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| 1 | Intragenic antagonistic roles of protein and circRNA in tumorigenesis显示文摘circRNAs arise from back splicing events during mRNA processing, and when deregulated can play an active role in cancer. Here we characterize a new circRNA (circPOK) encoded by the Zbtb7a gene (also kown as POKEMON, LRF) in the context of mesenchymal tumor progression. circPOK functions as a non-coding proto-oncogenic RNA independently and antithetically to its linear transcript counterpart, which acts as a tumor suppressor by encoding the Pokemon transcription factor. We find that circPOK regulates pro-proliferative and pro-angiogenic factors by co-activation of the ILF2/3 complex. Importantly, the expression of Pokemon protein and circRNA is aberrantly uncoupled in cancer through differential post-transcriptional regulation. Thus, we identify a novel type of genetic unit, the iRegulon, that yields biochemically distinct RNA products, circular and linear, with diverse and antithetical functions. Our findings further expand the cellular repertoire towards the control of normal biological outputs, while aberrant expression of such components may underlie disease pathogenesis including cancer. | Jlenia Guarnerio Yang Zhang Giulia Cheloni Riccardo Panella Jesse Mae Katon Mark Simpson Akinobu Matsumoto Antonella Papa Cristian Loretelli Andreas Petri Sakari Kauppinen Cassandra Garbutt Gunnlaugur Petur Nielsen Vikram Deshpande Mireia Castillo-Martin Carlos Cordon-Cardo Spentzos Dimitrios John G. Clohessy Mona Batish Pier Paolo Pandolfi | 2019 | Cell Research2019，29，8： | 15 |
| 2 | Polidocanol injection decreases the bleeding rate after colon polypectomy: a propensity score analysis显示文摘 | Antonio Facciorusso Marianna Di Maso Matteo Antonino Valentina Del Prete Carmine Panella Michele Barone Nicola Muscatiello | 2015 | Gastrointestinal Endoscopy2015，，2： | 2 |
| 3 | From chronic liver disorders to hepatocellular carcinoma: Molecular and genetic pathways显示文摘Hepatocarcinogenesis is a process attributed to progressive genomic changes that alter the hepatocellular phenotype producing cellular intermediates that evolve into hepatocellular carcinoma (HCC). During the preneoplastic phase, the liver is often the site of chronic hepatitis and/or cirrhosis, and these conditions induce liver regeneration with accelerated hepatocyte cycling in an organ that is otherwise proliferatively at rest. Hepatocyte regeneration is accelerated by upregulation of mitogenic pathways involving molecular and genetic mechanisms. Hepatic growth factors, inhibitors and triggers may also play a role. This process leads to the production of monoclonal populations of aberrant and dysplastic hepatocytes that have telomerase reexpression, microsatellite instability, and occasionally structural aberrations in genes and chromosomes. Development of dysplastic hepatocytes in foci and nodules and the emergence of HCC are associated with the accumulation of irreversible structural alterations in genes and chromosomes even if the genomic basis of the malignant phenotype is largely heterogeneous. Therefore, a malignant hepatocyte phenotype may be produced by changes in genes acting through different regulatory pathways, thus producing several molecular variants of HCC. On these bases, a key point for future research will be to determine whether the deletions are specific, due to particular loci in the minimally deleted regions of affected chromosome arms, or whether they are nonspecific with loss of large portions of chromosomes or entire chromosome arms leading to passive deletion of loci. The final aim is the possibility of identifying a step where carcinogenetic processes could be terminated. | Enzo Ierardi Rosa Rosania Mariangela Zotti Floriana Giorgio Simonetta Prencipe Nicola Della Valle Vincenzo De Francesco Carmine Panella | 2010 | World Journal of Gastrointestinal Oncology2010，2，6： | 2 |
| 4 | Effect of welding parameters on mechanical and microstructural properties of AA6082 joints produced by friction stir welding显示文摘 | P. Cavaliere A. Squillace F. Panella | 2007 | Journal of Materials Processing Tech2007，，1： | 2 |
