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| 1 | Numerical Simulation of Direct-contact Condensation from a Supersonic Steam Jet in Subcooled Water显示文摘直接接触的冷凝作用的现象,在驾驶的蒸气使用喷气注射者,核反应堆紧急情况核心冷却系统和直接接触的热 exchangers,被在使过冷的水里为蒸气的直接接触的冷凝作用介绍一个热平衡模型计算地调查。介绍的冷凝作用模型是在接口的双方上照顾热转移过程并且使用一条可变蒸气水泡直径的二个抵抗模型。在使过冷的水坦克的超声的蒸气喷气的注射用 Euler-Euler 多相的流动模型被模仿流畅与冷凝作用模型一起的 6.3 代码合并了。模拟与出版试验性的数据和相当好的同意相比的计算液体动力学(CFD ) 的调查结果被观察在之间二,因此验证冷凝作用模型。为羽毛从 2.73-7.33 改变的蒸气的无尺寸的穿入长度的 CFD 模拟的结果,当冷凝作用热转移系数从 0.75-0.917 MW 汯敹桴牥?晬湯 ? 变化时 ???? 琠楲敭潳汹?? | Ajmal Shah Imran Rafiq Chughtai Mansoor Hameed Inayat | 2010 | Chinese Journal of Chemical Engineering2010，18，4： | 13 |
| 2 | Does urodynamics predict voiding after benign prostatic hyperplasia surgery in patients with detrusor underactivity?显示文摘Objective:We sought to determine if urodynamic study(UDS)predicted voiding outcomes in men with detrusor underactivity(DU)and benign prostatic enlargement(BPE)who underwent photovaporization of the prostate(PVP).Methods:Between September 2010 and July 2015,106 male patients with BPE and DU were identified.All patients underwent PVP.Urinary retention was noted by the preoperative necessity for an indwelling or intermittent catheter.Data collection included comorbidities,quality of life(QoL)scores,prostate volume,prostate-specific antigen(PSA),UDS and perioperative outcomes.UDS parameters included volume at first desire to void,volume at first urge to void,volume of severe urge,volume at capacity,compliance,detrusor contractions,maximum urinary flow rate(Qmax),and postvoid residual(PVR).Results:A total of 106 men were included in this analysis,who had urinary retention with a Foley catheter or clean intermittent catheterization(CIC)at the time of surgery.At baseline we found patients who voided had a detrusor pressure at Qmax(Pdet@Qmax)of 10.05±6.45 cmH2O compared to 16.78±12.17 cmH2O in those who did not void(p=0.071).Postoperatively,96(90.6%,mean age 76.9±26.2 years)of patients voided successfully while 10(9.4%,mean age 80.52±9.61 years)of patients remained in urinary retention.Mean baseline Qmax was 4.895±5.452 mL/s and 2.900±3.356 mL/s(p=0.087)in those who voided and did not respectively.PVR was 319.23±330.62 mL in those who voided and 276.88263.27 mL(p=0.344)in those who did not void.No UDS parameter predicted who would void postoperatively or improvements in QoL.Conclusions:The patients with DU and BPE might be able to successfully void after undergoing PVP regardless of UDS findings.All men who voided had improved international prostate symptom score and QoL scores compared to baseline and these parameters were durable up to 12 months. | Dominique Thomas Kevin C.Zorn Nadir Zaidi Stephanie Ashley Chen Yiye Zhang Alexis Te Bilal Chughtai | 2019 | Asian Journal of Urology2019，6，3： | 8 |
| 3 | 睾酮和良性前列腺增生症显示文摘由于医患双方对于男性迟发性腺功能减退症状的警觉,使得近期针对此类患者的睾酮治疗增多。但是考虑到睾酮治疗对前列腺的影响,尤其可能增加前列腺癌发病风险,促进了该方面的研究进展。出乎意料的是大量的回顾性或小样本随机研究提示睾酮治疗或可改善男性下尿路症状。虽然此改善的确切机理仍在争论中,但或许和代谢综合征密切相关。对于临床医生,这些研究的结果虽然让人期待,但是缺乏高等级证据支持。因此在诊断迟发性腺功能减退症或考虑睾酮治疗前,仍需对患者进行包括病史、体检和睾酮测量在内的全面临床检查。睾酮补充治疗可能导致尿潴留和加重下尿路症状,这些产品说明上标注的风险依然存在,应该在用药前向患者解释说明。 | Thomas R Jarvis Bilal Chughtai Steven A Kaplan | 2015 | Asian Journal of Andrology2015，17，2： | 7 |
| 4 | The role of photovaporization of the prostate in small volume benign prostatic hyperplasia and review of the literature显示文摘Objective:Our objective was to characterize the safety and efficacy of the 180 W XPS-GreenLight laser in men with lower urinary tract symptoms secondary to a small volume benign prostatic hyperplasia(BPH).Methods:A retrospective analysis was performed for all patients who underwent 180 W XPSlaser photoselective vaporization of the prostate(PVP)vaporization of the prostate between 2012 and 2016 at two-tertiary medical centers.Data collection included baseline comorbidities,disease-specific quality of life scores,maximum urinary flow rate(Qmax),postvoid residual(PVR),complications,prostate volume and prostate-specific antigen(PSA).The secondary endpoints were the incidence of intraoperative and postoperative adverse