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| 1 | Multiple model particle flter track-before-detect for range ambiguous radar显示文摘The middle pulse repetition frequency(MPRF)and high pulse repetition frequency(HPRF)modes are widely adopted in airborne pulse Doppler(PD)radar systems,which results in the problem that the range measurement of targets is ambiguous.The existing data processing based range ambiguity resolving methods work well on the condition that the signal-to-noise ratio(SNR)is high enough.In this paper,a multiple model particle flter(MMPF)based track-beforedetect(TBD)method is proposed to address the problem of target detection and tracking with range ambiguous radar in low-SNR environment.By introducing a discrete variable that denotes whether a target is present or not and the discrete pulse interval number(PIN)as components of the target state vector,and modeling the incremental variable of the PIN as a three-state Markov chain,the proposed algorithm converts the problem of range ambiguity resolving into a hybrid state fltering problem.At last,the hybrid fltering problem is implemented by a MMPF-based TBD method in the Bayesian framework.Simulation results demonstrate that the proposed Bayesian approach can estimate target state as well as the PIN simultaneously,and succeeds in detecting and tracking weak targets with the range ambiguous radar.Simulation results also show that the performance of the proposed method is superior to that of the multiple hypothesis(MH)method in low-SNR environment. | Wang Guohong Tan Shuncheng Guan Chengbin Wang Na Liu Zhaolei | 2013 | Chinese Journal of Aeronautics2013，26，6： | 15 |
| 2 | Output Characteristics of a Series Three-port Axial Piston Pump显示文摘Driving a hydraulic cylinder directly by a closed-loop hydraulic pump is currently a key research area in the field of electro-hydraulic control technology,and it is the most direct means to improve the energy efficiency of an electro-hydraulic control system.So far,this technology has been well applied to the pump-controlled symmetric hydraulic cylinder.However,for the differential cylinder that is widely used in hydraulic technology,satisfactory results have not yet been achieved,due to the asymmetric flow constraint.Therefore,based on the principle of the asymmetric valve controlled asymmetric cylinder in valve controlled cylinder technology,an innovative idea for an asymmetric pump controlled asymmetric cylinder is put forward to address this problem.The scheme proposes to transform the oil suction window of the existing axial piston pump into two series windows.When in use,one window is connected to the rod chamber of the hydraulic cylinder and the other is linked with a low-pressure oil tank.This allows the differential cylinders to be directly controlled by changing the displacement or rotation speed of the pumps.Compared with the loop principle of offsetting the area difference of the differential cylinder through hydraulic valve using existing technology,this method may simplify the circuits and increase the energy efficiency of the system.With the software SimulationX,a hydraulic pump simulation model is set up,which examines the movement characteristics of an individual piston and the compressibility of oil,as well as the flow distribution area as it changes with the rotation angle.The pump structure parameters,especially the size of the unloading groove of the valve plate,are determined through digital simulation.All of the components of the series arranged three distribution-window axial piston pump are designed,based on the simulation analysis of the flow pulse characteristics of the pump,and then the prototype pump is made.The basic characteristics,such as the pressure,flow and noise of the pumps under different rotation speeds,are measured on the test bench.The test results verify the correctness of the principle.The proposed research lays a theoretical foundation for the further development of a new pump-controlled cylinder system. | ZHANG Xiaogang QUAN Long YANG Yang WANG Chengbin YAO Liwei | 2012 | Chinese Journal of Mechanical Engineering2012，25，3： | 10 |
