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| 1 | Acute cerebrovascular disease following COVID-19: a single center, retrospective, observational study显示文摘Background and purpose COVID-19 is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2).Apart from respiratory complications,acute cerebrovascular disease(CVD)has been observed in some patients with COVID-19.Therefore,we described the clinical characteristics,laboratory features,treatment and outcomes of CVD complicating SARS-CoV-2 infection.Materials and methods Demographic and clinical characteristics,laboratory findings,treatments and clinical outcomes were collected and analysed.Clinical characteristics and laboratory findings of patients with COVID-19 with or without new-onset CVD were compared.Results Of 219 patients with COVID-19,10(4.6%)developed acute ischaemic stroke and 1(0.5%)had intracerebral haemorrhage.COVID-19 with new onset of CVD were significantly older(75.7±10.8 years vs 52.1±15.3 years,p<0.001),more likely to present with severe COVID-19(81.8%vs 39.9%,p<0.01)and were more likely to have cardiovascular risk factors,including hypertension,diabetes and medical history of CVD(all p<0.05).In addition,they were more likely to have increased inflammatory response and hypercoagulable state as reflected in C reactive protein(51.1(1.3-127.9)vs 12.1(0.1-212.0)mg/L,p<0.05)and D-dimer(6.9(0.3-20.0)vs 0.5(0.1-20.0)mg/L,p<0.001).Of 10 patients with ischemic stroke;6 received antiplatelet treatment with aspirin or clopidogrel;and 3 of them died.The other four patients received anticoagulant treatment with enoxaparin and 2 of them died.As of 24 March 2020,six patients with CVD died(54.5%).Conclusion Acute CVD is not uncommon in COVID-19.Our findings suggest that older patients with risk factors are more likely to develop CVD.The development of CVD is an important negative prognostic factor which requires further study to identify optimal management strategy to combat the COVID-19 outbreak. | Yanan Li Man Li Mengdie Wang Yifan Zhou Jiang Chang Ying Xian David Wang Ling Mao Huijuan Jin Bo Hu | 2020 | Stroke & Vascular Neurology2020，5，3： | 22 |
| 2 | Consensus for prevention and management of coronavirus disease 2019 (COVID-19) for neurologists显示文摘Coronavirus disease 2019(COVID‐19)has become a pandemic disease globally.Although COVID-19 directly invades lungs,it also involves the nervous system.Therefore,patients with nervous system involvement as the presenting symptoms in the early stage of infection may easily be misdiagnosed and their treatment delayed.They become silent contagious sources or‘virus spreaders’.In order to help neurologists to better understand the occurrence,development and prognosis,we have developed this consensus of prevention and management of COVID‐19.It can also assist other healthcare providers to be familiar with and recognise COVID-19 in their evaluation of patients in the clinic and hospital environment. | Huijuan Jin Candong Hong Shengcai Chen Yifan Zhou Yong Wang Ling Mao Yanan Li Quanwei He Man Li Ying Su David Wang Longde Wang Bo Hu | 2020 | Stroke & Vascular Neurology2020，5，2： | 3 |
| 3 | Purple-bluish tongue is associated with platelet counts, and the recurrence of epithelial ovarian cancer显示文摘ObjectiveTo 评估在紫色带蓝色的舌头和血小板计数之间的关系,并且推进与 82 个上皮的卵巢的癌症病人全部的上皮的卵巢的 cancer.MethodsA 的复发检验他们的协会在这研究被注册。簇分析被用于组织 patients’P 红绿蓝 (Red-R;Green-G;Blue-B;红绿蓝的平均百分比, P 红绿蓝 ) 价值。接收装置操作特征(巨鸟) 曲线为检测紫色带蓝色的舌头的诊断标准被执行。2 测试被用来估计在紫色带蓝色的舌头和血小板之间的关系上皮的卵巢的癌症的计数,和复发。perioperative (外科手术前) 血小板水平是 examinedwith 舌头图象,疾病 recurrence.ResultsTongue 图象被分类进基于 P 由簇分析的图象的红绿蓝 价值。在簇 “1” 的盒子的数字(正常颜色舌头) 是 16 并且聚类 “2”(紫色带蓝色的舌头) 是 66。二组 P 红绿蓝 价值,由簇分析分类,显著地与基于视觉的舌头颜色识别被相关(Kappa = 0.852, P < 0.001 ) 。巨鸟曲线证明 P b 到 P r 有最高诊断的价值。敏感和 P b 到 P r 分别地是 95.3% 和 88.9% ,最佳的截止的点是 0.71。紫色带蓝色的舌头显著地与增加的血小板计数被相关(P < 0.001 ) 。两个都,增加的血小板数( P = 0.01 )并且紫色带蓝色的舌头与上皮的卵巢的癌症的复发被联系( P < 0.001 ) P b 到 P 当为紫色带蓝色的舌头诊断的指示物在症状模式使用了,比 0.71 大的 r 能服务在繁体中文药的鉴定。紫色带蓝色的舌头,与增加的血小板计数联系了,密切也与上皮的卵巢的癌症的复发被相关。 | Hao Jian Zhu Cuihong Cao Rui Yang Xue Ding Xiuli Man Yanan Wu Xiongzhi | 2016 | Journal of Traditional Chinese Medicine2016，36，3： | 2 |
| 4 | Chromatin architectural alterations due to null mutation of a major CG methylase in rice显示文摘Associations between 3D chromatin architectures and epigenetic modifications have been characterized in animals.However,any impact of DNA methylation on chromatin architecture in plants is understudied,which is confined to Arabidopsis thaliana.Because plant species differ in genome size,composition,and overall chromatin packing,it is unclear to what extent findings from A.thaliana hold in other species.Moreover,the incomplete chromatin architectural profiles and the low-resolution high-throughput chromosome conformation capture(Hi-C)data from A.thaliana have hampered characterizing its subtle chromatin structures and their associations with DNA methylation.We constructed a high-resolution Hi-C interaction map for the null OsMET1-2(the major CG methyltransferase in rice)mutant(osmet1-2)and isogenic wild-type rice(WT).Chromatin structural changes occurred in osmetl-2,including intra-/inter-chromosomal interactions,compartment transition,and topologically associated domains(TAD)variations.Our findings provide novel insights into the potential function of DNA methylation in TAD formation in rice and confirmed DNA methylation plays similar essential roles in chromatin packing in A,thaliana and rice. | Jinbin Wang Xiaochong Li Qianli Dong Changping Li Juzuo Li Ning Li Baoxu Ding Xiaofei Wang Yanan Yu Tianya Wang Zhibin Zhang Yiyang Yu Man Lang Zixian Zeng Bao Liu Lei Gong | 2022 | Journal of Integrative Plant Biology2022，64，12： | 0 |
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