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| 1 | emerging role of the β-catenin-PPARγ axis in the pathogenesis of colorectal cancer显示文摘Multiple lines of evidence indicate that Wnt/β-catenin signaling plays a fundamental role in colorectal cancer(CRC)initiation and progression.Recent genome-wide data have confirmed that in CRC this pathway is one of the most frequently modified by genetic or epigenetic alterations affecting almost 90%of Wnt/β-catenin gene members.A major challenge is thus learning how the corrupted coordination of this pathway is tied to other signalings to enhance cell growth.Peroxisome proliferator activated receptorγ(PPARγ)is emerging as a growth-limiting and differentiation-promoting factor.In tumorigenesis it exerts a tumor suppressor role and is potentially linked with the Wnt/β-catenin pathway.Based on these results,the identification of new selective PPARγmodulators with inhibitory effects on the Wnt/β-catenin pathway is becoming an interesting perspective.Should,in fact,these molecules display such properties,new research avenues would be opened aimed at developing new molecular targeted drugs.Herein,we review the basic principles and present new hypotheses underlying the crosstalk between Wnt/β-catenin and PPARγsignaling.Furthermore,we discuss the advances in our understanding as to how their altered regulation can culminate in colon cancer and the efforts aimed at designing novel PPARγagonists endowed with Wnt/β-catenin inhibitory effects to be used as therapeutic and/or preventive agents. | Lina Sabatino Massimo Pancione Carolina Votino Tommaso Colangelo Angelo Lupo Ettore Novellino Antonio Lavecchia Vittorio Colantuoni | 2014 | World Journal of Gastroenterology2014，20，23： | 8 |
| 2 | Neural plasticity and adult neurogenesis: the deep biology perspective显示文摘The recognition that neurogenesis does not stop with adolescence has spun off research towards the reduction of brain disorders by enhancing brain regeneration. Adult neurogenesis is one of the tougher problems of developmental biology as it requires the generation of complex intracellular and pericellular anatomies, amidst the danger of neuroinflammation. We here review how a multitude of regulatory pathways optimized for early neurogenesis has to be revamped into a new choreography of time dependencies. Distinct pathways need to be regulated, ranging from neural growth factor induced differentiation to mitochondrial bioenergetics, reactive oxygen metabolism, and apoptosis. Requiring much Gibbs energy consumption, brain depends on aerobic energy metabolism, hence on mitochondrial activity. Mitochondrial fission and fusion, movement and perhaps even mitoptosis, thereby come into play. All these network processes are interlinked and involve a plethora of molecules. We recommend a deep thinking approach to adult neurobiology. | Anna Maria Colangelo Giovanni Cirillo Lilia Alberghina Michele Papa Hans V.Westerhoff | 2019 | Neural Regeneration Research2019，14，2： | 3 |
| 3 | 颈动脉硬化进展与病程≥10年的高血压治疗之间的关系:多种族动脉粥样硬化研究显示文摘尚未有前瞻性多种族队列对抗高血压药物类别和动脉硬化进展的相关性进行研究。该研究所有受试者基线均患高血压,定义为血压≥140/90 mm Hg(1mm Hg=0.133kPa)或服用降压药物治疗。在5个时间点评估药物的服用情况和血压水平。通过超声在基线时和平均随访(9.4±0.5)年后测定右颈总动脉的杨氏弹性模量和扩张系数。 | Gepner AD Tedla Y Colangelo LA Tattersall MC Korcarz CE Kaufman JD Liu K Burke GL Shea S Greenland P Stein JH 刘莉 叶鹏 | 2016 | 中华高血压杂志2016，24，11： | 2 |
| 4 | Neoadjuvant radiotherapy dose escalation for locally advanced rectal cancers in the new era of radiotherapy:A review of literature显示文摘BACKGROUND The standard treatment of locally advanced rectal cancers(LARC)consists on neoadjuvant chemoradiotherapy followed by total mesorectal excision.Different data in literature showed a benefit on tumor downstaging and pathological complete response(pCR)rate using radiotherapy dose escalation,however there is shortage of studies regarding dose escalation using the innovative techniques for LARC(T3-4 or N1-2).AIM To analyze the role of neoadjuvant radiotherapy dose escalation for LARC using innovative radiotherapy techniques.METHODS In December 2020,we conducted a comprehensive literature search of the following electronic databases:PubMed,Web of Science,Scopus and Cochrane library.The limit period of research included articles published from January 2009 to December 2020.Screening by title and abstract was carried out to identify only studies using radiation doses equivalent dose 2 Gy fraction(EQD2)≥54 Gy and Volumetric Modulated Arc Therapy(VMAT),intensity-modulated radiotherapy or image-guided radiotherapy(IGRT)techniques.The authors’searches generated