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| 1 | Dual Functions of Microglia in Ischemic Stroke显示文摘Ischemic stroke is a leading cause of morbidity and mortality worldwide. Resident microglia are the principal immune cells of the brain, and the first to respond to the pathophysiological changes induced by ischemic stroke. Traditionally, it has been thought that microglial activation is deleterious in ischemic stroke, and therapies to suppress it have been intensively explored. However,increasing evidence suggests that microglial activation is also critical for neurogenesis, angiogenesis, and synaptic remodeling, thereby promoting functional recovery after cerebral ischemia. Here, we comprehensively review the dual role of microglia during the different phases of ischemic stroke, and the possible mechanisms controlling the post-ischemic activity of microglia. In addition, we discuss the dynamic interactions between microglia and other cells, such as neurons, astrocytes, oligodendrocytes,and endothelial cells within the brain parenchyma and the neurovascular unit. | Chuan Qin Luo-Qi Zhou Xiao-Tong Ma Zi-Wei Hu Sheng Yang Man Chen Dale B. Bosco Long-Jun Wu Dai-Shi Tian | 2019 | Neuroscience Bulletin2019，35，5： | 64 |
| 2 | Near-diffraction-limited linearly polarized narrow-linewidth random fiber laser with record kilowatt output显示文摘In this paper, we propose and experimentally investigate a linearly polarized narrow-linewidth random fiber laser(RFL) operating at 1080 nm and boost the output power to kilowatt level with near-diffraction-limited beam quality using a master oscillation power amplifier. The RFL based on a half-opened cavity, which is composed of a linearly polarized narrow-linewidth fiber Bragg grating and a 500 m piece of polarization-maintained Ge-doped fiber, generates a 0.71 W seed laser with an 88 pm full width at half-maximum(FWHM) linewidth and a 22.5 dB polarization extinction ratio(PER) for power scaling. A two-stage fiber amplifier enhances the seed laser to the maximal 1.01 k W with a PER value of 17 dB and a beam quality of M_x^2=1.15 and M_y^2=1.13. No stimulated Brillouin scattering effect is observed at the ultimate power level, and the FWHM linewidth of the amplified random laser broadens linearly as a function of the output power with a coefficient of about 0.1237 pm∕W.To the best of our knowledge, this is the first demonstration of a linearly polarized narrow-linewidth RFL with even kilowatt-level near-diffraction-limited output, and further performance scaling is ongoing. | JIANGMING XU LONG HUANG MAN JIANG JUN YE PENGFEI MA JINYONG LENG JIAN WU HANWEI ZHANG PU ZHOU | 2017 | Photonics Research2017，5，4： | 20 |
| 3 | First experimental demonstration of coherent beam combining of more than 100 beams显示文摘Coherent beam combining of 107 beams has been demonstrated for the first time to the best of our knowledge.When the system was in closed loop,the pattern in far-field was stable and the fringe contrast was>96%.The impact of the dynamic tilt error,the piston error,and power inconsistency was theoretically analyzed.Meanwhile,the distribution law of dynamic tilt error was estimated and the correlation of the tilt dithering of different axis was analyzed statistically.The ratio of power in the central lobe was^22.5%.The phase residue error in the closed loop was~λ∕22,which was evaluated by the root-mean-square error of the signal generated from the photoelectric detector. | HONGXIANG CHANG QI CHANG JIACHAO XI TIANYUE HOU RONGTAO SU PENGFEI MA JIAN WUCAN LI MAN JIANG YANXING MA PU ZHOU | 2020 | Photonics Research2020，8，12： | 17 |
