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| 1 | Predicting oral disintegrating tablet formulations by neural network techniques显示文摘Oral disintegrating tablets(ODTs) are a novel dosage form that can be dissolved on thetongue within 3 min or less especially for geriatric and pediatric patients. Current ODT for-mulation studies usually rely on the personal experience of pharmaceutical experts andtrial-and-error in the laboratory, which is inefficient and time-consuming. The aim of cur-rent research was to establish the prediction model of ODT formulations with direct com-pression process by artificial neural network(ANN) and deep neural network(DNN) tech-niques. 145 formulation data were extracted from Web of Science. All datasets were dividedinto three parts: training set(105 data), validation set(20) and testing set(20). ANN andDNN were compared for the prediction of the disintegrating time. The accuracy of the ANNmodel have reached 85.60%, 80.00% and 75.00% on the training set, validation set and testingset respectively, whereas that of the DNN model were 85.60%, 85.00% and 80.00%, respec-tively. Compared with the ANN, DNN showed the better prediction for ODT formulations.It is the first time that deep neural network with the improved dataset selection algorithmis applied to formulation prediction on small data. The proposed predictive approach couldevaluate the critical parameters about quality control of formulation, and guide researchand process development. The implementation of this prediction model could effectivelyreduce drug product development timeline and material usage, and proactively facilitatethe development of a robust drug product. | Run Han Yilong Yang Xiaoshan Li Defang Ouyang | 2018 | Asian Journal of Pharmaceutical Sciences2018，13，4： | 6 |
| 2 | Molecular Epidemiological Study on Prevalence of Human Papillomaviruses in Patients with Common Warts in Beijing Area显示文摘Objective To study the circulation,distribution,and genomic diversity of HPVs in common warts in Beijing area of China.Methods Forty eight patients with pathologically diagnosed common warts were screened for the presence of HPV with HPV type-specific PCR and direct sequencing analysis.The genomic diversity of HPVs prevalent in Chinese patients was analyzed based on LCR.Results Forty one(85.5%)samples were positive for HPV DNA,13(31.7%)-HPV-57, 12(29.3%)-HPV-1a,7(17%)-HPV-27 and 5(12.2%)HPV-2a.Four cases were infected with two different HPV types,two(4.9%) with HPV-1a and HPV-27,one(2.4%)with HPV-1 and HPV-57 and one(2.4%)with HPV-27 and HPV-57.In contrast to the prevalence of single strain of novel HPV-57 variant and HPV-1 prototype.two HPV-2 and three HPV-27 novel variants were found to circulate in Beijing.Conclusion HPV-1.-2.-27 and-57 are predominantly prevalent in patients with common warts in Beijing. | YAN-JUN LEI CHEN GAO CHEN WANG JUN HAN JIAN-MING CHEN GUANG-CAI XIANG QI SHI HUI-YING JIANG WEI ZHOU RUN AN CHEN-FANG DONG YU-KANG YUAN XIAO-PING DONG | 2009 | Biomedical and Environmental Sciences2009，22，1： | 4 |
| 3 | Establishment of a Sandwich ELISA Method for Detection of Vascular Endothelial Growth Factor in Serum Samples of Hepatocellular Carcinoma Patients显示文摘Objective To establish a sandwich ELISA method for detecting vascular endothelial growth factor (VEGF) in sera of population and the patients with hepatocellular carcinoma (HCC). Methods Full length and two truncated human VEGF cDNA sequences were amplified from a commercial plasmid pBLAST49-hVEGF by PCR and inserted into the prokaryotic-expression plasmid pET-32a or pGEX-2T. Various VEGF proteins were expressed and purified from E. coli in His-Trx or GST fusion forms. The specific VEGF antibodies were elicited in experimental rabbits and mice by immunization of the full length VEGF fusion protein His-Trx-VEGF1-165. After purification of antibodies with chromatograph of Protein G, a sandwich ELISA technique was established. Serum VEGF levels were evaluated in 229 adults and 291 HCC patients. Results SDS-PAGE displayed that the molecular weights of the expressed full length (His-Trx-VEGF1-165), N-terminal (His-Trx-VEGF1-100) and C-terminal (GST-VEGF100-165) human VEGF fusion