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| 1 | Fecal lactoferrin accurately reflects mucosal inflammation in inflammatory bowel disease显示文摘BACKGROUND Studies have demonstrated a potential role for fecal biomarkers such as fecal calprotectin(FC)and fecal lactoferrin(FL)in monitoring inflammatory bowel diseases(IBD)-Crohn's disease(CD)and ulcerative colitis(UC).However,their correlation to endoscopic scores,disease severity and affected intestinal surface has not been extensively investigated.AIM To correlate FL,and for comparison white blood cell(WBC)and C-reactive protein(CRP),with endoscopic scores,disease extent and location in CD and UC.METHODS Retrospective analysis in 188 patients who had FL,CRP and WBC determined within 30 d of endoscopy.Disease location,disease extent(number of intestinal segments involved),disease severity(determined by endoscopic scores),timing of FL testing in relation to colonoscopy,as well as the use of effective fast acting medications(steroids and biologics)between colonoscopy and FL measurement,were recorded.RESULTS In 131 CD and 57 UC patients,both CRP and FL-but not WBC-distinguished disease severity(inactive,mild,moderate,severe).In patients receiving fastacting(steroids or biologics)treatment in between FL and colonoscopy,FL showed a higher correlation to endoscopic scores when tested before vs after the procedure(r=0.596,P<0.001,vs r=0.285,P=0.15 for the Simple Endoscopic Score for CD;and r=0.402,P=0.01 vs r=0.054 P=0.84 for Disease Activity Index).Finally,FL was significantly correlated with the diseased mucosal surface(colon-ileocolon>small bowel)and the number of inflamed colon segments.CONCLUSION FL and CRP separated disease severity categories with FL showing lower discriminating P-values.FL showed a close correlation with the involved mucosal surface and with disease extent and was more closely correlated to endoscopy when determined before the procedure–this indicating that inflammatory activity changes associated with therapy might be rapidly reflected by FL levels.FL can accurately and timely characterize intestinal inflammation in IBD. | Marrieth G Rubio Kofi Amo-Mensah James M Gray Vu Q Nguyen Sam Nakat Douglas Grider Kim Love James H Boone Dario Sorrentino | 2019 | World Journal of Gastrointestinal Pathophysiology2019，10，5： | 4 |
| 2 | Comparative transcriptomics of Central Asian Vitis vinifera accessions reveals distinct defense strategies against powdery mildew显示文摘Grape powdery mildew(PM),caused by the biotrophic ascomycete Erysiphe necator,is a devastating fungal disease that affects most Vitis vinifera cultivars.We have previously identified a panel of V.vinifera accessions from Central Asia with partial resistance to PM that possess a Ren1-like local haplotype.In this study,we show that in addition to the typical Ren1-associated late post-penetration resistance,these accessions display a range of different levels of disease development suggesting that alternative alleles or additional genes contribute to determining the outcome of the interaction with the pathogen.To identify potential Ren1-dependent transcriptional responses and functions associated with the different levels of resistance,we sequenced and analyzed the transcriptomes of these Central Asian accessions at two time points of PM infection.Transcriptomes were compared to identify constitutive differences and PM-inducible responses that may underlie their disease resistant phenotype.Responses to E.necator in all resistant accessions were characterized by an early up-regulation of 13 genes,most encoding putative defense functions,and a late down-regulation of 32 genes,enriched in transcriptional regulators and protein kinases.Potential Ren1-dependent responses included a hotspot of co-regulated genes on chromosome 18.We also identified 81 genes whose expression levels and dynamics correlated with the phenotypic differences between the most resistant accessions‘Karadzhandahal’,DVIT3351.27,and O34-16 and the other genotypes.This study provides a first exploration of the functions associated with varying levels of partial resistance to PM in V.vinifera accessions that can be exploited as sources of genetic resistance in grape breeding programs. | Katherine C H Amrine Barbara Blanco-Ulate Summaira Riaz Dániel Pap Laura Jones Rosa Figueroa-Balderas M Andrew Walker Dario Cantu | 2015 | Horticulture Research2015，2，1： | 3 |
