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| 1 | Fatigue behavior of Ti-6Al-4V cellular structures fabricated by additive manufacturing technique显示文摘Porous titanium and its alloys have been considered as promising replacement for dense implants, as they possess low elastic modulus comparable to that of compact human bones and are capable of providing space for in-growth of bony tissues to achieve a better fixation. Recently, the additive manufacturing(AM) method has been successfully applied to the fabrication of Ti-6 Al-4 V cellular meshes and foams.Comparing to traditional fabrication methods, the AM method offers advantages of accurate control of complex cell shapes and internal pore architectures, thus attracting extensive attention. Considering the long-term safety in the human body, the metallic cellular structures should possess high fatigue strength.In this paper, the recent progress on the fatigue properties of Ti-6 Al-4 V cellular structures fabricated by the AM technique is reviewed. The various design factors including cell shapes, surface properties, post treatments and graded porosity distribution affecting the fatigue properties of additive manufactured Ti-6 Al-4 V cellular structures were introduced and future development trends were also discussed. | Dechun Ren Shujun Li Hao Wang Wentao Hou Yulin Hao Wei Jin Rui Yang R.Devesh K.Misra Lawrence E.Murr | 2019 | Journal of Materials Science & Technology2019，35，2： | 15 |
| 2 | Immunopathobiology and therapeutic targets related to cytokines in liver diseases显示文摘Chronic liver injury with any etiology can progress to fibrosis and the end-stage diseases cirrhosis and hepatocellular carcinoma.The progression of liver disease is controlled by a variety of factors,including liver injury,inflammatory cells,inflammatory mediators,cytokines,and the gut microbiome.In the current review,we discuss recent data on a large number of cytokines that play important roles in regulating liver injury,inflammation,fibrosis,and regeneration,with a focus on interferons and T helper(Th)1,Th2,Th9,Th17,interleukin(IL)-1 family,IL-6 family,and IL-20 family cytokines.Hepatocytes can also produce certain cytokines(such as IL-7,IL-11;and IL-33),and the functions of these cytokines in the liver are briefly summarized.Several cytokines have great therapeutic potential,and some are currently being tested as therapeutic targets in clinical trials for the treatment of liver diseases,which are also described. | Yong He Seonghwan Hwang Yeni Ait Ahmed Dechun Feng Na Li Marcelle Ribeiro Fouad Lafdil Tatiana Kisseleva Gyongyi Szabo Bin Gao | 2021 | Cellular & Molecular Immunology2021，18，1： | 14 |
| 3 | Assessing the numbers of SNPs needed to establish molecular IDs and characterize the genetic diversityof soybean cultivars derived from Tokachi nagaha显示文摘The development of a core set of SNP molecular markers that could be widely used in soybean genetic research would greatly facilitate research into the genetic diversity of soybean.We conducted an analysis of Tokachi nagaha and 137 of its descendant soybean cultivars using 4044 SNP markers with the goal of determining the appropriate number of single-nucleotide polymorphisms(SNPs)needed to construct unambiguous molecular IDs and characterize genetic diversity based on a genetic distance matrix correlation method.When the number of SNPs was held constant,the number of accession pairs that could be distinguished increased as the polymorphism informative content(PIC)value of the SNPs increased.A core panel of 20 selected SNPs from 11 linkage groups with a mean PIC value of 0.3703 and a range of 0.3640–0.3749 was able to identify almost all of the accession pairs in our study[9445 pairs(99.92%)].The eight accession pairs that could not be identified with this core SNP set all originated from the same province and some of them had the same parental cultivars.The molecular IDs of the 138 accessions were constructed using the core 20 SNPs.It is known that both the number of SNPs and PIC values should be considered when SNPs are selected for use in the analysis of genetic diversity.In this study,when the PIC value was 0.3460,the correlation coefficient between the genetic distance matrices associated with a panel of 200 SNPs and the total population was>0.800,indicating satisfactory correlation.Our high-accuracy,high-resolution core SNP panel for germplasm fingerprinting and our findings about assessing genetic diversity will likely markedly improve the management and utilization efficiency of soybean germplasm resources. | Zhangxiong Liu Jun Li Xuhong Fan Nang Myint Phyu Sin Htwe Shuming Wang Wen Huang Jiyu Yang Lili Xing Lijun Chen Yinghui Li Rongxia Guan Ruzhen Chang Dechun Wang Lijuan Qiu | 2017 | The Crop Journal2017，5，4： | 10 |
