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| 1 | γ-secretase inhibitor DAPT prevents neuronal death and memory impairment in sepsis associated encephalopathy in septic rats显示文摘 | Huang Man Liu chunhui Hu Yueyu Wang Pengfei Ding Meiping | 2014 | Chinese Medical Journal2014，，5： | 12 |
| 2 | Diluted ferromagnetic semiconductor(LaCa)(ZnMn)SbO isostructural to “1111” type iron pnictide superconductors显示文摘We report discovery of ferromagnetism in(LaCa)(ZnMn)SbO isostructural to the well-studied iron-based superconductor LaFeAs(O1 xFx).Spin is induced by partial substitution of Mn2+for Zn2+,while charge is induced by substitution of Ca2+for La3+within the parent compound LaZnSbO.Ferromagnetism with Curie temperature(TC)is observed up to 40 K at the spin doping 0.15 by introducing Mn2+into the Zn2+sites for(La0.95Ca0.05)(Zn1 xMnx)SbO.The Hall coefficient measurement indicates p-type carrier for(La0.95Ca0.05)(Zn0.9Mn0.1)SbO with concentration of n^1020cm 3showing anomalous Hall effect below TC. | HAN Wei ZHAO Kan WANG XianCheng LIU QingQing NING FanLong DENG Zheng LIU Ying ZHU JinLong DING Cui MAN HuiYuan JIN ChangQing | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，11： | 8 |
| 3 | Surface free energy of copper-zinc alloy for energy-saving of boiler显示文摘Cu-Zn, Cu-Zn-Sn, Cu-Zn-Ni alloys were melted by vacuum smelter. The effect factors to the surface free energy of the alloys such as chemical composition, crystal structure and surface crystal lattice distortion etc. were investigated by OCA30 automatic contact angle test instrument, metallography microscope and XRD instrument etc. Results suggests: adding alloy element to Cu may increase its surface free energy, and the more kinds of alloy elements are added, the more surface free energy increases; the alloy element Sn an increase the surface free energy of Cu-Zn alloy; Cu-Zn alloy with fir-tree crystal structure, great phase discrepancy and obvious composition aliquation has greater surface free energy; Cu-Zn alloy with compounds and serious surface crystal lattice distortion has greater surface free energy. | WANG Man LIANG Jinsheng TANG Qingguo MING Xing MENG Junping DING Yan | 2006 | Rare Metals2006，25，z1： | 6 |
| 4 | Understanding the impact of mountain landscapes on water balance in the upper Heihe River watershed in northwestern China显示文摘Estimating the impact of mountain landscape on hydrology or water balance is essential for the sustainable development strategies of water resources.Specifically,understanding how the change of each landscape influences hydrological components will greatly improve the predictability of hydrological responses to mountain landscape changes and thus can help the government make sounder decisions.In the paper,we used the VIC(Variable Infiltration Capacity)model to conduct hydrological modeling in the upper Heihe River watershed,along with a frozen-soil module and a glacier melting module to improve the simulation.The improved model performed satisfactorily.We concluded that there are differences in the runoff generation of mountain landscape both in space and time.About 50% of the total runoff at the catchment outlet were generated in mid-mountain zone(2,900-4,000 m asl),and water was mainly consumed in low mountain region(1,700-2,900 m asl)because of the higher requirements of trees and grasses.The runoff coefficient was 0.37 in the upper Heihe River watershed.Barren landscape produced the largest runoff yields(52.46% of the total runoff)in the upper Heihe River watershed,followed by grassland(34.15%),shrub(9.02%),glacier(3.57%),and forest(0.49%).In order to simulate the impact of landscape change on hydrological components,three landscape change scenarios were designed in the study.Scenario 1,2 and 3 were to convert all shady slope landscapes at 2,000-3,300 m,2,000-3,700 m,and 2,000-4,000 m asl respectively to forest lands,with forest coverage rate increased to 12.4%,28.5% and 42.0%,respectively.The runoff at the catchment outlet correspondingly declined by 3.5%,13.1% and 24.2% under the three scenarios.The forest landscape is very important in water conservation as it reduced the flood peak and increased the base flow.The mountains as 'water towers' play important roles in water resources generation and the impact of mountain landscapes on hydrology is significant. | Jia QIN YongJian DING JinKui WU MingJie GAO ShuHua YI ChuanCheng ZHAO BaiSheng YE Man LI ShengXia WANG | 2013 | Journal of Arid Land2013，5，3： | 6 |