a total of 2287 results and,according to PRISMA Group(2009)screening process,21 publications fulfil selection criteria and were included for the review.RESULTS The main radiotherapy technique used consisted in VMAT and IGRT modality.The mainly dose prescription was 55 Gy to high risk volume and 45 Gy as prophylactic volume in 25 fractions given with simultaneous integrated boosts technique(42.85%).The mean pCR was 28.2%with no correlation between dose prescribed and response rates(P value≥0.5).The R0 margins and sphincter preservation rates were 98.88%and 76.03%,respectively.After a mean follow-up of 35 months local control was 92.29%.G3 or higher toxicity was 11.06%with no correlation between dose prescription and toxicities.Patients receiving EQD2 dose>58.9 Gy and BED>70.7 Gy had higher surgical complications rates compared to other group(P value=0.047).CONCLUSION Dose escalation neoadjuvant radiotherapy using innovative techniques is safe for LARC achieving higher rates of pCR.EQD2 doses>58.9 Gy is associated with higher rate of surgical complications. | Durim Delishaj Ilaria Costanza Fumagalli Stefano Ursino Agostino Cristaudo Francesco Colangelo Antonio Stefanelli Alessandro Alghisi Giuseppe De Nobili Romerai D’Amico Alessandra Cocchi Antonio Ardizzoia Carlo Pietro | 2021 | World Journal of Clinical Cases2021，9，30： | 2 |
| 5 | Cellular proteins in influenza virus particles显示文摘 | Shaw Megan L Stone Kathryn L Colangelo Christopher M | 2008 | PLoS pathogens2008，4，10： | 1 |
| 6 | Prognostic and predictive roles of high-degree microsatellite instability in colon cancer: a National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project Collaborative Study显示文摘 | Kim GP Colangelo LH Wieand HS | 2007 | J Clin Oncol2007，25，7： | 1 |
| 7 | In vivo antiviral effects of pidotimod显示文摘 | Dianzani C Colangelo D Tonso E Guidotto S Viano I | 1994 | Arzneimittelforsch1994，44，： | 1 |
| 8 | Identification of kalirin-7as a potential post-synaptic density signaling hub 显示文摘 | Kiraly DD Stone KL Colangelo CM | 2011 | J ProteomeRes2011，10，6： | 1 |
| 9 | Preoperative multi- modality therapy improves disease-free survival in patients with carcinoma of the rectum: NSABP R-O3显示文摘 | Roh MS Colangelo LH OConnell MJ | 2009 | J Clin Oncol2009，27，31： | 1 |
| 10 | Preoperative multimodality therapy improves disease-free survival in patients with carcinoma of the rectum: NSABP R03显示文摘 | Roh MS Colangelo LH O'Connell MJ | 2009 | J Clin Oncol2009，27，： | 1 |
| 11 | Effect of metal-based anticancer drugs on wild type and metallothionein null cell lines显示文摘 | Mahboobi H Viarengo A Colangelo D | 2003 | Biometals2003，16，3： | 1 |
| 12 | European Union bans at- razine, while the United States negotiates continued use显示文摘 | BETHSASS J COLANGELO A | 2006 | In- ternational Journal of Occupational and Environmental Health2006，12，8： | 1 |
| 13 | Vacuum-assisted venous drainage in extrathoracic cardiopulmonary bypass management during minimally invasive cardiac surgery显示文摘 | Colangelo N Torracca L Lapenna E | 2006 | Perfusion2006，26，： | 1 |
| 14 | Prognostic value of thymidylate synthase,Ki-67,and p53 in patients with Dukes' B and C colon cancer:a National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project collaborative study显示文摘 | Allegra CJ Paik S Colangelo LH | 2003 | J Clin Oncol2003，21，2： | 1 |
| 15 | Case report : Inflammato ry myofibroblastic tumor of pancreatic origin in a patient with down syndrome: The role of diagnostic ultrasound显示文摘 | Colangelo M Di Renzo D Persico A | 2011 | J Ultrasound2011，14，1： | 1 |
| 16 | Comparing protein abundance and mRNA expression levels on a genomic scale显示文摘 | Greenbaum D Colangelo C Williams K | | 0，，09： | 1 |
| 17 | Risk factors for coronary artery disease in men 18 to 39 years of age显示文摘 | Navas-Nacher EL Colangelo L Beam C | 2001 | Ann Intern Med2001，134，： | 1 |
| 18 | Concurrent blockade of platelet-activating factor and histamine prevents lifethreatening pea- nutinduced anaphylactic reactions 显示文摘 | Arias K Baig M Colangelo M | 2009 | J Allergy Clin Immunol2009，124，2： | 1 |
| 19 | Prognostic and predic- five roles of high-degree microsateUite instability in colon cancer: a National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project Collaborative Study显示文摘 | Kim GP Colangelo LH Wieand HS | 2007 | J Clin Oncol2007，25，7： | 1 |
| 20 | Lycopene induces cell growth inhibition by altering mevalonate pathway and Ras signaling in cancer cell lines 显示文摘 | Palozza P Colangelo Ms Simone R | 2010 | Carcinogenesis2010，31，10： | 1 |
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