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| 1 | Wnt signaling control of bone cell apoptosis显示文摘Wnts 是调停的生长因素的一个大家庭象胚胎开始,形态发生和瀑形成一样的必要生物学过程。这些蛋白质也在 oncogenesis 起一个作用,并且他们在许多纸巾调整 apoptosis。Wnts 把 G-protein-coupled 受体和低密度的脂蛋白(LDL ) 绑在由 frizzled (FZD ) 组成的膜受体建筑群受体相关的蛋白质(LRP ) 。这 ligand 受体建筑群的形成开始象几条不在经典中的小径一样包括 canonical/beta-catenin 小径的很多发信号的串联。在最近的年里,发信号的正规 Wnt 被报导了在骨生成的控制起一个重要作用。临床的研究发现了在 LRP-5 的变化与减少的骨头矿物质密度(BMD ) 和破裂被联系。Wnt 小径部件的猛烈、转基因的老鼠模型的调查证明了发信号的正规 Wnt 包括增长,区别,功能和 apoptosis 调制造骨细胞生理学的大多数方面。在骨头表示 LRP-5 的函数异种的获得的转基因的鼠标,或缺乏 Wnt 对手的鼠标分泌了卷发相关的 protein-1,展出提高的 BMD 和压制的造骨细胞 apoptosis。另外,有象禁止肝糖 synthase kinase-3beta 的那些那样的 pharmacologic 混合物的现出症状之前的潜的研究在骨生成和造骨细胞 apoptosis 的调整支持正规 Wnt 小径的重要性。 | Bodine,PV | 2008 | Cell Research2008，18，2： | 30 |
| 2 | Bilirubin in coronary artery disease:Cytotoxic or protective?显示文摘Bilirubin has traditionally been considered a cytotoxic waste product.However,recent studies have shown bilirubin to have anti-oxidant,anti-inflammatory,vasodilatory,anti-apoptotic and anti-proliferative functions.These properties potentially confer bilirubin a new role of protection especially in coronary artery disease(CAD),which is a low grade inflammatory process exacerbated by oxidative stress.In fact,recent literature reports an inverse relationship between serum concentration of bilirubin and the presence of CAD.In this article,we review the current literature exploring the association between levels of bilirubin and risk of CAD.We conclude that current evidence is inconclusive regarding the protective effect of bilirubin on CAD.A causal relationship between low serum bilirubin level and increased risk of CAD is not currently established. | Nancy Gupta Tavankit Singh Rahul Chaudhary Sushil K Garg Gurprataap Singh Sandhu Varun Mittal Rahul Gupta Roxana Bodin Sachin Sule | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，4： | 14 |
| 3 | Regulation of hematopoiesis and the hematopoietic stem cell niche by Wnt signaling pathways显示文摘造血的干细胞(HSC ) 是为所有系的血细胞的终生的产生负责的房间的一张稀罕人口。以便维持他们的数字, HSC 必须建立在自强的反对房间命运之间的平衡(在哪个作为 HSC 工作的能力被保留) 并且造血的区别的开始。Multiplesignaling 小径在 HSC 房间命运的规定被含有。小径的一个如此的集合是 ligands 的 Wnt 家庭激活的那些。Wnt 发信号小径玩关键角色 duringembryogenesis,这些小径的解除管制在稳固的肿瘤的形成被含有。发信号的 Wnt 也从多重纸巾在干细胞的规定起一个作用,例如胚胎、表皮、肠的干细胞。然而,在 HSCbiology 发信号的 Wnt 的功能仍然是争论的。在这评论,我们将讨论成年 HSC 的基本特征,集中于 HSCand 的规定并且它的规章的微型环境,“壁龛”它由表明小径的 Wnt 的壁龛。 | Michael J Nemeth David M Bodine | 2007 | Cell Research2007，17，9： | 9 |
| 4 | Alignment of social and ecological structures increased the ability of river management显示文摘Large hydrologic basins involve multiple stakeholders, and coupled dynamic social and ecological processes. Managing such basins has long been a challenge. Balancing the demand for water from nature against that from humans is always difficult, particularly in arid watersheds. Here, we analyze potential institutional causes of ecological degradation and how it can be reversed by introducing new forms of governance. The framework and assumptions are illustrated using China’s second-largest endorheic basin, where empirical evidence shows that the introduction of a new governing authority connecting midstream and downstream actors facilitated the establishment of a new governance regime that is better aligned with the biophysical scales of the watershed. A trans-regional water allocation project initiated by the new higher-level authority successfully rescued downstream oases and restored a dried terminal lake. These outcomes suggest that when social and ecological structures are better aligned our ability to manage the interplay between social and ecological processes increases. However, the lack of direct connection between the actors of the middle and lower reaches resulted in the paradox of an increase in water demand. We therefore suggest that measures to stimulate the emergence of horizontal social ties linking different critical groups of actors across the watershed could further the alignment of the institutional and biophysical structures-without these changes sustainable management of river basins and other common pool resources will remain problematic. | Shuai Wang Bojie Fu Orjan Bodin Jianguo Liu Mengmeng Zhang Xiaoyan Li | 2019 | Science Bulletin2019，64，18： | 6 |
| 5 | Routing and Scheduling of Vehicles and Crews 显示文摘 | Bodin L D Golden B L Assad A A Ball M O | 1983 | Computers and Operations Research1983，10，2： | 2 |