| 5 | Malnutrition in Relation with Dietary, Geographical, and Socioeconomic Factors among Older Chinese显示文摘Objective Nutrition is closely related to the health of the elderly population. This study aimed to provide a comprehensive picture of the nutrition status of elderly Chinese and its related dietary,geographical, and socioeconomic factors.Methods A total of 13,987 ≥ 60-year-old persons from the 2010–2013 Chinese National Nutrition and Health Survey were included to evaluate various aspects of malnutrition, including underweight,overweight or obesity, and micronutrient inadequacy.Results Overall, the prevalence of obesity, overweight, and underweight was 12.4%, 34.8%, and 5.7%,respectively, with disparities both geographically and socioeconomically. The prevalence of underweight was higher among the older old(≥ 75 years), rural residents and those with low income, with low education status, and residing in undeveloped West areas. More than 75% of the elderly do not meet the Dietary Reference Intakes for vitamins A, B1, B2, and E, folate, calcium, selenium, potassium, biotin,and choline, with the prevalence of inadequate intake increasing with age for most nutrients. At the population level, the mean intakes of numerous food groups did not meet the recommendations by the Chinese Dietary Guideline.Conclusions Obesity epidemic, inadequacy of micronutrient intake, and high prevalence of underweight and anemia in susceptible older people are the major nutrition challenges for the rapidly aging population in China. | ZHANG Jian SONG Peng Kun ZHAO Li Yun SUN Ye YU Kai YIN Jing PANG Shao Jie LIU Zhen MAN Qing Qing HE Li LI Cheng ARIGONI Fabrizio BOSCO Nabil DING Gang Qiang ZHAO Wen Hua | 2021 | Biomedical and Environmental Sciences2021，34，5： | 5 |
| 6 | Comparison of the oncological,perioperative and functional outcomes of partial nephrectomy versus radical nephrectomy for clinical T1b renal cell carcinoma:A systematic review and metaanalysis of retrospective studies显示文摘Objective:To conduct a meta-analysis assessing the perioperative,functional and oncological outcomes of partial nephrectomy(PN)and radical nephrectomy(RN)for T1b tumours.The primary endpoints were the oncological outcomes.The secondary endpoints were the perioperative and functional outcomes.Methods:A systematic literature review was performed by searching multiple databases through February 2019 to identify eligible comparative studies according to the Preferred Reporting Items for Systematic Review and Meta-analysis statement.Identified reports were assessed according to the Newcastle-Ottawa Scale for nonrandomized controlled trials.Results:Overall,13 retrospective cohort studies were included in the analysis.Patients undergoing PN were younger(weighted mean difference[WMD]3.49 years,95%confidence interval[CI]5.16 to1.82;p<0.0001)and had smaller masses(WMD0.45 cm,95%CI0.59 to0.31;p<0.0001).There were no differences in the oncological outcome,which was demonstrated by progression-free survival(hazard ratio[HR]0.70;pZ0.22),cancerspecific mortality(HR 0.91;pZ0.57)and all-cause mortality(HR 1.01;pZ0.96).The two procedures were similar in estimated blood loss(WMD16.47 mL;pZ0.53)and postoperative complications(risk ratio[RR]1.32;pZ0.10),and PN provided better renal function preservation and was related to a lower likelihood of chronic kidney disease onset(RR 0.38;pZ0.006).Conclusion:PN is an effective treatment for T1b tumours because it offers similar surgical morbidity,equivalent cancer control,and better renal preservation compared to RN. | Yucong Zhang Gongwei Long Haojie Shang Beichen Ding Guoliang Sun Wei Ouyang Man Liu Yuan Chen Heng Li Hua Xu Zhangqun Ye | 2021 | Asian Journal of Urology2021，8，1： | 4 |