| 4 | A PP2C-1 Allele Underlying a Quantitative Trait Locus Enhances Soybean l O0-Seed Weight显示文摘栽培大豆可以在驯服期间失去某有用基因 loci。从野大豆的基因的基因渗入能拓宽基因背景并且改进大豆农学的特点。在这研究,通过 recombinant 的整个染色体的定序,生来的线人口源于在野大豆 ZYD7 和栽培大豆 HN44 之间的一个十字,并且为种子重量量的特点 loci 印射,我们发现从野大豆 ZYD7 的磷酸酶 2C-1 ( PP2C-1 )等位基因在种子重量/尺寸贡献增加。PP2C-1 可以由提高覆盖物的房间尺寸并且激活一个子集完成这功能播种特点相关的基因。我们发现 PP2C-1 与 GmBZR1 被联系, Arabidopsis BZR1 的大豆 ortholog,之一在发信号的 brassinosteroid (BR ) 给抄写因素调音,并且便于 dephosphorylated GmBZR1 的累积。相反,有在 N 终点的一些氨基酸的变化的 PP2C-2 等位基因没展出这功能。而且,我们证明 GmBZR1 能在转基因的植物支持种子重量 / 尺寸。通过栽培大豆就职的分析,我们发现 40% 检验就职没有 PP2C-1 等位基因,建议这些就职能被这等位基因的介绍改进。一起拿,我们的学习识别精英等位基因 PP2C-1,它能在由分子帮助繁殖的这等位基因的那操作可以增加的大豆,和针尖提高种子重量或尺寸在大豆的生产和另外的荚 / 庄稼。 | Xiang Lu Qing Xiong Tong Cheng Qing-Tian Li Xin-Lei Liu Ying-Dong Bi Wei Li Wan-Ke Zhang Biao Ma Yong-Cai Lai Wei-Guang Du Wei-Qun Man Shou-Yi Chen Jin-Song Zhang | 2017 | Molecular Plant2017，10，5： | 17 |
| 5 | A rapid method for chemical fingerprint analysis of Panax notoginseng powders by ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry显示文摘A method coupling ultra-performance liquid chromatography(UPLC) with quadrupole time-of-flight mass spectrometer(Qtof MS) using the electrospray ionization(ESI) source was developed for the identification of the major saponins from Panax notoginseng powder(PNP). Ten different PNP samples were analyzed and evaluated for their quality by similarity evaluation and principle component analysis(PCA). Based on the accurate mass, summarized characteristic fragmentation behaviors, retention times of different types of saponins, related botanical biogenesis, and reported chromatographic behavior of saponins, fifty-one common peaks were effectively separated and identified, including 28 protopanaxadiol saponins and 18 protopanaxatriol saponins. Simultaneously, 15 significant discrepancy compounds were identified from the disqualified PNP samples. The established UPLC/Qtof MS fingerprint method was successfully applied for profiling and identifying the major saponins of PNP, providing a fast quality evaluation tool for distinguishing the authentic PNP and the adulterated products. | LIU Peng YU He-Shui ZHANG Li-Juan SONG Xin-Bo KANG Li-Ping LIU Jing-Yuan ZHANG Jie CAO Man YU Kate KANG Ting-Guo MA Bai-Ping | 2015 | Chinese Journal of Natural Medicines2015，13，6： | 13 |
| 6 | The effects of microRNA-34a regulating Notch-1/NF-κB signaling pathway on lipopolysaccharide-induced human umbilical vein endothelial cells显示文摘BACKGROUND: Notch-1/NF-κB signaling plays a key role in the cecal ligation and puncture(CLP)-induced sepsis. This study aims to investigate the intervention effects of microRNA-34a(miR-34a) lentivirus regulating Notch-1/NF-κB signaling pathway on lipopolysaccharide(LPS)-induced human umbilical vein endothelial cells(HUVEC).METHODS: HUVEC were divided into four groups as the following: they were infected with negative control lentivirus(NC group) or miR-34a lentivirus(OE group); LPS(1 g/mL) was added on the third day on the basis of NC group and OE group for 24 hours(NC+LPS group or OE+LPS group). The levels of TNF-α, IL-1β, IL-6, and IL-10 in the cell supernatants, and the mRNA and protein expression of Notch-1 and NF-κB in the HUVEC were evaluated.RESULTS: After 24 hours, the levels of TNF-α, IL-1β, IL-6 in the cell supernatants and the protein expression of NF-κB from NC+LPS group were significantly higher than those of NC group, but IL-10 level and the protein expression of Notch-1 in NC+LPS group were the opposite. After intervention of miR-34a lentivirus, the cell supernatants TNF-α and the protein expression of NF-κB in OE+LPS group after 24 hours markedly decreased compared to NC+LPS group. While the cell supernatants IL-1β and IL-6 and the mRNA expression of NF-κB slightly decreased in OE+LPS group, IL-10 and the mRNA and protein expression of Notch-1 were the opposite.CONCLUSION: miR-34a regulating Notch-1/NF-κB signaling pathway can reduce the HUVEC damage caused by LPS stimulation. | Yun Ge Man Huang Yue-feng Ma | 2017 | World Journal of Emergency Medicine2017，8，4： | 13 |
