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| 1 | Generation of haploid embryonic stem cells from Macaca fascicularis monkey parthenotes显示文摘在从经由单性生殖和男性单性生殖的老鼠的胚胎的干细胞(haESCs ) 启用了在修改基因的动物的哺乳动物的房间和代的基因屏蔽的 haploid 的推导的最近的成功。然而, haESCs 是否能从首领被导出,仍然保持未知。这里,我们从 Macaca fascicularis 猴子的单性生殖的胚囊报导 haESCs 的推导。这些房间,作为 PG-haESCs 称为,是 pluripotent 并且能在 vitro 或在 vivo 区分到三胚胎的细菌层的房间。有趣地,一根猴子 PG-haESC 线(MPH1 ) 的 haploidy 与另一个(MPH2 ) 的相比是更稳定的,作为没有排序的激活荧光的房间(FACS ) ,由 haploid 房间的存在出现超过 140 天 haploid 房间的丰富。重要地,转基因的猴子 PG-haESC 线能被 lentivirus- 和 piggyBac 产生调停 transposon 的基因转移。而且,基因屏蔽在猴子 PG-haESCs 是可行的。我们的结果证明 PG-haESCs 能从猴子被产生,提供为在首领的基因分析的一个理想的工具。 | Hui Yang Zhen Liu Yu Ma Cuiqing Zhong Qi Yin Chikai Zhou Linyu Shi Yijun Cai Hanzhi Zhao Hui Wang Fan Tang Yan Wang Chenchen Zhang Xin-yuan Liu Dongmei Lai Ying Jin Qiang Sun Jinsong Li | 2013 | Cell Research2013，23，10： | 22 |
| 2 | dentification of TRA2B-DNAH5 fusion as a novel oncogenic driver in human lung squamous cell carcinoma显示文摘 | Fei Li Zhaoyuan Fang Jian Zhang Chen Li Hongyan Liu Jufeng Xia Hongwen Zhu Chenchen auo Zhen Qin Fuming Li Xiangkun Han Yuetong Wang Yan Feng Ye Wang Wenjing Zhang Zuoyun Wang Yujuan Jin Yihua Sun Wenyi Wei Rong Zeng Haiquan Chen Hongbin Ji | 2016 | Cell Research2016，26，10： | 9 |
| 3 | Exosomal PD-L1 induces osteogenic differentiation and promotes fracture healing by acting as an immunosuppressant显示文摘A moderate inflammatory response at the early stages of fracture healing is necessary for callus formation.Over-active and continuous inflammation,however,impairs fracture healing and leads to excessive tissue damage.Adequate fracture healing could be promoted through suppression of local over-active immune cells in the fracture site.In the present study,we achieved an enriched concentration of PD-L1 from exosomes(Exos)of a genetically engineered Human Umbilical Vein Endothelial Cell(HUVECs),and demonstrated that exosomes overexpressing PD-L1 specifically bind to PD-1 on the T cell surface,suppressing the activation of T cells.Furthermore,exosomal PD-L1 induced Mesenchymal Stem Cells(MSCs)towards osteogenic differentiation when pre-cultured with T cells.Moreover,embedding of Exos into an injectable hydrogel allowed Exos delivery to the surrounding microenvironment in a time-released manner.Additionally,exosomal PD-L1,embedded in a hydrogel,markedly promoted callus formation and fracture healing in a murine model at the early over-active inflammation phase.Importantly,our results suggested that activation of T cells in the peripheral lymphatic tissues was inhibited after local administration of PD-L1-enriched Exos to the fracture sites,while T cells in distant immune organs such as the spleen were not affected.In summary,this study provides the first example of using PD-L1-enriched Exos for bone fracture repair,and highlights the potential of Hydrogel@Exos systems for bone fracture therapy through immune inhibitory effects. | Ze Lin Yuan Xiong Weilin Meng Yiqiang Hu Lili Chen Lang Chen Hang Xue Adriana CPanayi Wu Zhou Yun Sun Faqi Cao Guodong Liu Liangcong Hu Chenchen Yan Xudong Xie Chuanchuan Lin Kaiyong Cai Qian Feng Bobin Mi Guohui Liu | 2022 | Bioactive Materials2022，7，7： | 4 |