| 4 | ROS signaling cascades:dual regulations for osteoclast and osteoblast显示文摘Accumulating evidence indicates that intracellular reactive oxygen species(ROS)production is highly involved in bone homeostasis by intervening osteoclast or osteoblast differentiation.Interestingly,ROS that are known as oxidizing agents exert dose-dependent biphasic properties in bone remodeling,including preventing osteoblast activity but accelerating osteoclast resorption.ROS mainly composed of superoxide anion radical,hydroxyl radical,nitric oxide,and two-electron reduction product hydrogen peroxide,which are important components to regulate bone cell metabolism and function in mammal skeleton.These free radicals can be partly produced in bone and boosted in an inflammation state.Although numerous researches have emphasized the impacts of ROS on bone cell biology and verified the mechanism of ROS signaling cascades,the recapitulatory commentary is necessary.In this review article,we particularly focus on the regulation of the intracellular ROS and its potential mechanism impacting on cell-signaling transduction in osteoclast and osteoblast differentiation for preferable understanding the pathogenesis and searching for novel therapeutic protocols for human bone diseases. | Huaqiang Tao Gaoran Ge Xiaolong Liang Weicheng Zhang Houyi Sun Meng Li Dechun Geng | 2020 | Acta Biochimica et Biophysica Sinica2020，52，10： | 8 |
| 5 | Resurrection of the Genus Leptomantis, with Description of a New Genus to the Family Rhacophoridae(Amphibia:Anura)显示文摘Genus Rhacophorus Kuhl and Van Hasselt, 1 822 is one of the most diverse genera of the family Rhacophoridae, and its taxonomy of genus Rhacophorus faces major challenges because of rapidly described new species and complex interspecies relations. In this study, we investigate the generic taxonomy within the genus Rhacophorus based on 1 972 bp of mitochondrial genes(12S rRNA, tRNA-val and 16S rRNA), containing 102 sequences from 58 species. The results reveal three well-supported and highly diverged matrilines that correspond with morphological characteristics and geographic distribution. Accordingly, we consider these three lineages as distinct genera: Rhacophorus sensu stricto, resurrected genus Leptomantis Peters, 1867, and the genus Zhangixalus gen. nov. | Dechun JIANG Ke JIANG Jinlong REN Jun WU Jiatang LI | 2019 | Asian Herpetological Research2019，10，1： | 8 |
| 6 | Regulation of the inflammatory cycle by a controllable release hydrogel for eliminating postoperative inflammation after discectomy显示文摘Surgery is the final choice for most patients with intervertebral disc degeneration(IDD).Operation-caused trauma will cause inflammation in the intervertebral disc.Serious inflammation will cause tissue defects and induce tissue degeneration,IDD recurrence and the occurrence of other diseases.Therefore,we proposed a scheme to treat recurrence after discectomy by inhibiting inflammation with an aspirin(ASP)-loaded hydrogel to restore the mechanical stability of the spine and relieve local inflammation.ASP-liposomes(ASP-Lips)were incorporated into a photocrosslinkable gelatin-methacryloyl(GelMA)via mixing.This material can effectively alleviate inflammation by inhibiting the release of high mobility group box 1(HMGB1)from the nucleus to the cytoplasm.We further assessed the expression of inflammatory cytokines,such as interleukin 6(IL-6)and tumor necrosis factor-α(TNF-α),and degeneration-related factors,such as type II collagen(COL-2),Aggrecan,matrix metallopeptidases-3(MMP-3),MMP-13,a