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| 1 | Recent progress in CFD for naval architecture and ocean engineering显示文摘An overview is provided of CFDShip-Iowa modeling, numerical methods and high performance computing(HPC), including both current V4.5 and V5.5 and next generation V6. Examples for naval architecture highlight capability and needs. High fidelity V6 simulations for ocean engineering and fundamental physics describe increased resolution for analysis of physics of fluids. Uncertainty quantification research is overviewed as the first step towards development stochastic optimization. | STERN Frederick WANG Zhaoyuan YANG Jianming SADAT-HOSSEINI Hamid MOUSAVIRAAD Maysam BHUSHAN Shanti DIEZ Matteo YOON Sung-Hwan WU Ping-Chen YEON Seong Mo DOGAN Timur KIM Dong-Hwan VOLPI Silvia CONGER Michael MICHAEL Thad XING Tao THODAL Robert S. GRENESTEDT Joachim L. | 2015 | Journal of Hydrodynamics2015，27，1： | 12 |
| 2 | Planetary Gear Profile Modification Design Based on Load Sharing Modelling显示文摘In order to satisfy the increasing demand on high performance planetary transmissions, an important line of research is focused on the understanding of some of the underlying phenomena involved in this mechanical system. Through the development of models capable of reproduce the system behavior, research in this area contributes to improve gear transmission insight, helping developing better maintenance practices and more efficient design processes. A planetary gear model used for the design of profile modifications ratio based on the levelling of the load sharing ratio is presented. The gear profile geometry definition, following a vectorial approach that mimics the real cutting process of gears, is thoroughly described. Teeth undercutting and hypotrochoid definition are implicitly considered, and a procedure for the incorporation of a rounding arc at the tooth tip in order to deal with corner contacts is described. A procedure for the modeling of profile deviations is presented, which can be used for the introduction of both manufacturing errors and designed profile modifications. An easy and flexible implementation of the profile deviation within the planetary model is accomplished based on the geometric overlapping. The contact force calculation and dynamic implementation used in the model are also introduced, and parameters from a real transmission for agricultural applications are presented for the application example. A set of reliefs is designed based on the levelling of the load sharing ratio for the example transmission, and finally some other important dynamic factors of the transmission are analyzed to assess the changes in the dynamic behavior with respect to the non-modified case. Thus, the main innovative aspect of the proposed planetary transmission model is the capacity of providing a simulated load sharing ratio which serves as design variable for the calculation of the tooth profile modifications. | IGLESIAS Miguel FERNáNDEZ DEL RINCóN Alfonso DE-JUAN Ana Magdalena GARCIA Pablo DIEZ Alberto VIADERO Fernando | 2015 | Chinese Journal of Mechanical Engineering2015，28，4： | 9 |
| 3 | 区域创新系统的管治框架演化——来自深圳和东莞的对比实证显示文摘本文在电子企业问卷调查的基础上,对比分析深圳和东莞的区域创新机制,并进一步从管治角度构建区域创新机制差异的理论框架,在中国转型的体制背景下阐释管治的演化逻辑。结果显示,改革开放初期自上而下的管治模式相对于自下而上的管治,在各自向网络化管治模式演化的过程中,由于先发制度优势和组织能力禀赋,更能顺利的推动工业基础薄弱地区向区域创新系统的转变。最后指出,演化视角分析必须注重时间和地理的特殊性。 | 符文颖 Javier Revilla Diez Daniel Schiller | 2013 | 人文地理2013，28，4： | 8 |
| 4 | Mobility of Arsenic and Heavy Metals in a Sandy-Loam Textured and Carbonated Soil显示文摘The continued effect of the pyrite-tailing oxidation on the mobility of arsenic, lead, zinc, cadmium, and copper was studied in a carbonated soil under natural conditions, with the experimental plot preserved with a layer of tailing covering the soil during three years. The experimental area is located in Southern Spain and was affected by a pyrite-mine spill. The climate in the area is typically Mediterranean, which determines the rate of soil alteration and element mobility. The intense alteration processes that occurred in the soil during three years caused important changes in its morphology and a strong degradation of the main soil properties. In this period, lead concentrated in the first 5 mm of the soil, with concentrations higher than 1500 mg kg?1, mainly associated to the neoformation of plumbojarosite. Arsenic was partially leached from the first 5 mm and mainly concentrated between 5–10 mm in the soil, with maximum values of 1239 mg kg-1; the retention of arsenates was related to the neoformation of iron hydroxysulfates (jarosite, schwertmannite) and oxyhydroxides (goethite, ferrihydrite), both with a variable degree of crystallinity. The mobility of Zn, Cd, and Cu was highly affected by pH, producing a stronger leaching in depth; their retention was related to the forms of precipitated aluminium and, in the case of Cu, also to the neoformation of hydroxysulfate. | I. GARC íA M. DIEZ F. MART íN M. SIMóN C. DORRONSORO | 2009 | Pedosphere2009，19，2： | 8 |