events.Complications were stratified using the Clavien-Dindo grading system up to 90 days after surgery.Results:Mean age of men was 67.8 years old,with a mean body mass index of 29.7 kg/m2.Mean prostate volume as measured by transrectal ultrasound was 29 mL.Anticoagulation use was 47%and urinary retention with catheter at time of surgery was 17%.Mean hospital stay and catheter time were 0.5 days.Median follow-up time was 6 months with the longest duration of follow-up being 22.5 months(interquartile range,3-22.5 months).The International Prostate Symptom Score improved from 22.8±7.0 at baseline to 10.7±7.4(p<0.01)and 6.3±4.4(p<0.01)at 1 and 6 months,respectively.The Qmax improved from 7.70±4.46 mL/s at baseline to 17.25±9.30 mL/s(p<0.01)and 19.14±7.19 mL/s(p<0.001)at 1 and 6 months,respectively,while the PVR improved from 216.0±271.0 mL preoperatively to 32.8±45.3 mL(p<0.01)and 26.2±46.0 mL(p<0.01)at 1 and 6 months,respectively.The PSA dropped from 1.97±1.76 ng/mL preoperatively to 0.71±0.61 ng/mL(p<0.01)and 0.74±0.63 ng/mL at 1 and 6 months,respectively.No patient had a bladder neck contracture postoperatively and no capsular perforations were noted intraoperatively.Conclusion:The 180 W GreenLight XPS system is safe and effective for men with small volume BPH.PVP produced improvements in symptomatic and clinical parameters without any safety concern.It represents a safe surgical option in this under studied population. | Dominique Thomas Kevin C.Zorn Malek Meskawi Ramy Goueli Pierre-Alain Hueber Lesa Deonarine Vincent Misrai Alexis Te Bilal Chughtai | 2019 | Asian Journal of Urology2019，6，4： | 6 |
| 5 | Para-aortic lymph node involvement should not be a contraindication to resection of pancreatic ductal adenocarcinoma显示文摘BACKGROUND Para-aortic lymph nodes(PALN)are found in the aortocaval groove and they are staged as metastatic disease if involved by pancreatic ductal adenocarcinoma(PDAC).The data in the literature is conflicting with some studies having associated PALN involvement with poor prognosis,while others not sharing the same results.PALN resection is not included in the standard lymphadenectomy during pancreatic resections as per the International Study Group for Pancreatic Surgery and there is no consensus on the management of these cases.AIM To investigate the prognostic significance of PALN metastases on the oncological outcomes after resection for PDAC.METHODS This is a retrospective cohort study of data retrieved from a prospectively maintained database on consecutive patients undergoing pancreatectomies for PDAC where PALN was sampled between 2011 and 2020.Statistical comparison of the data between PALN+and PALN-subgroups,survival analysis with the Kaplan-Meier method and risk analysis with univariable and multivariable time to event Cox regression analysis were performed,specifically assessing oncological outcomes such as median overall survival(OS)and disease-free survival(DFS).RESULTS 81 cases had PALN sampling and 17(21%)were positive.Pathological N stage was significantly different between PALN+and PALN-patients(P=0.005),while no difference was observed in any of the other characteristics.Preoperative imaging diagnosed PALN positivity in one case.OS and DFS were comparable between PALN+and PALN-patients with lymph node positive disease(OS:13.2 mo vs 18.8 mo,P=0.161;DFS:13 mo vs 16.4 mo,P=0.179).No difference in OS or DFS was identified between PALN positive and negative patients when they received chemotherapy either in the neoadjuvant or in the adjuvant setting(OS:23.4 mo vs 20.6 mo,P=0.192;DFS:23.9 mo vs 20.5 mo,P=0.718).On the contrary,when patients did not receive chemotherapy,PALN disease had substantially shorter OS(5.5 mo vs 14.2 mo;P=0.015)and DFS(4.4 mo vs 9.8 mo;P<0.001).PALN involvement was not identified as an independent predictor for OS after multivariable analysis,while it was for DFS doubling the risk of recurrence.CONCLUSION PALN involvement does not affect OS when patients complete the indicated treatment pathway for PDAC,surgery and chemotherapy,and should not be considered as a contraindication to resection. | Rupaly Pande Shafiq Chughtai Manish Ahuja Rachel Brown David C Bartlett Bobby V Dasari Ravi Marudanayagam Darius Mirza Keith Roberts John Isaac Robert P Sutcliffe Nikolaos A Chatzizacharias | 2022 | World Journal of Gastrointestinal Surgery2022，14，5： | 2 |
