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| 1 | Biomarkers in diabetic nephropathy: Present and future显示文摘Diabetic nephropathy(DN) is the leading cause of end stage renal disease in the Western world. Microalbuminuria(MA) is the earliest and most commonly used clinical index of DN and is independently associated with cardiovascular risk in diabetic patients. Although MA remains an essential tool for risk stratification and monitoring disease progression in DN, a number of factors have called into question its predictive power. Originally thought to be predictive of future overt DN in 80% of patients, we now know that only around 30% of microalbuminuric patients progress to overt nephropathy after 10 years of follow up. In addition, advanced structural alterations in the glomerular basement membrane may already have occurred by the time MA is clinically detectable.Evidence in recent years suggests that a significant proportion of patients with MA can revert to normoalbuminuria and the concept of nonalbuminuric DN is well-documented, reflecting the fact that patients with diabetes can demonstrate a reduction in glomerular filtration rate without progressing from normo-to MA. There is an unmet clinical need to identify biomarkers with potential for earlier diagnosis and risk stratification in DN and recent developments inthis field will be the focus of this review article. | Gemma Currie Gerard Mc Kay Christian Delles | 2014 | World Journal of Diabetes2014，5，6： | 26 |
| 2 | 中国北京恐龙足迹的首次记录显示文摘北京市延庆县在筹报世界地质公园的地质遗迹野外调查中,在延庆硅化木国家地质公园核心区晚侏罗世-早白垩世土城子组地层发现的大批恐龙足迹,初步研究表明这批标本可归属于覆盾甲龙类(cf.Deltapodusisp.)、兽脚类、鸟脚类及疑似蜥脚类恐龙足迹.其中大量的覆盾甲龙类足迹表明,早在晚侏罗世,冀北-辽西地区就活动着覆盾甲龙类,它们承接了辽宁朝阳下白垩统义县组发现的甲龙类化石.而罕见的,极高速奔跑的兽脚类恐龙足迹揭示了独特的古行为学.延庆发现的恐龙足迹群不但是北京地区首次发现恐龙存活过的证据,而且极大丰富了土城子组的恐龙类群,为承接其后的热河动物群提供了绝好的演化样本. | 张建平 邢立达 GIERLINSKI Gerard D. 武法东 田明中 CURRIE Philip | 2012 | 科学通报2012，57，2： | 14 |
| 3 | Generation of iPS cells using defined factors linked via the self-cleaving 2A sequences in a single open reading frame显示文摘导致的 pluripotent 的产生从体的细胞的茎(iPS ) 细胞被定义 reprogramming 抄写因素(TF ) 的同时的病毒的 transduction 成功地完成了。然而,这个过程为基因交货要求多重病毒的向量。作为结果,产生了 iPS 房间港口在他们的染色体的众多的病毒的集成地点。这能增加基因 mutagenesis 和 genomic 不稳定性的概率,并且介绍重要障碍给研究和 iPS 房间的临床的申请研究。在这篇论文,我们在场定义因素是的一个简单 lentivirus reprogramming 在系统经由自我劈开的 2A 序列熔化了在里面框架进一个单个开的读物框架(ORF ) 。一个 GFP 标记下游地被放 transgene 启用 transgene 表示追踪。我们证明这个 polycistronic 表示系统高效地产生 iPS 房间。产生 iPS 房间有正常 karyotypes 并且类似于鼠标在形态学和基因表示的胚胎的干细胞。而且,他们能在 vitro 并且在 vivo 试金在两个区分进三胚胎的细菌层的房间类型。显著地,大多数这些 iPS 房间仅仅怀有病毒的向量的一个单个拷贝。这个系统提供一个珍贵工具因为 iPS 房间的产生,和我们的数据建议在每个房间的 transduced reprogramming TF 的表示的平衡为 reprogramming 进程是必要的。更重要地,当由非集成的基因交货系统交付了时,这重新设计的单个 ORF 将没有基因修正便于人的 iPS 房间的有效产生。 | Lijian Shao Wei Feng Yan Sun Hao Bai Jun Liu Caroline Currie Jaejung Kim Rafael Gama Zack Wang Zhijian Qian Lucy Liaw Wen-Shu Wu | 2009 | Cell Research2009，19，3： | 12 |
