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| 1 | Dual Functions of Microglia in Ischemic Stroke显示文摘Ischemic stroke is a leading cause of morbidity and mortality worldwide. Resident microglia are the principal immune cells of the brain, and the first to respond to the pathophysiological changes induced by ischemic stroke. Traditionally, it has been thought that microglial activation is deleterious in ischemic stroke, and therapies to suppress it have been intensively explored. However,increasing evidence suggests that microglial activation is also critical for neurogenesis, angiogenesis, and synaptic remodeling, thereby promoting functional recovery after cerebral ischemia. Here, we comprehensively review the dual role of microglia during the different phases of ischemic stroke, and the possible mechanisms controlling the post-ischemic activity of microglia. In addition, we discuss the dynamic interactions between microglia and other cells, such as neurons, astrocytes, oligodendrocytes,and endothelial cells within the brain parenchyma and the neurovascular unit. | Chuan Qin Luo-Qi Zhou Xiao-Tong Ma Zi-Wei Hu Sheng Yang Man Chen Dale B. Bosco Long-Jun Wu Dai-Shi Tian | 2019 | Neuroscience Bulletin2019，35，5： | 64 |
| 2 | Correction of a genetic disease by CRISPR-Cas9-mediated gene editing in mouse spermatogonial stem cells显示文摘Spermatogonial 干细胞(SSC ) 能在移植以后生产众多的男配偶子进接受者睾丸,介绍为基因治疗和修改基因的动物的连续生产的一条珍贵途径。然而, SSC 的成功的基因操作被限制了,部分由于复杂性和当前可得到的基因编辑技术的低效率。这里,我们证明有效基因修正能用 CRISPR-Cas9 系统被介绍进 SSC。我们使用了 CRISPR-Cas9 系统变异在 SCC 的 EGFP transgene 或内长的 Crygc 基因。变异的 SSC 在移植以后经历了精子发生进不肥沃的老鼠睾丸的生精的小管。圆 spermatids 被产生并且在进成熟卵母细胞的注射以后,支持了显示相应变异的显型的异质接合的后代的生产。而且,在 Crygc 的一个引起疾病的变化(在 SSC 先存在的 Crygc −/−) 能乐意地到加入的 CRISPR-Cas9-induced nonhomologous 结束(NHEJ ) 或指导相同的修理(HDR ) 被修理,导致没有是的离开目标修正的证据带改正的基因的 SSC 线由整个染色体的定序出现。用从这些线产生的圆 spermatids 的授精在 100% 的效率与改正的显型产生了后代。我们的结果表明有效基因由 CRISPR-Cas9 系统在老鼠 SSC 编辑,并且提供在 SSC 经由基因修正治好基因疾病的原则的证明。 | Yuxuan Wu Hai Zhou Xiaoying Fan Ying Zhang Man Zhang Yinghua Wang Zhenfei Xie Meizhu Bai Qi Yin Dan Liang Wei Tang Jiaoyang Liao Chikai Zhou Wujuan Liu Ping Zhu Hongshan Guo Hong Pan Chunlian Wu Huijuan Shi Ligang Wu Fuchou Tang Jinsong Li | 2015 | Cell Research2015，25，1： | 37 |
| 3 | A comparison of the Medieval Warm Period, Little Ice Age and 20th century warming simulated by the FGOALS climate system model显示文摘To compare differences among the Medieval Warm Period (MWP), Little Ice Age (LIA), and 20th century global warming (20CW), six sets of transient and equilibrium simulations were generated using the climate system model FGOALS_gl. This model was developed by the State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics, Institute of Atmospheric Physics, Chinese Academy of Sciences. The results indicate that MWP warming is evident on a global scale, except for at mid-latitudes of the North Pacific. However, the magnitude of the warming is weaker than that in the 20th century. The warming in the high latitudes of the Northern Hemisphere is stronger than that in the Southern Hemisphere. The LIA cooling is also evident on a global scale, with a strong cooling over the high Eurasian continent, while the cooling center is over the Arctic domain. Both the MWP and the 20CW experiments exhibit the strongest warming anomalies in the middle troposphere around 200-300 hPa, but the cooling center of the LIA experiment is seen in the polar surface of the Northern Hemisphere. A comparison of model simulation against the reconstruction indicates that model's performance in simulating the surface air temperature changes during the warm periods is better than that during the cold periods. The consistencies between model and reconstruction in lower latitudes are