in a longitudinal comparison of pre-diabetes mellitus(Pre-DM) subjects who transitioned to type 2 diabetes mellitus(T2DM).METHODS: We performed DNA methylation study in bisulphite converted DNA from Pre-DM(n = 11) at baseline and at their transition to T2 DM using Illumina Infinium Human Methylation27 Bead Chip, that enables the query of 27578 individual cytosines at Cp G loci throughout the genome, which are focused on the promoter regions of 14495 genes.RESULTS: There were 694 Cp G sites hypomethylated and 174 Cp G sites hypermethylated in progression from Pre-DM to T2 DM, representing putative genes involved in glucose and fructose metabolism, inflammation, oxidative and mitochondrial stress, and fatty acid metabolism. These results suggest that this high throughput platform is able to identify hundreds of prospective Cp G sites associated with diverse genes that may reflect differences in Pre-DM compared with T2 DM. In addition, there were Cp G hypomethylation changes associated with a number of genes that may be associated with development of complications of diabetes, such as nephropathy. These hypomethylation changes were observed in all of the subjects.CONCLUSION: These data suggest that some epigenomic changes that may be involved in the progression of diabetes and/or the development of complications may be apparent at the Pre-DM state or during the transition to diabetes. Hypomethylation of a number of genes related to kidney function may be an early marker for developing diabetic nephropathy. | Thomas A Vander Jagt Monica H Neugebauer Marilee Morgan Donald W Bowden Vallabh O Shah | 2015 | World Journal of Diabetes2015，6，9： | 5 |
| 2 | Heart Disease and Stroke Statistics—2006 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee显示文摘 | Thomas Thom Nancy Haase Wayne Rosamond Virginia J. Howard John Rumsfeld Teri Manolio Zhi-Jie Zheng Katherine Flegal Christopher O’Donnell Steven Kittner Donald Lloyd-Jones David C. Goff Yuling Hong Robert Adams Gary Friday Karen Furie Philip Gorelick Bret | 2006 | Circulation2006，，6： | 3 |
| 3 | Linaclotide Improves Abdominal Pain and Bowel Habits in a Phase IIb Study of Patients With Irritable Bowel Syndrome With Constipation显示文摘 | Jeffrey M. Johnston Caroline B. Kurtz James E. MacDougall Bernard J. Lavins Mark G. Currie Donald A. Fitch Chris O’Dea Mollie Baird Anthony J. Lembo | 2010 | Gastroenterology2010，，6： | 3 |
| 4 | A comparison of inflammation-based prognostic scores in patients with cancer. A Glasgow Inflammation Outcome Study显示文摘 | Michael J. Proctor David S. Morrison Dinesh Talwar Steven M. Balmer Colin D. Fletcher Denis St.J. O’Reilly Alan K. Foulis Paul G. Horgan Donald C. McMillan | 2011 | European Journal of Cancer2011，，17： | 2 |
| 5 | Gray-scale masks for diffractive-optics fabrication:Ⅱ Spatially filtered halftone screens 显示文摘 | DONALD C O WILLIE S R | 1995 | Appl Opt1995，34，32： | 2 |
| 6 | Gray-scale ma-sks for diffractive-optics fabrication:I Commercial slide imagers显示文摘 | Thomas J Suleski Donald C O'Shea | 1995 | Applied Optics1995，34，32： | 1 |
| 7 | Heart Disease and Stroke Statistics—2008 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee显示文摘 | Wayne Rosamond Katherine Flegal Karen Furie Alan Go Kurt Greenlund Nancy Haase Susan M. Hailpern Michael Ho Virginia Howard Brett Kissela Steven Kittner Donald Lloyd-Jones Mary McDermott James Meigs Claudia Moy Graham Nichol Christopher O’Donnell Veroniqu | 2008 | Circulation2008，，4： | 1 |
| 8 | Production of Boiling-Stable Granular Resistant Starch by Partial Acid Hydrolysis and Hydrothermal Treatments of High-Amylose Maize Starch显示文摘 | Jorge O Brumovsky Donald B Thompson | | Cereal chem0，78，6： | 1 |
| 9 | Reassessment of the unbound concentrations of unconjugated bilirubin in relation to neurotoxicity in vitro显示文摘 | Donald O Lorella P Claudio T | 2003 | Pediatr Res2003，54，： | 1 |
| 10 | Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles显示文摘 | Donald E O Nicholas A P | 2006 | Int J Pharm2006，307，1： | 1 |
| 11 | Prehospital thrombolysis of amassive pulmonary embolus 显示文摘 | Perkins ZB Mitchell C Donald O | 2008 | Emerg Med J2008，25，5： | 1 |
| 12 | Extracellular Matrix-Associated Serine Protease Inhibitors ( M r 33,000, 31,000, and 27,000) Are Single-Gene Products with Differential Glycosylation: cDNA Cloning of the 33-kDa Inhibitor Reveals Its Identity to Tissue Factor Pathway Inhibitor-2显示文摘 | C.N. Rao Prasad Reddy Yueying Liu Edel O’toole Dennis Reeder Donald C. Foster Walter Kisiel David T. Woodley | 1996 | Archives of Biochemistry and Biophysics1996，，1： | 1 |
| 13 | The Barley stripe mosaic virus gamma b gene encodes a multifunctional cysteine-rich protein that affects pathogenesis显示文摘 | Donald R G Jackson A O | 1994 | Plant Cell1994，6，11： | 1 |
| 14 | Information Behavior显示文摘 | DONALD C O | 2006 | Annual Review of In- formation Science and Technology2006，40，1： | 1 |
| 15 | Hepatic toxi- city during chemotherapy for severe tuberculosis meningitis 显示文摘 | DONALD P R SCHOEMAN J F O'KENNEDY A | 1987 | Am J Dis Child1987，141，7： | 1 |
| 16 | Biochemical and biological properties of staphylococcal enterotoxin K显示文摘 | PAUL M O DONALD Y LEUNG M | | 0，，： | 1 |
| 17 | Wood versus concrete and steel in house construction--a life cycle assessment 显示文摘 | Joanna G Donald O W Timothy A G | 2002 | Journal of Forestry2002，100，8： | 1 |
| 18 | Specific human capital : an application to quit rates and layoff rates 显示文摘 | Parsons Donald O | 1972 | Journal of Political Economy1972，80，6： | 1 |
| 19 | 2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction显示文摘 | Patrick T. O’Gara Frederick G. Kushner Deborah D. Ascheim Donald E. Casey Mina K. Chung James A. de Lemos Steven M. Ettinger James C. Fang Francis M. Fesmire Barry A. Franklin Christopher B. Granger Harlan M. Krumholz Jane A. Linderbaum David A. Morrow L. | 2013 | Journal of the American College of Cardiology2013，，： | 1 |
| 20 | Electrophilic C-H activation at fCp* Ix}: Ancillary- ligand control of the mechanism of CH activation显示文摘 | DAVIES D L DONALD S M AL- DUAIJ O | 2006 | Journal of the American Chemistry Society2006，128，13： | 1 |
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