| 5 | A one-dimensional polynomial chaos method in CFD–Based uncertainty quantification for ship hydrodynamic performance显示文摘A one-dimensional non-intrusive Polynomial Chaos(PC)method is applied in Uncertainty Quantification(UQ)studies for CFD–based ship performances simulations.The uncertainty properties of Expected Value(EV)and Standard Deviation(SD)are evaluated by solving the PC coefficients from a linear system of algebraic equations.The one-dimensional PC with the Legendre polynomials is applied to:(1)stochastic input domain and(2)Cumulative Distribution Function(CDF)image domain,allowing for more flexibility.The PC method is validated with the Monte-Carlo benchmark results in several high-fidelity,CFD-based,ship UQ problems,evaluating the geometrical,operational and environmental uncertainties for the Delft Catamaran 372.Convergence is studied versus PC order P for both EV and SD,showing that high order PC is not necessary for present applications.Comparison is carried out for PC with/without the least square minimization when solving the PC coefficients.The least square minimization,using larger number of CFD samples,is recommended for current test cases.The study shows the potentials of PC method in Robust Design Optimization(RDO)and Reliability-Based Design Optimization(RBDO)of ship hydrodynamic performances. | 贺伟 DIEZ Matteo CAMPANA Emilio Fortunato STERN Frederick 邹早建 | 2013 | Journal of Hydrodynamics2013，25，5： | 5 |
| 6 | Less common etiologies of exocrine pancreatic insufficiency显示文摘Exocrine pancreatic insufficiency(EPI), an important cause of maldigestion and malabsorption, results from primary pancreatic diseases or secondarily impaired exocrine pancreatic function. Besides cystic fibrosis and chronic pancreatitis, the most common etiologies of EPI, other causes of EPI include unresectable pancreatic cancer, metabolic diseases(diabetes); impaired hormonal stimulation of exocrine pancreatic secretion by cholecystokinin(CCK); celiac or inflammatory bowel disease(IBD) due to loss of intestinal brush border proteins; and gastrointestinal surgery(asynchrony between motor and secretory functions, impaired enteropancreatic feedback, and inadequate mixing of pancreatic secretions with food). This paper reviews such conditions that have less straightforward associations with EPI and examines the role of pancreatic enzyme replacement therapy(PERT). Relevant literature was identified by database searches. Most patients with inoperable pancreatic cancer develop EPI(66%-92%). EPI occurs in patients with type 1(26%-57%) or type 2 diabetes(20%-36%) and is typically mild to moderate; by definition, all patients with type 3 c(pancreatogenic) diabetes have EPI. EPI occurs in untreated celiac disease(4%-80%), but typically resolves on a gluten-free diet. EPI manifests in patients with IBD(14%-74%) and up to 100% of gastrointestinal surgery patients(47%-100%; dependent on surgical site). With the paucity of published studies on PERT use for these conditions, recommendations for or against PERT use remain ambiguous. The authors conclude that there is an urgent need to conduct robust clinical studies to understand the validity and nature of associations between EPI and medical conditions beyond those with proven mechanisms, and examine the potential role for PERT. | Vikesh K Singh Mark E Haupt David E Geller Jerry A Hall Pedro M Quintana Diez | 2017 | World Journal of Gastroenterology2017，23，39： | 5 |