| 7 | Dicer1/miR-29/HMGCR axis contributes to hepatic free cholesterol accumulation in mouse non- alcoholic steatohepatitis显示文摘Dicer1 是为 microRNA (miRNA ) 的酶必需品成熟。miRNAs 的损失源于 Dicer1 缺乏极大地贡献许多疾病的前进,包括在在非酒精的 steatohepatitis (NASH ) 的发展是批评的免费胆固醇(FC ) 的肝的累积的类脂化合物 dysregulation,而是它的角色遗体逃犯。在这研究,我们使用了肝特定的 Dicer1 大美人老鼠识别涉及肝的 FC 累积的 miRNAs。在一个广泛地使用的饮食的 NASH 模型,老鼠被喂 methionine-choline-deficient (MCD ) 节食 3 个星期,它在肝象 Dicer1 mRNA 层次的减少一样导致了肝的 FC 层次的重要增加。肝特定的 Dicer1 大美人在 5-6 星期导致了肝的 FC 累积,由增加的 mRNA 和 3-hydroxy-3-methylglutaryl 辅酶的蛋白质层次伴随了 reductase (HMGCR ) ,在肝的胆固醇合成的限制率的酶。十一预言 miRNAs 被屏蔽,表明 miR-29a/b/c 显著地压制了由指向 HMGCR mRNA 3-UTR 的 HMGCR 表示。在 SMMC-7721 房间的 miR-29a 的 Overexpression,脂肪变性肝的房间模型,显著地减少的 HMGCR 表示和 FC 铺平。而且, miR-29a 的表达式层次相反地与在 MCD 食谱鼠标的表达式层次在 vitro 在 vivo 并且在肝的房间建模的 2 脂肪变性(SMMC-7721 和 HL-7702 房间) 建模的 HMGCR 被相关。我们的结果证明那 Dicer1/miR-29/HMGCR 轴在老鼠 NASH 贡献肝的免费胆固醇累积,并且 miR-29 可以用作肝的胆固醇动态平衡的一个重要管理者。因此, miR-29a 能为非酒精的脂肪肝疾病的处理以及为与 FC 累积联系的另外的肝疾病作为一个潜在的治疗学的目标被利用。 | Ming-xia LIU Man GAO Chun-zhu LI Cun-zhi YU Hong YAN Chun PENG Yu LI Cheng-gang LI Ze-long MA Yang ZHAO Meng-fan PU Ling-ling MIAO Xin-ming QI Jin RENI | 2017 | Acta Pharmacologica Sinica2017，38，5： | 12 |
| 8 | Ursolic acid reduces hepatocellular apoptosis and alleviates alcohol-induced liver injury via irreversible inhibition of CASP3 in vivo显示文摘Alcoholic liver disease (ALD) is one of the pathogenic factors of chronic liver disease with the highest clinical morbidity worldwide. Ursolic acid (UA), a pentacyclic terpenoid carboxylic acid, has shown many health benefits including antioxidative, anti- inflammatory, anticancer, and hepatoprotective activities. We previously found that UA was metabolized in vivo into epoxy- modified UA containing an epoxy electrophilic group and had the potential to react with nucleophilic groups. In this study we prepared an alkynyl-modified UA (AM-UA) probe for tracing and capturing the target protein of UA from liver in mice, then investigated the mode by which UA bound to its target in vivo. By conducting proteome identification and bioinformatics analysis, we identified caspase-3 (CASP3) as the primary target protein of UA associated with liver protection. Molecule docking analysis showed that the epoxy group of the UA metabolite reacted with Cys-163 of CASP3, forming a covalent bond with CASP3. The binding mode of the UA metabolites (UA, CM-UA, and EM-UA) was verified by biochemical evaluation, demonstrating that the epoxy group produced by metabolism played an important role in the inhibition of CASP3. In alcohol-treated HepG2 cells, pretreatment with the UA metabolite (10 μM) irreversibly inhibited CASP3 activities, and subsequently decreased the cleavage of PARP and cell apoptosis. Finally, pre-administration of UA (20–80 mg· kg−1 per day, ig, for 1 week) dose-dependently alleviated alcohol-induced liver injury in mice mainly via the inhibition of CASP3. In conclusion, this study demonstrates that UA is a valuable lead compound for the treatment of ALD. | Xiao-yao Ma Man Zhang Ge Fang Chuan-jing Cheng Mu-kuo Wang Yi-man Han Xiao-tao Hou Er-wei Hao Yuan-yuan Hou Gang Bai | 2021 | Acta Pharmacologica Sinica2021，42，7： | 11 |
