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| 1 | Blood glucose changes surrounding initiation of tumor-necrosis factor inhibitors and conventional disease-modifying anti-rheumatic drugs in veterans with rheumatoid arthritis显示文摘AIM To determine the scope of acute hypoglycemic effects for certain anti-rheumatic medications in a large retrospective observational study. METHODS Patients enrolled in the Veterans Affairs Rheumatoid Arthritis (VARA) registry were selected who, during follow-up, initiated treatment with tumor necrosis factor inhibitors (TNFi's, including etanercept, adalimumab, infliximab, golimumab, or certolizumab), prednisone, or conventional disease-modifying anti-rheumatic drugs(DMARDs), and for whom proximate random blood glucose (RBG) measurements were available within a window 2-wk prior to, and 6 mo following, medication initiation. Similar data were obtained for patients with proximate values available for glycosylated hemoglobin A1C values within a window 2 mo preceding, and 12 mo following, medication initiation. RBG and A1C measurements were compared before and after initiation events using paired t-tests, and multivariate regression analysis was performed including established comorbidities and demographics.RESULTS Two thousands one hundred and eleven patients contributed at least one proximate measurement surrounding the initiation of any examined medication. A significant decrease in RBG was noted surrounding 653 individual hydroxychloroquine-initiation events(-3.68 mg/dL, P = 0.04), while an increase was noted for RBG surrounding 665 prednisone-initiation events(+5.85 mg/d L, P < 0.01). A statistically significant decrease in A1C was noted for sulfasalazine initiation, as measured by 49 individual initiation events(-0.70%, P < 0.01). Multivariate regression analyses, using methotrexate as the referent, suggest sulfasalazine (β =-0.58, P = 0.01) and hydroxychloroquine(β =-5.78, P = 0.01) use as predictors of lower post-medicationinitiation RBG and A1C values, respectively. Analysis by drug class suggested prednisone (or glucocorticoids) as predictive of higher medication-initiation event RBG among all start events as compared to DMARDs, while this analysis did not show any drug class-level effect for TNFi. A diagnosis of congestive heart failure(β = 4.69, P = 0.03) was predictive for higher post-initiation RBG values among all medication-initiation events.CONCLUSION No statistically significant hypoglycemic effects surrounding TNFi initiation were observed in this large cohort. Sulfasalazine and hydroxychloroquine may have epidemiologically significant acute hypoglycemic effects. | Patrick R Wood Evan Manning Joshua F Baker Bryant England Lisa Davis Grant W Cannon Ted R Mikuls Liron Caplan | 2018 | World Journal of Diabetes2018，9，2： | 8 |
| 2 | Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease显示文摘AIM To determine if manipulation of dietary advanced glycation end product(AGE), intake affects nonalcoholic fatty liver disease(NAFLD) progression and whether these effects are mediated via RAGE. METHODS Male C57Bl6 mice were fed a high fat, high fructose, high cholesterol(HFHC) diet for 33 wk and compared with animals on normal chow. A third group were given a HFHC diet that was high in AGEs. Another group was given a HFHC diet that was marinated in vinegar to prevent the formation of AGEs. In a second experiment, RAGE KO animals were fed a HFHC diet or a high AGE HFHC diet and compared with wildtype controls. Hepatic biochemistry, histology, picrosirius red morphometry and hepatic mR NA were determined. RESULTS Long-term consumption of the HFHC diet generated significant steatohepatitis and fibrosis after 33 wk. In this model, hepatic 4-hydroxynonenal content(a marker of chronic oxidative stress), hepatocyte ballooning, picrosirius red staining, α-smooth muscle actin and collagen type 1A gene expression were all significantly increased. Increasing the AGE content of the HFHC diet by baking further increased these markers of liver damage, but this was abrogated by pre-marination in acetic acid. In response to the HFHC diet, RAGE-/-animals