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| 1 | Expression of apoptosis-related factors in chronic cyclosporine nephrotoxicity after cyclosporine withdrawal显示文摘AIM: To examine whether the reversibility of chronic cyclosporine A (CsA) nephrotoxicity is associated with apoptotic cell death and its regulatory factors. METHODS: Chronic CsA nephrotoxicity was induced in Sprague- Dawley rats by administering CsA (15 mg/kg, sc) for 5 weeks, and then withdrawing it for 5 or 10 weeks. The effect of CsA withdrawal on apoptotic cell death was evaluated by an in situ TdT-mediated deoxyuridine triphos- phate-biotin nick end-labeling (TUNEL) assay and the expression of pro-apoptotic [(transforming growth factor- beta1 (TGF-β1) and Fas] and anti-apoptotic [epidermal growth factors (EGF) and Bcl-2] factors. RESULTS: Discontinuation of CsA induced significant decreases in TUNEL-positive cells in a time-dependent manner and the reduction in TUNEL-positive cells was correlated with the tubulointerstitial fibrosis score (r=0.919, P<0.01). Upregulation of TGF-β1 and Fas expression in CsA-treated rat kidneys was decreased significantly after with- drawal of CsA. In contrast, downregulated EGF and Bcl-2 expression returned to normal or supernormal levels. CONCLUSION: CsA withdrawal is associated with a decrease in apoptotic cell death and with changes in the expression of pro-apoptotic and anti-apoptotic molecules involved in renal wound repair. This may constitute one of the mechanisms underlying the reversibility of chronic CsA nephrotoxicity. | CanLI Sun-wooLIM Bo-kyungSUN Bum-soonCHOI SylviaGLOWACKA AlisonJCOX DarrenJKELLY Yong-sooKIM JinKIM Byung-keeBANG Chul-wooYANG | 2004 | Acta Pharmacologica Sinica2004，25，4： | 16 |
| 2 | Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties显示文摘 | Sarah Schwitalla Alexander A. Fingerle Patrizia Cammareri Tim Nebelsiek Serkan I. G?ktuna Paul K. Ziegler Ozge Canli Jarom Heijmans David J. Huels Guenievre Moreaux Rudolf A. Rupec Markus Gerhard Roland Schmid Nick Barker Hans Clevers Roland Lang Jens Neu | 2013 | Cell2013，，： | 3 |
| 3 | An fMRI Study of Personality Influences on Brain Reactivity to Emotional Stimuli显示文摘 | Canli T Zhao Z Desmond E J Kang E Gross J Gabrieli J D E | | 0，，01： | 1 |
| 4 | Imaging gender differences in sexual arousal显示文摘 | Canli T Gabrieli JD | 2004 | Nat Neurosci2004，4，18： | 1 |
| 5 | A Cross - Layer Optimization Approach for Efficient Data Gathering in Wireless Sensor Networks 显示文摘 | Turkmen Canli Farid Nait- Abdesselam Ashfaq Khokhar | 2008 | IEEE International2008，，3： | 1 |
| 6 | The relationships between heavy metal (Cd, Cr, Cu, Fe, Pb, Zn) levels and the size of six mediterranean fish species 显示文摘 | Canli M Atli G | 2003 | Environment Pollution2003，12，11： | 1 |
| 7 | Anakinra for resistant Behcet uveitis: why not显示文摘 | Emmi G Silvestri E Canli AM | 2013 | Clin Exp Rheumatol2013，31，3： | 1 |
| 8 | In Vitro separaation of a rose chimera 显示文摘 | Canli F A Skirvin R M | 2008 | Plant Cell Tissue Organ Cult2008，95，3： | 1 |
| 9 | Heavy metal concentrations in fish tissues from the Northeast Mediterrenean Sea显示文摘 | Kalay M Ay 0 Canli M | 1999 | Bull Environ Contam Toxicol1999，63，： | 1 |
| 10 | Brain activation to emotional words in depressedvs healthy subjects显示文摘 | Canli T Sivers H Thomason ME | 2004 | Neurology Report2004，15，17： | 1 |
| 11 | The relationships between heavy metal (Cd, Cr, Cu, Fe, Pb, Zn) levels and the size of six Mediterranean fish species显示文摘 | Canli M Atli G | 2003 | Environ Pollut2003，121，1： | 1 |
| 12 | When Corporate Image Af- fects Product Evaluations: The Moderating Role of Perceived Risk 显示文摘 | Gurhan- Canli Z Rajeev B | 2004 | Journal of Marketing Research2004，41，5： | 1 |
| 13 | Significance of Genetic information in Risk Asses s ment and Individual Classification Using Silicosisasa Case Model显示文摘 | ERI N M c CANLI ES DOUGLAS P LANDSI TTE | 2002 | British Occupational Hygiene Society2002，46，4： | 1 |
| 14 | Copper and Lead Accumulation in Tissues of a Freshwater Fish Tilapia zillii and Its Effects on the Branchial Na,K-ATPase Activity显示文摘 | ?. Ay M. Kalay L. Tamer M. Canli | 1999 | Bulletin of Environmental Contamination and Toxicology1999，，2： | 1 |
| 15 | Response of antioxidant system of freshwater fish Oreochromis niloticus to acute and chronic metal (Cd, Cu, Cr, Zn, Fe) exposure 显示文摘 | ATLI G CANLI M | 2010 | Ecotoxicology and Environmental Safety2010，73，： | 1 |
| 16 | Regeneration of adventitious shppts from mature stored cotyledons of Japanese plum (Prunus salicina Lind 1 )显示文摘 | CANLI F A TIAN L | 2009 | Scientia Horticulture2009，120，： | 1 |
| 17 | Effect of estrogen-serotonin inter-actions on mood and cognition显示文摘 | Amin Z Canli T Epperson CN | 2005 | Behav Cogn Neurosci Rev2005，4，： | 1 |
| 18 | Amygdala responses to emotionally valenced stimuli in older and younger adults 显示文摘 | MATHER M CANLI T ENGLISH 1 | 2004 | Psychological Science2004，15，4： | 1 |
| 19 | Influence of SLC6A3 and COMT variation on neural activation during response inhibition显示文摘 | Congdon E Constable R.T Lesch K.P Canli T | | 0，，03： | 1 |
| 20 | Response of antioxidant system of freshwa- ter fish Oreochromis niloticus to acute and chronic metal (Cd, Cu, Cr, Zn, Fe) exposures 显示文摘 | ALTI G CANLI M | 2010 | Ecotoxicology and Environ- mental Safety2010，73，8： | 1 |
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