| 7 | 细胞应激和氧化还原活性蛋白参与硫氧还蛋白-1高表达幽门螺杆菌感染所致胃黏膜的癌变(英文)显示文摘目的:探索高表达硫氧还蛋白-1(Trx1)的幽门螺杆菌在致胃黏膜癌变过程中的作用机制。创新点:首次分析临床分离菌株感染蒙古沙土鼠的胃黏膜疾病动物模型,首次对不同菌株感染所致的胃黏膜癌变相关分子机制进行探索。方法:用同位素标记相对和绝对定量(i TRAQ)蛋白质组学及生物信息学分析方法进行分析,并用免疫印迹法(Western blot)对重要分子进行验证。结论:高表达Trx1的幽门螺杆菌在致胃黏膜癌变过程中,三个重要的细胞应激和氧化还原活性蛋白包括14-3-3α/β、谷胱甘肽转移酶(GST)和热休克蛋白(HSP70)参与致病。 | Yan-yan SHI Jing ZHANG Ting ZHANG Man ZHOU Ye WANG He-jun ZHANG Shi-gang DING | 2018 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2018，19，10： | 4 |
| 8 | UBE2S interacting with TRIM28 in the nucleus accelerates cell cycle by ubiquitination of p27 to promote hepatocellular carcinoma development显示文摘Genomic sequencing analysis of tumors provides potential molecular therapeutic targets for precision medicine.However,identifying a key driver gene or mutation that can be used for hepatocellular carcinoma(HCC)treatment remains difficult.Here,we performed whole-exome sequencing on genomic DNA obtained from six pairs of HCC and adjacent tissues and identified two novel somatic mutations of UBE2S(p.Gly57Ala and p.Lys63Asn).Predictions of the functional effects of the mutations showed that two amino-acid substitutions were potentially deleterious.Further,we observed that wild-type UBE2S,especially in the nucleus,was significantly higher in HCC tissues than that in adjacent tissues and closely related to the clinicopathological features of patients with HCC.Functional assays revealed that overexpression of UBE2S promoted the proliferation,invasion,metastasis,and G1/S phase transition of HCC cells in vitro,and promoted the tumor growth significantly in vivo.Mechanistically,UBE2S interacted with TR1M28 in the nucleus,both together enhanced the ubiquitination of p27 to facilitate its degradation and cell cycle progression.Most importantly,the small-molecule cephalomannine was found by a luciferase-based sensitive high-throughput screen(HTS)to inhibit UBE2S expression and significantly attenuate HCC progression in vitro and in vivo,which may represent a promising strategy for HCC therapy. | Ren-Yu Zhang Ze-Kun Liu Ding Wei Yu-Le Yong Peng Lin Hao Li Man Liu Nai-Shan Zheng Ke Liu Cai-Xia Hu Xiao-Zhen Yang Zhi-Nan Chen Huijie Bian | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 3 |
| 9 | Fusobacterium nucleatum enhances the efficacy of PD-L1 blockade in colorectal cancer显示文摘Given that only a subset of patients with colorectal cancer(CRC)benefit from immune checkpoint therapy,efforts are ongoing to identify markers that predict immunotherapeutic response.Increasing evidence suggests that microbes influence the efficacy of cancer therapies.Fusobacterium nucleatum induces different immune responses in CRC with different microsatellite-instability(MSI)statuses.Here,we investigated the effect of F.nucleatum on anti-PD-L1 therapy in CRC.We found that high F.nucleatum levels correlate with improved therapeutic responses to PD-1 blockade in patients with CRC.Additionally,F.nucleatum enhanced the antitumor effects of PD-L1 blockade on CRC in mice and prolonged survival.Combining F.nucleatum supplementation with immunotherapy rescued the therapeutic effects of PD-L1 blockade.Furthermore,F.nucleatum induced PD-L1 expression by activating STING signaling and increased the accumulation of interferon-gamma(IFN-γ)^(+)CD8^(+)tumor-infiltrating lymphocytes(TILs)during treatment with PD-L1 blockade,thereby augmenting tumor sensitivity to PD-L1 blockade.Finally,patient-derived organoid models demonstrated that increased F.nucleatum levels correlated with an improved therapeutic response to PD-L1 blockade.These findings suggest that F.nucleatum may modulate immune checkpoint therapy for CRC. | Yaohui Gao Dexi Bi Ruting Xie Man Li Jing Guo Hu Liu Xianling Guo Juemin Fang Tingting Ding Huiyuan Zhu Yuan Cao Meichun Xing Jiayi Zheng Qing Xu Qian Xu Qing Wei Huanlong Qin | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 3 |