| 4 | Cu3(PO4)2: Novel Anion Convertor for Aqueous Dual‑Ion Battery显示文摘Electrode materials which can reversibly react with anions are of interest for aqueous dual-ion batteries.Herein,we propose a novel anion electrode,Cu3(PO4)2,for constructing an aqueous dual-ion cell.The Cu3(PO4)2 electrode can operate in a quasi-neutral condition and deliver a reversible capacity of 115.6 mAh g^−1 with a well-defined plateau at−0.17 V versus Ag/AgCl.Its reaction mechanism shows that Cu3(PO4)2 decomposes into Cu2O and subsequently is converted into Cu during the initial discharge process.In the following charge process,Cu is oxidized into Cu2O.It suggests Cu3(PO4)2 reacts with OH−ions instead of PO43−ions after the initial discharge process and its potential thereby depends upon the OH−ions concentration in electrolyte.Additionally,an aqueous dual-ion cell is built by using pretreated Cu3(PO4)2 and Na0.44MnO2 as anode and cathode,respectively.During cycling,OH−ions and Na^+ions in electrolyte can be stored and released.Such a cell can provide a discharge capacity of 52.6 mAh g^−1 with plateaus at 0.70 and 0.45 V,exhibiting the potential of application.This work presents an available aqueous dual-ion cell and provides new insights into renewable energy storage and adjustment of the OH−ions concentration in aqueous buffer solution. | Haoxiang Yu Chenchen Deng Huihui Yan Maoting Xia Xikun Zhang Zhen‑Bo Wang Jie Shu | 2021 | Nano-Micro Letters2021，13，3： | 3 |
| 5 | miR-345 inhibits migration and stem-like cell phenotype in gastric cancer via inactivation of Rac1 by targeting EPS8显示文摘Tumor metastasis is the main cause of treatment failure and death in patients with late stage of gastric cancer(GC).Studies showed that microRNAs(miRNAs)are important regulators in the process of tumor metastasis.In this study,we used miRNA array analysis to search for metastasisassociated miRNAs in primary and matched metastasis tissues of patients with GC and found that miR-345-5p(miR-345)was significantly higher in primary sites.Decreased expression of miR-345 was observed in GC tissues and cell lines,which was correlated with aggressive stage and grade.Patients with a higher level of miR-345 had a better prognosis,miR-345 could inhibit the migration and spheroid formation abilities in GC cell lines in transwell assay and spheroid formation assay.RNA sequencing and bioinformatics analysis revealed that miR-345 downregulated the epidermal growth factor receptor pathway substrate 8(EPS8)and its downstream Rac1 signaling.Mechanistically,we confirmed that miR-345 could target EPS8 by directly binding to its 3'untranslated region by luciferase reporter assay.Further rescue assay showed that the ability of miR-345 in inhibiting the migration,stem-like cell phenotype,and epithelial-mesenchymal transition(EMT)in GC was partly dependent on targeting EPS8.In conclusion,miR-345 plays an inhibitory role in GC metastasis through inhibiting cell migration,EMT,and cancer stem cell phenotype via inactivation of Rac1 signaling by targeting EPS8,which provides the potential therapeutic and predictive value of miR-345 in GC. | Jieyun Zhang Chenchen Wang Shican Yan Yanan Yang Xiaowei Zhang Weijian Guo | 2020 | Acta Biochimica et Biophysica Sinica2020，52，3： | 3 |
| 6 | Congestive heart failure in COX2 deficient rats显示文摘Non-steroidal anti-inflammatory drugs(NSAIDs)inhibit prostaglandin(PG)formation by targeting cyclooxygenase(COX)1 and 2.Long-term use of NSAIDs that selectively inhibit COX2 increases the risk for thrombotic events,cardiac failure,and hypertension.However,the underlying mechanisms remain unclear.In this study,COX1-and COX2-deficient rats were created via Cas9/RNA-mediated gene targeting.DNA genotyping and Western blot analysis confirmed successful generation of COX1^(-/-) and COX2^(-/-) rats.Adult COX1^(-/-) rats grew normally,while more than 70%of COX2^(-/-) rats after wean died within 2 months.Echocardiography showed markedly reduced left ventricular ejection fraction and fractional shortening in adult COX2^(-/-) rats compared to those in wildtype(WT)controls.Histological analysis revealed accumulation of inflammatory cells and