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| 1 | Stem cell therapy for the treatment of Leydig cell dysfunction in primary hypogonadism显示文摘The production of testosterone occurs within the Leydig cells of the testes. When production fails at this level from either congenital, acquired, or systemic disorders,the result is primary hypogonadism. While numerous testosterone formulations have been developed, none are yet fully capable of replicating the physiological patterns of testosterone secretion. Multiple stem cell therapies to restore androgenic function of the testes are under investigation. Leydig cells derived from bone marrow, adipose tissue, umbilical cord, and the testes have shown promise for future therapy for primary hypogonadism. In particular, the discovery and utilization of a group of progenitor stem cells within the testes, known as stem Leydig cells(SLCs), has led not only to a better understanding of testicular development, but of treatment as well. When combining this with an understanding of the mechanisms that lead to Leydig cell dysfunction, researchers and physicians will be able to develop stem cell therapies that target the specific step in the steroidogenic process that is deficient. The current preclinical studies highlight the complex nature of regenerating this steroidogenic process and the problems remain unresolved. In summary, there appears to be two current directions for stem cell therapy in male primary hypogonadism. The first method involves differentiating adult Leydig cells from stem cells of various origins from bone marrow, adipose, or embryonic sources. The second method involves isolating, identifying, and transplanting stem Leydig cells into testicular tissue. Theoretically, in-vivo re-activation of SLCs in men with primary hypogonadism due to age would be another alternative method to treat hypogonadism while eliminating the need for transplantation. | Taylor C Peak Nora M Haney William Wang Kenneth J DeLay Wayne J Hellstrom | 2016 | World Journal of Stem Cells2016，8，10： | 5 |
| 2 | Obesity and cardiometabolic disease risk factors among US adolescents with disabilities显示文摘AIM: To generate prevalence estimates of weight status and cardiometabolic disease risk factors among adolescents with and without disabilities.METHODS: Analysis of the 1999-2010 National Health and Nutrition Examination Survey data was conducted among 12-18 years old with(n = 256) and without disabilities(n = 5020). Mean values of waist circumference, fasting glucose, high-density-lipoprotein cholesterol, triglycerides, systolic and diastolic blood pressure and metabolic syndrome(Met S, ≥ 3 risk factors present) were examined by the following standardized body mass index(BMI) categories for those with and without disabilities; overweight(BMI ≥ 85th- < 95 th percentile for age and sex), obesity(BMI ≥ 95 th percentile) and severe obesity(BMI ≥35 kg/m2). Linear regression models were fit with each cardiometabolic disease risk factor independently as continuous outcomes to show relationships with disability status. RESULTS: Adolescents with disabilities were significantlymore likely to be overweight(49.3%), obese(27.6%) and severely obese(12%) vs their peers without disabilities(33.1%, 17.5% and 3.6%, respectively, P ≤ 0.01 for all). A higher proportion of overweight, obese and severely obese children with disabilities had abnormal SBP, fasting lipids and glucose as well as Met S(18.9% of overweight, 32.3% of obese, 55% of severely obese) vs their peers without disabilities(9.7%, 16.8%, 36.3%, respectively). US adolescents with disabilities are over three times as likely to have Met S(OR = 3.45, 95%CI: 1.08-10.99, P = 0.03) vs their peers with no disabilities.CONCLUSION: Results show that adolescents with disabilities are disproportionately affected by obesity and poor cardiometabolic health vs their peers with no disabilities. Health care professionals should monitor the cardiometabolic health of adolescents with disabilities. | Sarah E Messiah Denise C Vidot Gabriel Somarriba Kanathy Haney Semra Aytur Ruby A Natale Jeffrey P Brosco Kristopher L Arheart | 2015 | World Journal of Diabetes2015，6，1： | 2 |
