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| 1 | Simultaneous intraductal papillary neoplasms of the bile duct and pancreas treated with chemoradiotherapy显示文摘Some authors have suggested that intraductal papillary mucinous neoplasms of the bile duct(IPMN-B) could be the the biliary counterpart of IPMN of the pancreas(IPMN-P) since they share several clinical-pathological features.These include prominent intraductal papil-lary proliferation pattern,a gastrointestinal phenotype,frequent mucin hyper-secretion and progression to mu-cinous carcinoma.To date there are just four reported cases of patients with synchronous IPMN-B and IPMN-P all of which were treated surgically.We hereby report the case of a 76-year-old woman who was incidentally diagnosed with both an asymptomatic 3 cm bulky uid lesion obstructing the bile duct lumen,diagnosed as a malignant IPMN-B,and synchronous multiple pancreatic cystic lesions(10-13 mm) communicating with an irreg-ular Wirsung,diagnosed as branch duct IPMN-P.Since surgery was ruled-out because of the patient's age and preferences,she underwent a conservative manage-ment regimen comprising both chemotherapy and radio-therapy.This was effective in decreasing the mass size and in resolving subsequent jaundice.This is also the f irst reported case of IPMN-B successfully treated with chemoradiotherapy.Clinicians should consider medical treatment as an option in this clinical scenario,in pa-tients who may be unf it for surgery. | Roberto Valente Gabriele Capurso Paola Pierantognetti Elsa Iannicelli Matteo Piciucchi Adriana Romiti Paolo Mercantini Alberto Larghi Giulia Francesca Federici Viola Barucca Maria Falchetto Osti Emilio Di Giulio Vincenzo Ziparo Gianfranco Delle Fave | 2012 | World Journal of Gastrointestinal Oncology2012，4，2： | 13 |
| 2 | Adjuvant radiochemotherapy for gastric cancer:should weuse prognostic factors to select patients?显示文摘Radiotherapy has a not well-established role in the pre-operative and in the post-operative setting in gastric cancer(GC) patients. Randomized trials report controversial outcomes and impact on survival. In the D2 loco-regional node resection era, after a wellperformed radical surgery, local treatment using radiotherapy combined to chemotherapy should be considered for locally advanced GC. Prognostic factors could help the better selection of subgroups that present high risk of loco-regional recurrence. Then, the addition of radiotherapy could improve the diseasefree survival and also quality of life. There are no large prospective studies that have assessed specific factors predicting for recurrence or survival, but only retrospective series, some of them including high number of patients with homogeneous characteristics. In locally advanced GC adding radiotherapy to the postoperative chemotherapy seems to improve outcomes and quality of life. Prognostic factors such as T-stage, N-status, nodal ratio, and other histological factors should be considered to submit patients to postoperative combined treatment. Larger prospective series are necessary to investigate the role of combined chemoradiation after radical D2-resection, especially in locally advanced GC. Further prospective investigations are needed to suggest prognostic factors that have significant impact on survival and recurrence, improving the management and outcomes, particularly in locally advanced GC patients. | Linda Agolli Riccardo Maurizi Enrici Mattia Falchetto Osti | 2016 | World Journal of Gastroenterology2016，22，3： | 3 |
| 3 | Fractionated stereotactic radiosurgery for patients with brain metastases显示文摘 | Giuseppe Minniti Rolando M. D’Angelillo Claudia Scaringi Luca E. Trodella Enrico Clarke Paolo Matteucci Mattia Falchetto Osti Sara Ramella Riccardo Maurizi Enrici Lucio Trodella | 2014 | Journal of Neuro-Oncology2014，，2： | 1 |
| 4 | Micro- structural characterization of asphalt mixtures contai- ning recycled asphalt materials 显示文摘 | Falchetto A C Montepara A Tebaldi G | 2013 | Journal of Materi- als in Civil Engineering2013，25，1： | 1 |
| 5 | Quality control in combinatorial chemistry: determinations of amounts and comparison of the 'purity' of LC-MS-purified samples by NMR,LC-UV and CLND显示文摘 | Letot E Koch G Falchetto R | 2005 | J Comb Chem2005，7，3： | 1 |