severe interstitial and perivascular fibrosis in COX2^(-/-)cardiac tissues.Moreover,cardiac ATP and acetyl-Co A production was dramatically decreased in COX2^(-/-) rats.Consistently,the expression of genes related to mitochondrial oxidation,such as those that encode for subunits of pyruvate dehydrogenase complex and acyl Co A dehydrogenases,were downregulated,while glycolytic hexokinase 1(HK1)was upregulated in COX2^(-/-) heart tissues.These observations indicate that COX2-deficient rats developed spontaneously heart failure,likely as a result of dysregulated cardiac energy metabolism. | Qiangyou Wan Deping Kong Qian Liu Shumin Guo Chenchen Wang Yan Zhao Zun-Ji Ke Ying Yu | 2021 | Science China(Life Sciences)2021，64，7： | 3 |
| 7 | Association of systemic inflammation and body mass index with survival in patients with resectable gastric or gastroesophageal junction adenocarcinomas显示文摘Objective:The systemic inflammation index and body mass index(BMI)are easily accessible markers that can predict mortality.However,the prognostic value of the combined use of these two markers remains unclear.The goal of this study was therefore to evaluate the association of these markers with outcomes based on a large cohort of patients with gastric cancer.Methods:A total of 2,542 consecutive patients undergoing radical surgery for gastric or gastroesophageal junction adenocarcinoma between 2009 and 2014 were included.Systemic inflammation was quantified by the preoperative neutrophil-to-lymphocyte ratio(NLR).High systemic inflammation was defined as NLR≥3,and underweight was defined as BMI<18.5 kg/m2.Results:Among 2,542 patients,NLR≥3 and underweight were common[627(25%)and 349(14%),respectively].In the entire cohort,NLR≥3 or underweight independently predicted overall survival(OS)[hazard ratio(HR):1.236,95%confidence interval(95%CI):1.069–1.430;and HR:1.600,95%CI:1.350–1.897,respectively]and recurrence-free survival(RFS)(HR:1.230,95%CI:1.054–1.434;and HR:1.658,95%CI:1.389–1.979,respectively).Patients with both NLR≥3 and underweight(vs.neither)had much worse OS(HR:2.445,95%CI:1.853–3.225)and RFS(HR:2.405,95%CI:1.802–3.209).Furthermore,we observed similar results in subgroup analyses according to pathological stage,age,and postoperative chemotherapy.Conclusions:Our results showed that preoperative elevated NLR and decreased BMI had a significant negative effect on survival.Underweight combined with severe inflammation could enhance prognostication.Taking active therapeutic measures to reduce inflammation and increase nutrition may help improve outcomes. | Xianchun Gao Yanan Pan Weili Han Caie Hu Chenchen Wang Ling Chen Yong Guo Yupeng Shi Yan Pan Huahong Xie Liping Yao Jianjun Yang Jianyong Zheng Xiaohua Li Xiaonan Liu Liu Hong Jipeng Li Mengbin Li Gang Ji Zengshan Li Jielai Xia Qingchuan Zhao Daiming Fan Kaichun Wu Yongzhan Nie | 2021 | Cancer Biology & Medicine2021，18，1： | 2 |
| 8 | GRP78 inhibits macrophage adhesion via SR-A显示文摘Class A scavenger receptor(SR-A)plays an important role in macrophage adhesion.However,the underlying mechanism remains unclear.We previously found that 78 kDa glucose-regulated protein(GRP78)inhibited SRA-mediated ligand internalization into macrophage by binding to SR-A.The aim of the study was to investigate whether GRP78 could regulate SR-A-mediated cell adhesion.We demonstrated that GRP78 bound directly to SR-A by fluorescence resonance energy transfer(FRET)assay.Overexpression of GRP78 inhibited macrophage adhesion via SR-A.These results suggest that GRP78 may act as an inhibitor of macrophage adhesion via SR-A. | Hui Bai Nan Li Xiaodan Zhou Chenchen Wang Yan Zhang Xudong Zhu Min Huang Yaoyu Chen Xiaoyu Li Qing Yang Chaojun Li Jingjing Ben Qi Chen | 2014 | The Journal of Biomedical Research2014，28，4： | 2 |