| 4 | 炎症与癌症:肿瘤的发生、进展和转移以及中药植物药(英文)显示文摘古往今来,癌症都被视为一个炎症过程。过去20多年的研究已经从分子水平证实大部分慢性疾病包括癌症都是由炎症反应失调所引起的。转录因子如核因子κB与信号转导和转录激活因子3以及它们的基因产物如肿瘤坏死因子、白细胞介素1、白细胞介素6、趋化因子、环氧合酶2、血管内皮生长因子、黏附分子等的发现为阐释炎症在癌症过程中的作用提供了分子基础。肿瘤的发生、发展和转移以及机体无法对其产生免疫抑制都可以部分地用慢性全身炎症反应来解释。中药用于治疗癌症及炎症具有悠久的历史。本文介绍了近期有关癌症与炎症的研究进展以及用于治疗癌症的中药和中药复方。 | Daniel Weber Janelle M Wheat Geoffrey M Currie | 2010 | 中西医结合学报2010，8，11： | 10 |
| 5 | A-type granites: geochemical characteristics, discrimination and petrogenesis显示文摘 | Joseph B. Whalen Kenneth L. Currie Bruce W. Chappell | 1987 | Contributions to Mineralogy and Petrology1987，，4： | 6 |
| 6 | Using induced pluripotent stem cells as a tool for modelling carcinogenesis显示文摘Cancer is a highly heterogeneous group of diseases that despite improved treatments remain prevalent accounting for over 14 million new cases and 8.2 million deaths per year. Studies into the process of carcinogenesis are limited by lack of appropriate models for the development and pathogenesis of the disease based on human tissues. Primary culture of patient samples can help but is difficult to grow for a number of tissues. A potential opportunity to overcome these barriers is based on the landmark study by Yamanaka which demonstrated the ability of four factors;Oct4, Sox2, Klf4, and c-Myc to reprogram human somatic cells in to pluripotency. These cells were termed induced pluripotent stem cells(i PSCs) and display characteristic properties of embryonic stem cells. This technique has a wide range of potential uses including disease modelling, drug testing and transplantation studies. Interestingly i PSCs also share a number of characteristics with cancer cells including self-renewal and proliferation, expression of stem cell markers and altered metabolism. Recently, i PSCs have been generated from a number of human cancer cell lines and primary tumour samples from a range of cancers in an attempt to recapitulate the development of cancer and interrogate the underlying mechanisms involved. This review will outline the similarities between the reprogramming process and carcinogenesis, and how these similarities have been exploited to generate i PSC models for a number of cancers. | Emma L Curry Mohammad Moad Craig N Robson Rakesh Heer | 2015 | World Journal of Stem Cells2015，7，2： | 5 |
| 7 | 大型国际活动交通组织规划方法综述显示文摘探讨夏季奥运会采用的交通组织规划方法,同时总结世界上最大规模的特殊活动——沙特阿拉伯麦加朝觐/副朝交通组织规划经验。每年一度的麦加朝觐已经延续几个世纪,在最近几十年人数持续增长,朝圣者已增至600万人,包括朝觐一周内300万人和斋月期间100万人。目前,这项活动是历史上规模最大且定期举行的特殊活动,其规模预计还将大幅增长。奥运会是世界上第二大特殊活动,每4年举办一次,在主办城市持续2周。通常奥运会主办城市自身的交通压力已经非常巨大,在奥运会期间同时还要额外满足4万名奥运官员和运动员以及800万名观众的出行需求。因此,奥运会交通组织规划对于保障赛事顺利开展至关重要。通过描述这两项活动的背景和交通供需特征,概述已有交通组织规划方法,旨在分析和总结大型活动交通组织规划的经验教训,探讨可供选择的规划策略。 | Graham Currie Amer Shalaby 赵莉 | 2013 | 城市交通2013，11，4： | 4 |
| 8 | 医学教育中的认知和学习风格显示文摘在过去的50年间,关于学习的研究已揭示存在种种的“风格”(style)”。假如学生的学习风格(Learming Style)与教学风格或者学习环境不相吻合,则必须为适应教学风格或者学习环境而作出努力,这也许就会给其学业成绩带来消极的影响。1 何为风格 人类的任何动作都是动作与完成动作之方法、形式或者“风格”的实质性组合。风格之所以被认识,是因为它是在一段时间内对个人持续呈现的。一些行为模式或风格在人生早期是明显的,一些行为模式或风格则贯穿于人的一生。有的研究者已报告,风格在性别上存在差异,有的研究则尚无发现在性别上存在持续的风格。 风格有别于能力(Ability)、策略(Strategy)或机智(Tac-tic)。能力是指特殊内容或者技能领域中的特别才能。 | lynn Curry 张国忠 | 2000 | 继续医学教育2000，14，2： | 4 |
