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| 1 | Distribution of pericellular matrix molecules in the temporomandibular joint and their chondroprotective effects against inflammation显示文摘The objectives of this study were to(1) determine the distribution and synthesis of pericellular matrix(PCM) molecules(collagen VI, collagen IV and laminin) in rat temporomandibular joint(TMJ) and(2) investigate the effects of PCM molecules on chondrocytes against inflammation in osteoarthritis. Four zones(fibrous, proliferating, mature and hypertrophic) of condylar cartilage and three bands(anterior, intermediate and posterior) of disc were analysed by immunohistochemistry for the presence of PCM molecules in rat TMJs. Isolated chondrocytes were pre-treated with PCM molecules before being subjected to interleukin(IL)-1β treatment to stimulate inflammation. The responses of the chondrocytes were analysed using gene expression, nitric oxide release and matrix metalloproteinase(MMP)-13 production measures. Histomorphometric analyses revealed that the highest areal deposition of collagen VI(67.4%), collagen IV(45.7%) and laminin(52.4%) was in the proliferating zone of TMJ condylar cartilage. No significant difference in the distribution of PCM molecules was noted among the three bands of the TMJ disc. All three PCM molecules were expressed intracellularly by chondrocytes cultured in the monolayer. Among the PCM molecules, pre-treatment with collagen VI enhanced cellular proliferation, ameliorated IL-1β-induced MMP-3, MMP-9, MMP-13 and inducible nitric oxide synthase gene expression, and attenuated the downregulation of cartilage matrix genes, including collagen I, aggrecan and cartilage oligomeric matrix protein(COMP). Concurrently, collagen VI pretreatment inhibited nitric oxide and MMP-13 production. Our study demonstrates for the first time the distribution and role of PCM molecules, particularly collagen VI, in the protection of chondrocytes against inflammation. | Wern Cui Chu Shipin Zhang Timothy J Sng Yu Jie Ong Wen-Li Tan Vivien Y Ang Casper B Foldager Wei Seong Toh | 2017 | International Journal of Oral Science2017，9，1： | 5 |
| 2 | Study protocol:A cross-sectional study on psychology and behavior investigation of Chinese residents,PBICR显示文摘Objective:This study protocol identifies the basic research route and framework of psychological and behavioral surveys among Chinese residents,aims establishing a database through a multicenter,large-sample cross-sectional survey in China to provide strong data support for research development in various fields and a more comprehensive and systematic understanding of the physical and mental health status of the public.Method:The study was conducted from June 20,2022 to August 31,2022,using stratified sampling and quota sampling methods,a total of 148 cities,202 districts and counties,390 townships/towns/sub-districts,and 780 communities/villages(excluding Hong Kong,Macao,and Taiwan)from 23 provinces,5 autonomous regions,and 4 municipalities directly under the central government in China were selected.The questionnaire was distributed one-on-one and face-to-face to the public by trained investigators,and the questionnaire included eight aspects:personal basic information,personal health status,family basic information,social environment in which they were located,psychological level scale,behavioral level scale,other scales,and attitude towards social hot issues.Data analysis will be performed after questionnaire return.Results:Data collection