| 9 | Prevention and management of hepatitis B virus reactivation in patients with hematological malignancies treated with anticancer therapy显示文摘Hepatitis due to hepatitis B virus(HBV) reactivation can be severe and potentially fatal, but is preventable. HBV reactivation is most commonly reported in patients receiving cancer chemotherapy, especially rituximabcontaining therapy for hematological malignancies and those receiving stem cell transplantation. All patients with hematological malignancies receiving anticancer therapy should be screened for active or resolved HBV infection by blood tests for hepatitis B surface antigen(HBs Ag) and antibody to hepatitis B core antigen(antiHBc). Patients found to be positive for HBs Ag should be given prophylactic antiviral therapy to prevent HBV reactivation. For patients with resolved HBV infection, no standard strategy has yet been established to prevent HBV reactivation. There are usually two options. One is pre-emptive therapy guided by serial HBV DNA monitoring, whereby antiviral therapy is given as soon as HBV DNA becomes detectable. However, there is little evidence regarding the optimal interval and period of monitoring. An alternative approach is prophylactic antiviral therapy, especially for patients receiving highrisk therapy such as rituximab, newer generation of anti-CD20 monoclonal antibody, obinutuzumab or hematopoietic stem cell transplantation. This strategy may effectively prevent HBV reactivation and avoid the inconvenience of repeated HBV DNA monitoring. Entecavir or tenofovir are preferred over lamivudine as prophylactic therapy. Although there is no well-defined guideline on the optimal duration of prophylactic therapy, there is growing evidence to recommend continuing prophylactic antiviral therapy for at least 12 mo after cessation of chemotherapy, and even longer for those who receive rituximab or who had high serum HBV DNA levels before the start of immunosuppressive therapy. Many novel agents have recently become available for the treatment of hematological malignancies, and these agents may be associated with HBV reactivation. Although there is currently limited evidence to guide the optimal preventive measures, we recommend antiviral prophylaxis in HBs Ag-positive patients receiving novel treatments, especially the Bruton tyrosine kinase inhibitors and the phosphatidylinositol 3-kinase inhibitors, which are B-cell receptor signaling modulators and reduce proliferation of malignant B-cells. Further studies are needed to clarify the risk of HBV reactivation with these agents and the best prophylactic strategy in the era of targeted therapy for hematological malignancies. | Man Fai Law Rita Ho Carmen KM Cheung Lydia HP Tam Karen Ma Kent CY So Bonaventure Ip Jacqueline So Jennifer Lai Joyce Ng Tommy HC Tam | 2016 | World Journal of Gastroenterology2016，22，28： | 10 |
| 10 | Mechanisms of organized atrial tachycardia during catheter ablation of chronic atrial fibrillation by stepwise approach显示文摘背景广泛的 atrial 纤维性颤动(AF ) 脱离在长期的 AF 病人和 atrial 心悸亢进的增加的率与导管脱离的增加的成功率被联系(在) 在过程期间。这些 Ats 的机制在以前的研究变化。我们的学习试图报导机制在发生在逐步的脱离期间组织了长期的 AF.Methods 的过程为长期的 atrial 纤维性颤动(CAF ) 经历了一个脱离过程的 86 个连续病人的一个未来的队被调查。逐步的过程在下列顺序被执行:环绕的肺的静脉脱离,复杂 fractionated atrial 电记录图脱离,印射并且脱离在。在湾穴节奏(SR ) 被恢复或过程时间在 6 hours.Results 以外以后,端点是 AF/AT 的 noninducibility (80%) 69 病人变换成 SR 经由在。179 持续 ATs 的一个总数在过程期间在 69 个病人被观察。有 81%(n=145 ) 包括了 65 个 perimitral 电路, 48 peritricuspid 心悸亢进和 32 个房顶依赖者电路的 macroreentrant ATs, 12%(n=21 ) 局部性重入并且 7%(n=13 ) 焦点的 ATs。三十(15%) 病人们在过程经历了重要左中庭(LA ) 和 LA 附器(LAA ) 传导延期或分离或在后续 period.Conclusions 期间,大多数 CAF 病人经由脱离变换成 SR 在发生在逐步的过程期间组织了。大多数这些 ATs 的机制是宏再废。 | NING Man DONG Jian-zeng LIU Xing-peng YU Rong-hui LONG De-yong TANG Ri-bo SANG Cai-hua MA Chang-sheng | 2010 | Chinese Medical Journal2010，，7： | 10 |