| 6 | Humoral immune responses to cathepsin D and glucose regulated protein 78 in ovarian cancer patients显示文摘 | Chinni SR Falchetto R Gercel-Taylor C | | 0，，09： | 1 |
| 7 | Speed screen : label-free liquid chromatography-mass spectrometry-based high- throughput screening for the discovery of orphan protein ligands 显示文摘 | Muckenschnabel I Falchetto R Mayr LM | 2004 | Anal Biochem2004，324，9： | 1 |
| 8 | Humoral immune responses to eathepsin D and glucose regulated protein 78 in ovarian cancer patients显示文摘 | Chinni SR Falchetto R Gercel TC | 1997 | Clin cancer Res1997，3，9： | 1 |
| 9 | Label-free liquid chromatography-mass spectrometry-based high-throughput screening for the discovery of orphan protein ligands显示文摘 | Muckenschnabel I Falchetto R Mayr L | | Analytical Chemistry0，，： | 1 |
| 10 | Investigation of limiting criteria for low temperature cracking of asphalt mixture显示文摘 | Moon K H Falchetto A C Marasteanu M O | 2014 | KSCE Journal of Civil Engineering2014，18，1： | 1 |
| 11 | Microstructural and rheologicalinvestigation of asphalt mixtures containing recycled asphaltmaterials 显示文摘 | AUGUSTO CANNONE FALCHETTO ANTONIO MONTEPARA GABRIELE TEBALDI | 2012 | Construction and Building Materials2012，35，2： | 1 |
| 12 | Identification of two domains which mediate the binding of activating phospholipids to the plasmamembrane Ca^2+ pump显示文摘 | Brodin P Falchetto R Vorherr T | 1992 | Eur J Biochem1992，204，2： | 1 |
| 13 | Investigation of limiting criteria for low temperature cracking of asphalt mixture显示文摘 | MOON K H FALCHETTO A C MARASTEANU M O | 2014 | Ksce Journal of Civil Engineering2014，18，1： | 1 |
| 14 | Humoral immune respmsestn cathepsin D and glucose-regulated protein 78 in ovarian cancer patients 显示文摘 | Chinni SR Falchetto R GercelTC | 1997 | Clin Cancer Res1997，3，9： | 1 |
| 15 | Microstructural investigation of hot mix asphalt ( HMA) mixtures using dig-ital image processing (DIP) 显示文摘 | MOON K H FALCHETTO A C | 2015 | Ksce J Civ Eng2015，19，6： | 1 |
| 16 | Microstructural analysis of asphalt mixtures using digital im-age processing techniques 显示文摘 | MOON K H FALCHETTO A C JEONG J H | 2014 | Can J Civ Eng2014，41，1： | 1 |
| 17 | Influence of computation algorithm on the accuracy of rut depth measurement显示文摘Rutting is one of the dominant pavement distresses,hence,the accuracy of rut depth measurements can have a substantial impact on the maintenance and rehabilitation(M &R) strategies and funding allocation.Different computation algorithms such as straightedge method and wire line method,which are based on the same raw data,may lead to rut depth estimation which are not always consistent.Therefore,there is an urgent need to assess the impact of algorithm types on the accuracy of rut depth computation.In this paper,a 13-point-based laser sensor detection technology,commonly accepted in China for rut depth measurements,was used to obtain a database of 85,000 field transverse profiles having three representative rutting shapes with small,medium and high severity rut levels.Based on the reconstruction of real transverse profiles,the consequences from two different algorithms were compared.Results showed that there is a combined effect of rut depth and profile shape on the rut depth computation accuracy.As expected,the difference between the results obtained with the two computation methods increases with deeper rutting sections:when the distress is above 15 mm(severe level),the average difference between the two computation methods is above 1.5 mm,normally,the wire line method provides larger results.The computation suggests that the rutting shapes have a minimal influence on the results.An in-depth analysis showed that the upheaval outside of the wheel path is a dominant shape factor which results in higher computation differences. | Di Wang Augusto Cannone Falchetto Matthias Goeke Weina Wang Tiantian Li Michael P.Wistuba | 2017 | Journal of Traffic and Transportation Engineering(English Edition)2017，4，2： | 0 |
