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| 1 | TCP14 and TCP15 Mediate the Promotion of Seed Germination by Gibberellins in Arabidopsis thaliana显示文摘Dear Editor, Seed germination is a major developmental transition in a plant's life that involves the concerted action of several genetic and physiological pathways (Holdsworth et al.,2008),and mostly consists of the resumption of embryo growth after a long quiescence imposed during seed maturation.In mature seeds,germination is repressed by abscisic acid (ABA),while favorable environmental conditions promote gibberellin (GA) biosynthesis and decrease ABA (Holdsworth et al.,2008).The increase in GA levels is essential for the rupture of testa and endosperm (Lee et al.,2002).The activation of cell division in the embryo is an integral part of germination that precedes the protrusion of the root through the seed coat.In Arabidopsis,this activation has been linked to significant early changes in the expression of cell-cycle elements (Masubelele et al.,2005). | Francesca Resentini Amelia Felipo-Benavent Lucia Colombo Miguel A. Blázquez David Alabadí Simona Masiero | 2015 | Molecular Plant2015，8，3： | 25 |
| 2 | 冠状动脉内影像学临床应用专家共识(第一部分):对冠状动脉介入治疗的指导与优化显示文摘欧洲心血管介入协会(EAPCI)专家组系统总结了血管内超声(IVUS)和光学相干断层成像(OCT)这两种血管内影像学检查临床应用指征的现有证据,提供了关于IVUS和OCT指导经皮冠状动脉介入治疗(PCI)的应用价值,并明确了最可能从腔内影像学指导的介入治疗中获得临床收益的患者或病变类型,同时详细论述了PCI前如何使用IVUS或OCT优化支架尺寸(支架长度和直径)和手术策略的选择。此外,专家推荐对支架失败(支架内再狭窄或支架内血栓形成)的患者应常规进行冠状动脉内影像学检查,并首选OCT。最后,重点论述了IVUS和OCT在指导PCI和评估支架失败两个方面的优势和局限性,并对未来需要深入研究的领域进行了展望。 | Lorenz Raber Gary S Mintz Konstantinos C Koskinas Thomas W Johnson Niels R Holm Yoshinubo Onuma Maria D Radu Michael Joner Bo Yu Haibo Jia Nicolas Meneveau Jose M.de la Torre Hemandez Javier Escaned Jonathan Hill Francesco Prati Antonio Colombo Carlo di Mario Evelyn Regar Davide Capodanno William Wijns Robert A Byme Giulio Guagliumi | 2019 | 中华心血管病杂志2019，47，1： | 17 |
| 3 | Visceral hypersensitivity and electromechanical dysfunction as therapeutic targets in pediatric functional dyspepsia显示文摘Functional gastrointestinal disorders(FGID) are common clinical syndromes diagnosed in the absence of biochemical,structural,or metabolic abnormalities. They account for significant morbidity and health care expenditures and are identifiable across variable age,geography,and culture. Etiology of abdominal pain associated FGIDs,including functional dyspepsia(FD),remains incompletely understood,but growing evidence implicates the importance of visceral hypersensitivity and electromechanical dysfunction. This manuscript explores data supporting the role of visceral hypersensitivity and electromechanical dysfunction in FD,with focus on pediatric data when available,and provides a summary of potential therapeutic targets. | John M Rosen Jose T Cocjin Jennifer V Schurman Jennifer M Colombo Craig A Friesen | 2014 | World Journal of Gastrointestinal Pharmacology and Therapeutics2014，5，3： | 16 |
| 4 | 城乡链接与农民合作显示文摘30年前的改革使农村土地所有权和经营权分离,并建立了两权分离架构下的家庭联产承包责任制度。以家庭为单位的小农经济体在生产要素市场化、人才城市化和资本全球化的多重压力下前途不明。农村的'原子化'倾向使社区文化和社会价值的再生产难以为继。这些困境促使我们对以城市、以资本为主体的发展方案进行反思。寻求生产者联合和农村社区文化重建的探索已经开始。这些宝贵的探索对21世纪中国的'三农'前途、对城乡关系的调整以及对重新认识和定义'发展',具有重大的理论和实践意义。2009年7月17日至21日,中山大学华南农村研究中心与香港理工大学—北京大学中国社会工作研究中心在中山大学联合举办了'农民合作组织与农村社会工作'的讲习班,参加者共65人,既有来自中国、意大利、英国、美国的学者,也有来自国内的农村基层组织者和致力于推动农民合作探索的社会工作者等。本刊择要发表此次讲习班的部分内容。标题为编者另拟。 | 何慧丽 古学斌 仝志辉 刘老石 贺雪峰 田力为 潘毅 毛刚强 吴重庆 文佳筠 Richard Sanders Luca Colombo Ada Cavazzani 陈雪 何海狮 黄小莉 | 2009 | 开放时代2009，，9： | 14 |