| 6 | On the Nature of the P-Wave Velocity Gradient in the Inner Core beneath Central America显示文摘We conduct an experiment to investigate whether linearity in the observed velocity gradient in the volume of the inner core sampled by the PKP ray paths beneath Central America is a robust approximation. Instead of solving an optimization problem, we approach it within the Bayesian inference. This is an ensemble approach, where model specification is relaxed so that instead of only one solution, groups of reasonable models are acceptable. Furthermore, in transdimensional Bayesian inference used here, the number of basis functions needed to model observations is by itself an unknown. Our modeling reveals that in the ensemble of models, the most likely are those containing only 2 nodes(linear trend). Thus our result justifies the assumption used for the determination of inner core rotation with respect to the rest of the mantle that the observed gradient is constant in its nature(linear). Recent observations in seismology suggest that it is likely that the spatial variability in elastic parameters is a widespread phenomenon in the inner core. Future array observations will further constrain spatial extent and magnitude of velocity changes and show whether there is a significant difference between these observations in the two quasi-hemispheres of the inner core. | Hrvoje Tkali Thomas Bodin Mallory Young Malcolm Sambridge | 2013 | Journal of Earth Science2013，24，5： | 2 |
| 7 | Prediction of fluid responsiveness in septic shock patients: comparing stroke volume variation by FloTrac/Vigileo and automated pulse pressure variation显示文摘 | Bodin Khwannimit Rungsun Bhurayanontachai | 2012 | European Journal of Anaesthesiology2012，，2： | 2 |
| 8 | Using 1 Hz GPS Data to Measure Deformations Caused by the Denali Fault Earthquake显示文摘 | Larson K Bodin P and Gomberg J | 2003 | Science2003，300，： | 1 |
| 9 | Mechanical properties of bacterial cellulose and interactions with smooth muscle cells显示文摘 | Backdahl H Helenius G Bodin A | 2006 | Biomaterials2006，，27： | 1 |
| 10 | A novel mutation in the BMP15 gene causing defective protein secretion is associated with both increased ovulation rate and sterility in Lacaune sheep显示文摘 | Bodin L Di Pasquale E Fabre S | 2007 | Endocrinology2007，148，1： | 1 |
| 11 | Ethanol stimulates bile acid formation in primary human hepatocytes显示文摘 | Lisa-Mari Nilsson Jan Sj?vall Stephen Strom Karl Bodin Greg Nowak Curt Einarsson Ewa Ellis | 2007 | Biochemical and Biophysical Research Communications2007，，4： | 1 |
| 12 | TMJ disordersand pain: assessment by contrast-enhanced MRI显示文摘 | Farina D Bodin C Gandolfi S | 2009 | Eur J Radiol2009，70，1： | 1 |
| 13 | Tissue-engineered conduit using urine-derived stem cells seeded bacterial cellulose polymer in urinary reconstruction and diversion显示文摘 | Aase Bodin Shantaram Bharadwaj Shaofeng Wu Paul Gatenholm Anthony Atala Yuanyuan Zhang | 2010 | Biomaterials2010，，： | 1 |
| 14 | Cytochrome P4502C9(CYP2C9) and Vitamin Z epoxide reductase(VKORC1)genotypes as determinants of acenocoumarol sensitivity显示文摘 | Bodin L Verstuyft C Tregouet DA | 2005 | Blood2005，106，： | 1 |
| 15 | Triggering of earthquake aftershocks by dynamic stresses显示文摘 | Kilb D Gomberg J Bodin P | 2000 | Nature2000，408，： | 1 |
| 16 | Free radical generator cause changes in endothelial and inducible nitric oxide synthase and endothelin-1 immuno-reacticity in endothefial cells from hyperfipidem is rabbits显示文摘 | Aliev G Bodin P Burnstock G | 1998 | Mol Genel Metab1998，63，3： | 1 |
| 17 | A novel mutation in the BMP15 gene causing defective protein secretion is associat- ed with both increased ovulation rate and sterility in Lacaune sheep 显示文摘 | Bodin L Di Pasquale E Fabre S | 2007 | Endocrinology2007，148，1： | 1 |
| 18 | Frost resistance of recycled aggregate concrete显示文摘 | Zaharieva R Buyle Bodin F Wirquin E | 2004 | Cement and Concrete Research2004，34，： | 1 |
| 19 | Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo显示文摘 | Bodine S C Stitt T N Gonzalez M | 2001 | Nature Cell Biol2001，3，： | 1 |
| 20 | Cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase ( VKORC1 ) genotypes as determinants of acenocoumarol sensitivity显示文摘 | Bodin L Verstuyft C Tregouet DA | 2005 | Blood2005，106，1： | 1 |
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