disintegrin and metalloproteinase with thrombospondin motifs-4(ADAMTS-4)and ADAMTS-5 in rat nucleus pulpous cells.The level of IDD was analyzed through H&E,safranin-O staining and immunohistochemistry in rabbit samples.In vitro,we found that ASP-Lip@GelMA treatment significantly decreased inflammatory cytokines,MMP-3 and-13,and ADAMTS-4 and-5 and up-regulated COL-2 and Aggrecan via the inhibited release of HMGB-1 from the nucleus.In vivo,ASP-Lip@GelMA can effectively inhibit inflammation of local tissue after disc surgery and fill local tissue defects.This composite hydrogel system is a promising way to treat the recurrence of IDD after surgery without persistent complications. | Yu Liu Jiacheng Du Peng Peng Ruoyu Cheng Jiayi Lin Congxin Xu Huilin Yang Wenguo Cui Haiqing Mao Yuling Li Dechun Geng | 2021 | Bioactive Materials2021，6，1： | 6 |
| 7 | Protective effects of sirtuin 3 on titanium particle-induced osteogenic inhibition by regulating the NLRP3 inflammasome via the GSK-3β/β-catenin signalling pathway显示文摘Periprosthetic osteolysis(PPO)remains the key factor in implant failure and subsequent revision surgery and is mainly triggered by wear particles.Previous studies have shown that inhibition of osteoblastic differentiation is the most widespread incident affecting the interface of trabecular and loosening prostheses.Additionally,the NLRP3 inflammasome is activated by prosthetic particles.Sirtuin3,an NAD+-dependent deacetylase of mitochondria,regulates the function of mitochondria in diverse activities.However,whether SIRT3 can mitigate wear debris-induced osteolysis by inhibiting the NLRP3 inflammasome and enhancing osteogenesis has not been previously reported.Therefore,we investigated the role of SIRT3 during the process of titanium(Ti)particle-induced osteolysis.We revealed that upregulated SIRT3 dramatically attenuated Ti particle-induced osteogenic inhibition through suppression of the NLRP3 inflammasome and improvement of osteogenesis in vivo and in vitro.Moreover,we found that SIRT3 interference in the process of Ti particle-induced osteolysis relied on the GSK-3β/β-catenin signalling pathway.Collectively,these findings indicated that SIRT3 may serve as a rational new treatment against debris-induced PPO by deacetylase-dependent inflammasome attenuation. | Kai Zheng Jiaxiang Bai Ning Li Meng Li Houyi Sun Weicheng Zhang Gaoran Ge Xiaolong Liang Huaqiang Tao Yi Xue Yuefeng Hao Chen Zhu Yaozeng Xu Dechun Geng | 2021 | Bioactive Materials2021，6，10： | 5 |
| 8 | Multilayer black phosphorus as saturable absorber for an Er:Lu_(2)O_(3) laser at~3 μm显示文摘Multilayer black phosphorus(BP) nanoplatelets of different thicknesses were prepared by the liquid phase exfoliation method and deposited onto yttrium aluminum garnet substrates to form saturable absorbers(SAs). These were characterized with respect to their thickness-dependent saturable absorption properties at 3 μm. The BP-SAs were employed in a passively Q-switched Er:Lu_2O_3 laser at 2.84 μm. By using BP exfoliated in different solvents,stable pulses as short as 359 ns were generated at an average output power of up to 755 m W. The repetition rate in the experiment was 107 k Hz, corresponding to a pulse energy of 7.1 μJ. These results prove that BP-SAs have a great potential for optical modulation in the mid-infrared range. | Mingqi Fan Tao Li Shengzhi Zhao Guiqiu Li Xiaochun Gao Kejian Yang Dechun Li Christian Krankel | 2016 | Photonics Research2016，4，5： | 5 |
| 9 | Asymmetric biotic interchange across the Bering land bridge between Eurasia and North America显示文摘The exchange of biotas between Eurasia and North America across the Bering land bridge had a major impact on ecosystems of both continents throughout the Cenozoic. This exchange has received particular attention regarding placental mammals dispersing into the Americas, including humans after the last glacial period, and also as an explanation for the disjunct distribution of related seed plants in eastern Asia and eastern North America. Here, we investigate bi-directional dispersal across the Bering land bridge from estimates of dispersal events based on time-calibrated phylogenies of