|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Epidemiology and Natural History of Inflammatory Bowel Diseases显示文摘 | Jacques Cosnes Corinne Gower–Rousseau Philippe Seksik Antoine Cortot | 2011 | Gastroenterology2011，，6： | 11 |
| 2 | Disease activity and cancer risk in inflammatory bowel disease associated with primary sclerosing cholangitis显示文摘AIM: To investigate the phenotype of inflammatory bowel disease associated with primary sclerosing cholangitis (PSC-IBD). METHODS: Data from 75 PSC-IBD patients evaluated in our tertiary center between 1963 and 2006 were collected and compared to 150 IBD patients without PSC, matched for sex, birth date, IBD diagnosis date and initial disease location regarding ileal, different colonic segments, and rectum, respectively. RESULTS: While PSC-IBD patients received more 5-aminosalicylates (8.7 years/patient vs 2.9 years/ patient, P < 0.001), they required less immuno-suppressors (24% vs 46% at 10 years; P < 0.001) and less intestinal resection (10% vs 44% at 10 years, P < 0.001). The 25-year cumulative rate of colectomy was 25.1% in PSC-IBD and 37.3% in controls (P = 0.004). The 25-year cumulative rate of colorectal cancer was 23.4% in PSC-IBD vs 0% in controls (P = 0.002). PSC was the only independent risk factor for the development of colorectal cancer (OR = 10.8; 95% CI, 3.7-31.3). Overall survival rate without liver transplantation was reduced in PSC-IBD patients (67% vs 91% in controls at 25 years, P = 0.001).CONCLUSION: This study confirms that patients with PSC-IBD have a particular disease phenotype independent of the initial disease location. Although their disease is less active and they use more 5-aminosalicylates, they present a higher risk of colorectal cancer. | Harry Sokol Jacques Cosnes Olivier Chazouilleres Laurent Beaugerie Emmanuel Tiret Raoul Poupon Philippe Seksik | 2008 | World Journal of Gastroenterology2008，14，22： | 10 |
| 3 | 低剂量白细胞介素-2在11种自身免疫疾病中的免疫学和临床疗效:单中心开放临床试验显示文摘背景调节性T(Tregs)细胞可以预防自身免疫并控制炎症,在各种自身免疫性或自身炎症性疾病中的研究都表明Treg细胞不足。由于低剂量白细胞介素-2(low-dose interleukin-2,ld-IL2)能够扩增并激活Tregs细胞,因此ld-IL2具有广泛的治疗潜力。目的我们通过一项临床试验观察ld-IL2治疗11种自身免疫性疾病中1种的效果,旨在评估ld-IL2的治疗潜力并选择疾病,以用于进一步的临床开发。方法本研究为前瞻开放性Ⅰ~Ⅱa期临床观察,入选了46例轻中度患者,诊断分别为类风湿关节炎、强直性脊柱炎、系统性红斑狼疮、牛皮癣、白塞病、肉芽肿性多血管炎、大动脉炎、克罗恩病、溃疡性结肠炎、自身免疫性肝炎或硬化性胆管炎。所有患者都接受了ld-IL2(100万IU/天)5天,然后每两周注射一次,维持6个月。所有患者均接受了深入的免疫监测和临床评估。结果在任何疾病类型以及任何合并药物治疗的患者中,ld-IL2都显示出了良好的耐受性。通过经典的免疫表型分析和广泛的免疫表型分析发现所有患者的Tregs细胞均被特异性地扩增激活,而效应T细胞没有被活化,提示ld-IL2具有临床疗效的前景。结论本研究中所采用的IL-2剂量和治疗方案可以选择性地激活和扩增Tregs细胞,并且对于不同的疾病种类以及不同的合并用药都是安全的。这一临床疗效以及初步结果可以为ld-IL2在各种自身免疫和自身炎症性疾病中开展Ⅱ期临床试验观察疗效提供了依据。试验注册号NCT01988506. | Michelle Rosenzwajg Roberta Lorenzon Patrice Cacoub Hang Phuong Pham Fabien Pitoiset Karim El Soufi Claire RIbet Claude Bernard Selim Aractingi Beatrice Banneville Laurent Beaugerie Francis Berenbaum Julien Champey Olivier Chazouilleres Christophe Corpechot Bruno Fautrel Arsfene Mekinian Elodie Regnier David Saadoun Joe-Elie Salem Jeremie Sellam Philippe Seksik Anne Daguenel-Nguyen Valene Doppler Jeremie Mariau Eric Vicaut David Klatzmann 杨新蕾(译) 张卓莉(校) | 2019 | 英国医学杂志中文版2019，22，2： | 2 |
