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| 1 | 晚期糖基化终产物及其受体RAGE在糖尿病血管并发症中的作用机制显示文摘糖尿病血管并发症是糖尿病致死、致残的主要原因,其发病机制尚未完全阐明。目前大量研究表明,晚期糖基化终产物(AGEs)及其受体RAGE在糖尿病血管并发症的发生、发展中起重要作用,将成为治疗糖尿病血管病变的一个新靶点。本文重点阐述AGEs-RAGE系统的信号转导机制及其在糖尿病血管病变中的作用,并探讨中药干预AGEs-RAGE系统治疗糖尿病血管病变的现状和发展趋势。 | 乔爱敏 李乐 刘青 | 2014 | 中国临床药理学与治疗学2014，19，11： | 28 |
| 2 | 在糖尿病的 nephropathy 吸烟: 在燃料坦克的火花吗?显示文摘 Diabetic nephropathy is associated with high morbidity and mortality and the prevalence of this disease is continuously increasing worldwide.Long-term diabetes increases the likelihood of developing secondary complications like nephropathy,the most common cause of end stage renal disease.Usually,other factors like hypertension,alcoholism and smoking also partly contribute to the progression of diabetic nephropathy.Among this,cigarette smoking in diabetes has been repeatedly confirmed as an independent risk factor for the onset and progression of diabetic nephropathy.Various studies suggest that smoking is a major fuel in the development of high oxidative stress and subsequently hyperlipidemia,accumulation of advanced glycation end products,activation of the renin angiotensin system and Rho-kinase,which are observed to play a pathogenic role in the progression of diabetic nephropathy.Furthermore,cigarette smoking in diabetic patients with vascular complications produces a variety of pathological changes in the kidney,such as thickening of the glomerular basement membrane and mesangial expansion with progression in glomerulosclerosis and interstitial fibrosis,which ultimately results in end stage renal failure.Strong associations are consistently found between chronic cigarette smoking and diabetic microvascular complications.A diverse group of studies unveil potentialmechanisms that may explain the role of cigarette smoking in the progression of diabetic nephropathy.Tremendous efforts are being made to control smoking mediated progression of diabetic nephropathy,but no promising therapy is yet available.The present review critically discusses the possible detrimental role of chronic cigarette smoking in the progression of diabetic nephropathy and various possible pharmacological interventions to attenuate the exacerbation of diabetic nephropathy. | Vishal Arvind Chakkarwar | 2012 | World Journal of Diabetes2012，3，12： | 4 |
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