| 9 | Freeze-drying and hot-pressing strategy to embed two-dimensional Ti_(0.87)O_(2) monolayers in commercial polypropylene films with enhanced dielectric properties显示文摘The dielectric capacitor has been widely used in advanced electronic and electrical power systems due to its capability of ultrafast charging–discharging and ultrahigh power density.Nevertheless,its energy density is still limited by the low dielectric constant(≈2.2)of the commercial dielectric polypropylene(PP).The conventional enhancement strategy by embedding inorganic fillers in PP matrix is still difficult and challenging due to that PP hardly dissolves in any inorganic/organic solvent.In this work,we develop a new strategy including freeze-drying,surface functionalization,and hot-pressing to incorporate Ti_(0.87)O_(2) monolayers in PP film.A series of uniform composited Ti_(0.87)O_(2)@PP film has been successfully fabricated with Ti0.87O2 content range of 0–15 wt%.The maximum dielectric constant of the as-prepared Ti_(0.87)O_(2)@PP film is 3.27 when the Ti_(0.87)O_(2) content is 9 wt%,which is about 1.5 times higher than that of pure PP.Our study provides a feasible strategy to embed two-dimensional material into commercial PP thin-film with superior dielectric performance for practical application. | Wenchao Tian Fei Yan Cailing Cai Zeyi Wu Chenchen Zhang Ting Yin Sijia Lao Linfeng Hu | 2021 | Journal of Advanced Ceramics2021，10，2： | 1 |
| 10 | Houttuynia cordata polysaccharides alleviate ulcerative colitis by restoring intestinal homeostasis显示文摘Houttuynia cordata is traditionally used as phytoantibiotics for treating lung disease in China.Houttuynia cordata polysaccharides(HCPs)have been reported to alleviate influenza virus-induced intestinal and lung immune injury by regulating the gutlung axis.The present study aims to investigate the effects and mechanisms of HCPs on ulcerative colitis(UC).Male C57BL/6 mice were induced by dextran sodium sulfate(DSS)to establish the UC animal model.Our results showed that HCPs significantly reduced the weight loss and the shortening of colon length in colitis mice,and relieved the pathological damage of colon mucosa and inhibited the expression of pro-inflammatory cytokines such as TNF-α,IL-1β,IL-6,etc.It was suggested that HCPs could significantly improve DSS-induced colitis in mice.HCPs directly protected intestinal epithelial cells,ameliorated epithelial barrier dysfunction and cell apoptosis,which was also proved in H2O2 stimulated cell apoptosis model.HCPs inhibited inflammation in the colon,which was related to suppressing the infiltration of macrophages,inhibiting the expression of pro-inflammatory cytokines and proteins(TLR4,NF-κB),and restoring the dysfunction of Th17 and Treg cells.HCPs also restored the alteration of intestinal flora induced by DSS,increased the abundance of Firmicutes and Bacteroides,and reduced the abundance of Proteobacteria.This study confirmed the protective effect of Houttuynia cordata polysaccharide extracted from traditional Chinese medicine on ulcerative colitis,of which the mechanism was closely related to the maintenance of intestinal homeostasis(intestinal barrier,immune cells,and intestinal bacteria). | CEN Lifeng YI Tong HAO Yuanzhen SHI Chenchen SHI Xunlong LU Yan CHEN Daofeng ZHU Haiyan | 2022 | Chinese Journal of Natural Medicines2022，20，12： | 1 |