| 10 | Chronic kidney disease and risks of adverse clinical events in patients with atrial fibrillation显示文摘BACKGROUND Chronic kidney disease(CKD)is highly prevalent in patients with atrial fibrillation(AF).However,the asso-ciation between CKD and clinical consequences in AF patients is still under debate.METHODS We included 19,079 nonvalvular AF patients with available estimated glomerular filtration rate(eGFR)values in the Chinese Atrial Fibrillation Registry from 2011 to 2018.Patients were classified into no CKD(eGFR≥90 mL/min per 1.73 m2),mild CKD(60≤eGFR<90 mL/min per 1.73 m2),moderate CKD(30≤eGFR<60 mL/min per 1.73 m2),and severe CKD(eGFR<30 mL/min per 1.73 m2)groups.The risks of thromboembolism,major bleeding,and cardiovascular mortality were estimated with Fine-Gray regression analysis according to CKD status.Cox regression was performed to assess the risk of all-cause mortal-ity associated with CKD.RESULTS Over a mean follow-up of 4.1±1.9 years,there were 985 thromboembolic events,414 major bleeding events,956 car-diovascular deaths,and 1,786 all-cause deaths.After multivariate adjustment,CKD was not an independent risk factor of throm-boembolic events.As compared to patients with no CKD,those with mild CKD,moderate CKD,and severe CKD had a 45%,47%,and 133%higher risk of major bleeding,respectively.There was a graded increased risk of cardiovascular mortality associated with CKD status compared with no CKD group:adjusted hazard ratio[HR]was 1.34(95%CI:1.07−1.68,P=0.011)for mild CKD group,2.17(95%CI:1.67−2.81,P<0.0001)for moderate CKD group,and 2.95(95%CI:1.97−4.41,P<0.0001)for severe CKD group,respectively.Risk of all-cause mortality also increased among patients with moderate or severe CKD.CONCLUSIONS CKD status was independently associated with progressively higher risks of major bleeding and mortality,but didn’t seem to be an independent predictor of thromboembolism in AF patients. | Si-Tong LI Chao JIANG Liu HE Qi-Fan LI Zuohan DING Jia-Hui WU Rong HU Qiang LV Xu LI Chang-Qi JIA Yan-Fei RUAN Man NING Li FENG Rong BAI Ri-Bo TANG Xin DU Jian-Zeng DONG Chang-Sheng MA | 2021 | Journal of Geriatric Cardiology2021，18，11： | 2 |
| 11 | Key Techniques and Applications of Adaptive Growth Method for Stiffener Layout Design of Plates and Shells显示文摘The application of the adaptive growth method is limited because several key techniques during the design process need manual intervention of designers.Key techniques of the method including the ground structure construction and seed selection are studied,so as to make it possible to improve the effectiveness and applicability of the adaptive growth method in stiffener layout design optimization of plates and shells.Three schemes of ground structures,which are comprised by different shell elements and beam elements,are proposed.It is found that the main stiffener layouts resulted from different ground structures are almost the same,but the ground structure comprised by 8-nodes shell elements and both 3-nodes and 2-nodes beam elements can result in clearest stiffener layout,and has good adaptability and low computational cost.An automatic seed selection approach is proposed,which is based on such selection rules that the seeds should be positioned on where the structural strain energy is great for the minimum compliance problem,and satisfy the dispersancy requirement.The adaptive growth method with the suggested key techniques is integrated into an ANSYS-based program,which provides a design tool for the stiffener layout design optimization of plates and