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| 1 | Protective effect of Radix Astragali injection on immune organs of rats with obstructive jaundice and its mechanism显示文摘AIM: To observe the protective effect of Radix Astragali injection on immune organs (lymph nodes, spleen and thymus) of rats with obstructive jaundice (OJ) and its mechanism. METHODS: SD rats were randomly divided into sham-operation group, model control group and Radix Astragali treatment group. On days 7, 14, 21 and 28 after operation, mortality rate of rats, pathological changes in immune organs, expression levels of Bax and nuclear factor (NF)-κB p65 proteins, apoptosis indexes and serum tumor necrosis factor (TNF)-α level in spleen and thymus were observed, respectively.RESULTS: Compared to model control group, the number of dead OJ rats in Radix Astragali treatment group decreased (P > 0.05). The TNF-α level (27.62 ± 12.61 vs 29.55 ± 18.02, 24.61 ± 9.09 vs 31.52 ± 10.95) on days 7 and 21, the pathological severity score for spleen [0.0 (0.0) vs 0.0 (2.0) on days 7 and 14 and for lymph nodes [0.0 (1.0) vs 1.0 (2.0), 1.0 (0.0) vs 2.0 (1.0)] on days 21 and 28, the product staining intensity and positive rate of Bax protein in spleen [0.0 (0.0) vs 1.0 (2.0), 0.0 (1.0) vs 2.0 (1.5) and thymus [0.0 (0.0) vs 1.0 (2.0), 0.0 (1.0) vs 2.0 (1.5)] on days 14 and 28, the apoptotic indexes [0.0 (0.0) vs 0.0 (0.01)] in spleen and thymus [0.0 (0.0) vs 0.0 (0.01) on days 14 and 21 were significantly lower in Radix Astragali treatment group than in model control group (P < 0.05). CONCLUSION: Radix Astragali has protective effects on immune organs of OJ rats by relieving the pathological changes in immune organs, reducing TNF-α level and inhibiting Bax expression and apoptosis in spleen and thymus. | Rui-Ping Zhang Xi-Ping Zhang Yue-Fang Ruan Shu-Yun Ye Hong-Chan Zhao Qi-Hui Cheng Di-Jiong Wu | 2009 | World Journal of Gastroenterology2009，15，23： | 23 |
| 2 | Genome analysis of Taraxacum kok-saghyz Rodin provides new insights into rubber biosynthesis显示文摘The Russian dandelion Taraxacum kok-saghyz Rodin(TKS), a member of the Composite family and a potential alternative source of natural rubber(NR) and inulin, is an ideal model system for studying rubber biosynthesis. Here we present the draft genome of TKS, the first assembled NR-producing weed plant. The draft TKS genome assembly has a length of 1.29 Gb, containing 46 731 predicted protein-coding genes and68.56% repeats, in which the LTR-RT elements predominantly contribute to the genome enlargement. We analyzed the heterozygous regions/genes, suggesting its possible involvement in inbreeding depression.Through comparative studies between rubber-producing and non-rubber-producing plants, we found that enzymes of the mevalonate(MVA) pathway and rubber elongation might be critical for rubber biosynthesis, and several key isoforms have been isolated and shown to be predominantly expressed in the latex, indicating their crucial functions in rubber biosynthesis. Moreover, for two important families in rubber elongation, the CPT/CPTL and REF/SRPP families, diverse evolutionary tracks have been revealed. These results provide valuable resources and new insights into the mechanism of NR biosynthesis,and facilitate the development of alternative NR-producing crops. | Tao Lin Xia Xu Jue Ruan Shizhong Liu Shigang Wu Xiujuan Shao Xiaobo Wang Lin Gan Bi Qin Yushuang Yang Zhukuan Cheng Suhua Yang Zhonghua Zhang Guosheng Xiong Sanwen Huang Hong Yu Jiayang Li | 2018 | National Science Review2018，5，1： | 22 |
