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| 1 | Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis显示文摘AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity.METHODS: Analyses of CD14 -260C>T, CARD15/NOD2 3020insC, Toll-like receptor (TLR)4 +896A>G,TLR9 -1237T>C, TLR9+ 2848G>A, and IRAKM +22148G>A SNPs were performed in 157 ileal-pouch anal anastomosis (IPAA) patients (79 patients who did not develop pouchitis, 43 infrequent pouchitis patients,35 chronic relapsing pouchitis patients) and 224 Italian Caucasian healthy controls.RESULTS: No significant differences were found in SNP frequencies between controls and IPAA patients.However, a significant difference in carriership frequency of the TLR9-1237C allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [P = 0.028, odd's ratio (OR) = 3.2, 95%CI = 1.2-8.6].This allele uniquely represented a 4-locus TLR9 haplotype comprising both studied TLR9 SNPs in Caucasians.Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3).CONCLUSION: There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis. | KM Lammers S Ouburg SA Morré JBA Crusius P Gionchetti F Rizzello C Morselli E Caramelli R Conte G Poggioli M Campieri AS Pea | 2005 | World Journal of Gastroenterology2005，11，46： | 7 |
| 2 | Cystatin C is associated with an increased coronary atherosclerotic burden and a stable plaque pheno- type in patients with ischemic heart disease and normal glomerular filtra- tion rate显示文摘 | Niccoli G Conte M Della Bona R | 2008 | Atherosclerosis2008，198，2： | 1 |
| 3 | Hydrochlorination of acetylene using supported bimetallic Au-based cata- lysts显示文摘 | Conte M Carley A Attard G | 2008 | Journal of Catalysis2008，257，1： | 1 |
| 4 | Adaptive detection schemes in cornpound-Gaussian clutter 显示文摘 | E Conte M Lops G Ricci | 1998 | IEEE Transactions on Aerospace and ElecllOnic Systems1998，34，4： | 1 |
| 5 | Accuracy of three electronic apex locators in anterior and posterior teeth:an ex vivo study显示文摘 | Mancini M Felici R Conte G | | 0，，05： | 1 |
| 6 | Controlled release of thymol from zein based film显示文摘 | Mastromatteo M Barbuzzi G Conte A | 2009 | Innov Food Sci Emerg2009，10，2： | 1 |
| 7 | Quantification of free circulating DNA as a diagnostic marker in lung cancer 显示文摘 | Sozzi G Conte D Leon M | 2003 | J Clin Oncol2003，21，21： | 1 |
| 8 | Un-derstanding the different functions of vitamin D显示文摘 | PASQUALI M MANDANICI G CONTE C | 2009 | GItal Nefrol2009，26，46： | 1 |
| 9 | Quantification of free circulating DNA as a diagnostic marker in lung cancer 显示文摘 | Sozzi G Conte D Leon M | 2003 | J Clin Oncol2003，21，21： | 1 |
| 10 | Cystatin C is associated with an increased coronary atherosclerotic burden and a stable plaque phenotype in patients with ischemic heart disease and normal glomerular filtration rate 显示文摘 | Niccoli G Conte M Bona RD | 2008 | Atherosclerosis2008，198，2： | 1 |
| 11 | Quantification of free circulating DNA as a diagnostic marker in lung cancer显示文摘 | SOZZI G CONTE D LEON M | 2003 | J Clin Oncol2003，21，： | 1 |
| 12 | Stearoyl-coenzyme A desaturase gene polymorphism and milk fatty acid composition in Italian Holsteins 显示文摘 | MELE M CONTE G CASTIGLIONI B | 2007 | J Dairy Sci2007，90，： | 1 |
| 13 | Remotely Operated Vehicle Depth Control 显示文摘 | Zanoli S M Conte G | 2003 | Control Engineering Practice2003，，11： | 1 |
| 14 | Quantification of free circulating DNA as a diagnostic marker in lung cancer显示文摘 | SOZZI G CONTE D LEON M | 2003 | J Clin Oncol2003，21，21： | 1 |
| 15 | Model matching and factorization for nonlinear systems: A structural approach显示文摘 | Perdon A M Conte G | 1991 | SIAM J Control and Optimez1991，29，7： | 1 |
| 16 | Serum and follicular fluid cytokines in polycystic ovary syndrome during stimulated cycles显示文摘 | Amato G Conte M Mazziotti G | 2003 | Obstet Gynecol2003，101，6： | 1 |
| 17 | As- sociation between a polymorphism at the stearoyl CoA desaturase locus and milk production traits in Italian Hol- steins显示文摘 | MACCIOTTA N P P MELM M CONTE G | 2008 | J Dairy Sci2008，91，： | 1 |
| 18 | Quantification of free circulatingDNA as a diagnostic marker in lung cancer 显示文摘 | Sozzi G Conte D Leon M | 2003 | J Clin Oncol2003，21，21： | 1 |
| 19 | Acid tolerance in Listeria monocytogenes influences invasiveness of enterocyte -like cells and macrophage-like cells显示文摘 | Conte M P Petrone G Di Biase A M | 2000 | Microb Pathog2000，29，： | 1 |
| 20 | Minimally invasive, videoassisted parathyroid surgery for primary hyperparathyroidism显示文摘 | Miccoli P Cecchini G Conte M | 1997 | J Endocrinol Invest1997，20，： | 1 |
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