is ongoing.These findings will support physical and mental health research and strategy development in China and even globally,guiding policy-makers and health care organizations to reform their programs to ensure the best interests of residents and their families. | Yu-Jia Wang Ayidana Kaierdebieke Si-Yuan Fan Rui-Feng Zhang Meng-Jie Huang Han Li Xiao-Nan Sun Qi-Yu Li Wen-Jia Meng Wen-Yu Wu Zhi Lin Jing-Yao Liu Xin-Pei Wang Yun-Chou Wu Jing-Qi Tang Yi-Ke Sun Ke Chen Pu Ge Wai-Kit Ming Casper Zhang Zheng Feei Ma Lei Feng Xin-Yue Zhang Yu-Yao Niu Yu-Pei Yan Yi-Le Jin Guang-Ze Gao Shuang Dai Yu-Liu Li Yue Tan Yi-Wei Wu Qi Zhang Gui Gui Xian-Li Pan Yan-Ming Liao Xian-Qi Zhao Ya-Ting Zhang Hui-Yi Chen Yue-Wei Qiu Xiao-Min Fu Jiang-Ling Zhou Dan Li Ke-Han Li Meng-Wei Xu Zhe Wang Yue-Qi Wang Yong Ma Xin-Ying Sun Yi-Bo Wu | 2022 | Psychosomatic Medicine Research2022，4，3： | 3 |
| 3 | Tumor suppressor ASXL1 is essential for the activation of INK4B expression in response to oncogene activity and anti-proliferative signals显示文摘ASXL1 变化经常在 hematological 肿瘤被发现,并且 Asxl1 的损失在老鼠支持 myeloid 转变。这里我们在 vivo 在在 Histone H2A (H2AK119ub1 ) 上的 mono-ubiquitylated 离氨酸 119 的 deubiquitylation 为 ASXL1-BAP1 建筑群支持一个角色的现在的数据。Polycomb 组蛋白质在正常开发期间控制 INK4B-ARF-INK4A 地点的表达式,部分地通过催化 H2AK119 的 mono-ubiquitylation。自从地点的激活, INK4B-ARF-INK4A 玩一设有自动保险装置机制免于 tumorigenesis,我们调查了 ASXL1 依赖的 H2A deubiquitylation 是否在它的激活起一个作用。有趣地,我们发现 ASXL1 明确地为 p15 响应 oncogenic 发信号和外来的 anti-proliferative 的 INK4B 发信号。因为我们发现 ASXL1 和 BAP1 两个都在 INK4B 地点被充实,我们的结果建议 INK4B 地点的激活要求 H2AK119ub1 的 ASXL1/BAP1-mediated deubiquitylation。一致地,我们 ASXL1 变化与被联系的结果表演降低 p15 INK4B 和在主要骨头髓房间的造血的祖先的一个 proliferative 优点,和在多重房间线的 ASXL1 的那弄空导致抵抗到生长禁止的信号。一起拿,这研究连接 INK4B 表示的调停 ASXL1 的 H2A deubiquitylation 和 transcriptional 激活到它的肿瘤 suppressor 函数。 | Xudong Wu Ida Holst Bekker-Jensen Jesper Christensen Kasper Dindler Rasmussen Simone Sidoli Yan Qi Yu Kong Xi Wang Yajuan Cui Zhijian Xiao Guogang Xu Kristine Williams Juri Rappsilber Casper Kaae Sonderby Ole Winther Ole N Jensens Kristian Helin | 2015 | Cell Research2015，25，11： | 3 |
| 4 | Early- and advanced non-enzymatic glycation in diabetic vascular complications: the search for therapeutics显示文摘 | Casper G. Schalkwijk Toshio Miyata | 2012 | Amino Acids2012，，4： | 2 |
| 5 | Early Endoscopic Retrograde Cholangiopancreatography in Predicted Severe Acute Biliary Pancreatitis: A Prospective Multicenter Study显示文摘 | Hjalmar C. van Santvoort Marc G. Besselink Annemarie C. de Vries Marja A. Boermeester Kathelijn Fischer Thomas L. Bollen Geert A. Cirkel Alexander F. Schaapherder Vincent B. Nieuwenhuijs Harry van Goor Cees H. Dejong Casper H. van Eijck Ben J. Witteman Ba | 2009 | Annals of Surgery2009，，1： | 2 |
| 6 | Tuberous sclerosis complex: renal imaging findings 显示文摘 | Casper KA Donnelly LF Chen B | 2002 | Radiology2002，225，： | 2 |
| 7 | 来曲唑或克罗米芬治疗不孕后怀孕的911例新生儿中的先天性畸形分析显示文摘Objective: To evaluate the incidence of congenital malformations among offspring of mothers who conceived with clomiphene citrate(CC) or with letrozole treatment for infertility. Design: Retrospective study. Setting: 5 fertility centers in Canada. Patients: 911 newborns from women who conceived following CC or letrozole treatment. Interventions: Examination of medical files of both mother and newborn, and cross-checked with the parents by telephone calls. Main Outcome Measures: Identified major and minor congenital malformations, birth weight, age of the mother, and type of treatment that led to the conception. Results: Overall, congenital malformations and chromosomal