| 3 | RESEARCH ON THE EVALUATION METHOD OF FRICTION AND LUBRICATION IN DEEP DRAWING显示文摘The deformation characteristic of bland in deep drawing is discussed. It is pointed out that the friction and lubrication conditions in for drawing are different from that in mechanical motion or machine work or other plastic process. The common test methods in laboratories are analyzed. It shows that though all those test methods can test the friction coefficient, the probe test method is most suitable for the research of friction and lubrication and the process in deep drawing, for this method is identical with the actual work condition either from the test principle or deformation status of the blank. Last the successful application in the deep drawing simulator newly developed the the probe method are intro- duced in detail. | D. N. He, X. F. Yin, H. Z. Thao, D. L*, X. Y. Ruan, J. L. Cheng and J. Y. Jiang 1) Shanghai Jiao Tong University, National Die & Mold CAD E. R. C, Shanghai 200030, China 2) Shanghai Vopkswagen Automotive Company Ltd., Shanghai 201805, China Manuscript re | 2000 | Acta Metallurgica Sinica(English Letters)2000，13，2： | 13 |
| 4 | Mapping Sea Level Rise Behavior in an Estuarine Delta System:A Case Study along the Shanghai Coast显示文摘 | H.Q. Cheng J.Y. Chen Z.J. Chen R.L. Ruan G.Q. Xu G. Zeng J.R. Zhu Z.J. Dai X.Y. Chen S.H. Gu X.L. Zhang H.M. Wang | 2018 | Engineering2018，4，1： | 11 |
| 5 | Increased activity of MdFRK2, a high-affinity fructokinase, leads to upregulation of sorbitol metabolism and downregulation of sucrose metabolism in apple leaves显示文摘To investigate the functions of fructokinase(FRK)in apple(Malus domestica)carbohydrate metabolism,we cloned the coding sequences of MdFRK1 and MdFRK2 from the‘Royal Gala’apple.The results showed that MdFRK2 expression was extremely high in shoot tips and young fruit.Analyses of heterologously expressed proteins revealed that MdFRK2 had a higher affinity for fructose than did MdFRK1,with Km values of 0.1 and 0.62 mM for MdFRK2 and MdFRK1,respectively.The two proteins,however,exhibited similar Vmax values when their activities were significantly inhibited by high concentrations of fructose.MdFRK2 ectopic expression was associated with a general decrease in fructose concentration in transgenic lines.In leaves,increased FRK activity similarly resulted in reduced concentrations of glucose and sucrose but no alterations in sorbitol concentration.When compared with those in the untransformed control,genes involved in sorbitol synthesis(A6PR)and the degradation pathway(SDH1/2)were significantly upregulated in transgenic lines,whereas those involved in sucrose synthesis(SPS1)and other degradation processes(SUSY4,NINV1/2,and HxK2)were downregulated.The activity of enzymes participating in carbohydrate metabolism was proportional to the level of gene expression.However,the growth performance and photosynthetic efficiency did not differ between the transgenic and wild-type plants.These results provide new genetic evidence to support the view that FRK plays roles in regulating sugar and sorbitol metabolism in Rosaceae plants. | Jingjing Yang Lingcheng Zhu Weifang Cui Chen Zhang Dongxia Li Baiquan Ma Lailiang Cheng Yong-Ling Ruan Fengwang Ma Mingjun Li | 2018 | Horticulture Research2018，5，1： | 9 |
| 6 | Review of the biological and engineering aspects of algae to fuels approach显示文摘Current biofuel production relies on limited arable lands on the earth,and is impossible to meet the biofuel demands.Oil producing algae are alternative biofuel feedstock with potential to meet the world’s ambitious goal to replace fossil fuels.This review provides an overview of the biological and engineering aspects in the production and processing technologies and recent advances in research and development in the algae to fuels approach.The article covers biology,selection and genetic modification of algae species and strains,production systems design,culture media and light management,harvest and dewatering,downstream processing,and environment and economic assessment.Despite the many advances made over several decades,commercialization of algal fuels remains challenging chiefly because of the techno-economic constraints.Technological breakthroughs in all major aspects must take place before commercial production of algal fuels becomes economically viable. | Paul Chen Min Min Yifeng Chen Liang Wang Yecong Li Qin Chen Chenguang Wang Yiqin Wan Xiaoquan Wang Yanling Cheng Shaobo Deng Kevin Hennessy Xiangyang Lin Yuhuan Liu Yingkuan Wang Blanca Martinez Roger Ruan | 2009 | International Journal of Agricultural and Biological Engineering2009，2，4： | 9 |