| 4 | Crypt abscess-associated microbiota in inflammatory bowel disease and acute self-limited colitis显示文摘AIM:To evaluate whether crypt abscesses frominflammatory bowel disease(IBD)patients containbacteria and to establish their nature.METHODS:We studied 17 ulcerative colitis patients,11 Crohn's disease patients,7 patients with acute selflimited colitis(ASLC)and normal colonic biopsies from5 subjects who underwent colonoscopy for colon cancer screening.A fluorescent in situ hybridization techniquewas applied to colonic biopsies to assess the microbiotacomposition of the crypts and crypt abscesses.RESULTS:Crypts colonized by bacteria were observedin 42.9%and 3.6%of ASLC and IBD patients,respectively(P=0.019).Crypt abscesses colonized bybacteria were observed in 28.6%and 0.0%of ASLCand IBD patients,respectively(P=0.035).CONCLUSION:These results do not support thehypothesis that crypt abscesses in IBD are the resultof localized dysbiosis arising from persistence of livingbacteria colonizing the crypts. | Harry Sokol Nadia Vasquez Nadia Hoyeau-Idrissi Philippe Seksik Laurent Beaugerie Anne Lavergne-Slove Philippe Pochart Philippe Marteau | 2010 | World Journal of Gastroenterology2010，16，5： | 2 |
| 5 | Tolerance of 4-amino salicylic acid enemas in patients with inflammatory bowel disease and 5-amino salicylic-induced acute pan creatitis 显示文摘 | DANIEL F SEKSIK P CACHEUX W | 2004 | Inflamm Bowel Dis2004，10，3： | 1 |
| 6 | Chest wall invasion by bronchogenic carcimoma:evaluation with MR imaging 显示文摘 | Padovani B Mouroux J Seksik L | 1993 | Radiology1993，187，1： | 1 |
| 7 | Alterations of the dominant faecal bacterial groups in patients with Crohn's disease of the colon显示文摘 | Seksik P Rigottier Gois L Gramet | 2003 | Gut2003，52，： | 1 |
| 8 | Incidence of benign upper respiratory tract infections, HSV and HPV cutaneous infections in inflammatory bowel disease patients treated with azathioprine显示文摘 | Seksik P Cosnes J Sokol H | 2009 | Aliment Pharmacol Ther2009，29，10： | 1 |
| 9 | Impact of the diagnosis and treatment of cancer on the course of inflammatory bowel disease显示文摘 | S. Rajca P. Seksik A. Bourrier H. Sokol I. Nion-Larmurier L. Beaugerie J. Cosnes | 2013 | Journal of Crohn’s and Colitis2013，，： | 1 |
| 10 | Ineffectiveness of Lactobaeillus johnsonii LA1 for prophylaxis of postoperative recurrence in Crohn's disease: a randomised, double blind, placebo controlled GETAID trial显示文摘 | Marteau P Lemann M Seksik P | 2006 | Gut2006，55，6： | 1 |
| 11 | 561 Successive Treatment with Cyclosporine and Infliximab in Severe Ulcerative Colitis (UC)显示文摘 | Sarah Leblanc Matthieu Allez Philippe Seksik Bernard Flourie Harald Peeters Jean-Louis Dupas Guillaume Bouguen Laurent Peyrin Biroulet Arnaud Bourreille Olivier Dewit Yoram Bouhnik Pierre F. Michetti Stanislas Chaussade Philippe de Saussure Jean-Frederic | 2009 | Gastroenterology2009，，5： | 1 |
| 12 | Prior appendectomy and the phenotype and course of Crohn's disease显示文摘瞄准:决定优先的阑尾切除术是否修改 Crohn 的疾病的显型和严厉。方法:阑尾切除术地位和吸烟习惯被直接会见在连续地在 1995 和 2004 之间看见的 2838 个病人指定。复杂并发症和治疗学的需要的出现回顾地被考察。另外,年度疾病活动在没有回盲肠切除术的病人并且一个匹配的控制组在 1995 和 2004 之间有希望地被估计。结果:比作 1770 个 non-appendectomized 病人,在 Crohn 的疾病诊断(n=716 ) 前的超过 5 年更经常是的 appendectomized 病人女性,吸烟者,与 i 一起忠实疾病。考克斯回归证明那优先的阑尾切除术是断然与肠的苛评的风险有关(调整危险比率, 1.24;95% 信心间隔, 1.13 ~ 1.36;P=0.02 ) 并且相反地与仙子的风险有关肛门成瘘 2. 造瘘术(调整危险比率, 0.75;95% 信心间隔, 0.68 ~ 0.83;P=0.002 ) 。没有差别关于治疗学的需要在二个组之间被观察,除了在 appendectomized 病人,的外科的增加的风险对 i 的增加的流行可归因忠实疾病。在 1995 和 2004 之间, Crohn 的疾病在在 appendectomized 病人的 50% 年期间是活跃的(1318 从 2637 耐心年) 并且 51% 在 non-appendectomized 病人(1454 从 2841 耐心年;NS ) 。结论:优先的阑尾切除术与更近似的疾病被联系并且有苛评的增加的风险和肛门成瘘 2. 造瘘术的更小的风险。然而,疾病的严厉是未受影响的。 | Jacques Cosnes Philippe Seksik Isabelle Nion-Larmurier Laurent Beaugerie Jean-Pierre Gendre | 2006 | World Journal of Gastroenterology2006，12，8： | 1 |