developed NASH of similar severity to RAGE+/+ animals but were protected from the additional harmful effects of the high AGE containing diet. Studies in isolated Kupffer cells showed that AGEs increase cell proliferation and oxidative stress, providing a likely mechanism through which these compounds contribute to liver injury. CONCLUSION In the HFHC model of NAFLD, manipulation of dietary AGEs modulates liver injury, inflammation, and liver fibrosis via a RAGE dependent pathway. This suggests that pharmacological and dietary strategies targeting the AGE/RAGE pathway could slow the progression of NAFLD. | Christopher Leung Chandana B Herath Zhiyuan Jia Sof Andrikopoulos Bronwyn E Brown Michael J Davies Leni R Rivera John B Furness Josephine M Forbes Peter W Angus | 2016 | World Journal of Gastroenterology2016，22，35： | 7 |
| 3 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density显示文摘 | W.S Simonet D.L Lacey C.R Dunstan M Kelley M.-S Chang R Lüthy H.Q Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero H.-L Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg T.M Hughes D Hill W Pattison P Campbell S Sander G Van | 1997 | Cell1997，，2： | 6 |
| 4 | Effect of variety,nitrogen fertilizer and various agronomic factors on the nutritive value of husked and naked oats grain显示文摘 | T W Davies R M Laverick | 2004 | Animal Feed Science and Technology2004，113，： | 1 |
| 5 | Quantitativemonitoring of gene expression patterns with a complementary DNA microarray显示文摘 | Schena M Shalon D Davis R W Brown P O | 1995 | Science1995，270，： | 1 |
| 6 | Thoracic epidural anesthesia reduces myocardial infarct size after coronary artery occlusion in dogs显示文摘 | Davis R F DeBoer L W Maroko P R | 1986 | Anesth Analg1986，65，7： | 1 |
| 7 | Quantitative monitoring of gene expressionpatterns with a complementary DNA microarray显示文摘 | Schena M Shalon D Davis R W | 1999 | Science1999，270，5235： | 1 |
| 8 | An electrophoretic karyotype of Neurospora crassa显示文摘 | Orbach M J Vollrath D Davis R W | 1988 | Mol Cell Biol1988，，8： | 1 |
| 9 | The assessment and monitoring of sparsely vegetated rangelands using calibrated Landsat data显示文摘 | Graetz R D Pech R R Davis A W | 1988 | International Journal of Remote Sensing1988，9，7： | 1 |
| 10 | Molecular cloning of a ligand for the inducible T cell gene 4-1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor 显示文摘 | Goodwin R G Din W S Davis Smith T | 1993 | Eur J Immunol1993，23，10： | 1 |
| 11 | Quantitative Monitoring of Gene Expression Patterns with a Complementary DNA Microarmy 显示文摘 | SCHENA M SHALQN D DAVIS R W | 1995 | Sclence1995，270，5235： | 1 |
| 12 | Quantitative monitoring of gene expression patterns with a complementary DNA microarray显示文摘 | SCHENA M SHALON D DAVIS R W | 1995 | Science1995，270，5235： | 1 |
| 13 | An Unusual form of Carbon显示文摘 | Davis W R Slawson R J Rigby G R | 1953 | Nature1953，171，： | 1 |
| 14 | Universal amplification and analysis of pathogen 16S rRNA for classification and identification of mycoplasmalike organisms 显示文摘 | Lee I M Hammond R W Davis R E | 1993 | Phytopathology1993，83，8： | 1 |
| 15 | The autonomous underwater glider 'Spray' 显示文摘 | Sherman J Davis R E Owens W B | 2001 | IEEE Journal of Oceanic Engineering2001，26，4： | 1 |
| 16 | High Performance Work Systems and Organizational Performance: The Mediating Role of Internal Social Structures 显示文摘 | EVANS W R DAVIS W D | 2005 | Journal of MarLagement2005，31，5： | 1 |
| 17 | Formation damage and the crastal chemistry of calys显示文摘 | Almon W R Davis D K | | 0，，07： | 1 |
| 18 | Mapping of city lights using DMSP Operational Linesean System data显示文摘 | Elvidge C D Baugh K E Kihn E A Kroehl H W Davis E R | 1997 | Photogrammetrie Engineering and Remote Sensing1997，63，6： | 1 |
| 19 | High-Performance Work Systems and Organizational Performance:The Mediating Role of Internal Social Structure显示文摘 | EVANS W R DAVIS W D | 2005 | Journal of Management2005，31，5： | 1 |
| 20 | Expression profiling using microarrays fabricated by an ink-jet oligonucleotide synthesizer显示文摘 | SCHENA M SHALON D DAVIS R W | 1995 | Science1995，270，5235： | 1 |
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