a broad range of plant, fungus and animal taxa. We reveal a long-lasting phase of asymmetrical biotic interchange, with a peak of dispersal from Asia into North America during the late Oligocene warming(26–24 Ma), when dispersal in the opposite direction was greatly decreased. Influx from North America into Asia was lower than in the opposite direction throughout the Cenozoic, but with peak rates of dispersal at the end of the Eocene(40–34 Ma)and again in the early to middle Miocene(16–14 Ma). The strong association between dispersal patterns and environmental changes suggests that plants, fungi and animals have likely dispersed from stable to perturbed environments of North America and Eurasia throughout the Cenozoic. | Dechun Jiang Sebastian Klaus Ya-Ping Zhang David M.Hillis Jia-Tang Li | 2019 | National Science Review2019，6，4： | 5 |
| 10 | Enhanced anti-tumor immunity ex vivo induced by GM-CSF gene transducted dendritic cell vaccine显示文摘学习的目的是调查是否的目的树枝状的房间(DC ) 先锋,由 chemokine ligand 的注射招募了 3 (CCL3 ) ,在 granulocyte 巨噬细胞殖民地刺激以后导致提高的反肿瘤免疫在老鼠前 vivo 的因素(GM-CSF ) transfection。615 只老鼠经由尾巴静脉与 CCL3 被注射的方法。刚孤立的 B220-CD11c+ 房间与 cytokines 是有教养的。为 adenoviral (广告) 调停的基因 transduction, DC 是在感染(MOI ) 的复合的不同比率的转移 AdGM-CSF 基因决定最佳的基因 transfection 条件,并且在 transfection 以后检测 GM-CSF 的表示。GM-CSF 修改基因的 DC 的变化被词法观察,显型分析,和混合淋巴细胞反应(MLR ) 分析。DC 被装载,胃的癌症抗原由冻结并且融化的方法获得了。刺激 DC 种痘导致了 T 淋巴细胞,和 T 房间的杀死的效果到胃的癌症房间是由 MTT 的 assayed。INF- 生产与 INF- ELISA 工具包被决定。结果 B220-CD11c+ 房间数字在 CCL3 注射以后增加了。ELISA 结果证明在 GM-CSF 基因修正以后, DC 能生产 GM-CSF 的高水平。DC 是什么时候,在等于 1:100 的 MOI 转移了 AdGM-CSF 基因,在文化上层清液的 GM-CSF 水平到达了浸透[(130.00 ???????????????? ″ ? 匠牵楶楶? 僚 ??? 吗?? | Songbing He Liang Wang Kang Sun Yanyun Zhang Dechun Li | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，3： | 3 |
| 11 | Changes in compressed neurons from dogs with acute and severe cauda equina constrictions following intrathecal injection of brain-derived neurotrophic factor-conjugated polymer nanoparticles显示文摘This study established a dog model of acute multiple cauda equina constriction by experimental constriction injury (48 hours) of the lumbosacral central processes in dorsal root ganglia neurons. The repair effect of intrathecal injection of brain-derived neurotrophic factor with 15 mg encapsulated biodegradable poly(lactide-co-glycolide) nanoparticles on this injury was then analyzed. Dorsal root ganglion cells (L7) of all experimental dogs were analyzed using hematoxylin-eosin staining and immunohistochemistry at 1, 2 and 4 weeks following model induction. Intrathecal injection of brain-derived neurotrophic factor can relieve degeneration and inflammation, and elevate the expression of brain-derived neurotrophic factor in sensory neurons of compressed dorsal root ganglion. Simultaneously, intrathecal injection of brain-derived neurotrophic factor obviously improved neurological function in the dog model of acute multiple cauda equina constriction. Results verified that sustained intraspinal delivery of brain-derived neurotrophic factor encapsulated in biodegradable nanoparticles promoted the repair of histomorphology and function of neurons within the dorsal root ganglia in dogs with acute and severe cauda equina syndrome. | Junming Tan Jiangang Shi Guodong Shi Yanling Liu Xiaohong Liu Chaoyang Wang Dechun Chen Shunming Xing Lianbing Shen Lianshun Jia Xiaojian Ye Hailong He Jiashun Li | 2013 | Neural Regeneration Research2013，8，3： | 2 |
| 12 | Effect of silver growth temperature on the contacts between Ag and ZnO thin films显示文摘Highly c-axis oriented ZnO thin films were deposited on Si substrates by the pulsed laser deposition (PLD) method. At different growth temperatures,200 nm silver films as the contact metal were deposited on the ZnO thin films. The growth temperatures have great influence on the crystal quality of Ag films. Current-voltage characteristics were measured at room temperature. The Schottky contacts between Ag and ZnO thin films were successfully obtained when silver electrodes were deposited at 150 ℃ and 200℃. Ohmic contacts were formed while the growth temperatures were lower than 150℃ or higher than 200 ℃. After analysis,the forming of Ag/ZnO Schottky contacts was shown to be dependent on the appearance of the p-type inversion layer at the interface between Ag and ZnO layers. | LI XinKun LI QingShan LIANG DeChun XU YanDong XIE XiaoJun | 2009 | Science China(Technological Sciences)2009，52，9： | 2 |