proteins were about 38KD, 31KD, and 33KD, respectively. Western blots confirmed that the prepared antisera were able to recognize both prokaryoticly and eukaryoticly expressed recombinant VEGF proteins. Assays of serially diluted His-Trx-VEGF1-100 by the established sandwich ELISA method showed that the linear range of the standard curve was 0.625-320 ng/mL, with the squared correlation coefficient R2=0.991. Screening of a serum panel containing 291 serum samples of HCC patients and 229 health adults revealed that the average VEGF level in HCC patients was higher than that in healthy controls, with a statically significant difference. Conclusion The established sandwich ELISA reflects the level of serum VEGF and provide scientific basis for screening metastasis and recurrence of HCC using serum VEGF as an index. | BING SHAN CHEN GAO JIAN-MING CHEN XIN-Yu BI BAO-YUN ZHANG YAN GUO CHEN-FANG DONG RUN AN QI SHI JING-QUN HU PING ZHAO JUN HAN XIAO-PING DONG | 2008 | Biomedical and Environmental Sciences2008，21，1： | 4 |
| 4 | p-Cresyl sulfate promotes the formation of atherosclerotic lesions and induces plaque instability by targeting vascular smooth muscle cells显示文摘冠的动脉粥样硬化是长期的肾疾病的主要复杂并发症。这个条件在分离病人贡献增加的死亡。p-Cresyl 硫酸盐(PCS ) 是蛋白质界限的一个原型不能高效地通过平淡的分离过程被移开的尿毒症的毒素。在现在的学习,也就是,经历了 5/6 肾切除术的 ApoE -/- 老鼠随机被划分成二个组对待车辆的组(n = 20 ) 并且对待 PCS 的组(n = 20 ) 。老鼠被牺牲为在在高脂肪的饮食的 8 或 24 个星期以后的脸和 immunohistological 分析。老鼠大动脉的脉管的光滑的肌肉房间(VSMC ) 与的磷酸盐缓冲区答案或 500 mol/L PCS 被对待在 vitro 评估。对待 PCS 的老鼠被观察在八星期 PCS 管理以后承受增加的动脉粥样硬化患者损害。而且, 24 星期 PCS 管理显著地也增加了大动脉的匾的危险索引。PCS 也被观察在疾病的前进期间便于 VSMC 的迁居和增长。而且, PCS 在匾以内扰乱了在矩阵 metalloproteinases 和 metalloproteinases 的织物禁止者之间的平衡。因此, PCS 在支持 atherogenesis 并且由指向 VSMC 可能扰乱形成的匾的稳定性起了一个重要作用。 | Hui Han Yanjia Chen Zhengbin Zhu Xiuxiu Su Jingwei Ni Run Du Ruiyan Zhang Wei Jin | 2016 | Frontiers of Medicine2016，10，3： | 3 |
| 5 | PHYTOCHROME-INTERACTING FACTORS Interact with the ABA Receptors PYL8 and PYL9 to Orchestrate ABA Signaling in Darkness显示文摘PHYTOCHROME-INTERACTING FACTORS(PIFs)are a group of basic helix-loop-helix transcription factors that can physically interact with photoreceptors,including phytochromes and cryptochromes.It was previously demonstrated that PIFs accumulated in darkness and repressed seedling photomorphogenesis,and that PIFs linked different photosensory and hormonal pathways to control plant growth and development.In this study,we show that PIFs positively regulate the ABA signaling pathway during the seedling stage specifically in darkness.We found that PIFs positively regulate ABI5 transcript and protein levels in darkness in response to exogenous ABA treatment by binding directly to the G-box motifs in the ABI5 promoter.Consistently,PIFs and the G-box motifs in the ABI5 promoter determine ABI5 expression in darkness,and overexpression of ABI5 could rescue the ABA-insensitive phenotypes of pifq mutants in the dark.Moreover,we discovered that PIFs can physically interact with the ABA receptors PYL8 and PYL9,and that this interaction is not regulated by ABA.Further analyses showed that PYL8 and PYL9 promote PIF4 protein accumulation in the dark and enhance PIF4 binding to the ABI5 promoter,but negatively regulate PIF4-mediated ABI5 activation.Taken together,our data demonstrate that PIFs interact with ABA receptors to orchestrate ABA signaling in darkness by controlling ABI5 expression,providing new insights into the pivotal roles of PIFs as signal integrators in regulating plant growth and development. | Lijuan Qi Shan Liu Cong Li Jingying Fu Yanjun Jing Jinkui Cheng Hong Li Dun Zhang Xiaoji Wang Xiaojing Dong Run Han Bosheng Li Yu Zhang Zhen Li William Terzaghi Chun-Peng Song Rongcheng Lin Zhizhong Gong Jigang Li | 2020 | Molecular Plant2020，13，3： | 3 |