| 7 | Subtyping Animal Influenza Virus with General Multiplex RT-PCR and Liquichip High Throughput (GMPLex)显示文摘This study developed a multiplex RT-PCR integrated with luminex technology to rapidly subtype simultaneously multiple influenza viruses. Primers and probes were designed to amplify NS and M genes of influenza A viruses HA gene of H1, H3, H5, H7, H9 subtypes, and NA gene of the N1 and N2 subtypes. Universal super primers were introduced to establish a multiplex RT-PCR (GM RT-PCR). It included three stages of RT-PCR amplification, and then the RT-PCR products were further tested by LiquiChip probe, combined to give an influenza virus (IV) rapid high throughput subtyping test, designated as GMPLex. The IV GMPLex rapid high throughput subtyping test presents the following features: high throughput, able to determine the subtypes of 9 target genes in H1, H3, H5, H7, H9, N1, and N2 subtypes of the influenza A virus at one time; rapid, completing the influenza subtyping within 6 hours; high specificity, ensured the specificity of the different subtypes by using two nested degenerate primers and one probe, no cross reaction occurring between the subtypes, no non-specific reactions with other pathogens and high sensitivity. When used separately to detect the product of single GM RT-PCR for single H5 or N1 gene, the GMPLex test showed a sensitivity of 10-5(= 280ELD50) forboth tests and the Luminex qualitative ratio results were 3.08 and 3.12, respectively. When used to detect the product of GM RT-PCR for H5N1 strain at the same time, both showed a sensitivity of 10-4(=2800 ELD50). The GMPLex rapid high throughput subtyping test can satisfy the needs of influenza rapid testing. | Zhi-feng Qin Jie Sun Ti-kang Lu Shao-ling Zeng Qun-yi Hua Qing-yan Ling Shu-kun Chen Jian-qiang Lv Cai-hong Zhang Bing Cheng Zhou-xi Ruan Ying-zuo Bi Joseph J Giambrone Hong-zhuan Wu | 2012 | Virologica Sinica2012，27，2： | 8 |
| 8 | CTRP1 Attenuates UUO-induced Renal Fibrosis via AMPK/NOX4 Pathway in Mice显示文摘Clq/TNF-related protein 1(CTRP1),a conserved protein of the Clq family,plays a key role in cardiovascular and metabolic diseases.However,the role of CTRP1 in renal injury is unclear.The purpose of this study is to explore the role of CTRP1 in unilateral ureteral obstruction(UUO)-induced renal fibrosis and to elucidate the underlying mechanism.Using gene delivery system,CTRP1 was overexpressed in the kidney,then the mice were operated to induce UUO model after adenovirus transfection.It was found that the expression of CTRP1 in the renal tissue was decreased in mice after UUO.CTRP1 overexpression decreased the kidney function and kidney weight index.Moreover,CTRP1 reduced oxidative stress and renal collagen deposition in vivo.As expected,we found that CTRP1 activated AMP-activated kinase(AMPK)and decreased NOX4 expression,while silencing AMPKal abolished the protective effects of CTRP1 overexpression in mice after UUO.In conclusion,CTRP1 may protect against UUO-induced renal injury via AMPK/NOX4 signaling.Our results indicate that CTRP1 exhibits potential effects to treat renal fibrosis caused by UUO. | Wen LI Fan CHENG Yi-yan SONGYANG Song-yi-sha YANG Jie WEI Yuan RUAN | 2020 | Current Medical Science2020，40，1： | 6 |
