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| 1 | Gastroesophageal reflux disease: Update on inflammation and symptom perception显示文摘Although gastroesophageal reflux disease(GERD)is a common disorder in Western countries,with a significant impact on quality of life and healthcare costs,the mechanisms involved in the pathogenesis of symptoms remain to be fully elucidated.GERD symptoms and complications may result from a multifactorial mechanism,in which acid and acid-pepsin are the important noxious factors involved.Prolonged contact of the esophageal mucosa with the refluxed content,probably caused by a defective anti-reflux barrier and luminal clearance mechanisms,would appear to be responsible for macroscopically detectable injury to the esophageal squamous epithelium.Receptors on acid-sensitive nerve endings may play a role in nociception and esophageal sensitivity,as suggested in animal models of chronic acid exposure.Meanwhile,specific cytokine and chemokine profiles would appear to underlie the various esophageal phenotypes of GERD,explaining,in part,the genesis of esophagitis in a subset of patients.Despite these findings,which show a significant production of inflammatory mediators and neurotransmitters in the pathogenesis of GERD,the relationship between the hypersensitivity and esophageal inflammation is not clear.Moreover,the large majority of GERD patients(up to 70%)do not develop esophageal erosions,a variant of the condition called non-erosive reflux disease.This summary aims to explore the inflammatory pathway involved in GERD pathogenesis,to better understand the possible distinction between erosive and non-erosive reflux disease patients and to provide new therapeutic approaches. | Annamaria Altomare Michele Pier Luca Guarino Silvia Cocca Sara Emerenziani Michele Cicala | 2013 | World Journal of Gastroenterology2013，19，39： | 16 |
| 2 | Ursodeoxycholic acid therapy in gallbladder disease,a story not yet completed显示文摘Gallstone disease represents an important issue in the healthcare system.The principal non-invasive nonsurgical medical treatment for cholesterol gallstones is still represented by oral litholysis with bile acids.The first successful and documented dissolution of cholesterol gallstones was achieved in 1972.Since then a large number of investigators all over the world,have been dedicated in biochemical and clinical studies on ursodeoxycholic acid(UDCA),demonstrating its extreme versatility.This editorial is aimed to provide a brief review of recent developments in UDCA use,current indications for its use and,the more recent advances in understanding its effects in terms of an antiinflammatory drug. | Michele Pier Luca Guarino Silvia Cocca Annamaria Altomare Sara Emerenziani Michele Cicala | 2013 | World Journal of Gastroenterology2013，19，31： | 16 |
| 3 | Isothermal and non- isothermal crystallization of poly ( L-lactic acid )/poly ( butylene terephthalate) blends 显示文摘 | LORENZO M L D RUB1NO P COCCA M | 2014 | Journal of Applied Polymer Science2014，131，12： | 1 |
| 4 | Molecular pathology of the FSH receptor: new insights into FSH physiology 显示文摘 | Medufi G Bachelot A Cocca MP | 2008 | Mol Cell Endocrinol2008，282，12： | 1 |
| 5 | Human colonic myogenic dysfunction induced by mucosal lipopolysaccharide translocation and oxidative stress显示文摘 | Michele Pier Luca Guarino Rosa Sessa Annamaria Altomare Silvia Cocca Marisa Di Pietro Simone Carotti Giovanni Schiavoni Rossana Alloni Sara Emerenzian Sergio Morini Carola Severi Michele Cicala | 2013 | Digestive and Liver Disease2013，，： | 1 |
| 6 | Genomic remnants of alpha-globin genes in the hemoglobinless antarctic icefishes显示文摘 | Cocca E Ratnayake-Lecamwasam M Parker SK Camardella L Ciaramella M di Prisco G Detrich HW | | 0，，： | 1 |
| 7 | RedOx status, pro- teasome and APEH: insights into anticancer mechanisms of t10, c12-conjugated linoleic acid isomer on A375 melanoma cells 显示文摘 | BERGAMO P COCCA E PALUMBO R | 2013 | PLoS One2013，8，80： | 1 |
| 8 | Thermoreversible luminescent organogels doped with Eu (TI'A) 3phen complex 显示文摘 | Maria Laura Di Lorenzo Mariacristina Cocca Gennaro Gentile | 2013 | Journal of Colloid and Interface Science2013，398，： | 1 |
| 9 | Regio-selective deprotection of peracetylated sugars via lipase hydrolysis 显示文摘 | Fernandez-Lorente G Palomo JM Cocca J | 2003 | Tetrahedron2003，59，： | 1 |
| 10 | Molecular pathology of the FSH receptor: new insights into FSH physiology 显示文摘 | Meduri G Bachelot A Cocca MP | 2008 | Mol Cell Endocrinol2008，282，12： | 1 |
| 11 | Fasting and post-prandial glycemia and their correlation with glycated hemoglobin in Type 2 diabetes显示文摘 | M. Monami C. Lamanna L. Lambertucci R. Longo C. Cocca F. Addante E. Lotti G. Masotti N. Marchionni E. Mannucci | 2006 | Journal of Endocrinological Investigation2006，，7： | 1 |
| 12 | Do the hemoglobinless icefishes have globin genes? 显示文摘 | COCCA E RATNAYAKE-LECAMWASAM M PARKER S K | 1997 | Comparative Biochemistry and Physiology Part A: Physiology1997，118，4： | 1 |
| 13 | Regio-selective deprotection of peracetylated sugars via lipase hydrolysis显示文摘 | FERNANDEZ-LORENTE G PALOMO J M COCCA J | 2003 | Tetrahedron2003，59，30： | 1 |
| 14 | Estrogen receptor profiles: changes in mouse and rat mammary tumors by treatment with selective estrogen receptor modifiers 显示文摘 | Actis A Cocca C Gutierrez A | 2004 | Med Princ Pract2004，13，4： | 1 |
| 15 | aEEG in preterm infants显示文摘 | Scoppa A Casani A Cocca F | 2012 | J Matem Fetal Neonatal Med2012，254，： | 1 |
| 16 | Biodegradable PVOH-based foams for packaging applications 显示文摘 | Avella M Cocca M Gentile G | 2011 | Journal of Cellular Plastics2011，47，： | 1 |
| 17 | Hexachlorobenzene is a tumor co-carcinogen and induces alterations in insulin-growth factors signaling pathway in the rat mammary gland 显示文摘 | Randi A S Cocca C Carbone V | 2006 | Toxicological Sciences2006，89，1： | 1 |
| 18 | The major adult α-globin gene of Antarctic teleosts and its remnants in the hemoglobinless icefishes calibration of the mutational clock for nuclear genes显示文摘 | Zhao Y Ratnayake-Lecamwasam M Parker SK Cocca E Camardella L di Prisco G Detrich HW | | 0，，： | 1 |
| 19 | Polyac rylates forconservation : chemical-physical proper ties and durability of different commercial prod ucts 显示文摘 | Cocca M D Arienzo L Orazio L D | 2004 | Polymer Testing2004，23，3： | 1 |
| 20 | Hexachlorobenzene is a tumor co-carcinogen and induces alterations in insu- lin-growth factors signaling pathway in the rat mammary gland 显示文摘 | Randi A S Cocca C Carbone V | 2006 | Toxicological Science2006，89，1： | 1 |
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