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| 1 | Pharmacogenetics of the systemic treatment in advanced hepatocellular carcinoma显示文摘Hepatocellular carcinoma (HCC) accounts for the majority of primary liver cancers. To date, most patients with HCC are diagnosed at an advanced tumor stage, excluding them from potentially curative therapies (i.e., resection, liver transplantation, percutaneous ablation). Treatments with palliative intent include chemoembolization and systemic therapy. Among systemic treatments, the small-molecule multikinase inhibitor sorafenib has been the only systemic treatment available for advanced HCC over 10 years. More recently, other smallmolecule multikinase inhibitors (e.g., regorafenib, lenvatinib, cabozantinib) have been approved for HCC treatment. The promising immune checkpoint inhibitors (e.g., nivolumab, pembrolizumab) are still under investigation in Europe while in the US nivolumab has already been approved by FDA in sorafenib refractory or resistant patients. Other molecules, such as the selective CDK4/6inhibitors (e.g., palbociclib, ribociclib), are in earlier stages of clinical development, and the c- MET inhibitor tivantinib did not show positive results in a phase III study. However, even if the introduction of targeted agents has led to great advances in patient response and survival with an acceptable toxicity profile, a remarkable inter-individual heterogeneity in therapy outcome persists and constitutes a significant problem in disease management. Thus, the identification of biomarkers that predict which patients will benefit from a specific intervention could significantly affect decision-making and therapy planning. Germ-line variants have been suggested to play an important role in determining outcomes of HCC systemic therapy in terms of both toxicity and treatment efficacy. Particularly, a number of studies have focused on the role of genetic polymorphisms impacting the drug metabolic pathway and membrane translocation as well as the drug mechanism of action as predictive/prognostic markers of HCC treatment. The aim of this review is to summarize and critically discuss the pharmacogenetic literature evidences, with particular attention to sorafenib and regorafenib, which have been used longer than the others in HCC treatment. | Elena De Mattia Erika Cecchin Michela Guardascione Luisa Foltran Tania Di Raimo Francesco Angelini Mario D’Andrea Giuseppe Toffoli | 2019 | World Journal of Gastroenterology2019，25，29： | 8 |
| 2 | Ultrasound evaluation of liver fibrosis: preliminary experience with acoustic structure quantification (ASQ) software显示文摘 | Paolo Ricci Chiara Marigliano Vito Cantisani Andrea Porfiri Andrea Marcantonio Pietro Lodise Ugo D’Ambrosio Giancarlo Labbadia Elena Maggini Ester Mancuso Giovanna Panzironi Mattia Segni Caterina Furlan Raffaele Masciangelo Gloria Taliani | 2013 | La radiologia medica2013，，6： | 2 |
| 3 | Pharmacogenetics of ABC and SLC transporters in metastatic colorectal cancer patients receiving first-line FOLFIRI treatment显示文摘 | Elena De Mattia Giuseppe Toffoli Jerry Polesel Mario D’Andrea Giuseppe Corona Vittorina Zagonel Angela Buonadonna Eva Dreussi Erika Cecchin | 2013 | Pharmacogenetics and Genomics2013，，10： | 2 |
| 4 | Diabetic endothelial dysfunction:effect of free radical scavenging in Type 2 diabetic patients显示文摘 | De Mattia G Laurenti O Fava D | 2003 | J Diabetes Complications2003，，： | 1 |
| 5 | A review of reverse osmosis membrane materials for desalination-development to date and future poten- tial 显示文摘 | Lee K P Amot T C Mattia D | 2011 | Journal of Membrane Science2011，370，12： | 1 |
| 6 | Assessing cortical functional connectivity by linear inverse estimation and directed transfer function: simulations and application to real data 显示文摘 | L Astolfi F Cincotti D Mattia | 2005 | Clinical Neurophysiology (S1388-2457)2005，116，4： | 1 |
| 7 | Diabetic endothelial dysfunction Effect of free radical scavenging in Type 2 diabetic patients显示文摘 | Giancarlo De Mattia O Laurenti and D Fava | 2003 | J Diabetes and its Complications2003，17，2： | 1 |
| 8 | Friction and wear testing of rail and wheel material显示文摘 | LUDGER D MATTIAS P | 2005 | Wear2005，258，： | 1 |
| 9 | A review of reverse osmosis membrane materials for desalination-Development to date and future potential 显示文摘 | Lee K P Amot T C Mattia D | 2011 | Joumal of Membrane Science2011，370，1： | 1 |
| 10 | A review of reverse osmosis membrane materials for desalination-Development to date and future potential 显示文摘 | Lee K P Amot T C Mattia D | 2011 | Journal of Membrane Science2011，370，1： | 1 |
| 11 | Population-based pediatric reference intervals for general clinical chemistry analytes on the Abbott Architect ci8200 instrument显示文摘 | Peter Ridefelt Mattias Aldrimer Per-Olof R?d?? Frank Niklasson Leif Jansson Jan Gustafsson Dan Hellberg | 2012 | Clinical Chemistry and Laboratory Medicine2012，，5： | 1 |
| 12 | Limestone Dissolution in Converter Slag at 1873 K (1600 C)显示文摘 | Tengfei D Patrice N Mattias E | 2013 | Metallurgical Materials Transactions B Process Metallurgy & Materials Processing Science2013，44，： | 1 |
| 13 | Characterization of olive oil produced with a new enzyme processing aid显示文摘 | Ranalli A Mattia G D | 1997 | J Am Oil Chem Sco1997，74，： | 1 |
| 14 | Assessing cortical functional connectivity by linear inverse estimation and directed transfer func?tion: simulations and application to real data显示文摘 | Astolfi L Cincotti F Mattia D | 2005 | Clin Neurophysiol2005，116，4： | 1 |
| 15 | Association of interleukin-(IL)10 haplotypes and serum IL-10 levels in the progression of childhood immune thrombocytopenic purpura显示文摘 | Tesse R Del Vecchio G C De Mattia D | 2012 | Gene2012，505，1： | 1 |
| 16 | Effect of graphitization on the wettability and electrical conductivity of CVD-carbon nanotubes and films显示文摘 | Mattia D Rossi M P Kim B M | 2006 | The Journal of Physical Chemistry B2006，110，20： | 1 |
| 17 | Fractionated stereotactic radiosurgery for patients with brain metastases显示文摘 | Giuseppe Minniti Rolando M. D’Angelillo Claudia Scaringi Luca E. Trodella Enrico Clarke Paolo Matteucci Mattia Falchetto Osti Sara Ramella Riccardo Maurizi Enrici Lucio Trodella | 2014 | Journal of Neuro-Oncology2014，，2： | 1 |
| 18 | Homocysteine induced arteriosclerosis - like alterations of the aorta in normotensive and hypertensive rats following application of high doses of methionine显示文摘 | Mattias D Becker CH Riezler R | 1996 | Atherosclerosis1996，122，2： | 1 |
| 19 | Diabetic endothelial dysfunction: effect of free radical scavenging in Type 2 diabetic patients显示文摘 | De Mattia G Laurenti O Fava D | 2003 | J Diabetes Complications2003，17，： | 1 |
| 20 | Quantitative EEG and dynamic susceptibility contrast MRI in Alzheimer's disease:a correlative study显示文摘 | Mattia D Babiloni F Romigi A | 2003 | Clin Neurophysiol2003，114，7： | 1 |
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