| 9 | Comparison of diagnostic efficacy between transrectal and transperineal prostate biopsy:a propensity score-matched study显示文摘This study compared the diagnostic efficacy of transrectal ultrasound(TRUS)-guided prostate biopsy(TRBx)and transperineal prostate biopsy(TPBx)in patients with suspected prostate cancer(PCa).We enrolled 2962 men who underwent transrectal(n=1216)or transperineal(n=1746)systematic 12-core prostate biopsy.Clinical data including age,prostate-specific antigen(PSA)level,and prostate volume(PV)were recorded.To minimize confounding,we performed propensity score-matching analysis?We measured and compared PCa detection rates between TRBx and TPBx,which were stratified by clinical characteristics and Gleason scores.The effects of clinical characteristics on PCa detection rate were assessed by logistic regression.For all patients,TPBx detected a higher proportion of clinically significant PCa(P<0.001).Logistic regression analyses illustrated that PV had a smaller impact on PCa detection rate of TPBx compared with TRBx.Propensity score-matching analysis showed that the detection rates in TRBx were higher than those in TPBx for patients aged≥80 years(80.4%vs 56.5%,P=0.004)and with PSA level 20.1-100.0 ng ml^-1(80.8%vs 69.1%,P=0.040).In conclusion,TPBx was associated with a higher detection rate of clinically significant PCa than TRBx was;however,because of the high detection rate at certain ages and PSA levels,biopsy approaches should be optimized according to patents'clinical characteristics. | Chen-Yi Jiang Peng-Fei Shen Cheng Wang Hao-Jun Gui Yuan Ruan Hao Zeng Shu-Jie Xia Qiang Wei Fu-Jun Zhao | 2019 | Asian Journal of Andrology2019，21，6： | 6 |
| 10 | Metabolite changes in the ipsilateral and contralateral cerebral hemispheres in rats with middle cerebral artery occlusion显示文摘Cerebral ischemia not only causes pathological changes in the ischemic areas but also induces a series of secondary changes in more distal brain regions(such as the contralateral cerebral hemisphere). The impact of supratentorial lesions, which are the most common type of lesion, on the contralateral cerebellum has been studied in patients by positron emission tomography, single photon emission computed tomography, magnetic resonance imaging and diffusion tensor imaging. In the present study, we investigated metabolite changes in the contralateral cerebral hemisphere after supratentorial unilateral ischemia using nuclear magnetic resonance spectroscopy-based metabonomics. The permanent middle cerebral artery occlusion model of ischemic stroke was established in rats. Rats were randomly divided into the middle cerebral artery occlusion 1-, 3-, 9-and 24-hour groups and the sham group. ~1H nuclear magnetic resonance spectroscopy was used to detect metabolites in the left and right cerebral hemispheres. Compared with the sham group, the concentrations of lactate, alanine, γ-aminobutyric acid, choline and glycine in the ischemic cerebral hemisphere were increased in the acute stage, while the concentrations of N-acetyl aspartate, creatinine, glutamate and aspartate were decreased. This demonstrates that there is an upregulation of anaerobic glycolysis(shown by the increase in lactate), a perturbation of choline metabolism(suggested by the increase in choline), neuronal cell damage(shown by the decrease in N-acetyl aspartate) and neurotransmitter imbalance(evidenced by the increase in γ-aminobutyric acid and glycine and by the decrease in glutamate and aspartate) in the acute stage of cerebral ischemia. In the contralateral hemisphere, the concentrations of lactate, alanine, glycine, choline and aspartate were increased, while the concentrations of γ-aminobutyric acid, glutamate and creatinine were decreased. This suggests that there is a difference in the metabolite changes induced by ischemic injury in the contralateral and ipsilateral cerebral hemispheres. Our findings demonstrate the presence of characteristic changes in metabolites in the contralateral hemisphere and suggest that they are most likely caused by metabolic changes in the ischemic hemisphere. | Lei Ruan Yan Wang Shu-chao Chen Tian Zhao Qun Huang Zi-long Hu Neng-zhi Xia Jin-jin Liu Wei-jian Chen Yong Zhang Jing-liang Cheng Hong-chang Gao Yun-jun Yang Hou-zhang Sun | 2017 | Neural Regeneration Research2017，12，6： | 6 |