| 9 | 哮喘治疗的新进展显示文摘没有强有力的循证医学证据表明饮食方法或Buteyko技术对哮喘的临床管理有很大益处需要进一步研究确定当哮喘控制欠佳时患者应该怎么做小剂量吸入皮质激素可以和长效β2激动剂联合应用,以提供安全有效的哮喘控制静脉镁制剂和白三烯受体拮抗剂对急性哮喘可能具有一些作用,但仍需进一步评价将来哮喘治疗是否能得到炎症生物标志或患者基因型认识的帮助。 | Graeme P Currie Graham S Devereux Daniel K C Lee Jon G Ayres 刘艳(译) 代华平(校) | 2005 | 英国医学杂志中文版2005，8，4： | 3 |
| 10 | Effect of fiber supplementation on the microbiota in critically ill patients显示文摘AIM:To determine tolerance to fiber supplementation of semi-elemental tube feeds in critically ill patients and measure its effect on colonic microbiota and fermentation.METHODS:Thirteen intensive care unit patients receiving jejunal feeding with a semi-elemental diet for predominantly necrotizing pancreatitis were studied.The study was divided into 2 parts:first,short-term (3-9 d)clinical tolerance and colonic fermentation as assessed by fecal short chain fatty acid(SCFA)concentrations and breath hydrogen and methane was measured in response to progressive fiber supplementation increasing from 4 g tid up to normal requirement levels of 8 g tid;second,4 patients with diarrhea were studied for 2-5 wk with maximal supplementation to additionally assess its influence on fecal microbiota quantitated by quantitative polymerase chain reaction (qPCR)of microbial 16S rRNA genes and Human Intestinal Tract Chip(HITChip)microarray analysis.Nearly all patients were receiving antibiotics(10/13)and acid suppressants(11/13)at some stage during the studies.RESULTS:In group 1,tolerance to progressive fiber supplementation was good with breath hydrogen and methane evidence(P=0.008 and P<0.0001,respectively)of increased fermentation with no exacerbation of abdominal symptoms and resolution of diarrhea in 2 of 4 patients.In group 2 before supplementation,fecal microbiota mass and their metabolites,SCFA,were dramatically lower in patients compared to healthy volunteers.From qPCR and HITChip analyses we calculated that there was a 97%reduction in the predominant potential butyrate producers and starch degraders.Following 2-5 wk of fiber supplementation there was a significant increase in fecal SCFA(acetate 28.4±4.1μmol/g to 42.5±3.1μmol/g dry weight,P=0.01;propionate 1.6±0.5 vs 6.22±1.1,P=0.006 and butyrate 2.5±0.6 vs 5.9±1.1,P=0.04)and microbial counts of specific butyrate producers,with resolution of diarrhea in 3 of 4 patients.CONCLUSION:Conventional management of critically ill patients,which includes the use of elemental diets and broad-spectrum antibiotics,was associated with gross suppression of the colonic microbiota and their production of essential colonic fuels,i.e.,SCFA.Our investigations show that fiber supplementation of the feeds has the potential to improve microbiota mass and function,thereby reducing the risks of diarrhea due to dysbiosis. | Stephen JD O'Keefe Junhai Ou James P DeLany Scott Curry Erwin Zoetendal H Rex Gaskins Scott Gunn | 2011 | World Journal of Gastrointestinal Pathophysiology2011，2，6： | 3 |
