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| 1 | Distribution of pericellular matrix molecules in the temporomandibular joint and their chondroprotective effects against inflammation显示文摘The objectives of this study were to(1) determine the distribution and synthesis of pericellular matrix(PCM) molecules(collagen VI, collagen IV and laminin) in rat temporomandibular joint(TMJ) and(2) investigate the effects of PCM molecules on chondrocytes against inflammation in osteoarthritis. Four zones(fibrous, proliferating, mature and hypertrophic) of condylar cartilage and three bands(anterior, intermediate and posterior) of disc were analysed by immunohistochemistry for the presence of PCM molecules in rat TMJs. Isolated chondrocytes were pre-treated with PCM molecules before being subjected to interleukin(IL)-1β treatment to stimulate inflammation. The responses of the chondrocytes were analysed using gene expression, nitric oxide release and matrix metalloproteinase(MMP)-13 production measures. Histomorphometric analyses revealed that the highest areal deposition of collagen VI(67.4%), collagen IV(45.7%) and laminin(52.4%) was in the proliferating zone of TMJ condylar cartilage. No significant difference in the distribution of PCM molecules was noted among the three bands of the TMJ disc. All three PCM molecules were expressed intracellularly by chondrocytes cultured in the monolayer. Among the PCM molecules, pre-treatment with collagen VI enhanced cellular proliferation, ameliorated IL-1β-induced MMP-3, MMP-9, MMP-13 and inducible nitric oxide synthase gene expression, and attenuated the downregulation of cartilage matrix genes, including collagen I, aggrecan and cartilage oligomeric matrix protein(COMP). Concurrently, collagen VI pretreatment inhibited nitric oxide and MMP-13 production. Our study demonstrates for the first time the distribution and role of PCM molecules, particularly collagen VI, in the protection of chondrocytes against inflammation. | Wern Cui Chu Shipin Zhang Timothy J Sng Yu Jie Ong Wen-Li Tan Vivien Y Ang Casper B Foldager Wei Seong Toh | 2017 | International Journal of Oral Science2017，9，1： | 5 |
| 2 | Tuberous sclerosis complex: renal imaging findings 显示文摘 | Casper KA Donnelly LF Chen B | 2002 | Radiology2002，225，： | 2 |
| 3 | Drought prolongs leaf life span in the herbaceous desert perennial Cryptantha flava显示文摘 | CASPER B B FORSETH I N KEMPENICH H | 2001 | Functional Ecology2001，15，6： | 1 |
| 4 | Self-compatibility in distylous Cryptantha flava(Boraginaceae)显示文摘 | CASPER B B | 1985 | New Phytologist1985，99，： | 1 |
| 5 | ' Making all the difference in the world' : How physicians can help HIV se- ropositive patients become more involved in their health care 显示文摘 | Gerbert B Love C Caspers N | 1999 | AIDS PATIENT CARE and STDs1999，13，1： | 1 |
| 6 | Seed bank formation during early secondary succession in a temperate deciduous forest显示文摘 | Hyatt L A Casper B B | 2000 | Journal of Ecology2000，88，： | 1 |
| 7 | Plant competition underground显示文摘 | Casper B B Jackson R B | 1997 | Annual Review of Ecology and Systematic1997，28，： | 1 |
| 8 | Tuberous sclerosis com- plex : renal imaging fingdings 显示文摘 | Casper KA Donnelly LF Chen B | 2002 | Radiology2002，225，： | 1 |
| 9 | Reso- nance Raman spectroscopy of red blood cells using near- infrared laser excitation显示文摘 | WOOD B R CASPERS P PUPPELS G J | 2007 | Analytical and Bioanalytical Chemistry2007，387，5： | 1 |
| 10 | The prognostic significance of acute phase proteins in patients with inoperable squamous cell carcinoma of the bronchus 显示文摘 | Caspers R J Pidcock N B Cooper E H | 1984 | Radiotherapy Oncology1984，2，2： | 1 |
| 11 | Differential post-dispersal seed predation in disturbed and intact temperature forest显示文摘 | SCHWANTES B CASPER B B | 1995 | American Midland Naturalist1995，134，： | 1 |
| 12 | Resonance Raman Spectroscopy of Red Blood Cells Using Near-Infrared Laser Excitation 显示文摘 | WOOD B R CASPERS P PUPPELS G J | 2007 | Analytical and Bioanalytical Chemistry2007，387，： | 1 |
| 13 | A biacore biosensor method for detailed kinetic binding analysis of small molecule inhibitors of p38a mitogen-activated protein kinase显示文摘 | Casper D Bukhtiyarova M Springman E B | 2004 | Anal Biochem2004，，325： | 1 |
| 14 | Resonance Raman Microspectroscopic Characterization of Eosinophil Peroxidase in Human Eosinophilic Granulocytes显示文摘 | SALMASO B L PUPPELS G J CASPERS P J | 1994 | Biophysical Journal1994，67，1： | 1 |
| 15 | Lateral root function and root overlap among mycorrhizal and nonmycorrhizal herbs in a Florida shrubland, measured using rubidium as a nutrient analog显示文摘 | Hawkes C V Casper B B | 2002 | American Journal of Botany2002，89，8： | 1 |
| 16 | Soil microbial community and extracellular enzyme activity in the New Jersey Pinelands 显示文摘 | Lucas R W Casper B B Jackson J K | 2007 | Soil Bio Biochem2007，39，10： | 1 |
| 17 | Effect of free stream noise on roughness-induced transition for a slender cone显示文摘 | Casper K M Johnson H B Schneider S P | 2011 | Journal of Spacecraft and Rockets2011，48，3： | 1 |
| 18 | Differential post-dispersal seed predation in disturbed and intact temperature forest显示文摘 | BOMAN J S CASPER B B | 1995 | The American Midland Naturist1995，34，： | 1 |
| 19 | Fate and development of naturally occurring Fusarium mycotoxins during malting and brewing 显示文摘 | Schwarz P B Casper H H | 1995 | Am Soc Brew Chem1995，53，： | 1 |
| 20 | Plant competition underground 显示文摘 | Casper B B Jackson R B | 1997 | Annual Review of Ecology and Systematics1997，28，1： | 1 |
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