| 6 | Black phosphorus-based van der Waals heterostructures for mid-infrared light-emission applications显示文摘Mid-infrared(MIR)light-emitting devices play a key role in optical communications,thermal imaging,and material analysis applications.Two-dimensional(2D)materials offer a promising direction for next-generation MIR devices owing to their exotic optical properties,as well as the ultimate thickness limit.More importantly,van der Waals heterostructures-combining the best of various 2D materials at an artificial atomic level-provide many new possibilities for constructing MIR light-emitting devices of large tuneability and high integration.Here,we introduce a simple but novel van der Waals heterostructure for MIR light-emission applications built from thin-film BP and transition metal dichalcogenides(TMDCs),in which BP acts as an MIR light-emission layer.For BP–WSe_(2) heterostructures,an enhancement of~200% in the photoluminescence intensities in the MIR region is observed,demonstrating highly efficient energy transfer in this heterostructure with type-Ⅰ band alignment.For BP-MoS_(2) heterostructures,a room temperature MIR light-emitting diode(LED)is enabled through the formation of a vertical PN heterojunction at the interface.Our work reveals that the BP-TMDC heterostructure with efficient light emission in the MIR range,either optically or electrically activated,provides a promising platform for infrared light property studies and applications. | Xinrong Zong Huamin Hu Gang Ouyang Jingwei Wang Run Shi Le Zhang Qingsheng Zeng Chao Zhu Shouheng Chen Chun Cheng Bing Wang Han Zhang Zheng Liu Wei Huang Taihong Wang Lin Wang Xiaolong Chen | 2020 | Light(Science & Applications)2020，9，1： | 3 |
| 7 | Over-expression of nm23-H1 in HeLa cells provides cells with higher resistance to oxidative stress possibly due to raising intracellular p53 and GPX显示文摘瞄准:决定反肿瘤因素 nm23 是否与反氧化是相关的。方法:全身的人的 nm23-H1 被克隆进哺乳动物表示的向量并且短暂地介绍了房间进 HeLa。结果:反应的氧种类(ROS ) 显著地低级的 A 在细胞被检测过去表示的 nm23-H1。3-(4,5-Dimethylthiazol-2-yl )-2,5-diphenyltetrazolium 溴化物和尝试平底锅蓝色试金发现有一个 nm23-H1-expressing 原生质标志的房间 transfected 有更高的生存能力和更强壮的抵抗到氧化应力。Immunoprecipitation 测试表明内长的 nm23-H1 与 p53 形成了蛋白质建筑群。而且, p53 的细胞内部的层次和 p53-regulatedgene GPX1 显然在表示 nm23-H1 上在房间被增加。下面在在表示 nm23-H1 上的房间的 p53 的规定导致了更高细胞的 ROS 水平和更低的房间生存能力。结论:调查结果建议 nm23-H1 可以对氧化应力充当一个细胞的保护者,可能触发 p53 相关的抗氧化的小径。 | Run AN Yong-lie CHU Chan TIAN Xiao-xia DAI Jing-hong CHEN Qi SHI Jun HAN Xiao-ping DONG | 2008 | Acta Pharmacologica Sinica2008，29，12： | 2 |
| 8 | A LexA-based yeast two-hybrid system for studying light- switchable interactions of phytochromes with their interacting partners显示文摘Phytochromes are a family of photoreceptors in plants that perceive the red(R)and far-red(FR)components of their light environment.Phytochromes exist in vivo in two forms,the inactive Pr form and the active Pfr form,that are interconvertible by treatments with R or FR light.It is believed that phytochromes transduce light signals by interacting with their signaling partners.A GAL4-based lightswitchable yeast two-hybrid(Y2H)system was developed two decades ago and has been successfully employed in many studies to determine phytochrome interactions with their signaling components.However,several pairs of interactions between phytochromes and their interactors,such as the phyACOP1 and phyA-TZP interactions,were demonstrated by other assay systems but were not detected by this GAL4 Y2H system.Here,we report a modified LexA Y2H system,in which the LexA DNA-binding domain is fused to the C-terminus of a phytochrome protein.The conformational changes of phytochromes in response to R and FR light are achieved in yeast cells by exogenously supplying phycocyanobilin(PCB)extracted from Spirulina.The well-defined interaction pairs,including phyA-FHY1 and phyB-PIFs,are well reproducible in this system.Moreover,we show that our system is successful in detecting the phyA-COP1 and phyA-TZP interactions.Together,our study provides an alternative Y2H system that is highly sensitive and reproducible for detecting light-switchable interactions of phytochromes with their interacting partners. | Hong Li Xinyan Qin Pengyu Song Run Han Jigang Li | 2021 | aBIOTECH2021，2，2： | 2 |
| 9 | Structure evolution and thermal stability of SMAT-derived nanograined layer on Ti–25Nb–3Mo–3Zr–2Sn alloy at elevated temperatures显示文摘 | Run Huang Yong Han | 2013 | Journal of Alloys and Compounds2013，，： | 2 |
| 10 | Comparison of linear and nonlinear analysis in estimating the Thomas model parameters for methylene blue adsorption onto natural zeolite in fixed-bed eolumn显示文摘 | HAN Run Ping WANG Yi ZOU Wei Hua | 2007 | J Hazard Mater2007，145，12： | 1 |