| 5 | 关于西罗莫司和紫杉醇洗脱支架用于新发冠状动脉病变的随机对照试验:REALITY试验显示文摘Context: Compared with bare metal stents, sirolimus-elut-ing and paclitaxel-eluting stents have been shown to markedly improve angiographic and clinical outcomes after percutaneous coronary revascularization, but their performance in the treatment of de novo coronary lesions has not been compared in a prospective multicenter study. Objective: To compare the safety and efficacy of sirolimus-eluting vs paclitaxel-eluting coronary stents. Design: Prospective, randomized comparative trial(the REALITY trial) conducted between August 2003 and February 2004, with angiographic follow-up at 8 months and clinical follow-up at 12 months. Setting: Ninety hospitals in Europe, Latin America, and Asia. Patients: A total of 1386 patients(mean age, 62.6 years; 73.1% men; 28.0% with diabetes)with angina pectoris and 1 or 2 de novo lesions(2.25-3.00 mm in diameter) in native coronary arteries. Intervention: Patients were randomly assigned in a 1 ∶ 1 ratio to receive a sirolimus-eluting stent(n=701) or a paclitaxel-eluting stent(n=685). Main Outcome Measures: The primary end point was in-lesion binary restenosis(presence of a more than 50% luminal diameter stenosis) at 8 months. Secondary end points included 1-year rates of target lesion and vessel revascularization and a composite end point of cardiac death, Q-wave or non-Q-wave myocardial infarction, coronary artery bypass graft surgery, or repeat target lesion revascularization. Results: In-lesion binary restenosis at 8 months occurred in 86 patients(9.6% ) with a sirolimus-eluting stent vs 95(11.1% ) with a paclitaxel-eluting stent(relative risk [RR], 0.84; 95% confidence interval [CI], 0.61-1.17; P=.31). For sirolimus- vs paclitaxel-eluting stents, respectively, the mean(SD) in-stent late loss was 0.09(0.43) mm vs 0.31(0.44) mm(difference,-0.22 mm; 95% CI,-0.26 to-0.18 mm; P<.001), mean(SD) in-stent diameter stenosis was 23.1% (16.6% ) vs 26.7% (15.8% )(difference,-3.60% ; 95% CI,-5.12% to-2.08% ; P< .001), and the number of major adverse cardiac events at 1 year was 73(10.7% ) vs 76(11.4% )(RR, 0.94; 95% CI, 0.69-1.27; P=.73). Conclusion: In this trial comparing sirolimus- and paclitaxel-eluting coronary stents, there were no differences in the rates of binary restenosis or major adverse cardiac events. Clinical Trial Registration: ClinicalTrials.gov Identifier: | Morice M. -C. Colombo A. Meier B. 任付先(译) 杜媛(校) | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，2，8： | 12 |
| 6 | Polymorphisms of DNA repair genes XRCC1 and XRCC3, interaction with environmental exposure and risk of chronic gastritis and gastric cancer显示文摘AIM: To evaluate the association between polymorphisms XRCC1 Arg194Trp and Arg399Gln and XRCC3Thr241Met and the risk for chronic gastritis and gastric cancer, in a Southeastern Brazilian population.METHODS: Genotyping by PCR-RFLP was carried out on 202 patients with chronic gastritis (CG) and 160 patients with gastric cancer (GC), matched to 202 (C1) and 150(C2) controls, respectively.RESULTS: No differences were observed among the studied grou ps with regard to the genotype distribution of XRCC1 codons 194 and 399 and of XRCC3 codon 241. However, the combined analyses of the three variant alleles (194Trp, 399Gln and 241Met) showed an increased risk for chronic gastritis when compared to the GC group. Moreover, an interaction between the polymorphic alleles and demographic and environmental factors was observed in the CG and GC groups. XRCC1 194Trp was associated with smoking in the CG group,while the variant alleles XRCC1 399Gln and XRCC3241Met were related with gender, smoking, drinking and H pylori infection in the CG and GC groups.CONCLUSION: Our results showed no evidence of a rela-tionship between the polymorphisms XRCC1Arg194Trp and Arg399Gln and XRCC3 Thr241Met and the risk of chronic gastritis and gastric cancer in the Brazilian population, but the combined effect of these variants may interact to increase the risk for chronic gastritis,considered a premalignant lesion. Our data also indicate a gene-environment interaction in the susceptibility to chronic gastritis and gastric cancer. | Márcia Cristina Duarte Jucimara Colombo Andrea Regina Baptista Rossit Alaor Caetano Aldenis Albaneze Borim Durval Wornrath Ana Elizabete Silva | 2005 | World Journal of Gastroenterology2005，11，42： | 11 |
| 7 | Clinical Management of Hepatocellular Carcinoma. Conclusions of the Barcelona-2000 EASL Conference显示文摘 | Jordi Bruix Morris Sherman Josep M Llovet Michel Beaugrand Riccardo Lencioni Andrew K Burroughs Erik Christensen Luigi Pagliaro Massimo Colombo Juan Rodés | 2001 | Journal of Hepatology2001，，3： | 11 |