| 11 | Stability of interacting grid-connected power converters显示文摘The power grid in a typical micro distribution system is non-ideal,presenting itself as a voltage source with significant impedance.Thus,grid-connected converters interact with each other via the non-ideal grid.In this study,we consider the practical scenario of voltage-source converters connected to a three-phase voltage source with significant impedance.We show that stability can be compromised in the interacting converters.Specifically,the stable operating regions in selected parameter space may be reduced when grid-connected converters interact under certain conditions.In this paper,we develop bifurcation boundaries in the parameter space with respect to Hopftype instability.A small-signal model in the dq-frame is adopted to analyze the system using an impedance-based approach.Moreover,results are presented in design-oriented forms so as to facilitate the identification of variation trends of the parameter ranges that guarantee stable operation. | Cheng WAN Meng HUANG Chi K.TSE Xinbo RUAN | 2013 | Journal of Modern Power Systems and Clean Energy2013，1，3： | 6 |
| 12 | A high time resolution multi-gap resistive plate chamber显示文摘Research on a single cell Multi-gap Resistive Plate Chamber (MRPC) was carried out for the Time Of Flight detector (TOF) R and D of the STAR experi- ment. The property of the single chamber was tested with the test beam facility T10 at CERN in Geneva. The MRPC was scanned with the test beam to get the efficiency and time resolution at different position of the active area. The HV plateau was also measured. The time resolution is 65 ps which satisfies the requirement of STAR. The working mechanism of the MRPC is also explained. | LI Cheng, WU Jian, WANG Xiao-Lian, CHEN Hong-Fang, XU Zi-Zong, SHAO Ming, YE Shu-Wei, RUAN Li-Juan, HUANG Sheng-Li (Department of Modern Physics, University of Science and Technology of China, Hefei 230027) | 2002 | Nuclear Science and Techniques2002，13，1： | 5 |
| 13 | Molecular characterization of transformation and halogenation of natural organic matter during the UV/chlorine AOP using FT-ICR mass spectrometry显示文摘UV/chlorine process,as an emerging advanced oxidation process(AOP),was effective for removing micro-pollutants via various reactive radicals,but it also led to the changes of natural organic matter(NOM)and formation of disinfection byproducts(DBPs).By using negative ion electrospray ionization coupled with Fourier transform ion cyclotron resonance mass spectrometry(ESI FT-ICR MS),the transformation of Suwannee River NOM(SRNOM)and the formation of chlorinated DBPs(Cl-DBPs)in the UV/chlorine AOP and subsequent post-chlorination were tracked and compared with dark chlorination.In comparison to dark chlorination,the involvement of Cl O·,Cl·,and HO·in the UV/chlorine AOP promoted the transformation of NOM by removing the compounds owning higher aromaticity(AI mod)value and DBE(double-bond equivalence)/C ratio and causing the decrease in the proportion of aromatic compounds.Meanwhile,more compounds which contained only C,H,O,N atoms(CHON)were observed after the UV/chlorine AOP compared with dark chlorination via photolysis of organic chloramines or radical reactions.A total of 833 compounds contained C,H,O,Cl atoms(CHOCl)were observed after the UV/chlorine AOP,higher than 789 CHOCl compounds in dark chlorination,and one-chlorine-containing components were the dominant species.The different products from chlorine substitution reactions(SR)and addition reactions(AR)suggested that SR often occurred in the precursors owning higher H/C ratio and AR often occurred in the precursors owning higher aromaticity.Post-chlorination further caused the cleavages of NOM structures into small molecular weight compounds,removed CHON compounds and enhanced the formation of Cl-DBPs.The results provide information about NOM transformation and Cl-DBPs formation at molecular levels in the UV/chlorine AOP. | Xiaoxue Ruan Yingying Xiang Chii Shang Shuangshuang Cheng Jingfu Liu Zhineng Hao Xin Yang | 2021 | Journal of Environmental Sciences2021，33，4： | 5 |
