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| 1 | 一种miRNA标记在胶质瘤侵袭性表型的确定与预后评估中的价值(英文)显示文摘Gliomas represent a disparate group of tumours for which there are to date no cure. Thus,there is a recognized need for new diagnostic and therapeutic approaches based on increased understanding of their molecular nature. We performed the comparison of the microRNA( miRNA) profile of 8 WHO grade II gliomas and 24 higher grade tumours( 2 WHO grade III and 22 glioblastomas) by using the Affymetrix Gene Chip miRNA Array v. 1. 0. A relative quantification method( RT-q PCR) with standard curve was used to confirm the 22 miRNA signature resulted by array analysis. The prognostic performances of the confirmed miRNAs were estimated on the Tumor Cancer Genome Atlas( TCGA) datasets. We identified 22 miRNAs distinguishing grade II gliomas from higher grade tumours.RT-q PCR confirmed the differential expression in the two patients' groups for 13 out of the 22 miRNAs. The analysis of the Glioblastoma Multiforme( GBM) and Lower Grade Glioma( LGG) datasets from TCGA demonstrated the association with prognosis for 6 of those miRNAs. Moreover,in the GBM dataset miR-21 and miR-210 were predictors of worse prognosis in both univariable and multivariable Cox regression analyses( HR 1. 19,P = 0. 04,and HR 1. 18,P = 0. 029 respectively). Our results support a direct contribution of miRNAs to glioma cancerogenesis and suggest that miR-21 and miR-210 may play a role in the aggressive clinical behaviour of glioblastomas. | Barbano R Palumbo O Pasculli B Galasso M Volinia S D'Angelo V Icolaro N Coco M Dimitri L Graziano P Copetti M Valori VM Maiello E Carella M Fazio VM Parrella P | 2014 | 中华神经外科疾病研究杂志2014，13，5： | 6 |
| 2 | Morgana/chp-1,a ROCK inhibitor involved in centrosome duplication and tumorigenesis显示文摘 | Ferretti R Palumbo V Di Savino A | 2010 | Dev Cell2010，18，3： | 1 |
| 3 | Smoothmusde cells in human atheroscle-rotic plaques secrete and proliferate in response to high mobility group box 1 protein显示文摘 | Porto A Palumbo R Pieroni M | 2006 | FASEB J2006，20，： | 1 |
| 4 | Shear stress downregulation of platelet-derived growth factor receptor-beta and matrix metalloprotease associated with inhibition of smooth muscle cell invasion and migration显示文摘 | Palumbo R Gaetano C Melillo G | 2000 | Circulation2000，102，2： | 1 |
| 5 | The production of zinc by thermal dissociation of zinc oxide solar chemical reactor design 显示文摘 | Haueter P Moeller S Palumbo R | 1999 | Solar Energy1999，67，3： | 1 |
| 6 | Simultaneous recovery of RNA and DNA from soils and sediments 显示文摘 | HURT R A QIU X WU L ROH Y PALUMBO A V TEIDJE J M ZHOU J | 2001 | Appl Environ Microbiol2001，67，： | 1 |
| 7 | In vitro effects of beta-carotene on human oral kerationocytes from precan-cerous iessions and squamous carcinoma显示文摘 | TOMA S ALBANESE E PALUMBO R | 1991 | Anticancer Drugs1991，2，6： | 1 |
| 8 | Smooth muscle cells in human atherosclerotic plaques secrete and proliferate in response to high mobility group box 1 protein 显示文摘 | Porto A Palumbo R Pieroni M | 2006 | FASEB2006，20，14： | 1 |
| 9 | Continuous lenalido- mide treatment for newly diagnosed multiple myeloma 显示文摘 | Palumbo A Hajek R Delforge M | 2012 | N Engl J Med2012，366，19： | 1 |
| 10 | Poly (orthoesteram- ides) : Acid - Labile Temperature - Responsive Copolymers for Potential Biomedical Applications 显示文摘 | Tang R Palumbo R N Ji W H | 2009 | Biomacromolecules2009，10，4： | 1 |
| 11 | Extracellular HMGB1, a signal of tissue damage, induces mesoangioblast migration and proliferation显示文摘 | Palumbo R Sampaolesi M De Marchis F | 2004 | J Cell Biol2004，164，3： | 1 |
| 12 | Different effects of high and low shear stress on platelet-derived growth factor isoform release by endothelial ceils: consequences for smooth muscle cell migration显示文摘 | Palumbo R Gaetano C Antouini A | 2002 | Arterioscler Thromb Vasc Biol2002，22，3： | 1 |
| 13 | Extracellular HMGB1, a signal of tissue damage, induces mesoangioblast migration and proliferation显示文摘 | Palumbo R Sampaolesi M De Marchis F | 2004 | J Cell Biol2004，164，3： | 1 |
| 14 | Shear stress downregulation of Platelet - derived growth factor receptor - beta and matrix metalloPro- tease associated with inhibition of smooth muscle cell invasion and mi-gration 显示文摘 | Palumbo R Gaetano C Melillo G | 2000 | Circulation2000，102，2： | 1 |
| 15 | Extracellular HMGB1,a signal of tissue damage,induces mesoangioblast migration and proliferation显示文摘 | Palumbo R Sampaoles M De Marchis F | 2004 | J Cell Bio2004，255，3： | 1 |
| 16 | Relaxing effects of Valeri- ana offieinalis extracts on isolated human non-pregnant uterine muscle 显示文摘 | OCCHIUTO F PINO A PALUMBO D R | 2009 | J Pharm Pharroaeo12009，61，2： | 1 |
| 17 | High mobility group box 1 protein,a cue for stem cell recruitment显示文摘 | Palumbo R Bianchi ME | 2004 | Biochem Pharmacol2004，68，6： | 1 |
| 18 | Hyperglycemia and Cardiovascular risk 显示文摘 | Palumbo F Bianchi C Miccoli R | 2003 | Acta Diabetol2003，40，2： | 1 |
| 19 | MicroRNA fin-gerprints during human megakaryocytopoiesis 显示文摘 | GARZON R PICHIORRI F PALUMBO T et ai | 2006 | Proc Natl AcadSci USA2006，103，13： | 1 |
| 20 | Histology of micropolyps in chronic endometritis显示文摘 | Resta L Palumbo M Rossi R | 2012 | Histopathology2012，60，4： | 1 |
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