| 11 | Andesite Geochemistry Features of Late Triassic Tumugou Formation, in Zhongdian, Yunnan Province显示文摘 | Huang Jian Guo Han Run Sheng Tao Ren Li Zhi Qiang | 2012 | 2012 (524)2012，，524： | 1 |
| 12 | SARS Patients-derived Human Recombinant Antibodies to S and M Proteins Efficiently Neutralize SARS-Coronavirus Infectivity显示文摘Objective To develop a specific SARS virus-targeted antibody preparation for emergent prophylaxis and treatment of SARS virus infection. Methods By using phage display technology, we constructed a naive antibody library from convalescent SARS patient lymphocytes. To obtain the neutralizing antibody to SARS virus surface proteins, the library panning procedure was performed on purified SARS virions and the specific Fab antibody clones were enriched by four rounds of repeated panning procedure and screened by highthroughput selection. The selected Fab antibodies expressed in the periplasma of E. Coli were soluble and further purified and tested for their binding properties and antiviral function to SARS virus. The functional Fab antibodies were converted to full human IgG antibodies with recombinant baculovirus/insect cell systems and their neutralizing activities were further determined. Results After four rounds of the panning, a number of SARS-CoV virus-targeted human recombinant Fab antibodies were isolated from the SARS patient antibody library. Most of these were identified to recognize both natural and recombinant SARS spike (S) proteins, two Fab antibodies were specific for the virus membrane (M) protein, only one bound to SARS-CoV nucleocapsid protein. The SARS-CoV S and M protein-targeted Fab or IgG antibodies showed significant neutralizing activities in cytopathic effect (CPE) inhibition neutralization test, these antibodies were able to completely neutralize the SARS virus and protect the Vero cells from CPE after virus infection. However, the N protein-targeted Fab or IgG antibodies failed to neutralize the virus. In addition, the SARS N protein-targeted human Fab antibody reacted with the denatured N proteins, whereas none of the S and M protein specific neutralizing antibodies did. These results suggested that the S and M protein-specific neutralizing antibodies could recognize conformational epitopes which might be involved in the binding of virions to cellular receptors and the fusion activity of the virus.Conclusion The SARS-CoV spike protein and membrane proteins are able to elicite efficient neutralizing antibodies in SARS patients. The neutralizing antibodies we generated in this study may be more promising candidates for prophylaxis and treatment of SARS infection. | MI-FANG LIANG RUN -LEI DU JING-ZHI LIU CHUAN LI QUAN-FU ZHANG LU-LU HAN JIAN-SHI YU SHU-MIN DUAN XIAO-FANG WANG KONG-XING WU ZHAO-HUI XION QI JIN DE-XIN LI | 2005 | Biomedical and Environmental Sciences2005，18，6： | 1 |
| 13 | The effect of SMAT-induced grain refinement and dislocations on the corrosion be- havior of Ti-25Nb-3Mo-3Zr-2Sn alloy 显示文摘 | Huang Run Han Yong | 2013 | Materials Science and Engineering : C2013，33，4： | 1 |
| 14 | Coexistence of meningioma and other intracranial benign tumors in non-neurofibromatosis type 2 patients:A case report and review of literature显示文摘BACKGROUND The coexistence of meningioma and other intracranial primary benign tumors is rare,especially in non-neurofibromatosis type 2,and there is limited guidance for the management of such patients.Here,we report a series of 5 patients with concomitant meningioma and other intracranial benign tumors,including subependymoma and pituitary adenoma.CASE SUMMARY Five non-neurofibromatosis type 2 patients with simultaneous occurrence of meningioma and other intracranial benign tumors were retrospectively reviewed.The patients had no history of previous irradiation.The clinical features,pre-and postoperative imaging,surgical procedure and pathological findings were extracted from electronic medical records.There were 4 female patients(80%)and 1 male patient(20%).The mean age was 42.8 years(range:29-52 years).The coexisting tumors included subependymoma in 1 case(20%)and pituitary adenoma in 4 cases(80%).The most common clinical symptom was headache(3/5,60%).Four