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| 1 | Icariin suppresses bone resorption activity of rabbit osteoclasts in vitro显示文摘The effect of icariin on the bone resorption activity of rabbit osteoclasts is assessed in vitro. Osteoclasts were isolated from Japanese white rabbits and cultured on plates with a sterilized bone slice in each well. After treatment with icariin at various concentrations, the bone resorption activity of osteoclasts was evaluated by examining pit areas, superoxide anion (·O2-) generation, size and number of actin rings and intracellular calcium concentration [Ca2+]i. As revealed by these data, icariin elicited continuous decline of [Ca2+]i, making actin ring constricted and ·O2- generation decreased. These events resulted in smaller and fewer pits which indicate suppressed bone resorption activity of rabbit osteoclasts by icariin. | HUANG Jian ZHANG JinChao ZHANG TianLan WANG Kui | 2007 | Chinese Science Bulletin2007，52，7： | 15 |
| 2 | Cytoskeleton reorganization and FAK phosphorylation are involved in lanthanum(Ⅲ)-promoted proliferation and differentiation in rat osteoblasts显示文摘The effect of lanthanum ion(La 3+ )on osteoblast function and cytoskeleton is assessed in vitro.Osteoblasts were isolated from Sprague- Dawley fetal neonatal rats.Cell proliferation and gene expression levels of cbfa-1,alkaline phosphatase(ALP),osteocalcin(OC),bone sialo- protein(BSP)and osteopontin(OPN)were examined by cell counting and RT-PCR.Cytoskeleton F-actin was stained with rhodamine-con- jugated phalloidin and was visualized by a confocal microscope.As the results,10à 8-10 à4M La 3+-induced osteoblast proliferation on day 2. Data from the RT-PCR assay revealed that 10à 6M La 3+up-regulated the expression levels of ALP,BSP,and cbfa-1 on day 4,while it enhanced the expressions of OC and OPN on day 21.The F-actin cytoskeleton was strengthened and reorganized under the exposure of La3 +.In addition, the phosphorylation of focal adhesion kinase(FAK)was significantly promoted in 24 h evaluated by Western blot analysis.These findings indi- cate that La3 +promotes osteoblast activity through the phosphorylation of FAK and reorganization of the cytoskeleton. | Xi Wang Jian Huang Tianlan Zhang Kui Wang | 2009 | Progress in Natural Science:Materials International2009，19，3： | 4 |
| 3 | The Human MSI2 Gene is Associated with Schizophrenia in the Chinese Han Population显示文摘It has been suggested that altered neurogenesis may be involved in the etiology of schizophrenia,so genes impacting on neurogenesis could be potential candidates for schizophrenia.A member of the Musashi family,the human MSI2 gene plays a substantial role in stem-cell maintenance,asymmetric division,and differentiation during neurogenesis.Our previous genome-wide association study(GWAS)implied an association of MSI2 with schizophrenia in a Han Chinese population.To further explore this association,three single-nucleotide polymorphisms(SNPs),rs9892791,rs11657292,and rs1822381,were selected for a replication study involving 921 schizophrenia cases and 1244 controls.After rigorous Bonferroni correction,two of the SNPs(rs9892791 and rs11657292) displayed significant differences in allele and genotype distribution frequencies between the case and control groups.When our GWAS and replication samples were combined,the three MSI2 SNPs were all strongly associated with schizophrenia(rs9892791:allelic P = 1.07E-5;rs11657292:allelic P = 1.95E-12;rs1822381:allelic P = 1.44E-4).These results indicate that the human MSI2 gene might be a susceptibility gene forschizophrenia and encourage future research on the functional relationship between this gene and schizophrenia. | Zhilin Luan Tianlan Lu Yanyan Ruan Weihua Yue Dai Zhang | 2016 | Neuroscience Bulletin2016，32，3： | 3 |
