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| 1 | Split liver transplantation: a reliable approach to expand donor pool显示文摘Orthotopic liver transplantation as a successful treatment of end-stage liver disease is hampered by a persistent lack of cadaveric organs. Split liver transplantation, which was first successfully performed by Medical School of Hannover in 1988, has become a mature surgical technique to expand the donor pool. Between 1993 and 1999, split liver transplantation activities have increased in Europe from 1. 2% to 10. 4% in all performed liver transplantations. Current data have strongly supported that the survival rate of patients after split liver transplantation is not significantly different from that of patients after whole-size orthotopic liver transplantation. The most important step of donor graft selection is surgeon’ s observation judged by the experience of individual transplant center. The paper aims to provide the guideline of donor selection, hepatic graft splitting, and recipient management as well. DATA SOURCES: Medical School of Hannover has accumulated plentiful experience of split liver transplantation for more than 10 cases ever since 1998. Besides that, we also reviewed a variety of literatures from other famous European and American centers specialized in this field for many years. RESULTS:According to our experience combined with the view points of others, the donor should meet the following criteria as well: (1) age less than 50 years; (2) hemodynamics stable; (3) ICU less than 5 days; (4) Na less than 170 mmol/L or better if less than 150 mmol/L. In 1996 and 1997, the Hamburg group and the UCLA group separately introduced a breakthrough technique performing split liver transplantation in situ. Evidently, the in situ technique has been limited by prolonged time of donor organ procurement , coordination with other organ procurement teams, and even extra burden on donor hospital. Some groups, therefore, have restored the ex situ or bench splitting technique , and fortunately the transplant outcomes of the ex situ technique are equivalent to those of the in situ one. Recently some new techniques have been introduced to split the liver for two adult patients, including the split-cava technique. CONCLUSIONS:It is clear that the most important factor for determining the prognosis of the patient is the time of receiving liver transplantation, not the type of liver transplantation. We still need to pay close attention to the graft to recipient weight ratio (GRWR) and the UNOS classification or MELD score before the patient is subjected to split liver transplantation. | Ji-Qi Yan, Thomas Becker, Cheng-Hong Peng, Hong-Wei Li and Juergen Klempnauer Department of Surgery, Ruijin Hospital Affiliated to Shanghai Second Medical University, Shanghai 200025, China ( Yan JQ, Peng CH and Li HW) Department of Abdominal and Transplant Surgery, Medical School of Hannover, Carl-Neuberg-Str. 1 , 30625 Hannover, Germany | 2005 | Hepatobiliary & Pancreatic Diseases International2005,4,3: | 3 |
| 2 | Homocysteine induced arteriosclerosis - like alterations of the aorta in normotensive and hypertensive rats following application of high doses of methionine显示文摘 | Mattias D Becker CH Riezler R | 1996 | Atherosclerosis1996,122,2: | 1 |
| 3 | Homocysteine induced arteriosclerosis like alteration of the aorta in normotensive and hypertensive rats 显示文摘 | Matthias D Becker CH Reizler R | 2002 | Arteriosclerosis2002,122,: | 1 |
| 4 | Homocysteine induced arteriosclerosis like alternations of the aortain noemotensive and hypertensive rats following application of high doses of methionine显示文摘 | Matthias D Becker CH Riezler R | 1996 | Atherosclerosis1996,122,: | 1 |
| 5 | Homocysteine induced arteriosclerosis like alteration of the aorta in normotensive and hypertensive rats显示文摘 | Matthias D Becker CH Reizler R | | 0,,: | 1 |
| 6 | Homocysteine induced arteriosclerosis-like alterations of the aorta in normotensive and hypertensive rats followign application of high doses of methionine显示文摘 | Matthias D Becker CH Riezler R | 1996 | Atherosclerosis1996,122,2: | 1 |
| 7 | Homocysteine induced arteriosclerosis-like alterations of the aorta in normotensive and hypertensive rats following application of high doses of methionine 显示文摘 | Matthias D Becker CH Riezier R | 1996 | Atherosclerosis1996,122,: | 1 |
| 8 | High-resolution miniprobe-based confocal microscopy in combination with video mosaicing(with video)显示文摘 | Becker V Vercauteren T von Weyhem CH | 2007 | Gastrointest Endosc2007,66,5: | 1 |
| 9 | Homocysteine induced arteriosclerosis-like alterations of the aorta in normotensive and hypertensive rats following application of high doses of methionine显示文摘 | Matthias D Becker CH Riezler R | 1996 | Atherosclerosis1996,12,2: | 1 |
| 10 | Homocysteine induced arteriosclerosislike alternations of the aorta in normotensive and hypertensive rats following application of high doses of methionine显示文摘 | Matthias D Becker CH Riezler R | 1996 | Atherosclerosis1996,122,: | 1 |
| 11 | Matrix-assisted laser desorption time-of-flight mass spectrometry of oligonucleotides using 3-hydroxypicolinic acid as an ultraviolet-sensitive matrix显示文摘 | Steding A Becker CH | 1993 | Rapid Commun Mass Spectrom1993,7,2: | 1 |
| 12 | Schlichtheitskriterien und Jordangebiete显示文摘 | Becker J and Pommerenke Ch | 1984 | J Reine Angew Math1984,354,: | 1 |
| 13 | Homocysteine induced arteriosclerosis-like alternations of the aorta in norm otensive and hypertensive rats following application of high doses of methionine显示文摘 | Matthias D Becker CH R iezler R | 1996 | Atherosclerosis1996,122,: | 1 |
| 14 | Homecysteine induced arteriosclerosis-like alterations of the aorta in normorensive and hypertensive rats following application of high doses of methionine显示文摘 | Matthias D Becker CH Riezler R | 1996 | Atherosclerosis1996,122,: | 1 |
| 15 | Schlichtheitskriterien und Jordangebiete显示文摘 | Becker J Pommerenke Ch | 1984 | Journal für die Reine und Angewandte Mathematik1984,354,: | 1 |
| 16 | The inner radius of univalence and Jordan curve显示文摘 | Pommerenker Ch | 1984 | J Reine Angew Math1984,354,: | 1 |
| 17 | Comprehensive phenotyping in multiple sclerosis: discovery based proteomics and the current understanding of putative biomarkers 显示文摘 | O'Connor KC Roy SM Becker CH | 2006 | Disease Marker2006,22,4: | 1 |
| 18 | Schlichttheitskriterien ang Jordangebietetialgle显示文摘 | Becker J Pommerenke Ch | 1986 | J Reine Angew Math1986,27,: | 1 |
| 19 | Cervical dystonia:about familial and sporadic cases in 88 patients显示文摘 | Camargo CH Camargos ST Becker N | 2014 | Arq Neuropsiquiatr2014,72,2: | 1 |
| 20 | Human amnion as a bioprosthesis for bile duct reconstruction in the pig显示文摘 | Scudamore CH Becker CD Fache JS | 1988 | Am J Surg1988,155,: | 1 |