| 5 | Altered molecular pattern of mucosal healing in Crohn's disease fibrotic stenosis显示文摘AIM: To investigate tumor necrosis factor-α (TNF-α), syndecan 1 and basic fibroblast growth factor (bFGF) balance in Crohn's disease (CD) strictures. METHODS: Our study was performed on 24 surgical specimens of CD fibrotic stenosis. Ten histological normal surgical samples were retrieved for both the large and small bowel from patients with benign conditions and healthy tissue represented control collection. Sex and age in controls did not differ from CD group. Three endoscopic biopsy specimens taken after informed consent in subjects with normal colon were also used as negative controls. TNF-α, syndecan 1 and bFGF were detected by both reverse transcriptase reverse transcriptase polymerase chain reaction after mRNA extraction (results expressed as fold-change) and immunohistochemistry.RESULTS: TNF-α did not show any significant difference between CD and control specimens (1.54 ± 1.19; P > 0.05). Very high levels of bFGF were observed in CD (11.76 ± 4.65; P < 0.001) unlike syndecan 1 which showed a moderate increase (5.53 ± 2.18; P < 0.005). analysis of variance (ANOVA) plus Student-NeumannKeuls showed: bFGF > syndecan 1 > TNF-α = control. Immunoreactivity for bFGF was observed in epithelial, stromal, endothelial cells and even in the muscular layer, whilst in normal tissue it was almost unexpressed. Syndecan 1 and TNF-α staining was confined to mucosal epithelial and stromal cells, while in controls syndecan 1 was found in its normal site, i.e. , basolateral area of the crypts and TNF-α very poorly expressed. CONCLUSION: Fibrotic stenosis of CD may be the final result of an irreversible transformation of different cells into fibrogenic phenotype no longer inhibited by posttranscriptional regulation. | Enzo Ierardi Floriana Giorgio Domenico Piscitelli Mariabeatrice Principi Santina Cantatore Maria Grazia Fiore Roberta Rossi Michele Barone Alfredo Di Leo Carmine Panella | 2013 | World Journal of Gastrointestinal Pathophysiology2013，4，3： | 2 |
| 6 | An input-output clustering approach to the synthesis of ANFIS networks显示文摘 | PANELLA M GALLO A S | 2005 | IEEE Transactions on Fuzzy Systems2005，13，1： | 1 |
| 7 | Mechanical and microstructural behaviour of 2024-7075 aluminium alloy sheets joined by friction stir welding 显示文摘 | P Cavaliere R Nobile F W Panella | 2006 | International Journal of Machine Tools & Manufacture2006，46，： | 1 |
| 8 | Information Systems Integration in Mergers and Acquisitions:A Normative model 显示文摘 | GIACOMAZZI F PANELLA C PERNICCI B | 1997 | Information & Management1997，32，6： | 1 |
| 9 | Effect of welding parameters on mechanical and microstructural proper- ties of AA6056 joints produced by friction stir welding显示文摘 | CAVALIERE P CAMPANILE G PANELLA F | 2006 | Jour- nal of Materials Processing Technology2006，180，： | 1 |
| 10 | Better Interprofessional Teamwork, Higher Level of Organized Care, and Lower Risk of Burnout in Acute Health Care Teams Using Care Pathways: A Cluster Randomized Controlled Trial显示文摘 | Svin Deneckere Martin Euwema Cathy Lodewijckx Massimiliano Panella Timothy Mutsvari Walter Sermeus Kris Vanhaecht | 2013 | Medical Care2013，，1： | 1 |
| 11 | Reduction in pulmonary vascular resistance with long-term epoprostenol (prostacyclin) therapy in primary pulmonary hypertension显示文摘 | McLaughlin W Genthner DE Panella MM | 1998 | N Engl J Med1998，338，5： | 1 |
| 12 | Hydrogen adsorption in metal-organic frameworks: Cu-MOFs and Zn MOFs compared 显示文摘 | Panella B | 2006 | Advanced Functional Materials2006，16，4： | 1 |
| 13 | Induction of HHV-8 lytic cycle replication by inflammatory cytokines produced by HIV-1-infeded T cells显示文摘 | Mercader M Taddeo B Panella J R | 2000 | Am J Pathol2000，156，： | 1 |
| 14 | Temperature, Moisture, and Fungicide Effects in Managing Rhizoetnnia Root and Crown Rot in Sugar Beet显示文摘 | Melvin D Bolton Lee Panella Larry Campbell Mohamed F R Khan | 2010 | Phytopathology2010，100，7： | 1 |
| 15 | Reducing clinical variations with clinical pathways: do pathways work?显示文摘 | PANELLA M MARCHISIO S DI STANISLAO F | 2003 | Int J Qual Health Care2003，15，6： | 1 |
| 16 | Role of estrogens and epidermal growth factor in hepatocellular carcinoma (HCC)显示文摘 | Francavilla A Panella C Amoruso A | 1991 | Dig Dis Sci1991，36，9： | 1 |
| 17 | Information systems integration in merger and acquisitions:A normative model显示文摘 | Giacomazzi K Panella C Pernici B | | 0，，6： | 1 |
| 18 | 2198 A1-Li plates joined by friction stir welding: Mechanical and microstructural behavior显示文摘 | CAVALIERE P CABIBBO M PANELLA F SQUILLACE A | 2009 | Materials & Design2009，30，9： | 1 |
| 19 | 2198 A1-Li plates joined by friction stir welding mechanical and microstructural behavior显示文摘 | Cavaliere P Cabibbo M Panella F | 2009 | Materials and Design2009，30，： | 1 |
| 20 | Does color Doppler sonography improve the clinical assessment of patients with acute scrotum?? 显示文摘 | Pepe P Panella P Pennisi M | 2006 | Eur J Radiol2006，60，1： | 1 |
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