better than those in high latitudes. Comparison of the inter-annual variability mode of East Asian summer monsoon (EASM) rainfall during the MWP, LIA and 20CW reveals a similar rainfall anomalies pattern. However, the time spectra of the principal component during the three typical periods of the last millennium are different, and the quasi-biannual oscillation is more evident during the two warm periods. At a centennial time scale, the external mode of the EASM variability driven by the changes of effective solar radiation is determined by the changes of large scale land-sea thermal contrast. The rainfall anomalies over the east of 110°E exhibit a meridional homogeneous change pattern, which is different from the meridional out-of-phase change of rainfall anomalies associated with the internal mode. | ZHOU TianJun LI Bo MAN WenMin ZHANG LiXia ZHANG Jie | 2011 | Chinese Science Bulletin2011，56，28： | 32 |
| 4 | Acute cerebrovascular disease following COVID-19: a single center, retrospective, observational study显示文摘Background and purpose COVID-19 is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2).Apart from respiratory complications,acute cerebrovascular disease(CVD)has been observed in some patients with COVID-19.Therefore,we described the clinical characteristics,laboratory features,treatment and outcomes of CVD complicating SARS-CoV-2 infection.Materials and methods Demographic and clinical characteristics,laboratory findings,treatments and clinical outcomes were collected and analysed.Clinical characteristics and laboratory findings of patients with COVID-19 with or without new-onset CVD were compared.Results Of 219 patients with COVID-19,10(4.6%)developed acute ischaemic stroke and 1(0.5%)had intracerebral haemorrhage.COVID-19 with new onset of CVD were significantly older(75.7±10.8 years vs 52.1±15.3 years,p<0.001),more likely to present with severe COVID-19(81.8%vs 39.9%,p<0.01)and were more likely to have cardiovascular risk factors,including hypertension,diabetes and medical history of CVD(all p<0.05).In addition,they were more likely to have increased inflammatory response and hypercoagulable state as reflected in C reactive protein(51.1(1.3-127.9)vs 12.1(0.1-212.0)mg/L,p<0.05)and D-dimer(6.9(0.3-20.0)vs 0.5(0.1-20.0)mg/L,p<0.001).Of 10 patients with ischemic stroke;6 received antiplatelet treatment with aspirin or clopidogrel;and 3 of them died.The other four patients received anticoagulant treatment with enoxaparin and 2 of them died.As of 24 March 2020,six patients with CVD died(54.5%).Conclusion Acute CVD is not uncommon in COVID-19.Our findings suggest that older patients with risk factors are more likely to develop CVD.The development of CVD is an important negative prognostic factor which requires further study to identify optimal management strategy to combat the COVID-19 outbreak. | Yanan Li Man Li Mengdie Wang Yifan Zhou Jiang Chang Ying Xian David Wang Ling Mao Huijuan Jin Bo Hu | 2020 | Stroke & Vascular Neurology2020，5，3： | 22 |
| 5 | Near-diffraction-limited linearly polarized narrow-linewidth random fiber laser with record kilowatt output显示文摘In this paper, we propose and experimentally investigate a linearly polarized narrow-linewidth random fiber laser(RFL) operating at 1080 nm and boost the output power to kilowatt level with near-diffraction-limited beam quality using a master oscillation power amplifier. The RFL based on a half-opened cavity, which is composed of a linearly polarized narrow-linewidth fiber Bragg grating and a 500 m piece of polarization-maintained Ge-doped fiber, generates a 0.71 W seed laser with an 88 pm full width at half-maximum(FWHM) linewidth and a 22.5 dB polarization extinction ratio(PER) for power