| 8 | GSTT1,GSTM1 and CYP2E1 genetic polymorphisms in gastric cancer and chronic gastritis in a Brazilian population显示文摘MIM:To test the hypothesis that,in the Southeastern Brazilian population,the GSTT1,GSTM1 and CYP2E1 polymorphisms and putative risk factors are associated with an increased risk for gastric cancer.METHODS:We conducted a study on 100 cases of gastric cancer(GC),100 cases of chronic gastritis(CG),and 150 controls(C).Deletion of the GSTT1 and GSTM1 genes was assessed by multiplex PCR.CYP2E1/PsА genotyping was performed using a PCR-RFLP assay.RESULTS:No relationship between GSTT1/GSTM1 deletion and the c1/c2 genotype of CYP2E1 was observed among the three groups.However,a significant difference between CG and C was observde,due to a greater number of GSTT1/GSTM1 positive genotypes in the CG group.The GSTT1 null genotype occurred more frequently in Negroid subjicts,and the GSTM1 null genotype was observed mainly in individuals with chronic gastritis infected with H pylori.CONCLUSION:Our findings indecate that there is no obvious relationship between the GSTT1,GSTM1 and CYP2E1 polymorphisms and gastric cancer. | Jucimara Colombo Ana Elizabete Silva Andréa Regina Baptista Rossit Alaor Caetano Aldenis Albaneze Borim Durval Wohnrath | 2004 | World Journal of Gastroenterology2004，10，9： | 11 |
| 9 | 欧洲肿瘤内科协会对新发和复发性卵巢上皮癌的诊断、治疗和随访制定的临床实践指南显示文摘发病率卵巢癌在女性常见癌症中(皮肤癌除外)位列第九,在癌症所致的女性死亡原因中居第五位。女性在一生中患卵巢浸润癌的风险是1/71,而死于卵巢浸润癌的风险是1/95。在美国,据估计每年有21 550例的新发病例,且有14 600人死于卵巢癌。然而,在世界不同地区卵巢癌的发病率大不相同,2004年欧盟国家估计每年新发病例42 700例,而病死率为12/10万。 | Colombo N Peiretti M Parma G Lapresa M Mancari R Carinelli S Sessa C Castiglione M 杨华 郎景和 | 2011 | 国际妇产科学杂志2011，38，3： | 9 |
| 10 | Endoscopic management of difficult common bile duct stones:Where are we now?A comprehensive review显示文摘Endoscopic management for difficult common bile duct(CBD)stones still presents a challenge for several reasons,including anatomic anomalies,patients’individual conditions and stone features.In recent years,variable methods have emerged that have attributed to higher stone removal success rates,reduced cost and lower adverse events.In this review,we outline a stepwise approach in CBD stone management.As first line therapy,endoscopic sphincterotomy and large balloon dilation are recommended,due to a 30%-50%reduction of the use of mechanical lithotripsy.On the other hand,cholangioscopy-assisted lithotripsy has been increasingly reported as an effective and safe alternative technique to mechanical lithotripsy but remains to be reserved in special settings due to limited large-scale evidence.As discussed,findings suggest that management needs to be tailored to the patient’s characteristics and anatomical conditions.Furthermore,we evaluate the management of CBD stones in various surgical altered anatomy(Billroth II,Roux-en-Y and Roux-en-Y gastric bypass).Moreover,we could conclude that cholangioscopy-assisted lithotripsy needs to be evaluated for primary use,rather than following a failed management option.In addition,we discuss the importance of dissecting other techniques,such as the primary use of interventional endoscopic ultrasound for the management of CBD stones when other techniques have failed.In conclusion,we recognize that endoscopic sphincterotomy and large balloon dilation,mechanical lithotripsy and intraductal lithotripsy substantiate an indication to the management of difficult CBD stones,but emerging techniques are in rapid evolution with encouraging results. | Alberto Tringali Deborah Costa Alessandro Fugazza Matteo Colombo Kareem Khalaf Alessandro Repici Andrea Anderloni | 2021 | World Journal of Gastroenterology2021，27，44： | 8 |