| 11 | Sofosbuvir and Ribavirin Prevent Recurrence of HCV Infection after Liver Transplantation: An Open-Label Study显示文摘 | Michael P. Curry Xavier Forns Raymond T. Chung Norah A. Terrault Robert Brown Jonathan M. Fenkel Fredric Gordon Jacqueline O’Leary Alexander Kuo Thomas Schiano Gregory Everson Eugene Schiff Alex Befeler Edward Gane Sammy Saab John G. McHutchison G. Mani S | 2014 | Gastroenterology2014，，： | 3 |
| 12 | The influence of glucose-lowering therapies on cancer risk in type 2 diabetes显示文摘 | C. J. Currie C. D. Poole E. A. M. Gale | 2009 | Diabetologia2009，，9： | 3 |
| 13 | Randomised clinical trials: linaclotide phase 3 studies in IBS ‐C – a prespecified further analysis based on European Medicines Agency‐specified endpoints显示文摘 | E. M. M. Quigley J. Tack W. D. Chey S. S. Rao J. Fortea M. Falques C. Diaz S. J. Shiff M. G. Currie J. M. Johnston | 2012 | Aliment Pharmacol Ther2012，，1： | 3 |
| 14 | 慢性阻塞性肺疾病知识(一) 诊断显示文摘和其他常见的疾病一样,慢性阻塞性肺疾病(COPD)的诊断依靠相关病史和适当的检查。确诊的客观证据依靠呼吸功能测量。对于35岁以上,有吸烟史及相关呼吸道症状的患者,医生应考虑到COPD的可能。 | Graeme P Currie Joe S Legge 陈奇 | 2007 | 英国医学杂志中文版2007，10，1： | 3 |
| 15 | Efficacy of Linaclotide for Patients With Chronic Constipation显示文摘 | Anthony J. Lembo Caroline B. Kurtz James E. MacDougall B.J. Lavins Mark G. Currie Donald A. Fitch Brenda I. Jeglinski Jeffrey M. Johnston | 2010 | Gastroenterology2010，，3： | 3 |
| 16 | Linaclotide Improves Abdominal Pain and Bowel Habits in a Phase IIb Study of Patients With Irritable Bowel Syndrome With Constipation显示文摘 | Jeffrey M. Johnston Caroline B. Kurtz James E. MacDougall Bernard J. Lavins Mark G. Currie Donald A. Fitch Chris O’Dea Mollie Baird Anthony J. Lembo | 2010 | Gastroenterology2010，，6： | 3 |
| 17 | Risk for Immune-Mediated Graft Dysfunction in Liver Transplant Recipients With Recurrent HCV Infection Treated With Pegylated Interferon显示文摘 | Josh Levitsky Maria Isabel Fiel John P. Norvell Edward Wang Kymberly D. Watt Michael P. Curry Sumeet Tewani Timothy M. McCashland Maarouf A. Hoteit Abraham Shaked Samuel Saab Amanda C. Chi Amy Tien Thomas D. Schiano | 2012 | Gastroenterology2012，，5： | 3 |
| 18 | Oxidation microstructure studies of reinforced carbon/carbon显示文摘 | Nathan S. Jacobson Donald M. Curry | 2005 | Carbon2005，，7： | 2 |
| 19 | Retinal vascular changes associated with transpupillary thermotherapy for choroidal melanomas显示文摘 | Currie ZI Rennie IF Talbot JF | 2000 | Retina2000，20，： | 2 |
| 20 | Sofosbuvir and Ribavirin for Treatment of Compensated Recurrent Hepatitis C Virus Infection After Liver Transplantation显示文摘 | Michael Charlton Edward Gane Michael P. Manns Robert S. Brown Michael P. Curry Paul Y. Kwo Robert J. Fontana Richard Gilroy Lewis Teperman Andrew J. Muir John G. McHutchison William T. Symonds Diana Brainard Brian Kirby Hadas Dvory-Sobol Jill Denning Sara | 2014 | Gastroenterology2014，，： | 2 |
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