| 4 | Interaction Between Variations in Dopamine D2 and Serotonin 2A Receptor is Associated with Short-Term Response to Antipsychotics in Schizophrenia显示文摘Dear Editor,Schizophrenia is a chronic and debilitating brain disorder,which has a strong genetic component with heritability ranging from 66%to 85%[1,2].Currently,antipsychotic drugs remain the most effective treatment for the psychotic symptoms of schizophrenia[3].Because of the severe sideeffects of first-generation antipsychotics(FGAs),secondgeneration antipsychotics(SGAs)have become more widely used in the treatment of schizophrenia. | Liansheng Zhao Huijuan Wang Yamin Zhang Jinxue Wei Peiyan Ni Hongyan Ren Gang Li Qiang Wang Gavin P Reynolds Weihua Yue Wei Deng Hao Yan Liwen Tan Qi Chen Guigang Yang Tianlan Lu Lifang Wang Fuquan Zhang Jianli Yang Keqing Li Luxian Lv Qingrong Tan Yinfei Li Hua Yu Hongyan Zhang Xin Ma Fude Yang Lingjiang Li Chuanyue Wang Huiyao Wang Xiaojing Li Wanjun Guo Xun Hu Yang Tian Xiaohong Ma Jeremy Coid Dai Zhang Chao Chen Tao Li Chinese Antipsychotics Pharmacogenomics Consortium | 2019 | Neuroscience Bulletin2019，35，6： | 3 |
| 5 | Testing the role of genetic variation of the MC4R gene in Chinese population in antipsychotic-induced metabolic disturbance显示文摘Antipsychotic-induced metabolic disturbance(AIMD) is a common adverse effect of antipsychotics with genetics partly underpinning variation in susceptibility among schizophrenia patients. Melanocortin4 receptor(MC4 R) gene, one of the candidate genes for AIMD, has been under-studied in the Chinese patients. We conducted a pharmacogenetic study in a large cohort of Chinese patients with schizophrenia. In this study, we investigated the genetic variation of MC4 R in Chinese population by genotyping two SNPs(rs489693 and rs17782313) in 1,991 Chinese patients and examined association of these variants with the metabolic effects that were often observed to be related to AIMD. Metabolic measures, including body mass index(BMI), waist circumference(WC), glucose, triglyceride, high-density lipoprotein(HDL), and low-density lipoprotein(LDL) levels were assessed at baseline and after 6-week antipsychotic treatment. We found that interaction of SNP×medication status(drug-na?ve/medicated) was significantly associated with BMI, WC, and HDL change %, respectively. Both SNPs were significantly associated with baseline BMI and WC in the medicated group. Moderate association of rs489693 with WC, Triglyceride, and HDL change % were observed in the whole sample. In the drug-na?ve group, we found recessive effects of rs489693 on BMI gain more than 7%, WC and Triglyceride change %, with AA incurring more metabolic adverse effects. In conclusion, the association between rs489693 and the metabolic measures is ubiquitous but moderate. Rs17782313 is less involved in AIMD. Two SNPs confer risk of AIMD to patients treated with different antipsychotics in a similar way. | Yamin Zhang Hongyan Ren Qiang Wang Wei Deng Weihua Yue Hao Yan Liwen Tan Qi Chen Guigang Yang Tianlan Lu Lifang Wang Fuquan Zhang Jianli Yang Keqing Li Luxian Lv Qingrong Tan Hongyan Zhang Xin Ma Fude Yang Lingjiang Li Chuanyue Wang Dai Zhang Liansheng Zhao Huiyao Wang Xiaojing Li Wanjun Guo Xun Hu Yang Tian Xiaohong Ma Tao Li Chinese Antipsychotics Pharmacogenomics Consortium | 2019 | Science China(Life Sciences)2019，62，4： | 3 |
| 6 | Association of ABCB1 Gene Polymorphisms with Efficacy and Adverse Reaction to Risperidone or Paliperidone in Han Chinese Schizophrenic Patients显示文摘Dear editor,P-glycoprotein(P-gp,also known as ATP-binding cassette transport sub-family B member 1,ABCB1)is a potent ATP-dependent efflux pump for a wide variety of drugs.Although studies of its substrates are abundant[1,2],and ABCB1 is a well-conserved gene,there is increasing evidence that its polymorphisms affect substrate specificity[3].A previous study reported that the synonymous | Weifeng Mi Feihu Liu Yongqiao Liu Bo Du Weidong Xiao Lingzhi Li Lan Huang Tianlan Lu Jia He Le Shi Weihua Yue Hongyan Zhang | 2016 | Neuroscience Bulletin2016，32，6： | 3 |