| 14 | Argininosuccinate synthase 1 suppresses cancer cell invasion by inhibiting STAT3 pathway in hepatocellular carcinoma显示文摘Metastasis is the main reason for high recurrence and poor survival of hepatocellular carcinoma(HCC).The molecular mechanism underlying HCC metastasis remains unclear.In this study,we found that argininosuccinate synthase 1(ASS1)expression was significantly decreased and down-regulation of ASS1 was closely correlated with poor prognosis in HCC patients.DNA methylation led to the down-regulation of ASS1 in HCC.Stable silencing of ASS1 promoted migration and invasion of HCC cells,whereas overexpression of ASS1-inhibited metastasis of HCC cells in vivo and in vitro.We also revealed that ASS1-knockdown increased the phosphorylation level of S727STAT3,which contributed to HCC metastasis by up-regulation of inhibitor of differentiation 1(ID1).These findings indicate that ASS1 inhibits HCC metastasis and may serve as a target for HCC diagnosis and treatment. | Xuemei Tao Qiaozhu Zuo Haoyu Ruan Hui Wang Haojie Jin Zhuoan Cheng Yuanyuan Lv Wenxin Qin Cun Wang | 2019 | Acta Biochimica et Biophysica Sinica2019，51，3： | 4 |
| 15 | Photonic matrix multiplication lights up photonicaccelerator and beyond显示文摘Matrix computation,as a fundamental building block of information processing in science and technology,contributes most of the computational overheads in modern signal processing and artificial intelligence algorithms.Photonic accelerators are designed to accelerate specific categories of computing in the optical domain,especially matrix multiplication,to address the growing demand for computing resources and capacity.Photonic matrix multiplication has much potential to expand the domain of telecommunication,and artificial intelligence benefiting from its superior performance.Recent research in photonic matrix multiplication has flourished and may provide opportunities to develop applications that are unachievable at present by conventional electronic processors.In this review,we first introduce the methods of photonic matrix multiplication,mainly including the plane light conversion method,Mach–Zehnder interferometer method and wavelength division multiplexing method.We also summarize the developmental milestones of photonic matrix multiplication and the related applications.Then,we review their detailed advances in applications to optical signal processing and artificial neural networks in recent years.Finally,we comment on the challenges and perspectives of photonic matrix multiplication and photonic acceleration. | Hailong Zhou Jianji Dong Junwei Cheng Wenchan Dong Chaoran Huang Yichen Shen Qiming Zhang Min Gu Chao Qian Hongsheng Chen Zhichao Ruan Xinliang Zhang | 2022 | Light(Science & Applications)2022，11，2： | 4 |
| 16 | Diosmetin has therapeutic efficacy in colitis regulating gut microbiota, inflammation, and oxidative stress via the circ-Sirt1/Sirt1 axis显示文摘Diosmetin (3',5,7 -trihydroxy-4'-methoxy flavone) is a natural flavonoid compound in the citrus species, it exhibits a variety of pharmacological activities, but little is known of its effects on colitis. In this study we evaluated the therapeutic effects of diosmetin on mouse models of chronic and acute colitis. Chronic colitis was induced in mice by drinking water containing 3% dextran sulfate sodium (DSS) from D0 to D8, followed by administration of diosmetin (25, 50 mg · kg−1 · d−1) for another 8 days. Acute colitis was induced by drinking water containing 5% DSS from D0 to D7, the mice concomitantly received diosmetin (25, 50 mg · kg−1 · d−1) from D1 to D7. During the experiments, body