| 11 | Allogeneic Vγ9Vδ2 T-cell immunotherapy exhibits promising clinical safety and prolongs the survival of patients with late-stage lung or liver cancer显示文摘Vγ9Vδ2 T cells are promising candidates for cellular tumor immunotherapy.Due to their HLA-independent mode of action,allogeneic Vγ9Vδ2 T cells can be considered for clinical application.To apply allogeneic Vγ9Vδ2 T cells in adoptive immunotherapy,the methodology used to obtain adequate cell numbers with optimal effector function in vitro needs to be optimized,and clinical safety and efficacy also need to be proven.Therefore,we developed a novel formula to improve the expansion of peripheralγδT cells from healthy donors.Then,we used a humanized mouse model to validate the therapeutic efficacy of expandedγδT cells in vivo;furthermore,the expandedγδT cells were adoptively transferred into late-stage liver and lung cancer patients.We found that the expanded cells possessed significantly improved immune effector functions,including proliferation,differentiation,and cancer cell killing,both in vitro and in the humanized mouse model.Furthermore,a phase I clinical trial in 132 late-stage cancer patients with a total of 414 cell infusions unequivocally validated the clinical safety of allogeneic Vγ9Vδ2 T cells.Among these 132 patients,8 liver cancer patients and 10 lung cancer patients who received≥5 cell infusions showed greatly prolonged survival,which preliminarily verified the efficacy of allogeneic Vγ9Vδ2 T-cell therapy.Our clinical studies underscore the safety and efficacy of allogeneic Vγ9Vδ2 T-cell immunotherapy,which will inspire further clinical investigations and eventually benefit cancer patients. | Yan Xu Zheng Xiang Mohammed Alnaggar Léonce Kouakanou Jiawei Li Junyi He Jiashuang Yang Yi Hu Yan Chen Li Lin Jianlei Hao Jingxia Li Jibing Chen Man Li Qingling Wu Christian Peters Qinghua Zhou Jianshuang Li Yingqing Liang Xiaohua Wang Baohui Han Meili Ma Dieter Kabelitz Kecheng Xu Wenwei Tu Yangzhe Wu Zhinan Yin | 2021 | Cellular & Molecular Immunology2021，18，2： | 8 |
| 12 | kW-level,narrow-linewidth linearly polarized fiber laser with excellent beam quality through compact one-stage amplification scheme显示文摘In this manuscript, we demonstrate high-power, narrow-linewidth linearly polarized fiber laser with excellent beam quality through compact one-stage amplification scheme. By employing a single-mode–multimode–single-mode structure seed laser, a linearly polarized Yb-doped fiber laser with narrow linewidth and high output power is achieved.This laser, when used as a master oscillator, can be capable of suppressing the ASE in the process of power amplification.Thus, only one-stage amplification structure is used to scale up the laser power, and linearly polarized output with a polarization extinction ration of 14 d B, a narrow linewidth of 0.3 nm and an output power of 1018 W are achieved.Moreover, due to the good beam quality of seed laser and the well-designed amplifier stage, the beam quality of the output laser is near-diffraction-limited with M_x^2 ~1.18 and M_y^2 ~ 1.24 at the maximum power, and without mode instability occurring. | Man Jiang Pengfei Ma Long Huang Jiangming Xu Pu Zhou Xijia Gu | 2017 | High Power Laser Science and Engineering2017，5，4： | 7 |
| 13 | Impact of different termination modes on atrial fibrillation termination in catheter ablation of persistent atrial fibrillation显示文摘 | WANG Ping DONG Jian-zeng LONG De-yong NING Man TANG Ri-bo YU Rong-hui XUE Zeng-ming SANG Cai-hua JIANG Chen-xi MA Chang-sheng | 2012 | Chinese Medical Journal2012，，11： | 7 |
