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| 1 | Intrahepatic distribution of hepatitis B virus antigens in patients with and without hepatocellular carcinoma显示文摘AIM: To study the intrahepatic expression of hepatitis B surface antigen(HBs Ag) and hepatitis B core antigen(HBc Ag) in chronic hepatitis B patients with and without hepatocellular carcinoma. METHODS: A total of 33 chronic hepatitis B patients(mean age of 40.3 ± 2.5 years), comprising of 14 HBe Ag positive and 19 HBe Ag negative patients; and 13 patients with hepatitis B virus related hepatocellular carcinoma(mean age of 49.6 ± 4.7 years), were included in our study. Immunohistochemical staining for HBc Ag and HBs Ag was done using standard streptavidin-biotin-immunoperoxidase technique on paraffin-embedded liver biopsies. The HBc Agand HBs Ag staining distributions and patterns were described according to a modified classification system. RESULTS: Compared to the HBe Ag negative patients, the HBe Ag positive patients were younger, had higher mean HBV DNA and alanine transaminases levels. All the HBe Ag positive patients had intrahepatic HBc Ag staining; predominantly with 'diffuse' distribution(79%) and 'mixed cytoplasmic/nuclear ' pattern(79%). In comparison, only 5% of the HBe Ag-negative patients had intrahepatic HBc Ag staining. However, the intrahepatic HBs Ag staining has wider distribution among the HBe Ag negative patients, namely; majority of the HBe Ag negative cases had 'patchy' HBs Ag distribution compared to 'rare' distribution among the HBe Ag positive cases. All but one patient with HCC were HBe Ag negative with either undetectable HBV DNA or very low level of viremia. Intrahepatic HBc Ag and HBs Ag were seen in 13(100%) and 10(77%) of the HCC patients respectively. Interestingly, among the 9 HCC patients on anti-viral therapy with suppressed HBV DNA, HBc Ag and HBs Ag were detected in tumor tissues but not the adjacent liver in 4(44%) and 1(11%) patient respectively. CONCLUSION: Isolated intrahepatic HBc Ag and HBs Ag can be present in tumors of patients with suppressed HBV DNA on antiviral therapy; that may predispose them to cancer development. | Parham Safaie Mugilan Poongkunran Ping-Ping Kuang Asad Javaid Carl Jacobs Rebecca Pohlmann Imad Nasser Daryl TY Lau | 2016 | World Journal of Gastroenterology2016，22，12： | 5 |
| 2 | Multi-spectral MWIR image classification using filters derived from Independent Component Analysis 显示文摘 | Srikant Chad Carl Halford Eddie Jacobs | 2007 | Proceedings of SPIE(S0277-786X)2007，6，： | 1 |
| 3 | Pegasus: A framework for mapping complex scientific workflows onto distributed systems显示文摘 | Ewa Deelman Gurmeet Singh Mei-Hui Su James Blythe Yolanda Gil Carl Kesselman Gaurang Mehta Karan Vahi G. Bruce Berriman John Good Anastasia Laity Joseph C. Jacob Daniel S. Katz | 2005 | Scientific Programming2005，，3： | 1 |
| 4 | Modeling the target acquisition performance of active imaging systems显示文摘 | Espinola Richard L Jacobs Eddie L Halford Carl E | 2007 | Optics Express2007，15，7： | 1 |
| 5 | Maturation of monocyte-derived dendritic cells with Toll-like receptor 3 and 7/8 ligands combined with prostaglandin E2 results in high interleukin-12 production and cell migration显示文摘 | A. C. Inge Boullart Erik H. J. G. Aarntzen Pauline Verdijk Joannes F. M. Jacobs Danita H. Schuurhuis Daniel Benitez-Ribas Gerty Schreibelt Mandy W. M. M. Rakt Nicole M. Scharenborg Annemiek Boer Matthijs Kramer Carl G. Figdor Cornelis J. A. Punt Gosse J. | 2008 | Cancer Immunology Immunotherapy2008，，11： | 1 |
| 6 | Cholesterol oxidation in butter and dairy spread during storage显示文摘 | Jacob HN Carl EO Claus J | 1996 | Journal of Dairy Research1996，63，： | 1 |
| 7 | Oxygen regulation of gene expression: a study in opposites 显示文摘 | Carl T Jacob N | 2000 | Molecular Genetics and Metabolism2000，71，： | 1 |
| 8 | A social contract with the ancestors—Culture and ecosystem services in southern Madagascar显示文摘 | Jacob von Heland Carl Folke | 2013 | Global Environmental Change2013，，： | 1 |