scaling. A two-stage fiber amplifier enhances the seed laser to the maximal 1.01 k W with a PER value of 17 dB and a beam quality of M_x^2=1.15 and M_y^2=1.13. No stimulated Brillouin scattering effect is observed at the ultimate power level, and the FWHM linewidth of the amplified random laser broadens linearly as a function of the output power with a coefficient of about 0.1237 pm∕W.To the best of our knowledge, this is the first demonstration of a linearly polarized narrow-linewidth RFL with even kilowatt-level near-diffraction-limited output, and further performance scaling is ongoing. | JIANGMING XU LONG HUANG MAN JIANG JUN YE PENGFEI MA JINYONG LENG JIAN WU HANWEI ZHANG PU ZHOU | 2017 | Photonics Research2017，5，4： | 20 |
| 6 | Diffusion tensor imaging detects Wallerian degeneration of the corticospinal tract early after cerebral infarction显示文摘To investigate the feasibility and time window of early detection of Wallerian degeneration in the corticospinal tract after middle cerebral artery infarction,23 patients were assessed using magnetic resonance diffusion tensor imaging at 3.0T within 14 days after the infarction.The fractional anisotropy values of the affected corticospinal tract began to decrease at 3 days after onset and decreased in all cases at 7 days.The diffusion coefficient remained unchanged.Experimental findings indicate that diffusion tensor imaging can detect the changes associated with Wallerian degeneration of the corticospinal tract as early as 3 days after cerebral infarction. | Ruiman Xie Min Fang Linjiang Zhou Shanghua Fan Jianying Liu Hongbo Quan Man Luo Dongying Qiu | 2012 | Neural Regeneration Research2012，7，12： | 20 |
| 7 | Special Section:SARS-CoV-2 Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19显示文摘Effective therapies are urgently needed for the SARS-CoV-2 pandemic.Chloroquine has been proved to have antiviral effect against coronavirus in vitro.In this study,we aimed to assess the efficacy and safety of chloroquine with different doses in COVID-19.In this multicenter prospective observational study,we enrolled patients older than 18 years old with confirmed SARS-CoV-2 infection excluding critical cases from 12 hospitals in Guangdong and Hubei Provinces.Eligible patients received chloroquinephosphate s00 mg,orally,once(half dose)or twice(full dose)daily.Patients treated with non-chloroquine therapy were included as historical controls.The primary endpoint is the time to undetectable viral RNA.Secondary outcomes include the proportion of patients with undetectable viral RNA by day 10 and 14,hospitalization time,duration of fever,and adverse events.A total of 197 patients completed chloroquine treatment,and 176patients were included as historical controls.The median time to achieve an undetectable viral RNA was shorter in chloroquine than in non-chloroquine(absolute difference in medians-6.0 days;95%CI-6.0 to—4.0).The duration of fever is shorter in chloroquine(geometric mean ratio 0.6;95%CIO.5 to 0.8).No serious adverse events were observed in the chloroquine group.Patients treated with half dose experienced lower rate of adverse events than with full dose.Although randomized trials are needed for further evaluation,this study provides evidence for safety and efficacy of chloroquine in COVID-19 and suggests that chloroquine can be a cost-effective therapy for combating the COVID-19 pandemic. | Mingxing Huang Man Li Fei Xiao Pengfei Pang Jiabi Liang Tiantian Tang Shaoxuan Liu Binghui Chen Jingxian Shu Yingying You Yang Li Meiwen Tang Jianhui Zhou Guanmin Jiang Jingfen Xiang Wenxin Hong Songmei He Zhaoqin Wang Jianhua Feng Changqing Lin Yinong Ye Zhilong Wu Yaocai Li Bei Zhong Ruilin Sun Zhongsi Hong Jing Liu Huili Chen Xiaohua Wang Zhonghe Li Duanqing Pei Lin Tian Jinyu Xia Shanping Jiang Nanshan Zhong Hong Shan | 2020 | National Science Review2020，7，9： | 20 |
