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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | An Improved Axenic System for Studying Pre - infection Development of the Parasitic Plant Orobanche ramose 显示文摘 | Clara Isabel Gonzalez - Verdejo | 2005 | Annals of Botany2005，96，6： | 1 |
| 3 | Deconjugation and bile salts hydrolase activity by Bifidobacterium strains with acquired resistance to bile显示文摘 | Luis Noriega Isabel Cuevas Abelardo Margolles Clara G. de los Reyes-Gavilán | 2005 | International Dairy Journal2005，，8： | 1 |
| 4 | Curemonitoring of catalysed cyanate ester resins显示文摘 | Isabel Harismendy Clara M Gómez Marcos Del Río | 2000 | Polymer Internation-al2000，49，7： | 1 |
| 5 | Cure monitoring of catalysed cyanate ester resins显示文摘 | ISABEL H CLARA M G MARCOS D R | 2000 | Polymer International2000，49，7： | 1 |
| 6 | A novel two-domain architecture within the amino acid kinase enzyme family revealed by the crystal structure of Escherichia coli glutamate 5-kinase显示文摘 | Clara Marco-Marín Fernando Gil-Ortiz Isabel Pérez-Arellano | | 0，，05： | 1 |
| 7 | Multi-residue analysis of 30 currently used pesticides in fine airborne particulate matter (PM 2.5) by microwave-assisted extraction and liquid chromatography–tandem mass spectrometry显示文摘 | Clara Coscollà Vicent Yusà Ma Isabel Beser Agustin Pastor | 2009 | Journal of Chromatography A2009，，51： | 1 |
| 8 | KIR Gene Mismatching and KIR/C Ligands in Liver Transplantation: Consequences for Short-Term Liver Allograft Injury显示文摘 | Isabel Legaz María R. López-álvarez José A. Campillo María R. Moya-Quiles José M. Bolarín Jesus de la Pe?a Gema Salgado Lourdes Gimeno Ana M. García-Alonso Manuel Muro Manuel Miras Clara Alonso María R. álvarez-López Alfredo Minguela | 2013 | Transplantation Journal2013，，8： | 1 |
| 9 | Cure monitoring of catalysed cyanate ester resins 显示文摘 | Isabel H Clara M G Marcos D R | 2000 | Polymer International2000，49，7： | 1 |
| 10 | Cure monitoring of catalysed cyanate ester resins 显示文摘 | ISABEL H CLARA M G MARCOS D R | 2000 | Polymer International2000，49，7： | 1 |
| 11 | Primary melanoma ofthe vagina显示文摘 | Judit Albareda Clara Olier Isabel Alemany | 2011 | A clinical case J Turkish-German Gynecol Assoc2011，12，1： | 1 |
| 12 | UHRF1 Overexpression Drives DNA Hypomethylation and Hepatocellular Carcinoma显示文摘 | Raksha Mudbhary Yujin Hoshida Yelena Chernyavskaya Vinitha Jacob Augusto Villanueva M. Isabel Fiel Xintong Chen Kensuke Kojima Swan Thung Roderick T. Bronson Anja Lachenmayer Kate Revill Clara Alsinet Ravi Sachidanandam Anal Desai Sucharita SenBanerjee Ch | 2014 | Cancer Cell2014，，2： | 1 |
| 13 | 4 - 20 Additive Interaction of Hillock Formation on CaF2 Surface Irradiated by Highly Charged Xenon Ions in MeV Energy Regime显示文摘 | Wang Yuyu Clara Grygiel Christian Dufour Sun Jianrong Wang Zhiguang Zhao Yongtao Xiao Guoqing ChengRui Zhou Xianming Ren Jieru Amine Cassimi Isabelle Monnet Serge Bouffard Fritz Aumayr Marcel Toulemonde | 2013 | IMP & HIRFL Annual Report2013，，1： | 0 |
| 14 | Historical Scope of Seasonal Influenza A and B Infections in Cuba and Their Impact on Mortality in the Elderly,1983-2005显示文摘Background:Influenza causes high mortality in the elderly.Its behavior has not been studied regularly in tropical and subtropical countries,like Cuba.The purposes of this study were to understand the circulation type and subtype of the influenza virus and to obtain evidence of their relationship with underlying P&I deaths in persons aged 65 years or older.Methods:A retrospective study was carried out with 7,252 positive sera from influenza A(H3N2),A(H1N1)or from type B by hemagglutination inhibition assay from 1983-1984 and 2004-2005 seasons,which created three series with the type/subtype prevalence percentages corresponding to the total of positive cases.The relationship between mortality by pneumonia and influenza in people aged 65 years or more was determined by calculating its mean rates when the type/subtype prevalence was above the median or not.Results:The circulation pattern of these viruses in Cuba was defined,and predominance of A(H3N2)in the 77%of seasons was corroborated.The mean rate of mortality increased 24.4%(p<0.001)when any pair of virus was above its medians and for the subtype A(H3N2)the increase was of 14.6%(p<0.05).Conclusions:For the first time the Health Authorities of Cuba received a“native”pattern on the circulation of influenza viruses in the period studied,showing increases in mortality for underlying pneumonia and influenza in people aged 65 years or older when the A(H3N2)or any pair of viruses were above their means and underscoring the need for better prevention measures and vaccination programs for elderly people in our country. | Oropesa Fernández Suset Gonzalez Ochoa Edilberto Alonso Ismell Savón Valdés Clara Armas Luisa Arencibia García Amely Gonzalez Munoz Grehete Martínez Motas Isabel Hernández Espinosa Bárbara Gonzalez Baéz Gelsys Roque Arrieta Rosmery | 2019 | Journal of US-China Medical Science2019，16，1： | 0 |
| 15 | Rare germline copy number variants in colorectal cancer predisposition characterized by exome sequencing analysis显示文摘Colorectal cancer(CRC)is one of the most common neoplasms and an important cause of mortality worldwide(http://gffzz8f6091545fcc473fhq95fkkkc56uq6vwk.ffgz.tsg.suse.edu.cn/).Approximately 35%of the variation in CRC susceptibility is likely due to heritable factors(Lichtenstein et al.,2000).Genetic variations in the human genome include single nucleotide variants(SNVs),short insertions and deletions,and larger structural vari- | Sebastia Franch-Exposito Clara Esteban-Jurado Pilar Garre Isabel Quintanilla Saray Duran-Sanchon Marcos Diaz-Gay Laia Bonjoch Miriam Cuatrecasas Esther Samper Jenifer Munoz Teresa Ocana Sabela Carballal Maria Lopez-Ceron Antoni Castells Maria Vila-Casadesus Sophia Derdak Steven Laurie Sergi Beltran Jaime carvajal Luis Bujanda Clara Ruiz-Ponte Jordi Camps Meritxell Gironella Juan Jose Lozano Francesc Balaguer Joaquin Cubiella Trinidad Caldes Sergi Castellvi-Bel | 2018 | Journal of Genetics and Genomics2018，45，1： | 0 |
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