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| 1 | Antioxidant activity and identification of bioactive compounds from leaves of Anthocephalus cadamba by ultra-performance liquid chromatography/electrospray ionization quadrupole time of flight mass spectrometry显示文摘Objective:To evaluate the antioxidant potential of different extract/fractions of Anthocephalus cadamba(A.cadamba)(Roxb.) Miq.(Rubiaceae) and study the tentative identification of their active constituents.Methods:The extract/fractions were screened for antioxidant activity using various in vitro assays viz.DPPH assay,ABTS assay,superoxide anion radical scavenging assay, reducing power assay and plasmid DNA nicking assay.Total phenolic content of extract/fractions was determined by colorimetric method.An ultra-performance LC-electrospray-quadrupoletime of flight mass spectrometry method was used to analyse the active constituents of extract/ fractions of A.cadamba.Results:The ethyl acetate fraction was found to be most active fraction in all the assays as compared to other extract/fractions.The IC50 value of ethyl acetate fraction (ETAC fraction) was 21.24μg/mL,1.12μg/mL,9.68μg/mL and S7.81μg/mL in DPPH assay, ABTS assay,reducing power assay and superoxide scavenging assay respectively.All the extract/ fractions also showed the potential to protect the plasmid DNA(pBR322) against the attack of hydroxyl radicals generated by Fenton’s reagent.The bioactive compounds were identified by UPLC-ESI-QTOF-MS,by comparing the mass andλmax with literature values.Conclusions:The potential of the extract/fractions to scavenge different free radicals in different systems indicated that they may be useful therapeutic agents for treating radical-related pathologic damage. | Madhu Chandel Upendra Sharma Neeraj Kumar Bikram Singh Satwinderjeet Kaur | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，12： | 6 |
| 2 | Effects of Different Nitrogen Fertilizer Levels and Native Soil Properties on Rice Grain Fe, Zn and Protein Contents显示文摘Deposition of protein and metal ions (Fe, Zn) in rice grains is a complex polygenic trait showing considerable environmental effect. To analyze the effect of nitrogen application levels and native soil properties on rice grain protein, iron (Fe) and zinc (Zn) contents, 32 rice genotypes were grown at three different locations each under 80 and 120 kg/hm2 nitrogen fertilizer applications. In treatments with nitrogen fertilizer application, the brown rice grain protein content (GPC) increased significantly (1.1% to 7.0%) under higher nitrogen fertilizer application (120 kg/hm2) whereas grain Fe/Zn contents showed non-significant effect of nitrogen application level, thus suggesting that the rate of uptake and translocation of macro-elements does not influence the uptake and translocation of micro-elements. The pH, organic matter content and inherent Fe/Zn levels of native soil showed significant effects on grain Fe and Zn contents of all the rice genotypes. Grain Zn content of almost all the tested rice genotypes was found to increase at Location III having loamy soil texture, neutral pH value (pH 6.83) and higher organic matter content than the other two locations (Locations I and II), indicating significant influence of native soil properties on brown rice grain Zn content while grain Fe content showed significant genotype × environment interaction effect. Genotypic difference was found to be the most significant factor to affect grain Fe/Zn contents in all the tested rice genotypes, indicating that although native soil properties influence phyto-availability of micronutrients and consequently influencing absorption, translocation and grain deposition of Fe/Zn ions, yet genetic makeup of a plant determines its response to varied soil conditions and other external factors. Two indica rice genotypes R-RF-31 (27.62 μg/g grain Zn content and 7.80% GPC) and R1033-968-2-1 (30.05 μg/g grain Zn content and 8.47% GPC) were identified as high grain Zn and moderate GPC rice genotypes. These results indicate that soil property and organic matter content increase the availability of Fe and Zn in rhizosphere, which in turn enhances the uptake, translocation and redistribution of Fe/Zn into rice grains. | G. CHANDEL S.BANERJEE S.SEE R.MEENA D.J.SHARMA S.B.VERULKAR | 2010 | Rice science2010，17，3： | 4 |
| 3 | Physiological Roles of Mitochondrial Reactive Oxygen Species显示文摘 | Laura A. Sena Navdeep S. Chandel | 2012 | Molecular Cell2012，，2： | 3 |
| 4 | Current status of pharmacological treatment of colorectal cancer显示文摘AIM: To review the clinical trials for the development in drugs for chemotherapeutic treatment of colorectal cancer(CRC).METHODS: A systematic review identified random-ized controlled trials(RCTs) assessing drugs for the treatment of CRC or adenomatous polyps from www.clinicaltrials.gov. Various online medical databases were searched for relevant publications.RESULTS: Combination treatment regimens of stan-dard drugs with newer agents have been shown to improve overall survival, disease-free survival, time to progression and quality of life compared to that with standard drugs alone in patients with advanced colorectal cancer. The FOLFOXIRI regimen has been associated with a significantly higher response rate, progression-free survival and overall survival compared to the FOLFIRI regimen. CONCLUSION: Oxaliplatin plus intravenous bolus fluo-rouracil and leucovorin has been shown to be superiorfor disease-free survival when compared to intravenous bolus fluorouracil and leucovorin. In addition, oxaliplatin regimens were more likely to result in successful surgi-cal resections. First line treatment with cetuximab plus fluorouracil, leucovorin and irinotecan has been found to reduce the risk of metastatic progression in patients with epidermal growth factor receptor-positive colorec-tal cancer with unresectable metastases. The addition of bevacizumab has been shown to significantly in-crease overall and progression-free survival when given in combination with standard therapy. | Reyhan Akhtar Shammy Chandel Pooja Sarotra Bikash Medhi | 2014 | World Journal of Gastrointestinal Oncology2014，6，6： | 3 |