| 9 | Multispectral MWIR image classification using filters derived from Independent Component Analysis显示文摘 | Srikant Chari Carl Halford Eddie Jacobs | 2007 | Proceedings of SPIE(S0277-786X)2007，6，： | 1 |
| 10 | Differential expression of orexin receptors 1 and 2 in the rat brain显示文摘 | Jacob N.Marcus Carl J.Aschkenasi Charlotte E.Lee Richard M.Chemelli Clifford B.Saper MasashiYanagisawa Joel K.Elmquist | 2001 | J Comp Neurol2001，，1： | 1 |
| 11 | Classification of humans and animals using an infrared profiling sensor显示文摘 | Chari Srikant Halford Carl Jacobs Eddie | 2009 | Proc of SPIE2009，7333，10： | 1 |
| 12 | The JAK2 V617F mutation involves B-and T-lymphocyte lineages in a subgroup of patients with Philadelphia-chromosome negative chronic myeloproliferative disorders 显示文摘 | Thomas Stauffer Larsen Jacob Haaber Christensen Hans Carl Hasselbalchl | 2007 | British Journal of Haematology2007，136，： | 1 |
| 13 | Final Results of the Can Routine Ultrasound Influence Stent Expansion (CRUISE) Study显示文摘 | Peter J. Fitzgerald Akio Oshima Motoya Hayase Jonas A. Metz Steven R. Bailey Donald S. Baim Michael W. Cleman Ezra Deutsch Daniel J. Diver Martin B. Leon Jeffrey W. Moses Stephen N. Oesterle Paul A. Overlie Carl J. Pepine Robert D. Safian Jacob Shani Char | 2000 | Circulation: Journal of the American Heart Association2000，，5： | 1 |
| 14 | Regulatory T cells in melanoma: the final hurdle towards effective immunotherapy?显示文摘 | Joannes FM Jacobs Stefan Nierkens Carl G Figdor I Jolanda M de Vries Gosse J Adema | 2012 | Lancet Oncology2012，，1： | 1 |
| 15 | The impact of out-of-pocket expenditures on missed appointments at HIV r care and treatment centers in Northern Tanzania显示文摘Background:Missed clinic appointments negatively impact clinic patient flow and health outcomes of people living with HIV(PLHIV).PLHIV likelihood of missing clinic appointments is associated with direct and indirect expenditures made while accessing HIV care.The objective of this study was to examine the relationship between out-of-pocket(OOP)health expenditures and the likelihood of missing appointments.Method:Totally 618 PLHIV older than 18 years attending two HIV care and treatment centres(CTC)in Northern Tanzania were enrolled in the study.Clinic attendance and clinical characteristics were abstracted from medical records.Information on OOP health expenditures,demographics,and socio-economic factors were self-reported by the participants.We used a hurdle model.The first part of the hurdle model assessed the marginal effect of a one Tanzanian Shillings(TZS)increase in OOP health expenditure on the probability of having a missed appointment and the second part assessed the probability of having missed appointments for those who had missed an appointment over the study period.Results:Among these 618 participants,242(39%)had at least one missed clinic appointment in the past year.OOP expenditure was not significantly associated with the number of missed clinic appointments.The median amount of OOP paid was 5100 TZS per visit,about 7%of the median monthly income.Participants who were separated from their partners(adjusted odds ratio[AOR]=1.83,95%confidence interval[CZ]:1.11-8.03)and those aged above 50 years(AOR=2.85,95%CI:1.01-8.03)were significantly associated with missing an appointment.For those who had at least one missed appointment over the study period,the probability of missing a clinic appointment was significantly associated with seeking care in a public CTC(P=0.49,95%CI:0.88-0.09)and aged between>25-35 years(P=0.90,95%CI:0.11-1.69).Conclusion:Interventions focused on improving compliance to clinic appointments should target public CTCs,PLHIV aged between>25-35 years,above 50 years of age and those who are separated from their partners. | Carl Mhina Hayden Bosworth John A.Bartlett Helene Vilme Joyce H.Mosha Deborah F.Shoo Tom J.Kakumbi Glory Jacob Charles Muiruri | 2021 | Global Health Journal2021，5，2： | 0 |
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