weight and disease activity index (DAI) were assessed daily. After the mice were sacrificed, colon tissue and feces samples were collected, and colon length was measured. We showed that in both models, diosmetin administration significantly decreased DAI score and ameliorated microscopic colon tissue damage;increased the expression of tight junction proteins (occludin, claudin-1, and zonula occludens-1), and reduced the secretion of proinflammatory cytokines IL-1β, IL-6, TNF-α, and Cox-2 in colon tissue. We found that diosmetin administration remarkably inhibited colon oxidative damage by adjusting the levels of intracellular and mitochondrial reactive oxygen species, GSH-Px, SOD, MDA and GSH in colon tissue. The protection of diosmetin against intestinal epithelial barrier damage and oxidative stress were also observed in LPS-treated Caco-2 and IEC-6 cells in vitro. Furthermore, we demonstrated that diosmetin markedly increased the expression of Nrf2 and HO-1 and reduced the ratio of acetylated NF-κB and NF-κB by activating the circ-Sirt1/Sirt1 axis, which inhibited oxidative stress and inflammation in vivo and in vitro. Diosmetin reversed the effects of si-circSirt1 and si-Sirt1 in LPS-treated Caco-2 and IEC-6 cells. When the gut microbiota was analyzed in the mouse model of colitis, we found that diosmetin administration modulated the abundance of Bacteroidetes, Actinobacteria, Cyanobacteria and Firmicutes, which were crucial for inflammatory bowel disease. Our results have linked colitis to the circ-Sirt1/Sirt1 signaling pathway, which is activated by diosmetin. The results imply that diosmetin may be a novel candidate to alleviate DSS-induced colitis and can be a lead compound for future optimization and modification. | Hai-long Li Yi-ying Wei Xiao-he Li Shan-shan Zhang Ruo-tong Zhang Jin-he Li Bo-wei Ma Shuai-bo Shao Zi-wei Lv Hao Ruan Hong-gang Zhou Cheng Yang | 2022 | Acta Pharmacologica Sinica2022，43，4： | 4 |
| 17 | Dehydroepiandrosterone anti-atherogenesis effect is not via its conversion to estrogen显示文摘 | Heng-hui CHENG Xiao-jing HU Qiu-rong RUAN | 2009 | Acta Pharmacologica Sinica2009，30，1： | 4 |
| 18 | The seismicity and tectonic stress field characteristics of the Longmenshan fault zone before the Wenchuan M_S8.0 earthquake显示文摘The seismicity of Longmenshan fault zone and its vicinities before the 12 May 2008 Wenchuan MS8.0 earthquake is studied.Based on the digital seismic waveform data observed from regional seismic networks and mobile stations, the focal mechanism solutions are determined.Our analysis results show that the seismicities of Longmenshan fault zone before the 12 May 2008 Wenchuan earthquake were in stable state.No obvious phenomena of seismic activity intensifying appeared.According to focal mechanism solutions of some small earthquakes before the 12 May 2008 Wenchuan earthquake, the direction of principal compressive stress P-axis is WNW-ESE.The two hypocenter fault planes are NE-striking and NW-striking.The plane of NE direction is among N50o?70oE, the dip angles of fault planes are 60o?70o and it is very steep.The faultings of most earthquakes are dominantly characterized by dip-slip reverse and small part of faultings present strike-slip.The azimuths of principal compressive stress, the strikes of source fault planes and the dislocation types calculated from some small earthquakes before the 12 May 2008 Wenchuan earthquake are in accordance with that of the main shock.The average stress field of micro-rupture along the Longmenshan fault zone before the great earthquake is also consistent with that calculated from main shock.Zipingpu dam is located in the east side 20 km from the initial rupture area of the 12 May 2008 Wenchuan earthquake.The activity increment of small earthquakes in the Zipingpu dam is in the period of water discharging.The source parameter results of the small earthquakes which occurred near the initial rupture area of the 12 May 2008 Wenchuan earthquake indicate that the focal depths are 5 to 14 km and the source parameters are identical with that of earthquake. | Zhiwei Zhang Wanzheng Cheng Xiang Ruan Peng Wu | 2009 | Earthquake Science2009，22，2： | 3 |