| 7 | Morphological Characterization and Hydrodynamic Behavior of Shortfin Mako Shark(Isurus oxyrinchus)Dorsal Fin Denticles显示文摘The shortfin mako shark(Isurus oxyrinchus)is one of the fastest marine fishes,reaching speeds of up to 70 km·h^-1.Their speed is related to the skin surface design composed of dermal denticles.Denticles vary in size and shape according to placement on the body and minimize turbulence around the body.The objective of this study is to analyze the interaction between seawater flow and denticles on the dorsal fin.High-resolution microscopy(scanning electron microscopy and confocal microscopy)were used to measure defined parts of the dermal denticles.These measurements,along with ratios based on length-to-width define three morphologies(rounded,semi-rounded,long)that were 3D reconstructed.Computational fluid dynamics simulated fluid passage over reconstructed denticles and describe hy-drodynamic efficiency under different conditions.An increase in angle of inclination produced a relevant increase in the drag coefficient,especially for high velocity inlets.The lowest drag coefficient values were found in long and semi-rounded,followed by rounded mor-phologies.The hydrodynamic behavior of shark skin demonstrates a relation to the morphological characteristics of dermal denticles on the dorsal fin.It is concluded that the best hydroefficiency relies on the rounded morphology and may serve to design hydrodynamically efficient surfaces or manmade assemblies. | Fernandez-Waid Patricia Diez Guzman Bidaguren Inigo Izagirre Urtzi Blanco Jesus Maria Soto Manu | 2019 | Journal of Bionic Engineering2019，16，4： | 3 |
| 8 | 维甲酸导致胎鼠神经脊源性器官异常显示文摘为证实我们的假设,即维甲酸物质不但能导致胎鼠颅面部的畸形,而且还能造成胸颈部内分泌腺(胸腺、甲状腺和甲状旁腺)的异常,这些器官的形成都是与神经脊细胞的移入有关的。于孕期第10天给母鼠125mg/kg全反型维甲酸(All-fran-retinoic acid),对照组给予相应量的载体溶液。分娩前24小时剖腹取出胎鼠,10%福尔马林浸泡固定10天,双管手术显微镜下解剖,检查颅、面部,心脏,大血管,胸腺,并对甲状腺,甲状旁腺进行组织学研究。对照组10只胎鼠未发现畸形,而实验组20只胎鼠中,有17只(85%)出现颅面部畸形,14只(70%)有心血管畸形,而胸腺、甲状腺、甲状旁腺和甲状腺畸形分别有14只(70%)、15只(75%)和7只(35%)。结果表明,维甲酸能导致胎鼠中鳃弓衍化而成并需神经脊参与的器官组织结构异常。 | 余家康 夏慧敏 Gonzalez S Diez Pardo JA Tovar JA | 2003 | 新生儿科杂志2003，18，6： | 3 |
| 9 | Pneumo-CT assessing response to neoadjuvant therapy in esophageal cancer: Imaging-pathological correlation显示文摘Pneumo-computed tomography (PnCT) is a technique primarily developed and used to study stenotic lesions of the esophagus, gastroesophageal junction and stom-ach for pre-surgical planning. It helps to define both upper and lower borders of neoplasms located in the aforementioned areas. It achieves maximum lumen distension with CO2 highlighting thickened areas of the esophageal wall, thus allowing an accurate quantifica-tion of their extents. Although there are other alterna-tives for distension (oral contrast agents, water and ef-fervescent granules), they may be suboptimal. Patients with locally advanced esophageal cancer have a dismal prognosis despite surgical resection. Therefore, neo-adjuvant treatment strategies using radiation therapy and chemotherapy were developed to improve sur-vival. Neoadjuvant therapy improves esophageal tumor prognosis in a substantial proportion of patients, and the use of imaging techniques is mandatory to detect their response. PnCT combined with virtual endoscopy and multiplanar reconstruction enhances morphologic details in esophageal cancer, and thus would allow animproved assessment of response to neoadjuvant treat-ment. Therefore, more information could be provided to assess the efficacy of pre-surgical treatment. We de-scribe the potential use of PnCT to assess the response to neoadjuvant therapy in esophageal cancer with an imaging pathologic correlation. | Marina Ulla Ernestina Gentile Ezequiel Levy Yeyati Maria L Diez Demetrio Cavadas Ricardo D Garcia-Monaco Pablo R Ros | 2013 | World Journal of Gastrointestinal Oncology2013，5，12： | 3 |
| 10 | Fast preparation route to high-performances textured Sr-doped Ca_3Co_4O_9 thermoelectric materials through precursor powder modification显示文摘This work presents a short and very efficient method to produce high performance textured Ca_3Co_4O_9 thermoelectric materials through initial powders modification. Microstructure has shown good grain orientation, and low porosity while slightly lower grain sizes were obtained in samples prepared from attrition milled powders. All samples show the high density of around 96% of the theoretical value.These similar characteristics are reflected in, approximately,the same electrical resistivity and Seebeck coefficient values for both types of samples. However, in spite of similar power factor(PF) at low temperatures, it is slightly higher at high temperature for the attrition milled samples. On the other hand, the processing time reduction(from 38 to 2 h) when using attrition milled precursors, leads to lower mechanical properties in these samples. All these data clearly point out to the similar characteristics of both kinds of samples, with a drastic processing time decrease when using attrition milled precursors, which is of the main economic importance when considering their industrial production. | Miguel Angel Torres Gustavo Garcia Idoia Urrutibeascoa Maria Antonieta Madre Juan Carlos Diez Andres Sotelo | 2019 | Science China Materials2019，62，3： | 2 |