| 18 | 多孔沥青混合料堵塞规律离散元仿真显示文摘为揭示多孔沥青混合料孔隙堵塞机理,开展了多孔沥青混合料堵塞模型试验与仿真模拟结合研究;基于电子计算机断层扫描与离散元软件PFC3D V5.0分析了多孔沥青混合料孔隙特征,得到了多孔沥青混合料的孔隙数据;在PFC3D V5.0中投放各粒径集料并根据孔隙特征生成压实虚拟试件,以MATLAB切片对比实际试件孔隙图像验证模型准确性;在自重条件下设置特定级配组成堵塞物侵入多孔沥青混合料试件模拟仿真,并以室内试验结果对照验证,改变投放堵塞物粒径,分析了试件孔隙衰变率,找出了堵塞敏感颗粒;在自重条件下引入流体模拟仿真试验,改变了流体渗流速度,分析了试件堵塞变化规律。研究结果表明:PFC3D V5.0生成的虚拟试件具备较高的精确度,仿真揭示了试件堵塞规律,小颗粒除堆积于喉孔处产生堵塞外,还会在嵌挤成型后与大粒径颗粒积聚产生堵塞;自重条件下的堵塞主要集中在混合料试件上层30 mm处,相应堵塞敏感颗粒粒径分布为0.150~0.600 mm,堵塞颗粒粒径分布对堵塞结果影响较大;在重力与流体条件下,随着渗流速度从0.005 m·s^(-1)增加到0.030 m·s^(-1),孔隙衰变率变化速度增加,残留在混合料内部的堵塞物减少,孔隙衰变率减小,排水沥青路面在设计与养护时也需将当地降雨条件带入考虑。 | 何亮 周子栋 VAN DEN BERGH Wim BALIEU Romain CANNONE FALCHETTO Augusto 朱继青 ALEXIADIS Alessio KOWALSKI Karol VALENTIN Jan 蔡皓东 李后君 乔亚宁 | 2023 | 交通运输工程学报2023，23，2： | 0 |
| 19 | 免疫疗法联合立体定向放疗治疗非小细胞肺癌脑转移:一项AIRO多中心回顾性研究显示文摘背景与目的 通过意大利放射治疗和临床肿瘤学学会(Italian Association of Radiotherapy and Clinical Oncology, AIRO)的一项多中心回顾性研究,明确免疫疗法(immunotherapy, IT)和立体定向放疗(stereotactic radiotherapy,SRT)包括放射外科治疗(radiosurgery, RS)或大分割立体定向放疗(hypofractionated stereotactic radiotherapy, HFSRT)治疗非小细胞肺癌(non-small cell lung cancer, NSCLC)脑转移的疗效和毒性。方法 对来自19个意大利中心接受SRT+IT的NSCLC伴脑转移患者进行分析,并与单独接受SRT的对照组患者进行比较。结果 共纳入SRT+IT组100例和单独SRT组50例。接受SRT+IT的患者有更长的颅内局部无进展生存期(intracranial local progression-free survival, i LPFS)(经倾向性评分调整后,P=0.007)。在诊断为脑转移时接受IT合并有颅外进展的患者中(n=24),接受SRT后再进行IT与较好的总生存期(overall survival, OS)相关(P=0.037)。多因素分析显示组织学类型为非腺癌、卡氏体能状态(Karnofsky performance status,KPS)评分=70分以及接受HFSRT与显著减少的生存期相关(P值分别为0.019、0.017和0.007)。与SRT和IT治疗间隔>7天(n=10)相比,治疗间隔≤7天(n=90)与更长的OS相关(经倾向性评分调整后,P=0.008)。联合治疗耐受性良好。在放射性坏死方面,接受SRT+IT的患者与单独SRT的患者无显著差异。SRT和IT的治疗间隔对毒性发生率无影响。结论 SRT+IT是一种安全的联合治疗方法,与单独SRT相比,具有更长的i LPFS。 | Silvia SCOCCIANTI Emanuela OLMETTO Valentina PINZI Mattia Falchetto OSTI Rossella Di FRANCO Saverio CAINI Paola ANSELMO Paolo MATTEUCCI Davide FRANCESCHINI Cristina MANTOVANI Giancarlo BELTRAMO Francesco PASQUALETTI Alessio BRUNI Paolo TINI Emilia GIUDICE Patrizia CIAMMELLA Anna MERLOTTI Sara PEDRETTI Marianna TRIGNANI Marco KRENGLI NiccolòGIAJ-LEVRA Isacco DESIDERI Guido PECCHIOLI Paolo MUTO Ernesto MARANZANO Laura FARISELLI Pierina NAVARRIA Umberto RICARDI Vieri SCOTTI Lorenzo LIVI 王绿化(翻译/校对) | 2022 | 中国肺癌杂志2022，25，4： | 0 |
| 20 | Experimental investigation of asphalt mixture containing Linz-Donawitz steel slag显示文摘Standard asphalt mixtures for road infrastructures consist of natural aggregate and bitumen. A number of research efforts have successfully investigated the possibility of replacing the conventional aggregate skeleton with industrial by-products such as slag originating from steel production process. However, little is known on the effect of steel slag on the mixtures performance properties such as resistance to low-temperature cracking and to permanent deformation, stiffness and fatigue. This paper presents a comprehensive investigation on the fundamental performance properties of different types of asphalt mixtures prepared with 100% LD slag aggregate and a conventional asphalt mixture containing natural Gabbro aggregate. Sophisticated testing methods were used to evaluate the key performance parameters for the set of asphalt mixtures investigated. In this study, low temperature cracking was addressed through thermal stress restrained specimen tests. Penetration tests and cyclic compression tests were used to evaluate the response of asphalt binder and asphalt mixture to permanent deformation due repeated loading, respectively. The cyclic indirect tensile test was selected for investigating both stiffness properties and fatigue resistance. For this purpose the complex stiffness modulus was measured to quantify material stiffness under different temperature and loading conditions providing information on the visco-elasto-plastic material behavior. Fatigue tests were used to determine the progressive and localized material damage caused by cyclic loading. The experimental results indicate that asphalt mixtures prepared with LD slag are suitable for asphalt pavement construction and that in most cases they perform better than conventional asphalt mixtures prepared with Gabbro aggregate. | Jens Groenniger Augusto Cannone Falchetto Ivan Isailovic Di Wang Michael P. Wistuba | 2017 | Journal of Traffic and Transportation Engineering(English Edition)2017，4，4： | 0 |
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