| 14 | Ultrasound screening of fetal structural abnormalities by standard ultrasound views during the first trimester显示文摘In China,ultrasound screening of fetal abnormalities is usually performed at 20 to 24 weeks of gestation.Recent data suggest that many fetal abnormalities can be detected as early as 11 to 14 weeks of gestation.1 In this study,we applied standard ultrasound views to screen for fetal structural abnormalities during the first trimester and investigated the effectiveness of the standard ultrasound views in the detection of fetal abnormalities. | WANG Li WU Qing-qing CHEN Yan MA Yu-qing YAO Ling LI Man | 2013 | Chinese Medical Journal2013，，5： | 7 |
| 15 | Effects of Toutongning capsule on enkephalin expression in a rat migraine headache model显示文摘Toutongning capsule is used for the treatment of migraine headaches,and has yielded therapeutically beneficial effects.However,whether Toutongning capsule exerts its effects via endogenous opioid peptides remains poorly understood.This study investigated the effects of Toutongning capsule on enkephalin expression in the midbrain of rats with nitroglycerin-induced migraine headache at the mRNA and protein levels.Results confirmed that proenkephalin mRNA levels were significantly upregulated following treatment with Toutongning capsule.The numbers of methionine-enkephalin and leucine-enkephalin-positive cells were significantly greater in the migraine headache rats following treatment with Toutongning capsule compared with the model group.Taken together,these results show that Toutongning capsule exerts potentially beneficial effects by promoting enkephalin expression in nitroglycerin-induced migraine headache rats. | Gang Yao Yuhong Man Jingjing Qi Tingmin Yu Dihui Ma | 2011 | Neural Regeneration Research2011，6，9： | 7 |
| 16 | Efficacy of catheter ablation of atrial fibrillation beyond HATCH score显示文摘 | TANG Ri-bo DONG Jian-zeng LONG De-yong YU Rong-hui NING Man JIANG Chen-xi SANG Cai-hua LIU Xiao-hui MA Chang-sheng | 2012 | Chinese Medical Journal2012，，19： | 7 |
| 17 | A novel approach of proteomics to study the mechanism of action of grape seed proanthocyanidin extracts on diabetic retinopathy in rats显示文摘背景糖尿病的 retinopathy (医生) 在职业年龄的人们之中是视觉缺陷和盲目的一个领先的原因。阻止视网膜损害的进步,向关键分子的目标指导的有效治疗被要求。葡萄种子 proanthocyanidin 摘录(GSPE ) 被报导了在对待糖尿病的复杂并发症有效,当很少关于功能的蛋白质变化被讨论时。我们使用了 streptozotocin (STZ ) 在老鼠导致糖尿病的方法。GSPE (250 mg/kg 身体重量每天) 被管理到糖尿病的老鼠 24 个星期。浆液葡萄糖, glycated 血红素和先进 glycation 结束产品(年龄) 是坚定的。因而, 2-D 差别胶化电气泳动和集体 spectrometry 被用来在控制,导致 STZ 的糖尿病的老鼠,和 GSPE 之中调查视网膜蛋白质侧面对待的糖尿病的老鼠。结果 GSPE 显著地减少了糖尿病的老鼠的年龄(P < 0.05 ) 。而且, GSPE 显著地压制了中央区域,减少的毛状的增大和 neovascularization 的脉管的损害,类似于那些在光下面的控制老鼠显微镜。十八蛋白质被发现在导致 STZ 的糖尿病的老鼠的视网膜起来调整或下面调整。并且在糖尿病的老鼠的视网膜的七蛋白质被发现对在 GSPE 治疗以后的正常层次调整背。这些调整背的蛋白质涉及象热吃惊, ubiquitin-proteasome 系统,房间增长,房间生长和葡萄糖新陈代谢那样的许多重要生物进程。这些调查结果可能为医生的机制支持更好的理解,并且为评估 GSPE 治疗的效果提供新奇目标的结论。 | LI Man MA Ya-bing GAO Hai-qing LI Bao-ying CHENG Mei XU Ling LI Xiao-li LI Xian-hua | 2008 | Chinese Medical Journal2008，，24： | 7 |
| 18 | Autotransfusion in the management of cardiac tamponade occurring during catheter ablation of atrial fibrillation显示文摘 | GAO Ling-yun TANG Ri-bo DONG Jian-zeng LIU Xing-peng LONG De-yong YU Rong-hui JIANG Chen-xi CHEN Gang SANG Cai-hua ZHANG Xin-yong NING Man MA Chang-sheng | 2010 | Chinese Medical Journal2010，，7： | 6 |
