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| 1 | Peritoneal carcinomatosis显示文摘Several gastrointestinal and gynecological malignancies have the potential to disseminate and grow in the peritoneal cavity.The occurrence of peritoneal carcinomatosis(PC)has been shown to significantly decrease overall survival in patients with liver and/or extraperitoneal metastases from gastrointestinal cancer.During the last three decades,the understanding of the biology and pathways of dissemination of tumors with intraperitoneal spread,and the understanding of the protective function of the peritoneal barrier against tumoral seeding,has prompted the concept that PC is a loco-regional disease:in absence of other systemic metastases,multimodal approaches combining aggressive cytoreductive surgery,intraperitoneal hyperthermic chemotherapy and systemic chemotherapy have been proposed and are actually considered promising methods to improve loco-regional control of the disease,and ultimately to increase survival.The aim of this review article is to present the evidence on treatment of PC in different tumors,in order to provide patients with a proper surgical and multidisciplinary treatment focused on optimal control of their locoregional disease. | Federico Coccolini Federico Gheza Marco Lotti Salvatore Virzì Domenico Iusco Claudio Ghermandi Rita Melotti Gianluca Baiocchi Stefano Maria Giulini Luca Ansaloni Fausto Catena | 2013 | World Journal of Gastroenterology2013，19，41： | 9 |
| 2 | 【原创论文】不育夫妇中男方的代谢综合征与前列腺异常的情况显示文摘目前尚无年轻男性不育症患者代谢综合征与前列腺相关的症状和体征之间关系的系统研究。我们研究了171对不育夫妇中的男性(36.5±8.3岁),代谢综合征是根据国家胆固醇教育计划成人治疗专题小组第三次报告确定。所有人接受了激素(包括总睾酮和胰岛素)、精液f包括白细胞介素8,精浆中白细胞介素8(SIL-8))、阴囊及经直肠超声评估。因为我们此前已有大样本队列研究了不育男性代谢综合征和阴囊检测指标之间的相关性,这里我们重点研究代谢综合征与经直肠前列腺B超资料的相关性。前列腺相关症状采用美国国立卫生研究院评估慢性前列腺炎症状指数(NIH-CPSI)和国际前列腺症状评分(iPSS)。22位受试者符合代谢综合征的诊断标准。经年龄调整后的有序多项Logistic回归模型分析显示:胰岛素水平增加是代谢综合征的一个组分(Wald=29.5,P〈0.0001)并与TT负相关(调整后的r=0.359,P〈O.0001)。未观察到代谢综合征和NIH.CPSI或IPSS评分之间有相关性。经年龄、睾酮、胰岛素校正后有序多项Logistic回归模型显示:代谢综合征组分数目的增加与正常精子形态负相关(Wald=5.59,P〈0.02)、与前列腺炎症的分子标志物血清sIL-8水平正相关(Wald=4.32,P〈0.05),与前列腺总体积和移行带体积(Wald=17.6和12.5,P〈0.0001)、动脉收缩期峰值流速(Wald=9.57,P=0.002)、质地不均匀性(HR=8711.05—3.33],P〈0.05)、钙化灶大小(Wald=3.11,P〈0.05)正相关,但不与精囊体积或功能指标正相关。总之,不育夫妇中的男性代谢综合征与前列腺增大、生化指标(sIL8)和前列腺炎症的超声指标呈正相关,而与前列腺相关症状无正相关,表明代谢综合征可能是良性前列腺增生症的早期亚临床表现的触发点。 | Francesco Lotti Giovanni Corona Linda Vignozzi Matteo Rossi Elisa Maseroli Sarah Cipriani Mauro Gacci Gianni Forti Mario Maggi | 2014 | Asian Journal of Andrology2014，16，2： | 6 |
| 3 | Long‐term outcome of hepatitis B virus‐related C hronic H epatitis under protracted nucleos(t)ide analogues显示文摘 | G. A. Niro A. M. Ippolito R. Fontana M. R. Valvano D. Gioffreda A. Iacobellis A. Merla M. Durazzo G. Lotti L. Di Mauro A. Andriulli | 2013 | J Viral Hepat2013，，7： | 3 |
| 4 | Almond diversity and homozygosity define structure, kinship, inbreeding, and linkage disequilibrium in cultivated germplasm, and reveal genomic associations with nut and seed weight显示文摘Almond[Prunus dulcis Miller(D.A.Webb)]is the main tree nut species worldwide.Here,genotyping-by-sequencing(GBS)was applied to 149 almond cultivars from the ex situ collections of the Italian Council for Agricultural Research(CREA)and the Spanish National Research Council(CSIC),leading to the detection of 93,119 single-nucleotide polymorphisms(SNPs).The study of population structure outlined four distinct genetic groups and highlighted diversification between the Mediterranean and Californian gene pools.Data on SNP diversity and runs of homozygosity(ROHs)allowed the definition of kinship,inbreeding,and linkage disequilibrium(LD)decay in almond cultivated germplasm.Four-year phenotypic observations,gathered on 98 cultivars of the CREA collection,were used to perform a genome-wide association study(GWAS)and,for the first time in a crop species,homozygosity mapping(HM),resulting in the identification of genomic associations with nut,shell,and seed weight.Both GWAS and HM suggested that loci controlling nut and seed weight are mostly independent.Overall,this study provides insights on the almond cultivation history and delivers information of major interest for almond genetics and breeding.In a broader perspective,our results encourage the use of ROHs in crop science to estimate inbreeding,choose parental combinations minimizing the risk of inbreeding depression,and identify genomic footprints of selection for specific traits. | Stefano Pavan Chiara Delvento Rosa Mazzeo Francesca Ricciardi Pasquale Losciale Liliana Gaeta Nunzio D’Agostino Francesca Taranto Raquel Sanchez-Perez Luigi Ricciardi Concetta Lotti | 2021 | Horticulture Research2021，8，1： | 2 |