shells.Typical design examples,including plate and shell structures to achieve minimum compliance and maximum bulking stability are illustrated.In addition,as a practical mechanical structural design example,the stiffener layout of an inlet structure for a large-scale electrostatic precipitator is also demonstrated.The design results show that the adaptive growth method integrated with the suggested key techniques can effectively and flexibly deal with stiffener layout design problem for plates and shells with complex geometrical shape and loading conditions to achieve various design objectives,thus it provides a new solution method for engineering structural topology design optimization. | DING Xiaohong JI Xuerong MA Man HOU Jianyun | 2013 | Chinese Journal of Mechanical Engineering2013，26，6： | 2 |
| 12 | Community dynamics of ammonia oxidizing bacteria in a fullscale wastewater treatment system with nitrification stability显示文摘To determine whether the functional stability of nitrification was correlated to a stable community structure of ammonia oxidizing bacteria(AOB)in a fullscale wastewater treatment plant,the AOB community dynamics in a wastewater treatment system was monitored over one year.The community dynamics were investigated using specific PCR followed by terminal restriction fragment length polymorphism(T-RFLP)analysis of the amoA gene.The T-RFLP results indicated that during the period of nitrification stability,the AOB community structure in the full-scale wastewater treatment system was relatively stable,and the average change rate every 15 d of the system was 6.6%±5.8%.The phylogenetic analysis of the cloned amoA gene showed clearly that the dominant AOB in the system was Nitrosomonas spp.The results of this study indicated that throughout the study period,the AOB community structure was relatively stable in the full-scale wastewater treatment system with functional stability of nitrification. | Xiaohui WANG Xianghua WEN Hengjing YAN Kun DING Man HU | 2011 | Frontiers of Environmental Science & Engineering2011，5，1： | 2 |
| 13 | EMC10 governs male fertility via maintaining sperm ion balance显示文摘Infertility is a severe public health problem worldwide that prevails up to 15% in reproductive-age couples,and male infertility accounts for half of total infertility.Studies on genetically modified animal models have identifed lots of genes involved in the pathogenesis of male infertility.The underlying causes,however,remain largely unclear.In this study,we provide evidence that EMCIO,one subunit of endoplasmic reticulum (ER)membrane protein complex (EMC),is required for male fertility.EMC10 is significantly decreased in spermatozoa from patients with asthenozoospermia and positively associated with human sperm motility. Male mice lacking Emc10 gene are completely sterile.Emc10-null spermatozoa exhibit multiple defects including abnormal morphology,decreased motility,impaired capacitation,and impotency of acrosome reaction,thereby which are incapable of fertilizing intact or ZP-free oocytes.However,intracytoplasmic sperm injection could rescue this defect caused by EMC10 deletion. Mechanistically,EMC10 deficiency leads to inactivation of Na/K-ATPase,in turn giving rise to an increased level of intraceltutar Na^+ in spermatozoa,which contributes to decreased sperm motility and abnormal morphology.Other mechanistic investigations demonstrate that the absence of EMC10 results in a reduction of HCO3^- entry and subsequent decreases of both cAMP-dependent protein kinase A substrate phosphorylation and protein tyrosine phosphorytation.These data demonstrate that EMC10 is indispensable to mate fertility via maintaining sperm ion balance of Na^+ and HCO3^-,and also suggest that EMC10 is a promising biomarker for male fertility and a potential pharmaceutical target to treat male infertility. | Yuchuan Zhou Fei Wu Man Zhang Zuquan Xiong Qianqian Yin Yanfei Ru Huijuan Shi Jinsong Li Shanhua Mao Yanliang Li Xinyi Cao Renming Hu Chong Wee Liew Qiang Ding Xuanchun Wang Yonglian Zhang | 2018 | Journal of Molecular Cell Biology2018，10，6： | 2 |