| 8 | Forced response of atmospheric oscillations during the last millennium simulated by a climate system model显示文摘Variations in global atmospheric oscillations during the last millennium are simulated using the climate system model FGOALS_gl. The model was driven by reconstructions of both natural forcing (solar variability and volcanic aerosol) and anthropogenic forcing (greenhouse gases and sulfate aerosol). The model results are compared against proxy reconstruction data. The reconstructed North Atlantic Oscillation (NAO) was out of phase with the Pacific Decadal Oscillation (PDO) in the last millennium. During the Medieval Warm Period (MWP), the NAO was strong while the PDO was weak. During the Little Ice Age (LIA), the NAO was weak while the PDO was strong. A La Ni a-like state prevailed in the MWP, while an El Ni o-like state dominated in the LIA. This phenomenon is particularly obvious in the 15th, 17th and 19th centuries. Analysis of the model output indicates that the NAO was generally positive during 1000-1400 AD and negative during 1650-1900 AD. There is a discrepancy between the sim- ulation and reconstruction during 1400-1650 AD. The simulated PDO generally varies in parallel with the reconstruction, which has a negative phase during the MWP and a positive phase during the LIA. The correlation coefficient between the reconstruction and simulation is 0.61, and the correlation is statistically significant at the 1% level. Neither the La Ni a-like state of the MWP nor the El Ni o-like state of the LIA is reproduced in the model. Both the reconstructed and the simulated Antarctic Oscillations had a negative phase in the early period of the last millennium and a positive phase in the late period of the last millennium. The Asian-Pacific Oscillation was generally strong during the WMP and weak during the LIA, and the correlation coefficient between the simulation and reconstruction is 0.50 for the period 1000 -1985 AD. The analysis suggests that the specified external forcings significantly affected the evolution of atmospheric oscillation during the last millennium. | MAN WenMin ZHOU TianJun | 2011 | Chinese Science Bulletin2011，56，28： | 18 |
| 9 | Experimental investigation of a 500 W traveling-wave thermoacoustic electricity generator显示文摘In this paper, an experimental investigation of a traveling-wave thermoacoustic electricity generator, which consists of a traveling-wave thermoacoustic heat engine and a linear alternator driven by that engine, is presented. Using the results of previous theoretical and experimental research, we designed and fabricated a traveling-wave thermoacoustic heat engine and a linear alternator. In the experiments, 450.9 W of electrical power was obtained with a maximum thermal-to-electrical efficiency of 15.03%, and a maximum electrical power of 481.0 W was achieved with 12.65% thermal-to-electrical efficiency. | WU ZhangHua MAN Man LUO ErCang DAI Wei ZHOU Yuan | 2011 | Chinese Science Bulletin2011，56，19： | 17 |
| 10 | First experimental demonstration of coherent beam combining of more than 100 beams显示文摘Coherent beam combining of 107 beams has been demonstrated for the first time to the best of our knowledge.When the system was in closed loop,the pattern in far-field was stable and the fringe contrast was>96%.The impact of the dynamic tilt error,the piston error,and power inconsistency was theoretically analyzed.Meanwhile,the distribution law of dynamic tilt error was estimated and the correlation of the tilt dithering of different axis was analyzed statistically.The ratio of power in the central lobe was^22.5%.The phase residue error in the closed loop was~λ∕22,which was evaluated by the root-mean-square error of the signal generated from the photoelectric detector. | HONGXIANG CHANG QI CHANG JIACHAO XI TIANYUE HOU RONGTAO SU PENGFEI MA JIAN WUCAN LI MAN JIANG YANXING MA PU ZHOU | 2020 | Photonics Research2020，8，12： | 17 |