| 3 | Regulatory effects of antitumor agent matrine on FOXO and PI3K-AKT pathway in castration-resistant prostate cancer cells显示文摘We previously demonstrated that matrine could inhibit the proliferating, migrating, as well as invading processes of both PC-3 and DU145 cells. However, the underlying molecular mechanisms have not yet been clearly defined. In this study, using various techniques such as high throughput sequencing technology, bioinformatics, quantitative real-time PCR, and immunoblot analysis,we aimed to understand whether matrine serves as a novel regulator of FOXO and PI3K-AKT signaling pathway. DU145 and PC-3 cell lines were cultured for 24 h in vitro. Cells were treated with either matrine or control serum for 48 h, followed by extraction of total RNA. The RNA was sequenced using HiSeq 2500 high-throughput sequencing platform (Illumina). A gene library was established and quality analysis of read data carried out. Integrated database from the website DAVID was used to analyze Gene Ontology (GO), and Kyoto encyclopedia of genes and genomes (KEGG) pathway of differential genes was used for pathway analysis, screening for fold differences of more than two times. The FOXO and PI3K-AKT signaling pathways were screened, and expression levels of mRNA and core protein detected by real-time PCR and immunoblotting, respectively. High throughput sequencing and GO analysis revealed that differentially expressed genes before and after treatment played an important role in cell metabolic process, growth process, anatomical structure formation, cellular component organization, and biological regulation. KEGG signal pathway analysis revealed that FOXO and PI3K-AKT signal pathways had a significant difference between before and after matrine-treated androgen-independent prostate cancer cells PC-3 and DU145. Real-time PCR showed that matrine treatment led to a significant increase in the expression levels of FOXO1A, FOXO3A, FOXO4, and FOXO6 in DU145 and PC-3 cells (P<0.01 or P<0.05), whereas the PI3K expression levels decreased (P<0.01). Similarly, immunoblotting revealed a significant increase (P<0.05) in the expression levels of FOXO1A FOXO3A, FOXO4, and FOXO6 in both PC-3 and DU145 cells, whereas PI3K expression levels decreased (P<0.05). Matrine had a broad regulating effect on the mRNA expression profiles of both PC-3 and DU145 cells. Matrine may inhibit cell proliferation, migration, as well as invasion, and induce apoptosis in both PC-3 and DU145 cells through FOXO and PI3K-AKT signaling pathways. Matrine could therefore be used as a complementary drug to present chemotherapeutic agents, for treating androgen-independent prostate cancer. | Qi Li HaiH uang Zheng He Yi Sun Yufeng Tang Xiaohong Shang Chengbin Wang | 2018 | Science China(Life Sciences)2018，61，5： | 9 |
| 4 | Targeted Mutagenesis of NAC Transcription Factor Gene,OsN AC041,Leading to Salt Sensitivity in Rice显示文摘Salinity is a major abiotic stress factor that seriously affects plant growth. Many genes are involved in the response to salt stress with various metabolism pathways. A number of plant transcription factor family genes have been found to be involved in the salt stress response, and NAM, ATAF and CUC(NAC) transcription factors are thought to act as active regulators during abiotic stress, especially salt stress. In this study, we detected a rice NAC transcription factor coding gene, OsNAC041, and confirmed that it influenced the germination of seeds under salt stress and salt tolerance of plants. OsNAC041 was primarily expressed in the leaves and located in the nucleus. Furthermore, the CRISPR/Cas9 method was used to obtain a targeted osnac041 mutant, of which the plant height was higher than that of the wild-type, showing increased salt sensitivity. Moreover, RNA-seq analysis revealed a number of differentially expressed genes(DEGs) involved in several important signaling pathways in the osnac041 mutant. Subsequently, Kyoto Encyclopedia of Genes and Genomes annotation also revealed differential expression of DEGs associated with mitogen-activated protein kinase signaling, peroxisome, eukaryotictype ABC transporters, photosynthesis and plant hormones, which are involved in stress-related signaling pathways. Overall, our study suggested that OsNAC041 was involved in the salt stress response in rice. These findings not only provide empirical evidence of OsNAC041 function, but also provide new insight into its potential application in rice resistance breeding. | WANG Bo ZHONG Zhaohui ZHANG Huanhuan WANG Xia LIU Binglin YANG Lijia HAN Xiangyan YU Deshui ZHENG Xuelian WANG Chunguo SONG Wenqin CHEN Chengbin ZHANG Yong | 2019 | Rice science2019，26，2： | 8 |