| 11 | Long-term outcomes following drug-eluting stent implantation in unprotected left main bifurcation lesions显示文摘背景 drug-eluting stents (DES ) 的安全和功效培植在没有防卫留给主要(LM ) 分叉损害还得被决定。现在的报告的目的是在我们识别了的没有防卫的 LM 分叉 lesions.Methods 评估 DES 的长期的结果追随者培植从 4 月 2003to 日 2005 年 1 月在没有防卫的 LM 分叉损害与 DES 对待的 70 个连续病人。他们, 42 个病人与 sirolimus-eluting stent (SES ) 被对待, 28 个病人与 paclitaxel-eluting stent (足) 被对待 .Results Stents 到左前面的下降并且到降声调符号在 62 个病人被植入。在 1 年的后续期间, 3 (4.3%) 病人们死于心脏的原因。他们之一有心肌的梗塞并且是判决了可能由于 stent 血栓。Angiographic 后续在 80% 病人是可得到的。per 损害狭窄率在全部队, 10.7% 在与 SES 对待的损害发生了是 13.4% , 16.1% 与足(P=0.58 ) 在那些对待。所有狭窄在与 stent 尺寸与 stent 对待到 procedural 以后参考容器直径比率 1.0 的损害焦点、发生(17.6% 对 0, P=0.04 ) 。在 1 年的 per 病人目标损害 revascularization 率是 17.1% 。从主要不利心脏的事件免费的一年幸存是用 DES 的 LM 分叉损害的 77.1%.Conclusions 治疗是有对在对改进的 17% 病人要求的 revascularization 的低一个年 mortality.The 需要的一个安全、可行的方法。 | GE Lei John Cosgrave Ioannis Iakovou QIAN Ju-ying Pierfrancesco Agostoni Giuseppe M. Sangiorgi Flavio Airoldi Iassen Michev Alaide Chieffo Nicola Corvaja Antonio Colombo GE Jun-bo | 2007 | Chinese Medical Journal2007，，7： | 5 |
| 12 | Comparison of 1,800 Laparoscopic and Open Partial Nephrectomies for Single Renal Tumors显示文摘 | Inderbir S. Gill Louis R. Kavoussi Brian R. Lane Michael L. Blute Denise Babineau J. Roberto Colombo Igor Frank Sompol Permpongkosol Christopher J. Weight Jihad H. Kaouk Michael W. Kattan Andrew C. Novick | 2007 | The Journal of Urology2007，，1： | 5 |
| 13 | Is transient elastography a useful tool for screening liver disease?显示文摘Transient elastography(TE)is a new non invasive tool for measuring liver stiffness,which is correlated to the histologic stage of liver fibrosis.Several studies in chronic liver disease(CLD)have determined a good accuracy of TE in predicting significant fibrosis and an optimal accuracy in predicting cirrhosis.Normal liver stiffness ranges between 3.3-7.8 KPa and using a cut off of 7.1 KPa,significant fibrosis and cirrhosis can be excluded with a very high negative predictive value(NPV).Positive predictive value(PPV)for the diagnosis of cirrhosis is lower using just a single scan but increases to 90% if high stiffness values are confirmed by a second independent scan.However the presence of fatty liver and metabolic syndrome slightly increases the readings and may reduce the accuracy of the test.It is uncertain if this increase is related to the presence of steatofibrosis or ifit is caused by steatosis itself.TE can be used in screening patients attending the liver clinics to identify those with signifi cant fi brosis or cirrhosis and may be particularly useful in discriminating HBV inactive carriers from chronic hepatitis B patients.TE,however,is not reliable in predicting the presence of esophageal varices in cirrhotics.Another potential indication for TE is the systematic screening of populations at high risk for CLD,such as intravenous drug users and alcoholics,but further studies are needed to determine its diagnostic accuracy in these settings. | Paolo Del Poggio Silvia Colombo | 2009 | World Journal of Gastroenterology2009，15，12： | 5 |
| 14 | Statements from the Taormina expert meeting on occult hepatitis B virus infection显示文摘 | Giovanni Raimondo Jean-Pierre Allain Maurizia R. Brunetto Marie-Annick Buendia Ding-Shinn Chen Massimo Colombo Antonio Craxì Francesco Donato Carlo Ferrari Giovanni B. Gaeta Wolfram H. Gerlich Massimo Levrero Stephen Locarnini Thomas Michalak Mario U. Mon | 2008 | Journal of Hepatology2008，，4： | 5 |
| 15 | Hypertension and chronic ethanol consumption: What do we know after a century of study?显示文摘The influences of life habits on the cardiovascularsystem may have important implications for publichealth, as cardiovascular diseases are among the lead-ing causes of shorter life expectancy worldwide. A linkbetween excessive ethyl alcohol(ethanol) consumptionand arterial hypertension was first suggested early lastcentury. Since then, this proposition has received con-siderable attention. Support for the concept of ethanolas a cause of hypertension derives from several epi-demiologic studies demonstrating that in the generalpopulation, increased blood pressure is significantlycorrelated with ethanol consumption. Although thelink between ethanol consumption and hypertension iswell established, the mechanism through which etha-nol increases blood pressure remains elusive. Possiblemechanisms underlying ethanol-induced hypertensionwere proposed based on clinical and experimental