| 13 | Receiving Information From Noising Signal Using Bistable Systems显示文摘An electric circuit is used to simulate a bistable system.The input signal is a word consisting of a sequence of pulses,which contains certain information,rat her than a purely sinusoidal signal.It is found that the portion of information received from the output of the bistable system can be greatly enhanced under the stochastic resonance condition. | HU Gang GONG Dechun WEN Xiaodong QIN Guangrong LI Rong | 1992 | Chinese Physics Letters1992，9，2： | 2 |
| 14 | Lateral epitaxial growth of two-dimensional heterostructure linked by gold adatoms显示文摘Lateral two-dimensional(2D)heterostructures have great potential for device engineering at the atomistic scale.Their production is hindered by difficulties in obtaining atomically sharp interface free from intermixture.Here we report the continuous construction of a lateral heterostructure using blue phosphorene and tetrafluoro-tetracyanoquinodimethane(F_(4)TCNQ)as the building blocks.The lateral heterostructure is achieved by linking the semiconducting F_(4)TCNQ-Au metal organic framework and the metallic blue phosphorene-Au network via Au adatoms.The structural and electronic properties of the heterostructure have been investigated by means of scanning tunneling microscopy and spectroscopy(STM/S),complemented by density functional theory(DFT)calculations,demonstrating a structurally and electrically abrupt interface.Our approach offers the possibility of high flexibility and control that can be extended to other metal-organic species and 2D materials,establishing a foundation for the development of atomically thin in-plane superlattice and devices. | Nan Si Tao Shen Xinyi Liu Dechun Zhou Qingmin Ji Wei Liu Shuang Li Tianchao Niu | 2021 | Nano Research2021，14，3： | 2 |
| 15 | Rational integration of defense and repair synergy on PEEK osteoimplants via biomimetic peptide clicking strategy显示文摘Polyetheretherketone(PEEK)has been widely used as orthopedic and dental materials due to excellent mechanical and physicochemical tolerance.However,its biological inertness,poor osteoinduction,and weak antibacterial activity make the clinical applications in a dilemma.Inspired by the mussel adhesion mechanism,here we reported a biomimetic surface strategy for rational integration and optimization of anti-infectivity and osteo-inductivity onto PEEK surfaces using a mussel foot proteins(Mfps)-mimic peptide with clickable azido terminal.The peptide enables mussel-like adhesion on PEEK biomaterial surfaces,leaving azido groups for the further steps of biofunctionalizations.In this study,antimicrobial peptide(AMP)and osteogenic growth peptide(OGP)were bioorthogonally clicked on the azido-modified PEEK biomaterials to obtain a dual-effect of host defense and tissue repair.Since bioorthogonal clicking allows precise collocation between AMP and OGP through changing their feeding molar ratios,an optimal PEEK surface was finally obtained in this research,which could long-term inhibit bacterial growth,stabilize bone homeostasis and facilitate interfacial bone regeneration.In a word,this upgraded mussel surface strategy proposed in this study is promising for the surface bioengineering of inert medical implants,in particular,achieving rational integration of multiple biofunctions to match clinical requirements. | Meng Li Jiaxiang Bai Huaqiang Tao Li Hao Weiling Yin Xiaoxue Ren Ang Gao Ning Li Miao Wang Shiyuan Fang Yaozeng Xu Liang Chen Huilin Yang Huaiyu Wang Guoqing Pan Dechun Geng | 2022 | Bioactive Materials2022，7，2： | 2 |
| 16 | On mechanism of the effect of rare earth on wear-ability of nickel base self-fluxing alloy 显示文摘 | Li Muqin Ma Chen Shao Dechun | 1991 | Journal of Rare Earths1991，9，3： | 1 |