| 13 | Probioties and health: new facts and ideas显示文摘 | Marteau P Seksik P Jian R | 2002 | Curr Opin Biotechnol2002，13，5： | 1 |
| 14 | Ineffectiveness of prophylaxis of postoperative recurrence in Crohn's disease: a randomised, double bhnd, placebo controlled GETAID trial 显示文摘 | Marteau P Lemann M Seksik Lactobacillus johnsonii LA1 for P | 2006 | Gut2006，55，6： | 1 |
| 15 | Successive treat- ment with eyclosporine and infliximab in steroid - refracto- ry ulcerative colitis 显示文摘 | Leblanc S Allez M Seksik P | 2011 | Am J Gastroenterol2011，106，4： | 1 |
| 16 | Alterations of the dominant faecal bacterial groups in patients with Crohn′s disease of the colon显示文摘 | Seksik P Rigottier GL Gramet G | 2003 | Gut2003，52，： | 1 |
| 17 | Low counts of Faecalibacterium prausnitzii in colitis microbiota 显示文摘 | Sokol H Seksik P Furct JP | 2009 | Inflamm Bowel Dis2009，15，8： | 1 |
| 18 | Specificities of fecal microbiota of four Crohn′s disease patients evidenced by culture-independent analysis of dominant species distribution显示文摘 | Mangin I Bonnet R Seksik P | 2003 | Gastroenterology2003，124，1： | 1 |
| 19 | Ineffectiveness of Lactobacillus johnsonii LA1 for prophylaxis of postoperative recurrence in Crohn' s disease: a randomised, double blind, placebo controlled GETAID trim 显示文摘 | Marteau P Lemann M Seksik P | 2006 | Gut2006，55，： | 1 |
| 20 | Gossip in the gut: Quorum sensing, a new player in the hostmicrobiota interactions显示文摘Bacteria are known to communicate with each other and regulate their activities in social networks by secreting and sensing signaling molecules called autoinducers,a process known as quorum sensing(QS).This is a growing area of research in which we are expanding our understanding of how bacteria collectively modify their behavior but are also involved in the crosstalk between the host and gut microbiome.This is particularly relevant in the case of pathologies associated with dysbiosis or disorders of the intestinal ecosystem.This review will examine the different QS systems and the evidence for their presence in the intestinal ecosystem.We will also provide clues on the role of QS molecules that may exert,directly or indirectly through their bacterial gossip,an influence on intestinal epithelial barrier function,intestinal inflammation,and intestinal carcinogenesis.This review aims to provide evidence on the role of QS molecules in gut physiology and the potential shared by this new player.Better understanding the impact of intestinal bacterial social networks and ultimately developing new therapeutic strategies to control intestinal disorders remains a challenge that needs to be addressed in the future. | Garance Coquant Doriane Aguanno Sandrine Pham Nathan Grellier Sophie Thenet Véronique Carrière Jean-Pierre Grill Philippe Seksik | 2021 | World Journal of Gastroenterology2021，27，42： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员