| 5 | Mitochondrial Genome Instability and ROS Enhance Intestinal Tumorigenesis in APC Min/+ Mice显示文摘 | Dong Kyun Woo Paula D. Green Janine H. Santos Anthony D. D'Souza Zenta Walther W. David Martin Brooke E. Christian Navdeep S. Chandel Gerald S. Shadel | 2012 | The American Journal of Pathology2012，，1： | 2 |
| 6 | Improved dielectric and electro-optical parameters of nematic liquid crystal doped with magnetic nanoparticles显示文摘This study investigates the effect of magnetic nanoparticles(NPs) on the weakly polar nematic liquid crystal(NLC).Different parameters of dielectric data were measured for both the homeotropic and planar aligned samples as a function of frequency and temperature and the substantial changes have been noticed for the doped systems. Dielectric permittivity has been increased after the dispersion of magnetic NPs in the pure NLC. Dielectric anisotropy has also been influenced by incorporating the magnetic NPs with the NLC molecules. These results were attributed to the dipole–dipole interaction between the magnetic nanoparticles and nematic liquid crystal molecules. Electro-optical study indicated the faster rise time and fall time of the doped systems as compare to pure NLC. Threshold voltage has been calculated and found to be decreased for the doped systems. Moreover, we have also calculated the rotational viscosity and the splay elastic constant for pure and the doped systems. Both the rotational viscosity and splay elastic constant of the doped systems are found to be considerably lower than those of pure NLC. Change in these properties has been explained on the basis of molecular disturbances created by the interaction between the magnetic nanoparticle and LC director. This study reveals that the inclusion of magnetic NPs in weakly polar NLC can be useful to enhance the basic properties of the weakly polar NLC and make it a promising material for many display applications. | Geeta Yadav Govind Pathak Kaushlendra Agrahari Mahendra Kumar Mohd Sajid Khan V S Chandel Rajiv Manohar | 2019 | Chinese Physics B2019，28，3： | 2 |
| 7 | Phenomena in interrupted tensile tests of heat treated aluminium alloy 6061 显示文摘 | SRITHARAN T CHANDEL R S | 1997 | Acta Materialia1997，45，8： | 1 |
| 8 | Diabetes education:artAsian perspective显示文摘 | Witson E Wardle EV Chandel P | 1993 | Diabete Med1993，10，2： | 1 |
| 9 | A rare case of primary supraclavicular lymphadenitis due to cryptococcus neoformans in an HIV infected patient显示文摘 | Sood A Chandel LR Chauhan S | 2014 | J Clin Diagn Res2014，8，2： | 1 |
| 10 | Leptin resistance protects mice from hyperoxia-induced acute lung injury显示文摘 | Bellmeyer A Martino JM Chandel NS | | 0，，06： | 1 |
| 11 | Detoxification of lignocellulose hydrolysates:biochemical and metabolic engineering toward white biotechnology显示文摘 | CHANDEL A K DA SILVA S S SINGH O V | | 0，，1： | 1 |
| 12 | Mitochondrial Genome Instability and ROS Enhance Intestinal Tumorigenesis in APC Min/+ Mice显示文摘 | Dong Kyun Woo Paula D. Green Janine H. Santos Anthony D. D’Souza Zenta Walther W. David Martin Brooke E. Christian Navdeep S. Chandel Gerald S. Shadel | 2012 | The American Journal of Pathology2012，，1： | 1 |
| 13 | Mitochondrial reactive oxygen species trigger hypoxia-induced transcription显示文摘 | Maltepe E Goldwasser E | 1998 | Proc Natl Acad Sci U S A1998，95，11： | 1 |
| 14 | The mitochondria regulated death pathway mediates asbestos-induced alveolar epithelial cell apoptosis 显示文摘 | Panduri V Weitzman SA Chandel N | 2003 | Am J Respir Cell Mol Biol2003，28，2： | 1 |
| 15 | Reactive oxygen species are downstream products of TRAF-nediated signal transduction 显示文摘 | Schumacker PT Arch RH | 2001 | J Biol Chem2001，276，42： | 1 |
| 16 | Outer mitochondrial membrane permeability can regulate coupled respiration and cell survival显示文摘 | Vander MG Chandel NS Li-XX | 1997 | Cell1997，91，5： | 1 |
| 17 | Mitochondrial reactive oxygen species trigger hypoxia-induced transcription显示文摘 | CHANDEL N S MALTEPE E GOLDWASSER E | 1998 | Proc Natl Acad Sci U S A1998，95，11： | 1 |
| 18 | Improved RAPD amplification of recalcitrant plant DNA by the use of activated charcoal during DNA extraction显示文摘 | Bi I V Harvengt L Chandeler A | 1996 | Plant Breed1996，115，： | 1 |
| 19 | Mitochondrial regulation of cell survival and death during low-oxygen conditions显示文摘 | Snyder CM Chandel NS | 2009 | Adv Exp Med Biol2009，648，8： | 1 |
| 20 | Role of oxidants in NF-kappa B activation and TNF-alpha gene transcription induced by hypoxia and endotoxin显示文摘 | Chandel NS Trzyna WC McClintock DS | 2000 | J Immunol2000，165，2： | 1 |
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