| 19 | Excavation of underground research laboratory ramp in granite using tunnel boring machine: Feasibility study显示文摘Underground research laboratory(URL)plays an important role in safe disposal of high-level radioactive waste(HLW).At present,the Xinchang site,located in Gansu Province of China,has been selected as the final site for China’s first URL,named Beishan URL.For this,a preliminary design of the Beishan URL has been proposed,including one spiral ramp,three shafts and two experimental levels.With advantages of fast advancing and limited disturbance to surrounding rock mass,the tunnel boring machine(TBM)method could be one of the excavation methods considered for the URL ramp.This paper introduces the feasibility study on using TBM to excavation of the Beishan URL ramp.The technical challenges for using TBM in Beishan URL are identified on the base of geological condition and specific layout of the spiral ramp.Then,the technical feasibility study on the specific issues,i.e.extremely hard rock mass,high abrasiveness,TBM operation,muck transportation,water drainage and material transportation,is investigated.This study demonstrates that TBM technology is a feasible method for the Beishan URL excavation.The results can also provide a reference for the design and construction of HLW disposal engineering in similar geological conditions.2020 Institute of Rock and Soil Mechanics,Chinese Academy of Sciences.Production and hosting by Elsevier B.V.This is an open access article under the CC BY-NC-ND license(http://gffzzeb6f7f563f66445dh50bxkwbwc5qc6wxw.ffgz.tsg.suse.edu.cn/licenses/by-nc-nd/4.0/). | Hongsu Ma Ju Wang Ke Man Liang Chen Qiuming Gong Xingguang Zhao | 2020 | Journal of Rock Mechanics and Geotechnical Engineering2020，12，6： | 6 |
| 20 | IL-17 sustains the plasma cell response via p38-mediated Bcl-xL RNA stability in lupus pathogenesis显示文摘Recent studies have demonstrated a central role for plasma cells in the development of autoimmune diseases,such as systemic lupus erythematosus(SLE).Currently,both the phenotypic features and functional regulation of autoreactive plasma cells during SLE pathogenesis remain largely unclear.In this study,we first found that a major subset of IL-17 receptor-expressing plasma cells potently produced anti-dsDNA IgG upon IL-17A(IL-17)stimulation in SLE patients and lupus mice.Using a humanized lupus mouse model,we showed that the transfer of Th17 cell-depleted PBMCs from lupus patients resulted in a significantly reduced plasma cell response and attenuated renal damage in recipient mice compared to the transfer of total SLE PBMCs.Moreover,long-term BrdU incorporation in lupus mice detected highly enriched long-lived BrdU+subsets among IL-17 receptor-expressing plasma cells.Lupus mice deficient in IL-17 or IL-17 receptor C(IL-17RC)exhibited a diminished plasma cell response and reduced autoantibody production with attenuated renal damage,while the adoptive transfer of Th17 cells triggered the plasma cell response and renal damage in IL-17-deficient lupus mice.In reconstituted chimeric mice,IL-17RC deficiency resulted in severely impaired plasma cell generation but showed no obvious effect on germinal center B cells.Further mechanistic studies revealed that IL-17 significantly promoted plasma cell survival via p38-mediated Bcl-xL transcript stabilization.Together,our findings identified a novel function of IL-17 in enhancing plasma cell survival for autoantibody production in lupus pathogenesis,which may provide new therapeutic strategies for the treatment of SLE. | Kongyang Ma Wenhan Du Fan Xiao Man Han Enyu Huang Na Peng Yuan Tang Chong Deng Lixiong Liu Yulan Chen Jingjing Li Shiwen Yuan Qin Huang Xiaoping Hong Dajun Hu Xiaoyan Cai Quan Jiang Dongzhou Liu Liwei Lu | 2021 | Cellular & Molecular Immunology2021，18，7： | 6 |
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