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| 1 | Fecal markers of inflammation used as surrogate markers for treatment outcome in relapsing inflammatory bowel disease显示文摘AIM: To evaluate fecal calprotectin (FC) as a surrogate marker of treatment outcome of relapse of inflammatory bowel disease (IBD) and, to compare FC with fecal myeloperoxidase (MPO) and fecal eosinophil protein X (EPX). METHODS: Thirty eight patients with IBD, comprising of 27 with ulcerative colitis (UC) and 11 with Crohn’s disease (CD) were investigated before treatment (inclusion), and after 4 and 8 wk of treatment. Treatment outcomes were evaluated by clinical features of disease activity and endoscopy in UC patients, and disease activity in CD patients. In addition, fecal samples were analyzed for FC by enzyme-linked immunosorbent assay (ELISA), and for MPO and EPX with radioimmunoassay (RIA). RESULTS: At inclusion 37 of 38 (97%) patients had elevated FC levels (> 94.7 μg/g). At the end of the study, 31 of 38 (82%) patients fulfilled predefined criteria of a complete response [UC 21/27 (78%); CD 10/11 (91%)]. Overall, a normalised FC level at the end of the study predicted a complete response in 100% patients, whereas elevated FC level predicted incomplete response in 30%. Normalised MPO or EPX levels predicted a complete response in 100% and90% of the patients, respectively. However, elevated MPO or EPX levels predicted incomplete response in 23% and 22%, respectively. CONCLUSION: A normalised FC level has the potential to be used as a surrogate marker for successful treatment outcome in IBD patients. However, patients with persistent elevation of FC levels need further evaluation. FC and MPO provide superior discrimination than EPX in IBD treatment outcome. | Michael Wagner Christer GB Peterson Peter Ridefelt Per Sangfelt Marie Carlson | 2008 | World Journal of Gastroenterology2008，14，36： | 9 |
| 2 | Antithrombin administration during experimental cardiopulmonary resuscitation 显示文摘 | Johansson J Ridefelt P Basu S | 2004 | Resuscita- tion2004，62，1： | 1 |
| 3 | Antithrombin reduction af- ter experimental eardiopulmonary resuscitation 显示文摘 | Johansson J Ridefelt P Basu S | 2003 | Resuscitation2003，59，2： | 1 |
| 4 | Population-based pediatric reference intervals for general clinical chemistry analytes on the Abbott Architect ci8200 instrument显示文摘 | Peter Ridefelt Mattias Aldrimer Per-Olof R?d?? Frank Niklasson Leif Jansson Jan Gustafsson Dan Hellberg | 2012 | Clinical Chemistry and Laboratory Medicine2012，，5： | 1 |
| 5 | Antithrombin administration during experimental cardiopulmonary resuscitation 显示文摘 | Johansson J Ridefelt P Basu S | 2004 | Resuscitation2004，62，1： | 1 |
| 6 | Ca2+-induced Ca2+ oscillations in parathyroid cells显示文摘 | Ridefelt P Bjorklund E Akerstrom G | 1995 | Biochem Biophys Res Commun1995，215，： | 1 |
| 7 | Alkaline phosphatase in healthy children: reference intervals and prevalence of elevated levels显示文摘 | Ridefelt P Gustafsson J Aldrimer M | 2014 | Horm Res Paediatr2014，，18： | 1 |
| 8 | Effects of calcium channel modulators on the regulation of cytoplasmic Ca^2+ and hormone secretion of parathyroid cells显示文摘 | Ridefelt P Hellman P Rastad J | 1996 | Pharmacol Toxicol1996，78，3： | 1 |
| 9 | Antithrombin reduction after experimental cardiopulmonary resuscitation显示文摘 | Johansson J Ridefelt P Basu S | 2003 | Resuscitation2003，59，2： | 1 |
| 10 | Lactonse intolerance: lactose tolerance test versus genotyping显示文摘 | Ridefelt P Hakansson LD | 2005 | Scand J Gastroenterol2005，40，7： | 1 |
| 11 | Reference intervals on the Abbot Architect for serum thyroid hormones, lipids and prolactin in healthy children in a population-based study显示文摘 | Aldrimer M Ridefelt P Rod P | 2012 | Scand J Clin Lab Invest2012，72，4： | 1 |
| 12 | Propofol induces a lowering of free cytosolic calcium in myocardial cells显示文摘 | Li YC Ridefelt P Wiklund L | 1997 | Acta Anaesthesiol Scand1997，41，5： | 1 |
| 13 | Antithrombin reduction after experimental cardiopulmonary resuscitation显示文摘 | Johansson J Ridefelt P Basu S | | 0，，： | 1 |
| 14 | Lactose intolerance: lactose tolerance test versus genotyping显示文摘 | Ridefelt P Hakansson LD | 2005 | Scand J Gastroenterol2005，40，7： | 1 |
| 15 | Lactose intolerance: lactose tolerance test versus genotyping显示文摘 | RIDEFELT P HAKANSSON L | 2005 | Scan J Gastroentero2005，40，7： | 1 |
| 16 | Propofol induces a lowering of free cytosolic calcium in myocardial cells显示文摘 | Li YC Ridefelt P Wiklund L | 1997 | Acta Anaesthesiol Scand1997，41，5： | 1 |
| 17 | Population-based pediatric reference intervals for HbAlc, bilirubin, albumin, CRP, myoglobin and serum enzymes显示文摘 | R6d66 P Ridefelt P Aldrimer M | 2013 | Scand J Clin Lab Invest2013，73，5： | 1 |
| 18 | Population-based pediatric reference intervals for general clinical chemistry analytes on the Abbott Architect ci8200 instrument显示文摘 | Peter Ridefelt Mattias Aldrimer Per-Olof R?d?? Frank Niklasson Leif Jansson Jan Gustafsson Dan Hellberg | 2012 | Clinical Chemistry and Laboratory Medicine2012，，5： | 1 |
| 19 | Antithrombin reduction after experimental cardiopulmonary resuscitation 显示文摘 | Johansson J Ridefelt P Basu S | 2003 | Resuscitation2003，59，2： | 1 |
| 20 | Antithrombinreduction after experimental cardiopulmonary resuscitation显示文摘 | Johansson J Ridefelt P Basu S | 2003 | Resuscitation2003，59，2： | 1 |
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