| 11 | Effects of casein glycomacropeptide on the early development of primary colorectal cancer in rats显示文摘In this paper,we utilized dimethylhydrazine(DMH)-induced colorectal cancer(CC)model rats to explore the effects of casein glycomacropeptide(CGMP)on colorectal cancer.Rats with CC were orally administrated with 10,50,or 100 mg/kg bw d CGMP,or the same volume of phosphatebuffered saline for 15 weeks.The total numbers of aberrant crypt foci(ACF)and crypts per focus in colon were scored using a light microscope at low magnification after the colon was stained with methylene blue solutions.The methylation level of DNA extracted from colon was detected using methylation-specific PCR.The expression of p16 and mucin 2(MUC2)proteins were measured by immunohistochemistry.The results showed that although ACF were found in rats treated with CGMP,their number was significantly decreased compared to that of model rats.In addition,methylation and expression levels of p16 and MUC2 were also inhibited by CGMP,which were more obvious in rats treated with 50 mg/kg bw d CGMP.In conclusion,CGMP has potential application as nutritional therapy for preventing colorectal cancer.©2013 Beijing Academy of Food Sciences.Production and hosting by Elsevier B.V.All rights reserved. | Qingsen Chen Yun Liang Chenchen Zhu Yali Yan Guangchang Pang | 2013 | Food Science and Human Wellness2013，2，3： | 1 |
| 12 | Enhanced tissue regeneration through immunomodulation of angiogenesis and osteogenesis with a multifaceted nanohybrid modified bioactive scaffold显示文摘Major traumatic tissue defects are common clinical problems often complicated by infection and local vascular dysfunction, processes which hinder the healing process. Although local application of growth factors or stem cells through various tissue engineering techniques are promising methods for the repair of tissue defects, limitations in their clinical application exist. Herein, we synthesized multifaceted nanohybrids composed of Quaternized chitosan (QCS), Graphene oxide (GO), and Polydopamine (PDA;QCS-GO-PDA). Covalent grafting of QCS and GO at a mass ratio of 5:1 (5QCS-1GO) displayed excellent biocompatibility and enhanced osteogenic ability, while addition of PDA (5QCS-1GO-PDA) reduced the level of reactive oxygen species (ROS). 5QCS-1GO-PDA was able to achieve wound tissue regeneration by reducing the inflammatory response and enhancing angiogenesis. Furthermore, Polylactic acid/hydroxyapatite (PLA/HA) composite scaffolds were printed using Selective Laser Sintering (SLS) and the hybrid nanomaterial (5QCS-1GO-PDA) was used to coat the PLA/HA scaffold (5QCS-1GO-PDA@PLA/HA) to be used for rapid bone regeneration. 5QCS-1GO-PDA not only improved angiogenesis and osteogenic differentiation, but also induced M2-type polarization of macrophages and promoted bone regeneration via the BMP2/BMPRs/Smads/Runx2 signaling pathway. The bidirectional enhanced healing ability of the multifaceted nanohybrids 5QCS-1GO-PDA provides a promising method of effectively treating tissue defects. | Hang Xue Zhenhe Zhang Ze Lin Jin Su Adriana CPanayi Yuan Xiong Liangcong Hu Yiqiang Hu Lang Chen Chenchen Yan Xudong Xie Yusheng Shi Wu Zhou Bobin Mi Guohui Liu | 2022 | Bioactive Materials2022，7，12： | 1 |
| 13 | Construction of Porcine Growth Hormone Eukaryotic Expression Vector and Its Transfection Mediated by Cationic Liposome in Mice显示文摘 | Chenchen Peng Lihong Wang Zizhu Chen Lei Ma Yan Wei Zhangfu Long | 2011 | Animal Biotechnology2011，，4： | 1 |