| 3 | The genetic basis of grape and wine aroma显示文摘The grape is one of the oldest and most important horticultural crops.Grape and wine aroma has long been of cultural and scientific interest.The diverse compound classes comprising aroma result from multiple biosynthetic pathways.Only fairly recently have researchers begun to elucidate the genetic mechanisms behind the biosynthesis and metabolism of grape volatile compounds.This review summarizes current findings regarding the genetic bases of grape and wine aroma with an aim towards highlighting areas in need of further study.From the literature,we compiled a list of functionally characterized genes involved in berry aroma biosynthesis and present them with their corresponding annotation in the grape reference genome. | Jerry Lin Mélanie Massonnet Dario Cantu | 2019 | Horticulture Research2019，6，1： | 3 |
| 4 | Recent advances in osteosarcoma显示文摘 | Sander M Botter Dario Neri Bruno Fuchs | 2014 | Current Opinion in Pharmacology2014，，： | 2 |
| 5 | Solvent Effects in SN2 Reactions Promoted by Macrocyclic Polyethers and Quaternary Onium Salts 显示文摘 | DARIO L ANGELAMARIA M | 2002 | Journal of Supramolecular Chemistry2002，2，： | 1 |
| 6 | The effect of diet, parity, year and number of kids on milk yield and milk composition in Maltese goat显示文摘 | CARNICELLA D DARIO M AYRES M C C | 2008 | Small Ruminant Res2008，77，1： | 1 |
| 7 | Effects of Self-pollination and Cross-pollination of Vaccinium darrowii (Ericaceae) and Other Low-chill Blueberries 显示文摘 | Dario J C Paul M L | 2009 | Hortscience2009，44，6： | 1 |
| 8 | Microrobotics for future gastrointestinal endoscopy显示文摘 | Menciassi A Quirini M Dario P | | 0，，： | 1 |
| 9 | Microfluidic and lab-on-a-chip preparation routes for organic nanoparticles and vesicular systems for nanomedicine applications显示文摘 | LORENZO C DARIO C STEFANIA M | 2013 | Advanced Drug Delivery Reviews2013，65，1112： | 1 |
| 10 | Fingerprint classification by directional image partitioning显示文摘 | Raffaele C Alessandra L Dario M | 1999 | IEEE Transactions on Pattern Analysis and Machine Intelligence1999，21，5： | 1 |
| 11 | Use offibrolytic enzymes to improve the nutritive value of ruminant diets A biochemical and in vitro runaen degradation assessment显示文摘 | Dario C Fergus L Mould M et (d | 2003 | Animal Feed Science and Technology2003，107，： | 1 |
| 12 | The extraction of neural strategies from the surface EMG 显示文摘 | DARIO FARINA ROBERTO MELERTTI ROGER M ENO- KA | 2004 | J Appl Physiol2004，，14： | 1 |
| 13 | Effects of N-acetylcysteine on outcomes in chronic obstructive pulmonary disease (Bronchitis Randomized on NAC Cost-Utility Study, BRONCUS): a randomised placebo-controlled trial显示文摘 | Marc Decramer Maureen Rutten-van M?lken PN Richard Dekhuijzen Thierry Troosters Cees van Herwaarden Riccardo Pellegrino CP Onno van Schayck Dario Olivieri Mario Del Donno Wilfried De Backer Ida Lankhorst Alfredo Ardia | 2005 | The Lancet2005，，9470： | 1 |
| 14 | Gene expression analysis of histamine receptors in peripheral blood mononuclear cells from individuals with clinically-isolated syndrome and different sta- ges of multiple sclerosis 显示文摘 | COSTANZA M DI DARIO M STEINMAN L | 2014 | J Neuroimmunol2014，277，12： | 1 |
| 15 | Inbreeding depres- sion in Leecese sheep显示文摘 | SELVAGGI M DARIO C PERETTI V | 2010 | Small Rumin Res2010，89，1： | 1 |
| 16 | Development and in vitro testing of a miniature robotic system for colonoscopy显示文摘 | Dario P Carrozza M C Pietrabissa A | 1999 | Journal of Computer Aided Surgery1999，4，1： | 1 |
| 17 | A distributed coordination framework for wireless sensor and actor network显示文摘 | Tommaso M Dario P | 2005 | ACM MobiHoc2005，，： | 1 |
| 18 | Galileo Italian National Telescope (TNG) drive system: components, methods, and performances显示文摘 | Dario M | 1994 | SPIE1994，2199，： | 1 |
| 19 | Galileo high-resolution encoder system显示文摘 | Dario M Enrico C Pietro S | 1997 | SPIE1997，3112，： | 1 |
| 20 | A contribution to the selection and calculation of screws in high duty bolted joints显示文摘 | Dario Croccolo Agostinis M D NicolòVincenzi | 2012 | International Journal of Pressure Vessels and Piping2012，，9697： | 1 |
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