| 17 | Research on the photoluminescence of spectral broadening by rapid thermal annealing on InAs/GaAs quantum dots显示文摘Photoluminescence (PL) test was conducted to investigate the effect of rapid thermal annealing (RTA) on the opticalperformance of self-assembled InAs/GaAs quantum dots (QDs) at the temperatures of 16 and 300 K. It was found that after RTAtreatment, the PL spectrum of the QDs sample had a large blue-shift and significantly broadened at 300 K. Compared with theas-grown InAs QDs sample, the PL spectral width has increased by 44.68 meV in the InAs QDs sample RTA-treated at800 ℃. The excitation power-dependent PL measurements showed that the broadening of the PL peaks of the RTA-treatedInAs QDs should be related to the emission of the ground state (GS) of different-sized InAs QDs, the InAs wetting layer (WL)and the In0.15Ga0.85As strain reduction layer (SRL) in the epitaxial InAs/GaAs layers. | Dandan Ning Yanan Chen Xinkun Li Dechun Liang Shufang Ma Peng Jin Zhanguo Wang | 2020 | Journal of Semiconductors2020，41，12： | 1 |
| 18 | High-quality 2-μm Q-switched pulsed solid-state lasers using spin-coating-coreduction approach synthesized Bi_2Te_3 topological insulators显示文摘In this paper, the fabrication process and characterization of Bi_2Te_3 topological insulators(TIs) synthesized by the spin-coating-coreduction approach(SCCA) is reported. With this approach, high-uniformity nano-crystalline TI saturable absorbers(TISAs) with large-area uniformity and controllable thickness are prepared. By employing these prepared TIs with different thicknesses as SAs in 2-μm solid-state Q-switched lasers, thickness-dependent output powers and pulse durations of the laser pulses are obtained, and the result also exhibits stability and reliability. The shortest pulse duration is as short as 233 ns, and the corresponding clock amplitude jitter is around 2.1%, which is the shortest pulse duration in Tl SA-based Q-switched 2-μm lasers to the best of our knowledge.Moreover, in comparison with the TISA synthesized by the ultrasound-assisted liquid phase exfoliation(UALPE)method, the experimental results show that lasers with SCCA synthesized TISAs have higher output powers, shorter pulse durations, and higher pulse peak powers. Our work suggests that the SCCA synthesized TISAs could be used as potential SAs in pulsed lasers. | JUNPENG QIAO SHENGZHI ZHAO KEJIAN YANG WEI-HENG SONG WENCHAO QIAO CHUNG-LUNG WU JIA ZHAO GUIQIU LI DECHUN LI TAO LI HONG LIU CHAO-KUEI LEE | 2018 | Photonics Research2018，6，4： | 1 |
| 19 | Primary Discussion of a Carbon Sink in the Oceans显示文摘As a consequence of global warming and rising sea levels, the oceans are becoming a matter of concern for more and more people because these changes will impact the growth of living organisms as well as people's living standards. In particular, it is extremely important that the oceans absorb massive amounts of carbon dioxide. This paper takes a pragmatic approach to analyzing the oceans with respect to the causes of discontinuities in oceanic variables of carbon dioxide sinks. We report on an application of chemical, physical and biological methods to analyze the changes of carbon dioxide in oceans. Based on the relationships among the oceans, land, atmosphere and sediment with respect to carbon dioxide, the foundation of carbon dioxide in shell-building and ocean acidification, the changes in carbon dioxide in the oceans and their impact on climate change, and so on, a vital conclusion can be drawn from this study. Specifically, under the condition that the oceans are not disturbed by external forces, the oceans are a large carbon dioxide sink. The result can also be inferred by the formula: C=A-B and G=E+F when the marine ecosystem can keep a natural balance and the amount of carbon dioxide emission is limited within the carrying capacity of the oceans. | MA Caihua YOU Kui JI Dechun MA Weiwei LI Fengqi | 2015 | Journal of Ocean University of China2015，14，2： | 1 |
| 20 | Effects of CYP2C19 and CYP2C9 genotypes on pharmacokinetic variability of valproic acid in Chinese epileptic patients: nonlinear mixed-effect modeling显示文摘 | Dechun Jiang Xiangrong Bai Qingxia Zhang Wei Lu Yuqin Wang Lin Li Markus Müller | 2009 | European Journal of Clinical Pharmacology2009，，12： | 1 |
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