| 5 | DNA fragmentation in two cytometric sperm populations: relationship with clinical and ultrasound characteristics of the male genital tract显示文摘我们调查了是否在二张 cytometric 精子人口的 DNA 破碎(PI 更暗淡的 和 PI 有不同生物特征和临床的关联的更明亮的 ) 与有关临床并且男生殖道的 color-Doppler 超声(CDUS ) 参数。没有基因畸形的不肥沃的夫妇的 160 男性被评估为临床,阴囊,并且 transrectal CDUS 特征,像前列腺炎的症状的存在(与公民一起,健康长期的前列腺炎症状的研究所索引)并且在 PI 更暗淡的和 PI 更明亮的人口(用 TUNEL/PI ,方法结合了流动 cytometry )。数据好久被调整(模型 1 ) 与腰围,睾丸激素层次,吸烟习惯,和性节制(模型 2 ) 一起。根据统计模型 2, PI 更暗淡的 sDF 与阴囊的畸形被联系,包括降低临床并且超声体积(r = 0.21 并且 r = 0.20 分别地;P < 0.05 ) ,更高的 FSH 层次(r = 0.34, P < 0.0001 ) 并且阴囊的不同类的出现(P < 0.05 ) 并且 hypoechogenicity (P < 0.05 ) 。 PI 更明亮的 sDF 与前列腺相关的症状和反常符号被联系包括全部的更高的 NIH-CPSI 和子域分数,像前列腺炎的症状并且象宏石灰化那样的 CDUS 改变的更高的流行,严重回响质地不同类, hyperemia (所有 P < 0.05 ),并且更高动脉的山峰收缩速度( r = 0.25 , P < 0.05 )。我们的结果在 PI 更暗淡的 精子,与差的精液质量有关,主要在睾丸发源,由于 apoptosis 可能。相反地,在 PI 更明亮的 精子看起来主要通过前列腺发源在期间或在运输以后,与机关的煽动性的地位的存在增加。这些结果能导致新观点让治疗学的目标的鉴定减少 sDF。 | Francesco Lotti Lara Tamburrino Sara Marchiani Elisa Maseroli Pasquale Vitale Gianni Forti Monica Muratori Mario Maggi Elisabetta Baldi | 2017 | Asian Journal of Andrology2017，19，3： | 2 |
| 6 | Identification and expansion of the tumorigenic lung cancer stem cell population显示文摘 | Eramo A Lotti F Sette G | 2008 | Cell Death Differ2008，15，： | 1 |
| 7 | Identification and expansion of the tumorigenic lung cancer stem cell population 显示文摘 | ERAMO A LOTTI F SETTE G | 2007 | Cell Death Differ2007，15，3： | 1 |
| 8 | Vitiligo: new and emerging treatments显示文摘 | Lotti T Gori A Zanieri F | 2008 | Dermatol Ther2008，21，2： | 1 |
| 9 | The effect of nitrite inhibition on the anammox process显示文摘 | T. Lotti W.R.L. van der Star R. Kleerebezem C. Lubello M.C.M. van Loosdrecht | 2012 | Water Research2012，，8： | 1 |
| 10 | Plasminogen activators, venous leg ulcers and reepithelialization显示文摘 | Lotti T Benci M | 1995 | Int J Dermatol1995，34，10： | 1 |
| 11 | Identification and expansion of the tu- morigenic lung cancer stem cell population 显示文摘 | Eramo A Lotti F Sette G | 2008 | Cell Death Differ2008，15，3： | 1 |
| 12 | Identification and expansion of the tumorigenic lung cancer stem cell population 显示文摘 | Eramo A Lotti F Sette G | 2008 | Cell Death Differ2008，15，3： | 1 |
| 13 | Increased serum level of N‐terminal Pro‐B‐type natriuretic peptide as a possible biomarker of cardiovascular risk in psoriatic patients显示文摘 | A. Pietrzak J. Bartosinska R. Blaszczyk G. Chodorowska W. Brzozowski J. Hercogova H. Donica T. Lotti | 2015 | J Eur Acad Dermatol Venereol2015，，： | 1 |
| 14 | Influence of expiratory flow-limitation during exercise on systemic oxygen delivery in humans 显示文摘 | Aliverti A Dellaca RL Lotti P | 2005 | European Journal of Applied Physiology2005，95，23： | 1 |
| 15 | Successful treatment of psoriasis with low-dose per os interleukins 4, 10, and 11 显示文摘 | Lotti T Hercogova J | 2015 | Dermatol Ther2015，28，1： | 1 |
| 16 | Iceberg discharges into the North Atlantic on millennial time scales during the last deglaciation 显示文摘 | Bond G C Lotti R | 1995 | Science1995，273，： | 1 |
| 17 | Employment, Innovation, and Productivity:Evidence from Italian Microdata 显示文摘 | Hall B H Lotti F Mairesse J | 2008 | Indus- trial and Corporate Change2008，17，： | 1 |
| 18 | Inhibition of DNA methylation sensitizes glioblastoma for tumor necrosis factor-related apoptosis-inducing ligand-mediated destruction 显示文摘 | Eramo A Pallini R Lotti F | 2005 | Cancer Res2005，65，11： | 1 |
| 19 | Identification and expansion of the tumorigenic lung cancer stem cell population显示文摘 | Eramo A Lotti F Sette G | 2008 | Cell Death Differ2008，15，7： | 1 |
| 20 | Identification and expan- sion of the tumorigenic lung cancer stem cell population 显示文摘 | Eramo A Lotti F Sette G | 2008 | Cell Death Differ2008，15，3： | 1 |
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