| 5 | Aggregation-induced emission (ALE) dye loaded polymer nanoparticles for gene silencing in pancreatic cancer and their in vitro and in vivo biocompatibility evaluation显示文摘 | Rui Hu Chengbin Yang Yucheng Wang Guimiao Lin Wei Qin Qingling Ouyang Wing-Cheung Law Quoc Toan Nguyen Ho Sup Yoon Xiaomei Wang Ken-Tye Yong Ben Zhong Tang | 2015 | Nano Research2015，8，5： | 4 |
| 6 | Screening and flocculating properties of bioflocculant-producing microorganisms显示文摘Screening of bioflocculant-producing microorganisms was carried out. A strain that secreted excellent bioflocculant was isolated from municipal sewage using the spread plate technique, identified as Klebsiella sp. by the analytical profile index (API) identification system, and named A9. Several important factors that had an effect on A9’s bioflocculant-producing and flocculating activity were studied. A total of 4 g/L Kaolin suspension was used to measure the flocculating activity of the bioflocculant from A9. It was found that maltose and urea were A9’s best carbon and nitrogen sources, respectively, and the flocculating activity of the floccu- lating agent from A9 was markedly increased by the addition of trivalent cations such as Fe3+ and Al3+; furthermore, the bioflocculant produced by A9 was most effective when the pH value was 6.0. | Yanling Sheng Qiang Zhang Yanru Sheng Chengbin Li and Huajun Wang | 2006 | Journal of University of Science and Technology Beijing2006，13，4： | 2 |
| 7 | Microcystin-LR biodegradation by Sphingopyxis sp.USTB-05显示文摘A promising bacterial strain for biodegradingmicrocystin-LR(MC-LR)as the sole carbon and nitrogensource was successfully isolated from Lake Dianchi,China.The strain was identified as Sphingopyxis sp.USTB-05,which was the first isolated MCs-biodegradingSphingopyxis sp.in China.The average biodegradationrate of MC-LR by Sphingopyxis sp.USTB-05 was 28.8mg·L^(-1)per day,which was apparently higher than those ofother bacteria reported so far.The optimal temperature andpH for both strain USTB-05 growth and MC-LRbiodegradation were 30℃and 7.0,respectively.Therelease of MC-LR from the cyanobacterial cells collectedfrom Lake Guishui and the biodegradation of MC-LR byboth strain and cell-free extract(CE)were investigated.The results indicated that MC-LR with the initialconcentration of 4.0 mg·L^(-1)in water was biodegraded bySphingopyxis sp.USTB-05 within 4 d,while MC-LR withthe initial concentration of 28.8 mg·L^(-1)could be completelyremoved in 3 h by CE of Sphingopyxis sp.USTB-05 containing 350 mg·L^(-1)protein.During enzymaticbiodegradation of MC-LR,two intermediate metabolitesand a dead-end product were observed on an HPLCchromatogram.Moreover,the similar scanning profiles ofMC-LR and its metabolic products indicate that the Addaside-chain of MC-LR was kept intact in all products. | Chengbin XIAO Hai YAN Junfeng WANG Wei WEI Jun NING Gang PAN | 2011 | Frontiers of Environmental Science & Engineering2011，5，4： | 2 |
| 8 | Implementation of remote robot manufacturing over Internet显示文摘 | Chub Chengbin Yina Chaowan | 2001 | Computers in Industry2001，，45： | 1 |
| 9 | Comprehensive Multi-Level Exploration of Buried Active Faults:an Example of the Yinchuan Buried Active Fault显示文摘The paper introduces the steps and methods of multi-approach,multi-level exploration of buried faults in thick Quaternary sediment regions by taking the test exploration of the Yinchuan active fault as example.Based on the comprehensive analyses of previous data,we choose the Xinqushao Village of Xingqing District of Yinchuan City as the test site for the comprehensive exploration.Firstly,we adopted shallow seismic investigation with group intervals of 10m,5m and 1m to gradually trace layer by layer the master fault of the Yinchuan buried fault from a deep depth to a shallow depth where drilling could be used.Then,with composite geological profile drilling,we determined the precise location and dip angle of the fault.The drilling show the buried depth of the upper offset point is 8.3m.Finally,large-scale trenching revealed that the actual buried depth of the upper offset point of the fault is 1.5m from the ground surface and there are paleoearthquake events of 5 stages.Combined with the preliminary result of corresponding sample age,we conclude the Yinchuan buried fault is a mid to late Holocene active fault. | Chai Chizhang Meng Guangkui Du Peng Wang Yin Liu Baojin Shen Weihua LeiQiyun Liao Yuhua Zhao Chengbin Feng Shaoying Zhang Xuehui Xie Xiaofeng | 2007 | Earthquake Research in China2007，21，3： | 1 |