| 11 | Up Close: Family Therapy Challenges and Innovations Around the World显示文摘 | Janine Roberts Khawla Abu‐Baker Cristina Diez Fernández Nelly Chong Garcia Glenda Fredman Hugo Kamya Yolanda Martín Higarza Jacqueline Fortes de Leff Philip Messent Shin‐Ichi Nakamura Fatma Torun Reid Timothy Sim Chitra Subrahmanian Roxana Zevallos Vega | 2014 | Fam. Proc2014，，： | 2 |
| 12 | Mercury uptake and effects on growth in Jatropha curcas显示文摘The use of metal-accumulating plants for the phytoremediation of contaminated soils is gaining more attention. Mercury(Hg)-contaminated soils from historical gold mines represent a potential risk to human health and the environment. Therefore, Jatropha curcas plant, that has shown its tolerance to these environments, is a species of particular interest to implement phytoremediation techniques in gold mining sites. In this work, the behavior of J. curcas was assessed in different hydroponic cultures fortified with Hg at concentrations of 5, 10, 20, 40, and 80 μg Hg/mL(T5, T10, T20, T40 and T80, respectively). After exposure,plant growth, net photosynthesis, leaf area, and Hg accumulation were determined and variables such as net Hg uptake, effective Hg accumulation, translocation and bioaccumulation factors were calculated. Accumulation of Hg in root and leaf tissues increased with respect to the Hg concentrations in the hydroponic culture, with statistically significant differences(p < 0.05) among treatments. Moreover, Hg concentration in roots was 7 and 12-fold higher in average than in plant leaves and shoots, respectively. Many effects were found in the development of plants, especially related with loss of biomass and leaf area,with significant growth inhibition related to control values(> 50% with treatment T5).Moreover, percentage of inhibition was even higher(> 60%) with same treatment for net photosynthesis. Finally, it should be highlighted that for T40 and T80 treatments, plant growth and photosynthesis were almost completely depleted(88%–95%). | Jose Marrugo-Negrete Jose Durango-Hernandez Jose Pinedo-Hernandez German Enamorado-Montes Sergi Diez | 2016 | Journal of Environmental Sciences2016，28，10： | 2 |
| 13 | Human monocyte-derived macrophages and dendritic cells are comparably effective in vitro in presenting HLA class l-restricted exogenous poptides显示文摘 | Toujas L Delcros J G Diez E | 1997 | Immunol1997，91，4： | 2 |
| 14 | Hysteroscopic hydrosalpinx occlusion with Essure device in IVF patients when salpingectomy or laparoscopy is contraindicated显示文摘 | Roberto Matorras Aintzane Rabanal Bego?a Prieto Santiago Diez I?aki Brouard Rosario Mendoza Antonia Exposito | 2013 | European Journal of Obstetrics and Gynecology2013，，1： | 2 |
| 15 | Bircle is the gene within the Lgnl locus associated with resistance to Legionella pneumophila显示文摘 | Diez E Lee S H Gauthier S | 2003 | Nat Genet2003，33，1： | 1 |
| 16 | Delivery to macrophages and toxic action of etoposide carried in mouse red blood cells显示文摘 | Olmos G Diez JC | 2003 | Biochim Biophys Acta2003，1620，13： | 1 |
| 17 | The Importance of Public Research Institutes in Innovative Networks-Empirical Results from the Metropolitan Innovation Systems Barcelona显示文摘 | | 2000 | Stockholm and Vienna European Planning Studies2000，8，4： | 1 |
| 18 | The role of the novel adipocyte-derived hormone adiponectin in human disease显示文摘 | Iglesias P | 2003 | Eur J Endocrinol2003，148，： | 1 |
| 19 | A Cost - benefit analysis of routine varicella vaccination in Spain显示文摘 | Diez - Domingo J Ridao M Latour J | 1999 | Vaccine1999，17，1112： | 1 |
| 20 | Development of multiple forms of mouse brain monoamlne oxidase in vivo and in vitro 显示文摘 | Diez JA Maderdrut JL | 1977 | Brain Res1977，128，1： | 1 |
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