patients(80%)underwent craniotomy.One patient(20%)underwent transsphenoidal surgery followed by transcranial operation.All tumor diagnoses were confirmed by histopathological examination.The mean follow-up was 38.8 mo(range:23-96 mo),and all 5 patients were in a stable condition at the last follow-up.CONCLUSION The simultaneous occurrence of meningioma and other intracranial benign tumors is a rare clinical event.Histological examination is necessary for the accurate diagnosis.Neurosurgeons should select the appropriate surgical strategy according to the clinical features of each patient,which may provide a more favorable prognosis for individual patients. | Tian-Hao Hu Run Wang Hai-Yun Wang Yi-Fu Song Juan-Han Yu Zi-Xun Wang Yu-Zhou Duan Ting Liu Sheng Han | 2022 | World Journal of Clinical Cases2022，10，13： | 1 |
| 15 | Design of high-performance molybdenum alloys via doping metal oxide and carbide strengthening:A review显示文摘Metal oxide and carbide strengthening molybdenum(Mo)alloys have been designed as promising ad-vanced materials in refractory metals to solve some of the core engineering problems in superalloy ap-plications.Hence,there is a need to summarize the results obtained and evaluate the opportunities for preparing high-performance Mo alloys by strengthening metal oxides and carbides to improve the per-formance characteristics of Mo metal materials.This paper reviews the results of the reported work con-cerning the structure and properties of Mo alloys with different metal oxide and carbide strengthening methods added to Mo matrix.The influence of the doping of La 2 O 3 and Y 2 O 3 particles,ceramic Al 2 O 3 and ZrO 2 particles,and refractory TiC and ZrC carbides particles of Mo alloys are discussed.The impacts of particle morphology,size,distribution and volume fractions of oxide and carbide are analyzed,as well as the specific features of different doping techniques for obtaining high-performance Mo alloys mate-rials.This work will guide future research on the design of high-performance refractory Mo alloys by adding oxides and carbide particles,helping to solve the core issues in the field of superalloy application research. | Hairui Xing Ping Hu Chaojun He Xiangyang Zhang Jiayu Han Fan Yang Run Bai Wen Zhang Kuaishe Wang Alex AVolinsky | 2023 | Journal of Materials Science & Technology2023，，29： | 1 |
| 16 | Nanograins on Ti-25Nb-3Mo-2Sn-3Zr alloy facilitate fabricating biological surface through dual-ion implantation to concurrently modulate the osteogenic functions of mesenchymal stem cells and kill bacteria显示文摘Surface mechanical attrition treatment(SMAT)method is an effective way to generate nanograined(NG)surface on Ti-25 Nb-3 Mo-2 Sn-3 Zr(wt.%)(named as TLM),a kind ofβ-type titanium alloy,and the achieved nanocrystalline surface was proved to promote positive functions of osteoblastic cells.In this work,to further endow the NG TLM alloy with both good osteogenic and antibacterial properties,magnesium(Mg),silver(Ag)ion or both were introduced onto the NG TLM surface by ion implantation process,as a comparison,the Mg and Ag ions were also co-implanted onto coarsegrained(CG)TLM surface.The obtained results show that subsequent ion implantation does not remarkably induce the surface roughness and topography alteration of the SMAT-treated layers,and it also has little impact on the microstructure of the SMAT-derivedβ-Ti nanograins.In addition,the implanted Mg and Ag ions are observed to exist as MgO and metallic Ag na noparticles(NPs)embedding tightly in theβ-Ti matrix with grain size of about 15 and 7 nm,respectively.Initial cell adhesion and functions(including proliferation,osteo-differentiation and extracellular matrix mineralization)of rabbit bone marrow mesenchymal stem cells(rBMMSCs)and the bacterial colonization of Staphylococcus aureus(S.aureus)on the different surfaces were investigated.The in-vitro experimental results reveal that the Mg and Ag single-ion implanted NG surface either significantly promotes the rBMMSCs response or inhibits the growth ofS.aureus,whereas the Mg/Ag coimplanted NG surface could concurrently enhance the rBMMSCs functions as well as inhibit the bacterial growth compared to the NG surface,and this efficacy is more pronounced as compared to the Mg/Ag co-implantation in the CG surface.The SMAT-achieved nanograins in the TLM surface layer are identified to not only play a leading role in determining the fate of rBMMSCs but also facilitate fabricating dualfunctio nal surface with both good osteogenic and antibacterial activities through co-implantation of Mg and Ag ions.Our investigation provides a new strategy to develop high-performance Ti-based implants for clinical application. | Run Huang Lei Liu Bo Li Liang Qin Lei Huang Kelvin W.K.Yeung Yong Han | 2021 | Journal of Materials Science & Technology2021，，14： | 1 |