| 14 | Dynamic evaluation of land productivity in China显示文摘For making rational and scientific land-use planning,an inventory indicator of land productivity subject to biophysical limitations and human disturbance is required.This study introduces agricultural land productivity(ALP)as the dynamic indicator to measure land productivity,involving factors that affect agricultural production,such as characteristics of climate,soil,and terrain.As a case study of this dynamic indicator,ALP was estimated at county level and aggregated into provincial level in the whole of China.The result shows that ALP increased during 2000-2010 in China,and the ratios of ALP to the actual grain yield were 65.40%and 66.38%in the years 2000 and 2005,respectively.The ALP is an effective dynamic indicator to estimate the land productivity and to represent the basic conditions about the supply of water,energy,nutrients,and the physical basis for plant growth,as well as the local input.ALP estimation could provide supporting information for policy-making about land production planning and land-use management. | Rui Yu Xiangzheng Deng Zhe Yan Chenchen Shi | 2013 | Chinese Journal of Population,Resources and Environment2013，11，3： | 0 |
| 15 | A New Discovery of Ag-Pb-Zn Mineralization via Modern Portable Analytical Technology and Stream Sediment Data Processing Methods in Dajiacuo Area, Western Tibet(China)显示文摘Tibet, which is rich in mineral resources, is a treasure trove for geological explorers. However, prospecting work has been slow, especially in the western part, due to the precipitous terrain, changeable climate and low access. Hence, modern advanced field analytical technology and effective data processing methods play significant roles in rapid and efficient exploration in Tibet. In this paper, spectrum-area fractal modeling and portable X-ray fluorescence analysis(pXRFA) were used to identify and verify geochemical anomalies associated with Ag-Pb-Zn mineralization based on a stream-sediment dataset of 39 elements in the Dajiacuo-Xurucuo region of western Tibet. First, staged factor analysis(SFA) was used to obtain the Ag-Pb-Zn-Cd geochemical assemblage. Second, the first-factor pattern obtained using SFA was dissociated by a spectrum-area(S-A) fractal model and a digital elevation model(DEM)-based geochemical model(DGM) was constructed. Finally, the sections of Ag, Cd, Pb, and Zn were obtained using pXRFA. The results show that Ag-Pb-Zn-Cd enrichment zones were mostly located around the contact belt of volcanic rocks and intrusions, or along SE-NW trending faults. Considering the variable terrain and catchment basin, the extension of long axes of Ag-Pb-Zn-Cd anomalies into higher elevation areas that are favorable for Ag-Pb-Zn mineralization should be investigated. Anomaly maps created with the aid of a DGM show promising potential for mineralization in the Dajiacuo-Xurucuo region, and abundant Ag-Pb-Zn mineralization was identified with the assistance of pXRFA in the source areas for the geochemical anomalies in the Dajiacuo. We conclude that SFA and the S-A fractal model constitute a valid tool to identify or verify geochemical anomalies in areas of low-density stream-sediment sampling. The pXRFA can accurately determine the source of geochemical anomalies and improve anomaly verification efficiency. | Xiaojia Jiang Xin Chen Shunbao Gao Youye Zheng Huan Ren Denghui Han Chenchen Yan Junsheng Jiang | 2020 | Journal of Earth Science2020，31，4： | 0 |
| 16 | The complete mitochondrial genome of Parnassius actius(Lepidoptera: Papilionidae: Parnassinae) with the related phylogenetic analysis显示文摘In this study, the complete mitochondrial genome of Parnassius actius(Lepidoptera: Papilionidae: Parnassinae) was reported. Meanwhile, the phylogenetic position of this Apollo species was inferred from this sequence combined with other available related sequence data. The results showed that the whole mitogenome is 15,386 bp in length, containing 13 typical protein-coding genes(PCGs), 22 transfer RNA genes(t RNAs), two