ob-servations. These mechanisms include an increase insympathetic nervous system activity, stimulation of therenin-angiotensin-aldosterone system, an increase of intracellular Ca2+ in vascular smooth muscle, increased oxidative stress and endothelial dysfunction. The pres-ent report reviews the relationship between ethanol intake and hypertension and highlights some mecha-nisms underlying this response. These issues are of interest for the public health, as ethanol consumption contributes to blood pressure elevation in the population. | Katia Colombo Marchi Jaqueline Jóice Muniz Carlos Renato Tirapelli | 2014 | World Journal of Cardiology2014，6，5： | 5 |
| 16 | Peptide aptamers:The versatile role of specific protein function inhibitors in plant biotechnology显示文摘In recent years,peptide aptamers have emerged as novel molecular tools that have attracted the attention of researchers in various fields of basic and applied science,ranging from medicine to analytical chemistry.These artificial short peptides are able to specifically bind,track,and inhibit a given target molecule with high affinity,even molecules with poor immunogenicity or high toxicity,and represent a remarkable alternative to antibodies in many different applications.Their use is on the rise,driven mainly by the medical and pharmaceutical sector.Here we discuss the enormous potential of peptide aptamers in both basic and applied aspects of plant biotechnology and food safety.The different peptide aptamer selection methods available both in vivo and in vitro are introduced,and the most important possible applications in plant biotechnology are illustrated.In particular,we discuss the generation of broadbased virus resistance in crops, 'reverse genetics' and aptasensors in bioassays for detecting contaminations in food and feed.Furthermore,we suggest an alternative to the transfer of peptide aptamers into plant cells via genetic transformation,based on the use of cell-penetrating peptides that overcome the limits imposed by both crop transformation and Genetically Modified Organism commercialization. | Monica Colombo Chiara Mizzotti Simona Masiero Martin M.Kater Paolo Pesaresi | 2015 | Journal of Integrative Plant Biology2015，57，11： | 4 |
| 17 | Enteropathic spondyloarthropathy:A common genetic background with inflammatory bowel disease?显示文摘The association between spondyloarthropathy and in flammatory bowel disease(IBD) is largely established, although prevalence is variable because of different population selection and diagnostic methodologies.Most studies indicate that as many as 10%15% of cases of IBD are complicated by ankylosing spondylitis(AS) or other forms of spondylarthritis(SpA).Of note, ileal inflammation resembling IBD has been reported in up to two thirds of cases of SpA, and it has been suggested that the presence of ileitis is associated with the chronic ity of articular complications.Although this observation is of interest to unravel the pathophysiology of the disease, systematic screening of patients with SpA by ileocolonos copy is not indicated in the absence of gut symptoms, as only a small proportion of patients with subclinical gut inflammation will develop overt IBD over time.The existence of familial clustering of both IBD and AS, the coexistence of both conditions in a patient, the evidence of an increased risk ratio among f irstand seconddegree relatives of affected AS or IBD patients and f inally, the increased crossrisk ratios between AS and IBD, strongly suggest a shared genetic background.So far, however, IL23R is the only identified susceptibility gene shared by both IBD and AS.Although functional studies are still needed to better understand its pathogenic role, great ef fort is being spent therapeutically targeting this pathway that may prove effective for both disorders. | Elisabetta Colombo Anna Latiano Orazio Palmieri Fabrizio Bossa Angelo Andriulli Vito Annese | 2009 | World Journal of Gastroenterology2009，15，20： | 4 |