| 11 | Phase 1 clinical trial demonstrated that MUC1 positive metastatic seminal vesicle cancer can be effectively eradicated by modified Anti-MUC1 chimeric antigen receptor transduced T cells显示文摘Recent progress in chimeric antigen receptor-modified T-cell(CAR-T cell) technology in cancer therapy is extremely promising, especially in the treatment of patients with B-cell acute lymphoblastic leukemia. In contrast, due to the hostile immunosuppressive microenvironment of a solid tumor, CAR T-cell accessibility and survival continue to pose a considerable challenge, which leads to their limited therapeutic efficacy. In this study, we constructed two anti-MUC1 CAR-T cell lines. One set of CAR-T cells contained SM3 single chain variable fragment(sc Fv) sequence specifically targeting the MUC1 antigen and co-expressing interleukin(IL) 12(named SM3-CAR). The other CAR-T cell line carried the SM3 sc Fv sequence modified to improve its binding to MUC1 antigen(named p SM3-CAR) but did not co-express IL-12. When those two types of CAR-T cells were injected intratumorally into two independent metastatic lesions of the same MUC1+ seminal vesicle cancer patient as part of an interventional treatment strategy, the initial results indicated no side-effects of the MUC1 targeting CAR-T cell approach, and patient serum cytokines responses were positive. Further evaluation showed that p SM3-CAR effectively caused tumor necrosis, providing new options for improved CAR-T therapy in solid tumors. | Fengtao You Licui Jiang Bozhen Zhang Qiang Lu Qiao Zhou Xiaoyang Liao Hong Wu Kaiqi Du Youcai Zhu Huimin Meng Zhishu Gong Yunhui Zong Lei Huang Man Lu Jirong Tang Yafen Li Xiaochen Zhai Xiangling Wang Sisi Ye Dan Chen Lei Yuan Lin Qi Lin Yang | 2016 | Science China(Life Sciences)2016，59，4： | 16 |
| 12 | Four IVa bHLH Transcription Factors Are Novel Interactors of FIT and Mediate JA Inhibition of Iron Uptake in Arabidopsis显示文摘工厂发展了复杂基因网络调整铁(Fe ) 为他们的幸存的动态平衡。包括 jasmonic 酸(JA ) 的工厂荷尔蒙的几个类被显示了涉及在工厂调整铁举起或缺乏应答的基因的表达式。然而, JA 由调整铁举起的分子的机制仍然保持不清楚。在这研究,我们发现 JA 否定地由 downregulating 调制铁举起表示合适(bHLH29 ) , bHLH38, bHLH39, bHLH100,和 bHLH101 并且支持合适的蛋白质的降级,在 Arabidopsis 的铁举起的一个关键管理者。我们进一步证明亚群 IVa bHLH 蛋白质, bHLH18, bHLH19, bHLH20,和 bHLH25,是新奇 interactors 适合,它支持导致 JA 的合适的蛋白质降级。这四 IVa bHLHs 冗余地工作反对 Ib bHLHs 的活动(例如 bHLH38 ) 在在铁下面调整合适的蛋白质稳定性缺乏。四 IVa bHLH 基因首先在根被表示,并且由 JA 处理是可诱导的。而且,我们发现了那 MYC2 和 JAR1 ,表明小径的 JA 的二个批评部件,在调停起关键作用表示的 JA 抑制合适并且 Ib bHLH 基因他们差别调制 bHLH18 的表示, bHLH19 , bHLH20 ,并且调整的 bHLH25 在铁缺乏下面适合累积。一起拿,这些结果显示由 transcriptionally 调整 bHLH 基因的不同集合的 ?表示,发信号的 JA 支持合适的降级,导致铁举起的减少的表示基因, IRT1 和 FRO2,和到铁的增加的敏感缺乏。我们的数据 ? 建议当面有铁缺乏反应的 multilayered 抑制在 Arabidopsis 的 JA。 | Yan Cui Chun-Lin Chen Man Cui Wen-Juan Zhou Hui-Lan Wu Hong-Qing Ling | 2018 | Molecular Plant2018，11，9： | 16 |
| 13 | Cr^(Ⅵ) adsorption on four typical soil colloids: equilibrium and kinetics显示文摘It is observed that the adsorption of chromium are greater on kaolinite minerals, red soil (R) and laterite (L) colloids than that on montmorillonite, indicotic black (IB) and yellow brown (YB) soil colloids. The adsorption process of Cr Ⅵ on these media can be further described by Langmuir or Freundlich equation quite well. The adsorption reaction of Cr Ⅵ is fast, and the adsorption equilibrium can be reached within the first two hours in moderate temperature. The adsorption quantity of Cr Ⅵ to kaolinite