ribosomal RNA genes(r RNAs) and a noncoding control region(A+T-rich region). The mitogenomic gene orientation and arrangement are the same with other sequenced Parnassius species. Thirteen protein coding genes is 11,195 bp in size, encoding 3,720 amino acids totally; the lr RNA and sr RNA genes are 1,351 bp and 779 bp, respectively. Eleven intergenic spacers ranging from 1 to 40 bp(129 bp in total), 10 overlapping regions from 1 to 8 bp(26 bp in total), and a 504 bp A+T-rich region harboring some Parnassius-specific sequences are scattered throughout the whole mitogenome. The maximum likelihood and Bayesian phylogenetic analyses showed that the genus Parnassiusof this study contained five major clades which can be categorized into the eight subgenera reported by the previous molecular studies; additionally, the P. actius was shown to be more closely related to P. nomion than other Parnassius species, suggesting that the P. actius stands as an effective species with its phylogenetic position awaiting further studies. | Bin Zheng Yunliang Wang Chenchen Xia Dunyuan Huang Yan Cao Jiasheng Hao Chaodong Zhu | 2018 | Zoological Systematics2018，43，1： | 0 |
| 17 | TiO_(2)@palygorskite composite for the efficient remediation of oil spills via a dispersion-photodegradation synergy显示文摘Removing spilled oil from the water surface is critically important given that oil spill accidents are a common occurrence.In this study,TiO_(2)@Palygorskite composite prepared by a simple coprecipitation method was used for oil spill remediation via a dispersion-photodegradation synergy.Diesel could be efficiently dispersed into small oil droplets by TiO_(2)@Palygorskite.These dispersed droplets had an average diameter of 20-30µm and exhibited good time stability.The tight adsorption of TiO_(2)@Palygorskite on the surface of the droplets was observed in fluorescence and SEM images.As a particulate dispersant,the direct contact of TiO_(2)@Palygorskite with oil pollutants effectively enhanced the photodegradation efficiency of TiO_(2)for oil.During the photodegradation process,·O_(2)^(−)and•OH were detected by ESR and radical trapping experiments.The photodegradation efficiency of diesel by TiO_(2)@Palygorskite was enhanced by about 5 times compared with pure TiO_(2)under simulated sunlight irradiation.The establishment of this new dispersion-photodegradation synergistic remediation system provides a new direction for the development of marine oil spill remediation. | Chenchen Li Lijie Yan Yiming Li Dan Zhang Mutai Bao Limei Dong | 2021 | Frontiers of Environmental Science & Engineering2021，15，4： | 0 |
| 18 | Identification of TAZ as the essential molecular switch in orchestrating SCLC phenotypic transition and metastasis显示文摘Small-cell lung cancer(SCLC)is a recalcitrant cancer characterized by high metastasis.However,the exact cell type contributing to metastasis remains elusive.Using a Rb1^(L/L)/Trp53^(L/L) mouse model,we identify the NCAM^(hi)CD44^(lo/–) subpopulation as the SCLC metastasizing cell(SMC),which is progressively transitioned from the non-metastasizing NCAM^(lo)CD44^(hi) cell(non-SMC).Integrative chromatin accessibility and gene expression profiling studies reveal the important role of the SWI/SNF complex,and knockout of its central component,Brg1,significantly inhibits such phenotypic transition and metastasis.Mechanistically,TAZ is silenced by the SWI/SNF complex during SCLC malignant progression,and its knockdown promotes SMC transition and metastasis.Importantly,ectopic TAZ expression reversely drives SMC-to-non-SMC transition and alleviates metastasis.Single-cell RNA-sequencing analyses identify SMC as the dominant subpopulation