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| 1 | emerging role of the β-catenin-PPARγ axis in the pathogenesis of colorectal cancer显示文摘Multiple lines of evidence indicate that Wnt/β-catenin signaling plays a fundamental role in colorectal cancer(CRC)initiation and progression.Recent genome-wide data have confirmed that in CRC this pathway is one of the most frequently modified by genetic or epigenetic alterations affecting almost 90%of Wnt/β-catenin gene members.A major challenge is thus learning how the corrupted coordination of this pathway is tied to other signalings to enhance cell growth.Peroxisome proliferator activated receptorγ(PPARγ)is emerging as a growth-limiting and differentiation-promoting factor.In tumorigenesis it exerts a tumor suppressor role and is potentially linked with the Wnt/β-catenin pathway.Based on these results,the identification of new selective PPARγmodulators with inhibitory effects on the Wnt/β-catenin pathway is becoming an interesting perspective.Should,in fact,these molecules display such properties,new research avenues would be opened aimed at developing new molecular targeted drugs.Herein,we review the basic principles and present new hypotheses underlying the crosstalk between Wnt/β-catenin and PPARγsignaling.Furthermore,we discuss the advances in our understanding as to how their altered regulation can culminate in colon cancer and the efforts aimed at designing novel PPARγagonists endowed with Wnt/β-catenin inhibitory effects to be used as therapeutic and/or preventive agents. | Lina Sabatino Massimo Pancione Carolina Votino Tommaso Colangelo Angelo Lupo Ettore Novellino Antonio Lavecchia Vittorio Colantuoni | 2014 | World Journal of Gastroenterology2014，20，23： | 8 |
| 2 | Genetic and Epigenetic Events Generate Multiple Pathways inColorectal Cancer Progression显示文摘 | Massimo Pancione Andrea Remo Vittorio Colantuoni Ka F. To | 2012 | Pathology Research International2012，，： | 3 |
| 3 | 足球教练(经理)合同的特性与解除——国际视野下的比较研究显示文摘本文对教练与俱乐部之间的关系以及该关系的解除和后果进行探析。首先概述该论题的总体框架,然后分析国际足联和欧洲足联制定的有关规则。鉴于在绝大多数国家的实践中,相关规则源自合同条款,因此,有必要对合同条款的性质特点予以关注。其次,本文将从国际层面的案例中概览该问题,尤其关注那些由国际足联球员身份委员会和国际体育仲裁院受理的案件。最后,本文将介绍欧盟和国际上一些国家的情况,回顾国内规则、法律问题以及相关案例。 | Lucio Colantuoni Edoardo Revello Andrea Cattaneo 唐勇 吴方圆 | 2015 | 体育科研2015，36，3： | 2 |
| 4 | Short-term mortality prediction for acute lung injury patients: External validation of the Acute Respiratory Distress Syndrome Network prediction model显示文摘 | Abdulla Damluji Elizabeth Colantuoni Pedro A. Mendez-Tellez Jonathan E. Sevransky Eddy Fan Carl Shanholtz Margaret Wojnar Peter J. Pronovost Dale M. Needham | 2011 | Critical Care Medicine2011，，5： | 1 |
| 5 | Sustain- ing reductions in catheter related bloodstream infections in Michigan intensive care units: observational study 显示文摘 | Pronovost PJ Goeschel CA Colantuoni E | 2010 | BMJ2010，340，4： | 1 |
| 6 | Treatment of small cell lung cancer in elderly显示文摘 | Rossi A Maione P Colantuoni G | 2005 | Oncologist2005，10，6： | 1 |
| 7 | Understanding the physiological role of retinol-binding protein in vitamin A metabo- lism using transgenic and knockout mouse models显示文摘 | Quadro L Hamberger L Colantuoni V | 2003 | Mol Aspects Med2003，24，6： | 1 |
| 8 | Early Physical Medicine and Rehabilitation for Patients With Acute Respiratory Failure: A Quality Improvement Project显示文摘 | Dale M. Needham Radha Korupolu Jennifer M. Zanni Pranoti Pradhan Elizabeth Colantuoni Jeffrey B. Palmer Roy G. Brower Eddy Fan | 2010 | Archives of Physical Medicine and Rehabilitation2010，，4： | 1 |
| 9 | Recent developments of targeted therapies in the treatment of non - small cell lung cancer 显示文摘 | Rossi A Malone P Colantuoni G | 2009 | Current Drug Discovery Techno12009，6，2： | 1 |
| 10 | Protective effects of leukopenia and tissue plasminogen activator in microvascular ischemia reperfusion injury显示文摘 | Bertuglia S Colantuoni A | 2000 | Am J Physiol Heart Circ Physiol2000，278，： | 1 |
| 11 | Recent developments of targeted therapies in the treatment of non-small cell lung cancer 显示文摘 | Rossi A Maione P Colantuoni G | 2009 | Curt Drug Diseov Teehnol2009，6，2： | 1 |
| 12 | Chemotherapy of non-small cell lung cancer in elderly patients显示文摘 | Gridelli C Maione P Colantuoni G | | 0，，16： | 1 |
| 13 | Lung protective mechanical ventilation and two year survival in patients with acute lung injury:prospective cohort study显示文摘 | Needham DM Colantuoni E Mendez-Tellez PA | 2012 | BMJ2012，344，2： | 1 |
| 14 | Pain prevalence, intensity,assessment and management in a hospitalized pediatric population显示文摘 | Kozlowski LJ Kost - Byerly S Colantuoni E | 2014 | Pain Manag Nurs2014，15，1： | 1 |
| 15 | MicroRNA-130b Promotes Tumor Development and Is Associated with Poor Prognosis in Colorectal Cancer显示文摘 | Tommaso Colangelo Alessandra Fucci Carolina Votino Lina Sabatino Massimo Pancione Carmelo Laudanna Monica Binaschi Mario Bigioni Carlo Alberto Maggi Domenico Parente Nicola Forte Vittorio Colantuoni | 2013 | Neoplasia2013，，： | 1 |
| 16 | Chemotherapy of non-small cell lung cancer in elderly patients 显示文摘 | Gridelli C Maione P Colantuoni G | 2002 | Curr Med Chem2002，9，16： | 1 |
| 17 | Geometric characteristics of arterial network of rat pial microcirculation显示文摘 | LAPI D MARCHIAFAVA P L COLANTUONI A | 2008 | Vasc Res2008，45，： | 1 |
| 18 | The role of new tar-geted therapies in small-cell lung Cancer显示文摘 | Rossi A Maione P Colantuoni G | | 0，，1： | 1 |
| 19 | Betting on Sport 显示文摘 | Lucio Colantuoni Cristiano Novazio Alessandro Izar Matteo Pozzi | 2010 | International Sports Law Review Pandektis2010，，8： | 1 |
| 20 | Lung pro- tective mechanical ventilation and two year survival in patients with acute lung injury: prospective cohort study显示文摘 | Needham DM Colantuoni E Mendez-Tellez PA | 2012 | BMJ2012，344，： | 1 |
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