| 10 | Clinical features and risk factors for post-partum depression in a large cohort of Chinese women with recurrent major depressive disorder显示文摘 | Tian Tian Yihan Li Dong Xie Yifeng Shen Jianer Ren Wenyuan Wu Chengbin Guan Zhen Zhang Danning Zhang Chengge Gao Xiaoming Zhang Jinbo Wu Hong Deng Gang Wang Yunshu Zhang Yun Shao Han Rong Zhaoyu Gan Yan Sun Bin Hu Jiyang Pan Yi Li Shufan Sun Libo Song Xue | 2011 | Journal of Affective Disorders2011，，3： | 1 |
| 11 | Puerarin Attenuates Ovalbumin-Induced Lung Inflammation and Hemostatic Unbalance in Rat Asthma Model显示文摘 | Feng Dong Chengbin Wang Jinyan Duan Weiyi Zhang Daijun Xiang Mianyang Li Tzeng-Ji Chen | 2014 | Evidence-Based Complementary and Alternative Medicine2014，，： | 1 |
| 12 | CD150 is a member of a family of genes that encode glycoproteins on the surface of hematopoietic cells显示文摘 | Wang Ninghai Morra Massimo Wu Chengbin | 2001 | Immunogenetics2001，53，5： | 1 |
| 13 | Direct electrodeposition of reduced graphene oxide on glassy carbon electrode and its electrochemical application显示文摘 | Liuyun Chen Yanhong Tang Ke Wang Chengbin Liu Shenglian Luo | 2010 | Electrochemistry Communications2010，，2： | 1 |
| 14 | Implementation of remote robot manufacturing over Internet显示文摘 | Chengen Wang Chengbin Chu Chaowan Yin | 2001 | Computers in Industry2001，45，： | 1 |
| 15 | Research on laser welding of aluminum matrix composite SiCw/6061显示文摘 | Jitai Niu Longxiu Pan Muzhen Wang Chengbin Fu Xiaodong Meng | 2006 | Vacuum2006，，11： | 1 |
| 16 | Algorithm for decomposition of binary morphological convex structuring elements based on periodic lines显示文摘 | ZHANG Chengbin WANG Kaifu SHEN Xueli | 2013 | The Imaging Science Journal2013，61，5： | 1 |
| 17 | High-intensity focused ultrasound (HIFU): effective and safe therapy for hepatocellular carcinoma adjacent to major hepatic veins显示文摘 | Lian Zhang Hui Zhu Chengbin Jin Kun Zhou Kequan Li Haibing Su Wenzhi Chen Jin Bai Zhibiao Wang | 2009 | European Radiology2009，，2： | 1 |
| 18 | Identification of Concealed Faults in a Grassland Area in Inner Mongolia, China, Using the Temperature Vegetation Dryness Index显示文摘Fault identification in vegetated area(e.g.,grassland) is a major challenge compared to that in outcrop areas. To identify concealed faults in a grassland covered area,a hybrid method combining the temperature vegetation dryness index(TVDI) and the singularity index was proposed in this paper to extract TVDI anomalies associated with concealed fractures in the Sonid Left Banner Grassland,Inner Mongolia,North China. In the triangle space of LST/NDVI(land surface temperature/normalized difference vegetation index),scattered points were concentrated in the areas of partial and full cover,while few data points were in the areas of bare soil with low values of NDVI and high values of LST;this result is consistent with the semiarid grassland landscape of the study area. Although TVDI imaging shows an obvious linear pattern with an NE-NNE trend,which indicates the existence of concealed faults,the surrounding background weakened and reduced the significance of the anomalies.To better delineate the concealed faults,the singularity index was employed to remove the influence of the background and enhance the TVDI anomalies associated with the concealed faults. The TVDI imaging and singularity index mapping showed NNE and NE orientations;this finding is consistent with the regional tectonic framework. Geological mapping footprints showed that the hybrid method is useful to identify concealed faults in covered areas of grassland. | Chengbin Wang Jianguo Chen Xi Chen Jinhui Chen | 2019 | Journal of Earth Science2019，30，4： | 1 |
| 19 | Microstructure and mechanical properties of silvergrass fiber cell walls evaluated by nanoindentation 显示文摘 | LIAO Chengbin DENG Yuhe WANG Siqun | 2012 | Wood Fiber Sci2012，44，1： | 1 |
| 20 | Characteristic of silvergrass and feasibility of silica used as water- proof agent of silvergrass particleboard 显示文摘 | LIAO Chengbin DENG Yuhe WANG wei | 2013 | Wood Fiber Sci2013，45，2： | 1 |
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