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| 1 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 2 | The future of cancer immunotherapy:microenvironmenttargeting combinations显示文摘Immunotherapy holds the potential to induce durable responses,but only a minority of patients currently respond.The etiologies of primary and secondary resistance to immunotherapy are multifaceted,deriving not only from tumor intrinsic faaors,but also from the complex interplay between cancer and its microenvironment.In addressing frontiers in clinical immunotherapy,we describe two categories of approaches to the design of novel drugs and combination therapies:the first involves direct modification of the tumor,while the second indirectly enhances immunogenicity through alteration of the microenvironment.By systematically addressing the factors that mediate resistance,we are able to identify mechanistically-driven novel approaches to improve immunotherapy outcomes. | Yonina R.Murciano-Goroff Allison Betof Warner Jedd D.Wolchok | 2020 | Cell Research2020，30，6： | 12 |
| 3 | Immune Modulation in Cancer with Antibodies显示文摘 | David B. Page Michael A. Postow Margaret K. Callahan James P. Allison Jedd D. Wolchok | 2014 | Annual Review of Medicine2014，，： | 2 |
| 4 | 五轴加工中心在大型零件加工中的竞争优势显示文摘正当Metalcraft公司面临着项目灵活性和性能需求所带来的巨大压力时,老式铣床发生了故障。从Toyoda公司购买的两台五轴加工中心成为公司顺应潮流发展的关键一步。众所周知,在美国Wisconsin州成立的Metalcraft公司是Scag Power Equipment公司商用割草机的制造商;但是,公司在West Bend的工厂主要是为其他OEM客户提供大型焊接和制造服务。 | JEDD COLE | 2021 | 现代制造2021，，6： | 2 |
| 5 | Relief of Profound Feedback Inhibition of Mitogenic Signaling by RAF Inhibitors Attenuates Their Activity in BRAFV600E Melanomas显示文摘 | Piro Lito Christine A. Pratilas Eric W. Joseph Madhavi Tadi Ensar Halilovic Matthew Zubrowski Alan Huang Wai Lin Wong Margaret K. Callahan Taha Merghoub Jedd D. Wolchok Elisa de Stanchina Sarat Chandarlapaty Poulikos I. Poulikakos James A. Fagin Neal Rose | 2012 | Cancer Cell2012，，5： | 1 |
| 6 | Woronin body function in Magnaporthe grisea is essential for efficient pathogenesis and for sur- vival during nitrogen starvation stress显示文摘 | Soundararajan S Jedd G Li X | 2004 | Plant Cell2004，16，6： | 1 |
| 7 | Tumor antigens for cancer immunotherapy: therapeutic potential of xenogeneic DNA vaccines显示文摘 | Roopa S Jedd DW | 2004 | J Transl Med2004，2，1： | 1 |
| 8 | Induction of autoantibodies against tyrosinase-related proteins following DNA vaccination:Unexpected reactivity to a protein paralogue显示文摘 | Roopa S Alan NH Jedd D | 2002 | Cancer Immunity2002，2，8： | 1 |
| 9 | The Ypt1 GTPase is essential for the first two steps of the yeast secretory pathway显示文摘 | Jedd G Richardson C Litt R | 1995 | J Cell Biol1995，131，3： | 1 |
| 10 | Single‐institution experience with ipilimumab in advanced melanoma patients in the compassionate use setting显示文摘 | Geoffrey Y.Ku JiandaYuan David B.Page Sebastian E. A.Schroeder Katherine S.Panageas Richard D.Carvajal Paul B.Chapman Gary K.Schwartz James P.Allison Jedd D.Wolchok | 2010 | Cancer2010，，7： | 1 |
| 11 | Woronin body function in Magnaporthe grisea is essential for efficient pathogenesis and for survival during nitrogen starvation stress显示文摘 | Sundararajan S Jedd G Li XL | 2004 | The Plant Cell2004，16，6： | 1 |
| 12 | Phase I/II study of pegylated arginine deiminase (ADI-PEG 20) in patients with advanced melanoma显示文摘 | Patrick A. Ott Richard D. Carvajal Neeta Pandit-Taskar Achim A. Jungbluth Eric W. Hoffman Bor-Wen Wu John S. Bomalaski Ralph Venhaus Linda Pan Lloyd J. Old Anna C. Pavlick Jedd D. Wolchok | 2013 | Investigational New Drugs2013，，2： | 1 |
| 13 | Tumor antigens for cancer immunotherapy: therapeutic potential of xenogeneic DNA vaccines显示文摘 | Roopa S Jedd DW | 2004 | J Transl Med2004，2，1： | 1 |
| 14 | Woronin body function in Magnaporthe grisea is essential for efficient pathogenesis and for survival during nitrogen starvation stress显示文摘 | Soundararajan S Jedd G Li XL | 2004 | Plant Cell2004，16，6： | 1 |
| 15 | Tumor antigens for cancer immunotherapy: therapeutic potential of xenogeneic DNA vaccines 显示文摘 | ROOPA SRINIVASAN JEDD D Wolchok | 2004 | J Transl Med2004，2，1： | 1 |
| 16 | 机加工车间采用光纤激光器填补模具维修空缺显示文摘接到客户的塑料注塑模具维修服务电话后,CMS Inc.发现问题已经超出了MIG和TIG焊机的处理能力范围。于是从LaserStar公司引入了光纤激光技术,以满足客户需求。 | JEDD COLE | 2020 | 现代制造2020，，27： | 1 |
| 17 | The Abscopal Effect Associated With a Systemic Anti-melanoma Immune Response显示文摘 | Emily F. Stamell Jedd D. Wolchok Sacha Gnjatic Nancy Y. Lee Isaac Brownell | 2012 | International Journal of Radiation Oncology Biology Physics2012，，： | 1 |
| 18 | Tumor antigens for cancer immuno therapy:therapeutic potential of xenogeneic DNA vaccines显示文摘 | ROOPA S JEDD D W | 2004 | J Transl Med2004，2，1： | 1 |
| 19 | Cortical networks subserving the perception of tinnitus Acta显示文摘 | Mirz FG Jedde A Ishizu K | 2000 | Otolaryyn Suppl2000，，： | 1 |
| 20 | Genetic interactions in yeast between Ypt GTPase and Arf guanine nueleotide exchangers显示文摘 | Jones S Jedd G Kahn R A | 1999 | Genetics1999，152，4： | 1 |
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