| 17 | Sand source and formation mechanism of riverine sand dunes: a case study in Xiangshui River, China显示文摘Riverine sand dunes develop as a result of fluvial-aeolian interactions. The primarily barchan dune chains along the Xiangshui River(a branch of the Xar Moron River in the western part of the Horqin Sandy Land of China) form a typical riverine dune field. We collected a series of samples from the riverine sand dunes parallel to the direction of the prevailing wind and investigated the sand sources and formation mechanisms of these dunes by determining the grain size, heavy mineral content and optically stimulated luminescence(OSL) of the samples. The sand of the near-river dunes was coarser than the sand of the dunes distant from the river, indicating that coarse sand of the valley mainly deposited on near-river dunes. The heavy mineral analysis suggested that wind-sand activity levels were intense on the upwind dunes, but relatively weak on the downwind dunes. This indicated that the sand sources for the near-river dunes were more abundant than those of the distant dunes. Our OSL analysis of samples suggested that the deposition rates on dunes near the river were greater than the deposition rates on dunes distant from the river. The development of dunes along the river indicated that the river played an important role in dune formation and development. In addition, airflow fluctuation and the formation of the waveform dunes had a type of feedback relationship. Grain size, heavy mineral and OSL analyses are widely used methods in wind-sand research. Sand dune grain size characteristics reflect the effects of airflow on the transport and separation of sand materials, as well as the physical characteristics of the sand sources. Heavy mineral characteristics are often used to investigate the relationships between sediments and sand sources. OSL indicates dune age, revealing formation of dunes. Therefore, it is useful to explore dune sand sources, as well as the mechanisms underlying dune formation, by determining grain size, heavy mineral content and OSL. This study investigated the sand sources of riverine dunes and provided new information about riverine dune formation and development. | WANG Yong YAN Ping HAN Guang WU Wei ZHANG Run | 2019 | Journal of Arid Land2019，11，4： | 1 |
| 18 | Mechanical model and finite element analysis of the loader drive axle housing in typical operating conditions 显示文摘 | Huang Yan- qun Han Ming Zheng Run - hao | 2010 | ICECE2010，1291，： | 1 |
| 19 | A new electrolytic method of preparing ultrafine metallic powders显示文摘 | He Feng Zhang Zhengyi Xiao Yaofu Wang Wuxiang Han Yafang Wang Run | 2002 | Journal of Materials Processing Tech2002，，1： | 1 |
| 20 | A Molecularly Imprinted Polymer Sensor Based on the Electropolymerization of p-Aminothiophenol-Functionalized Au Nanoparticles Electrode for the Detection of Nonylphenol显示文摘Endocrine disruptors(EDCs),also known as Environmental Hormones(EHs),refer to substances in the environment that interfere with the endocrine systems of humans and animals.These substances can lead to genital disorders in humans and animals[1].Nonylphenol(Nph)is a kind of relatively distributed substance of EDCs.Nph is the metabolite of nonylphenol polyethoxy and an important fine chemical,raw material,and intermedium[2]。 | KOU Jing LU Li Li FAN Zhao Yu HAN Yi Qun ZHOU Run Zhe XIA Ying Zhao LYU Fang Zhi ZHANG Xiu Jaffrezic-Renault NICOLE GUO Zhen Zhong | 2020 | Biomedical and Environmental Sciences2020，33，11： | 1 |
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