abnormalities were found in 14 of 514 newborns in the letrozole group(2.4%) and in 19 of 397 newborns in the CC group(4.8%). The major malformation rate in the letrozole group was 1.2%(6/514) and in the CC group was 3.0%(12/397). One newborn in the letrozole group was found to have a ventricular septal defect(0.2%)-compared to 4 newborns in the CC group(1.0%). In addition, the rate of all congenital cardiac anomalies was significantly higher(P: 0.02) in the CC group(1.8%) compared to the letrozole group(0.2%). Conclusion: There was no difference in the overall rates of major and minor congenital malformations among newborns from mothers who conceived after letrozole or CC treatments. However, it appears that congenital cardiac anomaly is less frequent in the letrozole group. The concern that letrozole use for ovulation induction could be teratogenic is unfounded based on our data. | Tulandi T. Martin J. Al-Fadhli R. R.F. Casper 李跃萍 | 2006 | 世界核心医学期刊文摘(妇产科学分册)2006，0，10： | 2 |
| 8 | Reduction of Peritoneal Trauma By Using Nonsurgical Gauze Leads to Less Implantation Metastasis of Spilled Tumor Cells显示文摘 | Petrousjka M. van den Tol Elma E. M. van Rossen Casper H. J. van Eijck Fred Bonthuis Richard L. Marquet Hans Jeekel | 1998 | Annals of Surgery1998，，2： | 2 |
| 9 | Prediction of implantation by the sonographic appearance of the endometrium during controlled ovarian stimulation for in vitro fertilization (IVF)显示文摘 | D. Schm?hl M. Habs Yael Gonen Robert F. Casper | 1990 | Journal of In Vitro Fertilization and Embryo Transfer1990，，3： | 2 |
| 10 | 天荒坪抽水蓄能电站球阀轴承异常磨损分析及建议改造方案显示文摘针对天荒坪进水球阀出现轴承钢套异常磨损的问题,分析其发生该异常磨损的原因,提出可行的处置方案并进行分析比较,最后筛选出较优的建议改造方案,同时对该处理方案需要注意的事项提出了建议。 | 郑凯 张亚武 楼勇 Casper Vogt-Svendsen 许立刚 姜泽界 曾辉 顾希明 李永耀 张忠良 | 2016 | 水电与抽水蓄能2016，2，6： | 2 |
| 11 | Use of an aromatse inhibitor for induction of ovulation in patients with an inadequate response to clomiphene citrate显示文摘 | Mitwally MF Casper RF | 2001 | Fertil Steril2001，75，2： | 1 |
| 12 | LH surge is associated with higher LH levels and more physiologic estradiol levels in aromatase inhibitor ovarian stimulation cycles显示文摘 | Mitwally MF Casper RF | 2004 | Fertil Steril2004，82，2： | 1 |
| 13 | Multifactorial analysis of long-term follow-up (more than 5 years) of primary extremity sarcoma显示文摘 | Leung D Casper ES | 1999 | Arch Surg1999，134，2： | 1 |
| 14 | Drought prolongs leaf life span in the herbaceous desert perennial Cryptantha flava显示文摘 | CASPER B B FORSETH I N KEMPENICH H | 2001 | Functional Ecology2001，15，6： | 1 |
| 15 | Use of an aromatase inhibitor for induction of ovulation in patients with an inadequate response to clomiphene cirate显示文摘 | Mitwally M Casper RF | 2001 | Fertil Steril2001，75，2： | 1 |
| 16 | Aromatase inhibitors in the treatment of severe endometriosis 显示文摘 | Mousa NA Bedaiwy MA Casper RF | 2007 | Obstet Gynecol2007，109，： | 1 |
| 17 | Controlling culture dynamics for the expansion of hematopoietic stem cells 显示文摘 | Madlambayan G J Rogers I Casper RF | 2001 | J Hematother Stem Cell Res2001，10，： | 1 |
| 18 | Variations of phosphorus release from sediments in stratified lakes 显示文摘 | Czyk T G Casper P Koschel R | 1997 | Water Air Soil Pollut1997，99，14： | 1 |
| 19 | Self-compatibility in distylous Cryptantha flava(Boraginaceae)显示文摘 | CASPER B B | 1985 | New Phytologist1985，99，： | 1 |
| 20 | Pregnancy outcome after the use of an aromatase inhibitor for ovarian stimulation显示文摘 | Mitwally MF Biljan MM Casper RF | 2005 | Am J Obstet Gynecol2005，192，： | 1 |
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