mineral increased with the increasing pH in the range of 2.0 to 7.0, then decreased at higher pH. But it showed some consistence among the four soil colloids. The lower the pH, the stronger the adsorption. The possible mechanisms are further discussed here. Meanwhile the influence of temperature on Cr Ⅵ adsorption on different soil colloid and clay minerals are also investigated. | ZHOU Dong\|mei, CHEN Huai\|man * (LMCP, Institute of Soil Science, Chinese Academy of Sciences, Nanjing 210008, China) | 2000 | Journal of Environmental Sciences2000，12，3： | 15 |
| 14 | High precision landing site mapping and rover localization for Chang'e-3 mission显示文摘This paper presents the comprehensive results of landing site topographic mapping and rover localization in Chang’e-3 mission.High-precision topographic products of the landing site with extremely high resolutions(up to 0.05 m)were generated from descent images and registered to CE-2 DOM.Local DEM and DOM with 0.02 m resolution were produced routinely at each waypoint along the rover traverse.The lander location was determined to be(19.51256°W,44.11884°N,-2615.451 m)using a method of DOM matching.In order to reduce error accumulation caused by wheel slippage and IMU drift in dead reckoning,cross-site visual localization and DOM matching localization methods were developed to localize the rover at waypoints;the overall traveled distance from the lander is 114.8 m from cross-site visual localization and 111.2 m from DOM matching localization.The latter is of highest accuracy and has been verified using a LRO NAC image where the rover trajeactory is directly identifiable.During CE-3 mission operations,landing site mapping and rover localization products including DEMs and DOMs,traverse maps,vertical traverse profiles were generated timely to support teleoperation tasks such as obstacle avoidance and rover path planning. | LIU ZhaoQin DI KaiChang PENG Man WAN WenHui LIU Bin LI LiChun YU TianYi WANG BaoFeng ZHOU JianLiang CHEN HongMin | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，1： | 15 |
| 15 | High levels of serum interleukin-6 increase mortality of hepatitis B virus-associated acute-on-chronic liver failure显示文摘BACKGROUND Patients with hepatitis B virus-associated acute-on-chronic liver failure(HBVACLF)present a complex and poor prognosis.Systemic inflammation plays an important role in its pathogenesis,and interleukin-6(IL-6)as a pro-inflammatory cytokine is related with severe liver impairment and also plays a role in promoting liver regeneration.Whether serum IL-6 influences HBV-ACLF prognosis has not been studied.AIM To determine the impact of serum IL-6 on outcome of patients with HBV-ACLF.METHODS We performed a retrospective study of 412 HBV-ACLF patients.The findings were analyzed with regard to mortality and the serum IL-6 level at baseline,as well as dynamic changes of serum IL-6 within 4 wk.RESULTS The serum IL-6 level was associated with mortality.Within 4 wk,deceased patients had significantly higher levels of IL-6 at baseline than surviving patients[17.9(7.3-57.6)vs 10.4(4.7-22.3),P=0.011].Patients with high IL-6 levels(>11.8 pg/mL)had a higher mortality within 4 wk than those with low IL-6 levels(≤11.8 pg/mL)(24.2%vs 13.2%,P=0.004).The odds ratios calculated using univariate and multivariate logistic regression were 2.10(95%confidence interval[CI]:1.26-3.51,P=0.005)and 2.11(95%CI:1.15-3.90,P=0.017),respectively.The mortality between weeks 5 and 8 in patients with high IL-6 levels at 4 wk was 15.0%,which was significantly higher than the 6.6%mortality rate in patients with low IL-6 levels at 4 wk(hazard ratio=2.39,95%CI:1.05-5.41,P=0.037).The mortality was 5.0%in patients with high IL-6 levels at