| 6 | Experimental and numerical analysis of steam jet pump显示文摘 | Ajmal Shah Imran Rafiq Chughtai Mansoor Hameed Inayat | 2011 | International Journal of Multiphase Flow2011，，10： | 2 |
| 7 | Commentary on“Solving the benign prostatic hyperplasia puzzle”显示文摘Benign prostatic hyperplasia(BPH)is a common condition affecting over 50% of men as they reach the 5th decade of their life[1].While over half of these patients have symptoms,it is not clear why some of these men do while others do not.The article Solving the benign prostatic hyperplasia puzzle by Keong Tatt Foo[2],delves into the different conundrums urologists face when trying to treat their patients. | Dominique Thomas Bilal Chughtai Steven Kaplan | 2018 | Asian Journal of Urology2018，5，1： | 2 |
| 8 | Experimental and numerical analysis of steam jet pump 显示文摘 | Shah A Chughtai I R Inayat M H | 2011 | International Journal of Multiphase Flow2011，37，10： | 1 |
| 9 | Spectroscopic studies of oxidized soots 显示文摘 | Akhter M S Chughtai A R Smith D M | 1991 | Applied Spectroscopy1991，45，4： | 1 |
| 10 | An expanding role for cardiopulmonary bypass in trauma 显示文摘 | Chughtai TS Gilardino MS Fleiszer DM | 2002 | Canadian Journal of Surgery2002，45，2： | 1 |
| 11 | Photoselective vaporization of the pros- tate for treating benign prostatic hyperplasia显示文摘 | CHUGHTAI B TE A | 2011 | Expert Rev Med Devices2011，8，5： | 1 |
| 12 | Experimental and numerical analysis of steam jet pump显示文摘 | Ajmal Shah Imran Rafiq Chughtai Mansoor Hameed Inayat | 2011 | International Journal of Multiphase Flow2011，，10： | 1 |
| 13 | 多层螺旋CT对肠管和(或)肠系膜钝性外伤手术指征评估的准确性研究显示文摘目的 探讨多层螺旋CT发现有外科手术指征的肠和(或)肠系膜钝性外伤的准确性,确定和描述肠和(或)肠系膜损伤最可靠的CT表现,评价不同水平阅片者的表现。材料和方法 本研究通过了审查委员会的审核,采用回顾性病例对照的方法研究96例经剖腹探查证实的病例:54例肠和(或)肠系膜损伤(有或无手术指征)病人[男性32例,女性22例;平均(40.4±17.6)岁,范围16~86岁]和42例没有肠和(或)肠系膜损伤病人[男性22例,女性20例;平均(36.8±20.1)岁,范围14~84岁], | M. Atri J.M. Hanson L. Grinblat N. Brofman T. Chughtai G. Tomlinson 胡鹏 郑伟良 | 2009 | 国际医学放射学杂志2009，32，1： | 1 |
| 14 | SHP- 2 regulates Kinase- 2 ubiquitanation/ degration downstream of the prolaction receptor 显示文摘 | Ali S Noughi Z Chughtai SOCS- 1 mediated Janus N | 2003 | J Biol Chem2003，278，52： | 1 |
| 15 | Multidetector high-resolution computed tomography of the lungs:protocols and applications显示文摘 | Sundaram B Chughtai AR Kazerooni EA | 2010 | Thorac Imaging2010，25，2： | 1 |
| 16 | Randomized, double- blind, placebo controlled pilot study of intradetrusor injec- tions of onabotulinumtoxinA for the treatment of refrac- tory overactive bladder persisting following surgical man- agement of benign prostatic hyperplasia 显示文摘 | Chughtai B Dunphy C Lee R et aI | 2014 | Canad JUrol2014，21，2： | 1 |
| 17 | Randomized, double -blind, placebo controlled pilot study of intradetrusor injections ofonabotulinumtoxinA for the treatment of refractory overactive blad-der persisting following surgical management of benign prostatic hy-perplasia显示文摘 | CHUGHTAI B DUNPHY C LEE R | 2014 | Can J Urol2014，21，2： | 1 |
| 18 | Work engagement and its relationship with state and trait trust: A conceptu- al analysis 显示文摘 | Aamir All Chughtai Finian Buckley | 2008 | Journal of Behavior & Applied Manage- ment2008，10，1： | 1 |
| 19 | Disparities in the Use of Sacral Neuromodulation among Medicare Beneficiaries显示文摘 | Melissa A. Laudano Stephan Seklehner Jaspreet Sandhu W. Stuart Reynolds Kelly A. Garrett Jeffrey W. Milsom Alexis E. Te Steven A. Kaplan Bilal Chughtai Richard K. Lee | 2015 | The Journal of Urology2015，，： | 1 |
| 20 | Measuring quality of life in pediatric patients with inflammatory bowel disease: psychometric and clinical characteristics 显示文摘 | Perrin JM Kuhlthau K Chughtai A | 2008 | J Pediatr Gastroenterol Nutr2008，46，2： | 1 |
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