| 14 | Purple-bluish tongue is associated with platelet counts, and the recurrence of epithelial ovarian cancer显示文摘ObjectiveTo 评估在紫色带蓝色的舌头和血小板计数之间的关系,并且推进与 82 个上皮的卵巢的癌症病人全部的上皮的卵巢的 cancer.MethodsA 的复发检验他们的协会在这研究被注册。簇分析被用于组织 patients’P 红绿蓝 (Red-R;Green-G;Blue-B;红绿蓝的平均百分比, P 红绿蓝 ) 价值。接收装置操作特征(巨鸟) 曲线为检测紫色带蓝色的舌头的诊断标准被执行。2 测试被用来估计在紫色带蓝色的舌头和血小板之间的关系上皮的卵巢的癌症的计数,和复发。perioperative (外科手术前) 血小板水平是 examinedwith 舌头图象,疾病 recurrence.ResultsTongue 图象被分类进基于 P 由簇分析的图象的红绿蓝 价值。在簇 “1” 的盒子的数字(正常颜色舌头) 是 16 并且聚类 “2”(紫色带蓝色的舌头) 是 66。二组 P 红绿蓝 价值,由簇分析分类,显著地与基于视觉的舌头颜色识别被相关(Kappa = 0.852, P < 0.001 ) 。巨鸟曲线证明 P b 到 P r 有最高诊断的价值。敏感和 P b 到 P r 分别地是 95.3% 和 88.9% ,最佳的截止的点是 0.71。紫色带蓝色的舌头显著地与增加的血小板计数被相关(P < 0.001 ) 。两个都,增加的血小板数( P = 0.01 )并且紫色带蓝色的舌头与上皮的卵巢的癌症的复发被联系( P < 0.001 ) P b 到 P 当为紫色带蓝色的舌头诊断的指示物在症状模式使用了,比 0.71 大的 r 能服务在繁体中文药的鉴定。紫色带蓝色的舌头,与增加的血小板计数联系了,密切也与上皮的卵巢的癌症的复发被相关。 | Hao Jian Zhu Cuihong Cao Rui Yang Xue Ding Xiuli Man Yanan Wu Xiongzhi | 2016 | Journal of Traditional Chinese Medicine2016，36，3： | 2 |
| 15 | Novel high-speed electromagnetic actuator with permanent-magnet shielding for high-pressure applications显示文摘 | Man Jun Ding Fan Li Qipeng | 2010 | IEEE Transactions on Magnetics2010，46，12： | 1 |
| 16 | Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory 显示文摘 | Takamiya K Han JS Man H Kim CH Rumbaugh G Yu S Ding L He C Petralia RS Wenthold RJ Gallagher M Huganir RL | 2003 | Cell2003，112，5： | 1 |
| 17 | Theoretical analysis and experiment of micromechanics and mechanics-optics coupling of distributed optic-fiber crack sensing显示文摘The micromechanical behaviors and mechanics-optics coupling effects of optic-fiber-concrete complex in the distributed optic-fiber sensing concrete-crack technology,which was used in health monitoring of Wu Gorge Bridge on Yangtze River and a large dam successfully,have been investigated.A micromechanical theoretical analysis method and micromechanical frictional contact bi-interface model,as well as a modified optical theoretical analysis method of the mechanics-optics coupling effects are presented.A series of verification experiments,including mechanical experiments and mechanics-optics coupling experiments,have been preformed.The results of micromechanical theoretical analysis and the analysis of the modified theory of mechanics-optics coupling along with mechanical and optical experimental data are shown to be in close agreement.Both the micromechanical theory and the modified theory of mechanics-optics coupling with their analysis methods can not only enhance credibility of this novel distributed sensing technology but also provide a way to understand its sensing mechanism and optimize its technical details and system. | LIU HaoWu 1,2,CHEN Jiang 2,SUN Man 3 & DING Rui 2 1 State Key Laboratory of Hydraulics and Mountain River Engineering,Sichuan University,Chengdu 610065,China 2 School of Water Resource Hydropower,Sichuan University,Chengdu 610065,China 3 School Electrical Engineering and Information,Sichuan University,Chengdu 610065,China | 2011 | Science China(Technological Sciences)2011，54，S1： | 1 |
| 18 | Prussian blue and collagen loaded chitosan nanofibers with NIR-controlled NO release and photothermal activities for wound healing显示文摘Nitric oxide(NO)has emerged as a potential wound therapeutic agent due to its pivotal role in the wound healing processes.Nevertheless,NO-based therapy for clinical applications is still restricted due to its gaseous state and short half-life.Here we exploited a wound dressing by incorporating sodium nitroprusside doped prussian blue nanoparticals and Type I collagen into the chitosan/poly(vinyl alcohol)nanofibers through the electrospinning method.This hybrid nanofibrous scaffold possess the excellent abilities of