baseline and low IL-6 levels at 4 wk,7.5%in patients with low IL-6 levels both at baseline and at 4 wk,11.5%in patients with low IL-6 levels at baseline and high IL-6 levels at 4 wk,and 16.7%in patients with high IL-6 levels both at baseline and at 4 wk.The increasing trend of the mortality rate with the dynamic changes of IL-6 was significant(P for trend=0.023).CONCLUSION A high level of serum IL-6 is an independent risk factor for mortality in patients with HBV-ACLF.Furthermore,a sustained high level or dynamic elevated level of serum IL-6 indicates a higher mortality. | Chao Zhou Ning Zhang Ting-Ting He Yao Wang Li-Fu Wang Yong-Qiang Sun Jing Jing Jing-Jing Zhang Shuang-Nan Fu Xuan Wang Xiao-Xiao Liang Xin Li Man Gong Jun Li | 2020 | World Journal of Gastroenterology2020，26，30： | 15 |
| 16 | COMPUTATIONAL FLUID DYNAMICS RESEARCH ON PRESSURE LOSS OF CROSS-FLOW PERFORATED MUFFLER显示文摘The pressure loss of cross-flow perforated muffler has been computed with the procedure of physical modeling,simulation and data processing. Three-dimensional computational fluid dynam-ics (CFD) has been used to investigate the relations of porosities,flow velocity and diameter of the holes with the pressure loss. Accordingly,some preliminary results have been obtained that pressure loss increases with porosity descent as nearly a hyperbolic trend,rising flow velocity of the input makes the pressure loss increasing with parabola trend,diameter of holes affects little about pressure loss of the muffler. Otherwise,the holes on the perforated pipes make the air flow gently and meanly,which decreases the air impact to the wall and pipes in the muffler. A practical perforated muffler is used to illustrate the available of this method for pressure loss computation,and the comparison shows that the computation results with the method of CFD has reference value for muffler design. | HU Xiaodong ZHOU Yiqi FANG Jianhua MAN Xiliang ZHAO Zhengxu | 2007 | Chinese Journal of Mechanical Engineering2007，20，2： | 14 |
| 17 | Zscan4 promotes genomic stability during reprogramming and dramatically improves the quality of iPS cells as demonstrated by tetraploid complementation显示文摘用 Yamanaka 因素产生的导致的 pluripotent 茎(iPS ) 细胞在自体同源的细胞治疗为使用有大潜力。然而, genomic 畸形充分在人的 iPS 房间,和房间不是的大多数老鼠 iPS 存在 pluripotent 由 tetraploid 互补试金评估了 TCA ) ;这很可能与 DNA 损坏反应(DDR ) 被联系在 Yamanaka 因素导致的早 reprogramming 发生了。相反,原子转移忠实地装改编体的房间进胚胎的茎(ES ) 满足 TCA 的房间。我们因此假设了涉及导致卵母细胞的 reprogramming 的因素可以在 reprogramming 期间稳定体的染色体,并且改进结果的 iPS 房间的质量。测试这个假设,我们在 iPS 期间为能减少的因素屏蔽了 DDR 信号房间正式就职。我们决定了那 Zscan4,在有 Yamanaka 因素的联合,不是仅仅显著地减少了 DDR 而且显著地支持了 iPS 房间产生的效率。Zscan4 的包括稳定了 genomic DNA,导致 p53 downregulation。而且, Zscan4 也提高了象通过 telomere 感染以后的 3 天一样早变长的 telomere 基于再结合的机制。作为结果,与 Zscan4 的增加产生的 iPS 房间比古典 iPS 房间展出了更长的 telomeres。惊人地,超过 50% iPS 房间线(11/19 ) 经由这生产了 “ Zscan4 protocol”产生了由 TCA 决定了的实时熊的 all-iPS 房间老鼠,与为用古典 Yamanaka 因素生产的线的 1/12 相比。我们的调查结果提供在 reprogramming 期间维持 genomic 稳定性支持的第一示范高质量的 iPS 房间的产生。 | Jing Jiang Wenjian Lv Xiaoying Ye Lingbo Wang Man Zhang Hui Yang Maja Okuka Chikai Zhou Xuan Zhang Lin Liu Jinsong Li | 2013 | Cell Research2013，23，1： | 14 |
| 18 | Generation of dopaminergic neurons directly from mouse fibroblasts and fibroblast-derived neural progenitors显示文摘 | Chao Sheng Qinyuan Zheng Jianyu Wu Zhen Xu Lisi Sang Libin Wang Changlong Guo Wanwan Zhu Man Tong Lei Liu Wei Li Zhong-Hua Liu Xiao-Yang Zhao Liu Wang Zhiguo Chen Qi Zhou | 2012 | Cell Research2012，22，4： | 12 |