| 18 | Eosinophils and mast cells as therapeutic targets in pediatric functional dyspepsia显示文摘There is an increasing appreciation for the importance of inflammation as a pathophysiologic entity that contributes to functional gastrointestinal disorders including functional dyspepsia(FD).Importantly,inflammation may serve as a mediator between psychologic and physiologic functions.This manuscript reviews the literature implicating two inflammatory cell types,mast cells and eosinophils,in the generation of dyspeptic symptoms and explores their potential as targets for the treatment of FD.There are a number of inciting events which may initiate an inflammatory response,and the subsequent recruitment and activation of mast cells and eosinophils.These include internal triggers such as stress and anxiety,as well as external triggers such as microbes and allergens.Previous studies suggest that there may be efficacy in utilizing medications directed at mast cells and eosinophils.Evidence exists to suggest that combining 'anti-inflammatory' medications with other treatments targeting stress can improve the rate of symptom resolution in pediatric FD. | Craig A Friesen Jennifer V Schurman Jennifer M Colombo Susan M Abdel-Rahman | 2013 | World Journal of Gastrointestinal Pharmacology and Therapeutics2013，4，4： | 4 |
| 19 | Individualized hepatocellular carcinoma risk: The challenges for designing successful chemoprevention strategies显示文摘Hepatocellular carcinoma (HCC) develops in the context of environmental risk factors like chronic viral hepatitis, diabetes and alcohol exposure, often associated to an increased risk of cirrhosis. Antiviral treatments that are effective to counteract hepatitis B and C may also attenuate the risk of tumor development. However, since hepatitis B-related carcinogenesis is promoted independently of the onset of cirrhosis, such antiviral treatments as nucleo(t)side analogs can promote regression of cirrhosis, prevent clinical decompensation and variceal bleeding but not HCC. This means that in successfully treated patients with cirrhosis, HCC is often the consequence of their extended survival. In hepatitis C patients, a sustained virological response to interferon-based therapies can reduce the rate of HCC development, even in patients with cirrhosis who experience histological regression of their liver disease. Future therapies aimed at this endpoint in at risk populations should take into consideration pretreatment patient stratification for host, viral and environmental risk factors. In this context the recent discovery of single nucleotide polymorphisms involved in the immune system function and tumorigenesis, might permit enrollment of populations of patients enriched with HCC risk factors for targeted chemopreventive therapies. This could finally pave the way to personalized algorithms, as already seen in the diagnosis and treatment schemes for chemoprevention. | Cristina Della Corte Alessio Aghemo Massimo Colombo | 2013 | World Journal of Gastroenterology2013，19，9： | 4 |
| 20 | Direct carotid puncture in acute ischaemic stroke intervention显示文摘Endovascular intervention for acute ischaemic stroke care is mostly performed in older patients,often with unfavourable aortic and supra-aortic anatomy,as well as cardiovascular comorbidities.A significant subset of them may benefit from transcervical access as the initial approach for mechanical thrombectomy.In fact,direct carotid artery puncture in these cases has the advantage to bypass the anatomical obstacles and achieve faster reperfusion.Caution is advised when common carotid artery access is pursued in order to avoid adverse events,including haematoma formation,iatrogenic arterial dissection and sheath kinking.In spite of potential complications,direct carotid puncture in acute ischaemic stroke intervention overcomes challenging angioarchitecture and may reduce the rate of poor clinical outcomes associated with delayed revascularisation in certain cases. | Elisa Colombo Lorenzo Rinaldo Giuseppe Lanzino | 2020 | Stroke & Vascular Neurology2020，5，1： | 4 |
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