| 7 | Effect of La^(3+) on osteoblastic differentiation of rat bone marrow stromal cells显示文摘In the present work, the effect of La3+ on osteoblastic differentiation of primary rat bone mar- row stromal cells (MSCs) as well as the related mechanisms are studied. Differentiation is monitored by detection of alkaline phosphatase (ALP) activity, osteocalcin secretion, the mRNA levels of Type I collagen and osteocalcin, and matrix mineralization. The results show that La3+ inhibits osteoblastic differentiation of MSCs in the early and middle stages of culture, as demonstrated by the decrease of ALP activity, osteocalcin secretion, and down-regulation of the mRNA level of osteocalcin. However, La3+ does not affect the matrix mineralization in advanced MSCs, because it up-regulates the mRNA levels of Type I collagen, and promotes ALP activity and os- teocalcin secretion in MSCs in the late stage of cul- ture. In addition, Western blot analysis exhibits that La3+ induces the phosphorylation and activation of mitogen-activated protein kinase (MAPK). Further- more, MAPK kinase inhibitor PD98059 completely blocks the inhibitory effect of La3+ on ALP activity of MSCs in the middle stage of culture. These results suggest that La3+ affects MSCs osteoblastic differen- tiation depending on differentiation stages. La3+ in- hibits osteoblastic differentiation of MSCs in the early and middle stages by a MAPK-dependent mecha- nism, but does not affect the matrix mineralization in advanced MSCs. | LIU Hongmei ZHANG Tianlan XU Shanjin WANG Kui | 2006 | Chinese Science Bulletin2006，51，1： | 1 |
| 8 | Calculating model of driving force of natural cycel for evaporators, Eleventh Internatinal Conference on Computational Methods and Experiments 显示文摘 | Yu Xiumin Yu Tianlan Pen Deqi | 2003 | (5): 12 - 142003，，5： | 1 |
| 9 | Research on twisted strip with asymmetric oblique teeth显示文摘 | Yu Tianlan Peng Deqi Yu Xiumin | 2004 | Enhanced Heat Transfer2004，11，4： | 1 |
| 10 | , Xiumin Yu, Reserch on Twisted Strip with Asymmetric Oblique Teeth显示文摘 | Tianlan Yu Deqi Peng | 2004 | Enhanced Heat Transfer2004，11，4： | 1 |
| 11 | The application of narrow pedicle flaps in reparing facial defects显示文摘 | Zhao Tianlan Yu Daojiang Xie Xiaoming | | 0，，07： | 1 |
| 12 | Meat quality and cooking attributes of thawed pork with different low field NMR T 21显示文摘 | Chunbao Li Dengyong Liu Guanghong Zhou Xinglian Xu Jun Qi Peilei Shi Tianlan Xia | 2011 | Meat Science2011，，2： | 1 |
| 13 | Applying realtime control for achieving nitrogen removal via nitrite in a labscale CAST system 显示文摘 | Shaopo Wang Jingiie Yu Tianlan Wei | 2012 | More Information Environ Technol2012，33，10： | 1 |
| 14 | Existence of positive periodic solutions of nonlinear first-order delayed differ- ential equations 显示文摘 | Ma Ruyun Chen Ruipeng Chen Tianlan | 2011 | Journal of Mathematical Analysis and Ap- plications2011，384，： | 1 |
| 15 | Progressinsolidacidcatalystsforbiodieselproduction显示文摘 | LiXiaoran TianLan LiJie etal | 2013 | ChemicalEngineer2013，3，： | 1 |
| 16 | Applying real-time control for achieving nitrogen removal via nitrite in a lab-scale CAST system显示文摘 | Shaopo Wang Jingjie Yu Tianlan Wei Yongzhi Chi Liping Sun Yongzhen Peng | 2012 | Environmental Technology2012，，10： | 1 |
| 17 | Reserch on Twisted Strip with Asymmetric Oblique Teeth显示文摘 | Tianlan Yu Deqi Peng Xiumin Yu | 2004 | Enhanced Heat Transfer2004，11，4： | 1 |
| 18 | Existence of positive periodic solutions of nonlinear first-order delayed differ- ential equations显示文摘 | Ma Ruyun Chen Ruipeng Chen Tianlan | 2011 | J Math Anal Appl2011，384，： | 1 |
| 19 | Existence of positive periodic solutions of nonlinear first order delayed differen- tial equations显示文摘 | MA Ruyun CHEN Ruipeng CHEN Tianlan | 2011 | J Math Anal Appl2011，384，2： | 1 |
| 20 | Positive period- ic solutions of nonlinear first-order functional difference equa- tions 显示文摘 | Ma Ruyun Chen Tianlan Lu Yanqiong | 2011 | Discrete Dynamics in Nature and Society2011，2011，96： | 1 |
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