| 19 | Regional-scale Surface Air Temperature and East Asian Summer Monsoon Changes during the Last Millennium Simulated by the FGOALS-gl Climate System Model显示文摘The spatial patterns and regional-scale surface air temperature(SAT) changes during the last millennium, as well as the variability of the East Asian summer monsoon(EASM) were simulated with a low-resolution version of Flexible Global Ocean–Atmosphere–Land–Sea-ice(FGOALS-gl) model. The model was driven by both natural and anthropogenic forcing agents. Major features of the simulated past millennial Northern Hemisphere(NH) mean SAT variations, including the Medieval Climate Anomaly(MCA), the Little Ice Age(LIA) and the 20th Century Warming(20CW), were generally consistent with the reconstructions. The simulated MCA showed a global cooling pattern with reference to the 1961–90 mean conditions, indicating the 20CW to be unprecedented over the last millennium in the simulation. The LIA was characterized by pronounced coldness over the continental extratropical NH in both the reconstruction and the simulation. The simulated global mean SAT difference between the MCA and LIA was 0.14°C, with enhanced warming over high-latitude NH continental regions. Consistencies between the simulation and the reconstruction on regional scales were lower than those on hemispheric scales. The major features agreed well between the simulated and reconstructed SAT variations over the Chinese domain, despite some inconsistency in details among different reconstructions. The EASM circulation during the MCA was stronger than that during the LIA The corresponding rainfall anomalies exhibited excessive rainfall in the north but deficient rainfall in the south. Both the zonal and meridional thermal contrast were enhanced during the MCA. This temperature anomaly pattern favored a stronger monsoon circulation. | MAN Wenmin ZHOU Tianjun | 2014 | Advances in Atmospheric Sciences2014，31，4： | 12 |
| 20 | Garcinol inhibits esophageal cancer metastasis by suppressing the p300 and TGF-β1 signaling pathways显示文摘Metastasis causes the main lethality in esophageal cancer patient.Garcinol,a natural compound extracted from Gambogic genera,is a histone acetyltransferase(HAT)inhibitor that has shown anticancer activities such as cell cycle arrest and apoptosis induction.In this study,we investigated the effects of garcinol on the metastasis of esophageal cancer in vitro and in vivo.We found that garcinol(5-15μM)dose-dependently inhibited the migration and invasion of human esophageal cancer cell lines KYSE150 and KYSE450 in wound healing,transwell migration,and Matrigel invasion assays.Furthermore,garcinol treatment dose-dependently decreased the protein levels of p300/CBP(transcriptional cofactors and HATs)and p-Smad2/3 expression in the nucleus,thus impeding tumor cell proliferation and metastasis.Knockdown of p300 could inhibit cell metastasis,but CBP knockdown did not affect the cell mobility.It has been reported that TGF-β1 stimulated the phosphorylation of Smad2/3,which directly interact with p300/CBP in the nucleus,and upregulating HAT activity of p300.We showed that garcinol treatment dose-dependently suppressed TGF-β1-activated Smad and non-Smad pathway,inhibiting esophageal cancer cell metastasis.In a tail vein injection pulmonary metastasis mouse model,intraperitoneal administration of garcinol(20 mg/kg)or 5-FU(20 mg/kg)significantly decreased the number of lung tumor nodules and the expression levels of Ki-67,p300,and p-Smad2/3 in lung tissues.In conclusion,our study demonstrates that garcinol inhibits esophageal cancer metastasis in vitro and in vivo,which might be related to the suppression of p300 and TGF-β1 signaling pathways,suggesting the therapeutic potential of Garcinol for metastatic tumors. | Jing Wang Man Wu Dan Zheng Hong Zhang Yue Lv Li Zhang Hong-sheng Tan Hua Zhou Yuan-zhi Lao Hong-xi Xu | 2020 | Acta Pharmacologica Sinica2020，41，1： | 12 |
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