in human SCLC metastasis,and immunostaining data show a positive correlation between TAZ and patient prognosis.These data uncover high SCLC plasticity and identify TAZ as the key molecular switch in orchestrating SCLC phenotypic transition and metastasis. | Yujuan Jin Qiqi Zhao Weikang Zhu Yan Feng Tian Xiao Peng Zhang Liyan Jiang Yingyong Hou Chenchen Guo Hsinyi Huang Yabin Chen Xinyuan Tong Jiayu Cao Fei Li Xueliang Zhu Jun Qin Dong Gao Xin-Yuan Liu Hua Zhang Luonan Chen Roman KThomas Kwok-Kin Wong Lei Zhang Yong Wang Liang Hu Hongbin Ji | 2022 | National Science Review2022，9，7： | 0 |
| 19 | Continuously Quantifying Oral Chemicals Based on Flexible Hybrid Electronics for Clinical Diagnosis and Pathogenetic Study显示文摘Simultaneous monitoring of diverse salivary parameters can reveal underlying mechanisms of intraoral biological processes and offer profound insights into the evolution of oral diseases.However,conventional analytical devices with bulky volumes,rigid formats,and discrete sensing mechanisms deviate from the requirements of continuous biophysiological quantification,resulting in huge difficulty in precise clinical diagnosis and pathogenetic study.Here,we present a flexible hybrid electronic system integrated with functional nanomaterials to continuously sense Ca^(2+),pH,and temperature for wireless real-time oral health monitoring.The miniaturized system with an island-bridge structure that is designed specifically to fit the teeth is only 0.4g in weight and 31.5×8.5×1.35 mm^(3) in dimension,allowing effective integration with customized dental braces and comfort attachment on teeth.Characterization results indicate high sensitivities of 30.3 and 60.6 mV/decade for Ca^(2+)and pH with low potential drifts.The system has been applied in clinical studies to conduct Ca^(2+)and pH mappings on carious teeth,biophysiological monitoring for up to 12 h,and outcome evaluation of dental restoration,providing quantitative data to assist in the diagnosis and understanding of oral diseases.Notably,caries risk assessment of 1o human subjects using the flexible system validates the important role of saliva buffering capacity in caries pathogenesis.The proposed flexible system may offer an open platform to carry diverse components to support both clinical diagnosis and treatment as well as fundamental researchfororaldiseases and induced systemicdiseases. | Wei Lingo Yinghui Wang ingyu Lu Xue Shang Ziyue Wu Zhaorun Chen Xueting Li Chenchen Zou Jinjie Yan Yunjie Zhou Jie Liu Hongjie Li Kehua Que Xian Huan | 2022 | Research2022，，4： | 0 |
| 20 | Correction to:Identification of TAZ as the essential molecular switch in orchestrating SCLC phenotypic transition and metastasis显示文摘This is a correction to:Yujuan Jin,Qiqi Zhao,Weikang Zhu,Yan Feng,Tian Xiao,Peng Zhang,Liyan Jiang,Yingyong Hou,Chenchen Guo,Hsinyi Huang,Yabin Chen,Xinyuan Tong,Jiayu Cao,Fei Li,Xueliang Zhu,Jun Qin,Dong Gao,Xin-Yuan Liu,Hua Zhang,Luonan Chen,Roman K Thomas,Kwok-Kin Wong,Lei Zhang,Yong Wang,Liang Hu,Hongbin Ji,Identification of TAZ as the essential molecular switch in orchestrating SCLC phenotypic transition and metastasis,National Science Review,Volume 9,Issue 7,July 2022,nwab232,http://gffzzd3cc09b8251d45dfsqqfbbffuqbk96pco.ffgz.tsg.suse.edu.cn/10.1093/nsr/nwab232. | Yujuan Jin Qiqi Zhao Weikang Zhu Yan Feng Tian Xiao Peng Zhang Liyan Jiang Yingyong Hou Chenchen Guo Hsinyi Huang Yabin Chen Xinyuan Tong Jiayu Cao Fei Li Xueliang Zhu Jun Qin Dong Gao Xin-Yuan Liu Hua Zhang Luonan Chen Roman KThomas Kwok-Kin Wong Lei Zhang Yong Wang Liang Hu Hongbin Ji | 2023 | National Science Review2023，10，12： | 0 |
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