| 3 | Twenty-One Years of Experience With Minimally Invasive Repair of Pectus Excavatum by the Nuss Procedure in 1215 Patients显示文摘 | Robert E. Kelly Michael J. Goretsky Robert Obermeyer Marcia Ann Kuhn Richard Redlinger Tina S. Haney Alan Moskowitz Donald Nuss | 2010 | Annals of Surgery2010，，6： | 2 |
| 4 | Malignancy in Endometriosis: Frequency and Comparison of Ovarian and Extraovarian Types显示文摘 | Robert C. Stern Rajesh Dash Rex C. Bentley Matthew J. Snyder Arthur F. Haney Stanley J. Robboy | 2001 | International Journal of Gynecological Pathology2001，，2： | 2 |
| 5 | Perioperative Use of Dexmedetomidine Is Associated With Decreased Incidence of Ventricular and Supraventricular Tachyarrhythmias After Congenital Cardiac Operations显示文摘 | Constantinos Chrysostomou Joan Sanchez-de-Toledo Peter Wearden Edmund H. Jooste Steven E. Lichtenstein Patrick M. Callahan Tunga Suresh Elizabeth O’Malley Dana Shiderly Jamie Haney Masahiro Yoshida Richard Orr Ricardo Munoz Victor O. Morell | 2011 | The Annals of Thoracic Surgery2011，，3： | 2 |
| 6 | A barrier composed of chemically cross-linked hyaluronic Acid (incert)reduces postoperative adhesion formation formation显示文摘 | Haney M D Elissa Doty B S | 1997 | Fertility and Sterility1997，70，： | 1 |
| 7 | Soil Microbial Activity is Affected by Roundup weather Max and Pesticides Applied to Cotton(Gossypium hirsutum)显示文摘 | LANCASTER S H Haney R L Senseman S A | 2006 | J Agric Food Chem2006，54，： | 1 |
| 8 | Thermal adaptation analyzed by comparison of protein sequences from mesophilic and extremely thermophilic Methanococcus species显示文摘 | Haney P J Badger J H Buldak G L | 1999 | Proc Natl Acad Sci1999，96，： | 1 |
| 9 | Mesoscale meteorological and air quality impacts of increased urban albedo and vegetation 显示文摘 | TAHA H DOUGLAS S HANEY J | 1997 | EnergBuild1997，25，： | 1 |
| 10 | Mast cells and matrix degradation at sites of tumour invasion in rat mammary ade- nocarcinoma显示文摘 | Dabbous MK Walker R Haney L | 1986 | Br J Cancer1986，54，3： | 1 |
| 11 | KRAS mutation: comparison of testing methods and tissue sampling techniques in colon cancer显示文摘 | Franklin WA Haney J Sugita M | 2010 | J Mol Diagn2010，12，1： | 1 |
| 12 | Flush of carbon dioxide following rewetting of dried soil relates to active organic pools显示文摘 | Franzluebbers A J Haney R L Honeycutt C W | 2000 | Soil Science Society of America Journal2000，64，2： | 1 |
| 13 | Host mediated effectors of tumor invasion: role of mast cells in matrix degradation显示文摘 | Dabbous MK Woolley DE Haney L | 1986 | Clin Exp Metastasis1986，4，2： | 1 |
| 14 | Mood and performance changes in women with premenstrual dysphoric disorder acute effects of alprazolam显示文摘 | Evans SM Haney M Levin FR | 1998 | Neuropsychopharmocology1998，19，： | 1 |
| 15 | Analysis of thermal stabilizing interactions in mesophilic and thermophilic adenylate kinases from the genus Methanococcus显示文摘 | Haney P J Stees M Konisky J | 1999 | J Biol Chem1999，274，28： | 1 |
| 16 | Representing Context, Cognition, and Crew Performance in a Shutdown Risk Assessment 显示文摘 | Gertman D I Haney L N Siu N O | 1996 | Reliability Engineering and System Safety1996，52，4： | 1 |
| 17 | Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex显示文摘 | Brugnera E Haney L Grimsley C | | 0，，： | 1 |
| 18 | Host mediated effectors of tumor invasion: role of mast cells in matrix degradation显示文摘 | Dabbous MK Woolley DE Haney L | 1986 | Clin Exp Metastasis1986，4，2： | 1 |
| 19 | Expanding the repertoire of RNA interference screensfor developing new anticancer drug targets显示文摘 | Haney SA | 2007 | Expert Opin TherTargets2007，11，11： | 1 |
| 20 | Serious complications of uterine artery embolization for conservative treatment of fibroids 显示文摘 | Payne J F Haney A F | 2003 | Fertil Steril2003，79，1： | 1 |
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