NIR controlled NO release,photothermal therapy,and imitation of extra-cellular matrix-like architecture.These synergistic effects could enhance their anti-bactericidal effects in vitro and furthermore accelerate wound healing in vivo when compared to control groups.Histological analysis demonstrated the scaffold could promote fibroblast growth and accelerate epithelialization.Moreover,no apparent histological toxicology and negligible damage to major organs were observed,which provided sufficient biosafety for in vivo application.These data indicate the fabricated hybrid nanofibrous scaffold could be used as an ideal candidate for accelerating wound healing and treating chronic wounds. | Wenyu Wang Dejun Ding Kunpeng Zhou Man Zhang Weifen Zhang Fang Yan Ni Cheng | 2021 | Journal of Materials Science & Technology2021，，34： | 1 |
| 19 | Evaluation of right-to-left shunt on contrast-enhanced transcranial Doppler in patent foramen ovale-related cryptogenic stroke: Research based on imaging显示文摘BACKGROUND Cardiogenic embolism caused by patent foramen ovale(PFO)is a common etiology of cryptogenic stroke(CS),particularly in young and middle-aged patients.Studies about right-to-left shunt(RLS)detection using contrast-enhanced transcranial Doppler(c-TCD)are numerous.According to the time phase and number of microbubbles detected on c-TCD,RLS can be classified and graded.We hypothesized that the characteristics of an infarction lesion on diffusion-weighted imaging differs when combining the type and grade of RLS on c-TCD in patients with PFO-related CS.AIM To explore the characteristics of infarction lesions on diffusion-weighted imaging when combining the RLS type and grade determined by c-TCD.METHODS We retrospectively evaluated CS patients from August 2015 to December 2019 at a tertiary hospital.In total,111 PFO-related CS patients were divided according to whether RLS was permanent(microbubbles detected both at resting state and after the Valsalva maneuver)or latent(microbubbles detected only after the Valsalva maneuver)on c-TCD.Each group was subdivided into small,mild and large RLS according to the grade of shunt on c-TCD.A normal control group was composed of 33 patients who suffered from simple dizziness.Intragroup and intergroup differences were analyzed in terms of clinical,laboratory and diffusion-weighted imaging lesion characteristics.The correlation between RLS grade evaluated by c-TCD and size of PFO determined by transesophageal echocardiography were also analyzed.RESULTS In 111 patients with PFO-related CS,68 had permanent RLS and 43 had latent RLS.Clinical characteristics and laboratory tests were not significantly different among the permanent RLS,latent RLS and normal control groups.The proportion of patients with multiple territory lesions in the permanent RLS group(50%)was larger than that in the latent RLS group(27.91%;P=0.021).Posterior circulation was more likely to be affected in the latent RLS group than in the permanent RLS group(30.23%vs 8.82%,P=0.004).Permanent-large and latent-large RLS were both more likely to be related to multiple(P_(trend)=0.017 and 0.009,respectively),small(P_(trend)=0.035 and 0.006,respectively)and cortical(P_(trend)=0.031 and 0.033,respectively)lesions.The grade of RLS evaluated by c-TCD was correlated to the size of PFO determined by transesophageal echocardiography(r=0.758,P<0.001).CONCLUSION Distribution of the infarct suggested the possible type of RLS.Multiple,small and cortical infarcts suggest large RLS induced by a large PFO. | Lei Xiao Yan-Hong Yan Ya-Fang Ding Man Liu Li-Juan Kong Chun-Hong Hu Pin-Jing Hui | 2022 | World Journal of Clinical Cases2022，10，1： | 1 |
| 20 | Research on Edge Detection of Gray-scale Image Based on Mathematical Morphology Algorithm and Rough Sets显示文摘 | DING Li MAN Chongzhao | 2008 | IEEE Computer Science2008，，60： | 1 |
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