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| 1 | Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis显示文摘AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity.METHODS: Analyses of CD14 -260C>T, CARD15/NOD2 3020insC, Toll-like receptor (TLR)4 +896A>G,TLR9 -1237T>C, TLR9+ 2848G>A, and IRAKM +22148G>A SNPs were performed in 157 ileal-pouch anal anastomosis (IPAA) patients (79 patients who did not develop pouchitis, 43 infrequent pouchitis patients,35 chronic relapsing pouchitis patients) and 224 Italian Caucasian healthy controls.RESULTS: No significant differences were found in SNP frequencies between controls and IPAA patients.However, a significant difference in carriership frequency of the TLR9-1237C allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [P = 0.028, odd's ratio (OR) = 3.2, 95%CI = 1.2-8.6].This allele uniquely represented a 4-locus TLR9 haplotype comprising both studied TLR9 SNPs in Caucasians.Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3).CONCLUSION: There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis. | KM Lammers S Ouburg SA Morré JBA Crusius P Gionchetti F Rizzello C Morselli E Caramelli R Conte G Poggioli M Campieri AS Pea | 2005 | World Journal of Gastroenterology2005，11，46： | 7 |
| 2 | Thirty years ofgraph matching in pattern recognition显示文摘 | CONTE D F()GGIA P SANSONE C | 2004 | International Jour-nal of Pattern Recognition and Artificial Intelligence2004，18，3： | 1 |
| 3 | Survivin expression in chronic myeloid leukemia显示文摘 | CONTE E STAGNO F GUGLIELMO P | 2005 | Cancer Lett2005，225，1： | 1 |
| 4 | Modal identification study of vincent thomas bridge using simulated wind-induced ambient vibration data 显示文摘 | He X F Babak M Conte J P | 2008 | Computer-Aided Civil and Infrastructure Engineering2008，23，： | 1 |
| 5 | Polycyclic aromatic hydrocarbons in farmed rainbow trout (Oncorhynchus mykiss) processed by traditional flue gas smoking and by liquid smoke flavorings显示文摘 | VISCIANO P PERUGINI M CONTE F | 2008 | Food and Chemical Toxicology2008，46，5： | 1 |
| 6 | Growth and feed efficiency of white sturgeon (Acipenser transmontanus) sub-yearling at different feeding rates 显示文摘 | Hung S SO Lutes P B Conte F S | 1989 | Aquaculture1989，80，12： | 1 |
| 7 | Long-term follow-up of neuroblastoma-associated op-soclonus-myoclonus-ataxia syndrome显示文摘 | De Grandis E Parodi S Conte M Angelini P Battaglia F Gan-dolfo C | 2009 | Neuropediatrics2009，40，3： | 1 |
| 8 | Fully nonstationary analytical earthquake ground - motion model 显示文摘 | CONTE J P PENG B F | 1997 | Journal of Engi- neering Mechanics1997，，1： | 1 |
| 9 | Lactoferrin functions current status and perspectives显示文摘 | Valenti P Berlutti F Conte M P | 2004 | Journal of Clinical Gastroenterology2004，38，6： | 1 |
| 10 | The curability of breast cancer and the treatment of advanced disease显示文摘 | Guarneri V Conte P F | 2004 | Eur J Nucl Med Mol Imaging2004，1，： | 1 |
| 11 | Growth and feed efficiency of white sturgeon(Acepenser transmontanus)subyearlings at diferent feeding rates显示文摘 | Hung S S O Lutes P B Conte F S | 1989 | Aquaculture1989，80，： | 1 |
| 12 | Hyperghrelinemia is a common feature of Prader-Willi syndrome and pituitary stalk interruption:A pathophysiological hypothesis显示文摘 | Tauber M Conte Auriol F Moulin P | 2004 | Horm Res2004，62，： | 1 |
| 13 | Fully nonstationary analytical earthquake ground-motion model显示文摘 | Conte J P Peng B F | 1997 | Journal of Engineering Mechanics1997，123，1： | 1 |
| 14 | Polycyclic aromatic hydrocarbons in farmed rainbow trout (Oncorhynchus mykiss) processed by traditional flue gas smoking and by liquid smoke flavourings显示文摘 | VISCIANO P PERUGINI M CONTE F | 2008 | Food and Chemical Toxicology2008，46，5： | 1 |
| 15 | The curability of breast cancer and the treatment of advanced disease显示文摘 | Guarneri V Conte P F | 2004 | Eur J Nucl Med MoI Imaging2004，311，： | 1 |
| 16 | A randomized trial of gemcitabine cisplatin versus mitomycin,ifosfamide and cisplatin(MIC) in advanced non-small cell lung cance(NSCLC): a multicenter phase Ⅲ study显示文摘 | Crino L Conte P De Marinis F | 1998 | Proc Am Soc Clin Oncol1998，17，45： | 1 |
| 17 | Lactoferrin functions:Current status and perspectives显示文摘 | Valenti P Berlutti F Conte MP | 2004 | J Clin Gastroenterol2004，38，6： | 1 |
| 18 | Polycyclic aromatic hydrocarbons in fanned rainbow trout (Oncorhynchus mykiss) processed by traditional flue gas smoking and by liquid smoke flavourings显示文摘 | VISCIANO P PERUGINI M CONTE F | 2008 | Food and Chemical Toxicology2008，46，5： | 1 |
| 19 | High-dose verus low-dose eisplatin in combination with cyclophosphamide and epidoxorubinein in suboptimal ovarian cancer: a randomized study of the Gruppo Oncologico Nord-Ovest 显示文摘 | Conte P Bruzzone M Carnino F | 1996 | J Clin Onco11996，14，2： | 1 |
| 20 | Polycyclic aromatichydrocarbons in farmed rainbow trout (Oncorhynchus mykiss) processedby traditional flue gas smoking and by liquid smoke favourings显示文摘 | VISCIANO P PERUGINI M CONTE F | 2008 | Foodand Chemical Toxicology2008，46，5： | 1 |
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