| 19 | First experimental constraints on WIMP couplings in the effective field theory framework from CDEX显示文摘We present weakly interacting massive particles(WIMPs) search results performed using two approaches of effective field theory from the China Dark Matter Experiment(CDEX), based on the data from both CDEX-1B and CDEX-10 stages. In the nonrelativistic effective field theory approach, both time-integrated and annual modulation analyses were used to set new limits for the coupling of WIMP-nucleon effective operators at 90% confidence level(C.L.) and improve over the current bounds in the low mχregion. In the chiral effective field theory approach, data from CDEX-10 were used to set an upper limit on WIMP-pion coupling at 90% C.L. We for the first time extended the limit to the m_(χ)<6 GeV/c^(2) region. | Yi Wang Zhi Zeng Qian Yue LiTao Yang KeJun Kang YuanJing Li Mehment Agartioglu HaiPeng An JianPing Chang JingHan Chen YunHua Chen JianPing Cheng Cheng Yi Chiang WenHan Dai Zhi Deng ChangHao Fang XinPing Geng Hui Gong QiuJu Guo XuYuan Guo HongJian He Li He ShengMing He JinWei Hu TuChen Huang HanXiong Huang HaiTao Jia LiPing Jia Xi Jiang HauBin Li JianMin Li Jin Li MingXuan Li RenMingJie Li Xia Li YuLan Li Bin Liao FongKay Lin ShinTed Lin ShuKui Liu YanDong Liu Yu Liu YuanYuan Liu ZhongZhi Liu Hao Ma YuCai Mao QiYuan Nie JinHua Ning Hui Pan NingChun Qi Jie Ren XiChao Ruan ChangSong Shang Vivek Sharma Ze She Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian Tang WeiYou Tang Yang Tian GuangFu Wang Li Wang Qing Wang Yu Chen Wang YunXiang Wang Zhen Wang Henry Tsz-King Wong ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue YuLu Yan Nan Yi ChunXu Yu HaiJun Yu JianFeng Yue Ming Zeng BingTao Zhang Lei Zhang FengShou Zhang ZhenYu Zhang KangKang Zhao MingGang Zhao JiFang Zhou ZuYing Zhou JingJun Zhu | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，8： | 3 |
| 20 | A super pan-genomic landscape of rice显示文摘Pan-genomes from large natural populations can capture genetic diversity and reveal genomic complexity.Using de novo longread assembly,we generated a graph-based super pan-genome of rice consisting of a 251-accession panel comprising both cultivated and wild species of Asian and African rice.Our pan-genome reveals extensive structural variations(SVs)and gene presence/absence variations.Additionally,our pan-genome enables the accurate identification of nucleotide-binding leucine-rich repeat genes and characterization of their inter-and intraspecific diversity.Moreover,we uncovered grain weight-associated SVs which specify traits by affecting the expression of their nearby genes.We characterized genetic variants associated with submergence tolerance,seed shattering and plant architecture and found independent selection for a common set of genes that drove adaptation and domestication in Asian and African rice.This super pan-genome facilitates pinpointing of lineage-specific haplotypes for trait-associated genes and provides insights into the evolutionary events that have shaped the genomic architecture of various rice species. | Lianguang Shang Xiaoxia Li Huiying He Qiaoling Yuan Yanni Song Zhaoran Wei Hai Lin Min Hu Fengli Zhao Chao Zhang Yuhua Li Hongsheng Gao Tianyi Wang Xiangpei Liu Hong Zhang Ya Zhang Shuaimin Cao Xiaoman Yu Bintao Zhang Yong Zhang Yiqing Tan Mao Qin Cheng Ai Yingxue Yang Bin Zhang Zhiqiang Hu Hongru Wang Yang Lv Yuexing Wang Jie Ma Quan Wang Hongwei Lu Zhe Wu Shanlin Liu Zongyi Sun Hongliang Zhang Longbiao Guo Zichao Li Yongfeng Zhou Jiayang Li Zuofeng Zhu Guosheng Xiong Jue Ruan Qian Qian | 2022 | Cell Research2022，32，10： | 3 |
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