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| 1 | Pancreatic steatosis: Is it related to either obesity or diabetes mellitus?显示文摘The accumulation of fat in the pancreatic gland has been referred to using various synonyms,such as pancreatic lipomatosis,fatty replacement,fatty infiltration,fatty pancreas,lipomatous pseudohypertrophy,non-alcoholic fatty pancreatic disease and pancreatic steatosis We believe that pancreatic steatosis is the best description of fat accumulation in the pancreatic gland without fat replacement,and this term also describes the possibility that the fat accumulation is a reversible process.A review of the existing literature was carried out,and it was found that there was notable evidence from both the pathological and the imaging point of view that pancreatic steatosis is an increasing problem due to the increasing incidence of obesity.The conclusion was that pancreatic steatosis was easily detectable using modern imaging techniques,such as ultrasonography,endoscopic ultrasonography,computed tomography and magnetic resonance imaging.Pancreatic steatosis was not due to the presence of diabetes mellitus but was highly associated with the metabolic syndrome.The possible presence of steatopancreatitis should be better evaluated,especially regarding the inflammatory cascade,and additional studies are needed which are capable of assessing whether non-alcoholic steatopancreatitis really exists as does non-alcoholic steatohepatitis.Finally,the presence of exocrine pancreatic function should be extensively evaluated in patients with pancreatic steatosis. | Raffaele Pezzilli Lucia Calculli | 2014 | World Journal of Diabetes2014，5，4： | 8 |
| 2 | A prospective study on radiofrequency ablation locally advanced pancreatic cancer显示文摘BACKGROUND:Radiofrequency ablation(RFA)has been suggested as a new treatment option for patients with locally advanced cancer.This study aimed to prospectively evaluate the efficacy and safety of intraoperative RFA in patients with unresectable,locally advanced,non-metastatic carcinoma of the pancreatic head.METHODS:RFA was the first step of the surgical procedure and was carried out on the mobilized pancreatic head followed by biliary by-pass and gastrojejunal-anastomosis.Intra-and post-operative morbidity and mortality,performance status, pain control,quality of life,and survival at 24 months were evaluated.RESULTS:Seven patients(3 men and 4 women;median age 66 years,range 47-80 years)were studied and 4 were eligible for treatment.The RFA procedure was carried out in 3 of the 4 patients;in one patient it was not carried out because of the upstaging of the neoplasm.In all 3 patients RFA achieved complete necrosis of the lesion.A biliary fistula developed 7 days after the procedure in one patient;all 3 patients developed ascites 8.6 days(range 7-9 days)on average after RFA.All patients died respectively,at 3,4,and 5 months after the treatment.CONCLUSIONS:In our experience,RFA is a feasible procedure, but it presents a very high rate of postoperative complications.Moreover,pain control,life quality and survival rate are poor.The few data suggest no impact on survival. | Riccardo Casadei Claudio Ricci Raffaele Pezzilli Carla Serra Lucia Calculli Antonio Maria Morselli-Labate Donatella Santini Francesco Minni | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，3： | 6 |
| 3 | Exocrine pancreatic function assessed by secretin cholangio-Wirsung magnetic resonance imaging显示文摘BACKGROUND:Magnetic resonance cholangiopancreato-graphy (MRCP) is useful to assess exocrine pancreatic function by combining rapid imaging acquisition with the administration of secretin, a gastrointestinal hormone that stimulates the secretion of bile and pancreatic juice. However, extensive data on this method are lacking. This study aimed to determine whether MRCP with secretin administration is able to simultaneously detect alterations of both the pancreatic ducts and exocrine pancreatic function. METHODS:All subjects older than 18 years who underwent magnetic resonance imaging (MRI) and cholangio-Wirsung magnetic resonance imaging (CWMRI) for suspicion of benign or malignant pancreatic diseases from January 2006 to December 2006 were enrolled in the study. MRI and CWMRI were carried out using a dedicated apparatus. RESULTS:Eighty-seven patients (46 males, 41 females, mean age 59.7±14.6, range 27-87 years) were enrolled. Of the 87 patients, 39 had a normal pancreas on imaging, 20 had an intrapapillary mucinous tumor (IPMT), and the rest had chronic pancreatitis (7), serous cystadenoma (6), a previous attack of acute biliary pancreatitis (5), congenital ductal abnormalities (5), mucinous cystadenoma (3), previous pancreatic head resection for autoimmune pancreatitis (1), or cholangiocarcinoma (1). Morphologically, we found two pseudocysts (one of the 7 patients with chronic pancreatitis, and one of the 5 patients after an attack of acute pancreatitis;the latter pseudocyst communicated with the main pancreatic duct). Calcifications were found in 3 of the 7 patients with chronic pancreatitis. All patients with IPMT and mucinous cystadenoma and 3 patients with serous cystadenoma were histologically confirmed. The remaining patients were followed up adequately to confirm the diagnosis by imaging. According to the Matos criteria, 73 patients (83.9%) were of grade 3, 8 grade 2, 4 grade 1, and 2 grade 0. The only pancreatic diseases which impaired the exocrine pancreatic secretion stimulated by secretin were chronic pancreatitis (57.1% of the patients, grade 0-1) and the IPMT mixed type in 2 of the 4 patients was grade 1. CONCLUSION:Secretin MRCP is a useful technique to simultaneously detect the presence of alterations of the pancreatic ducts and exocrine pancreatic function. | Lucia Calculli Raffaele Pezzilli Marta Fiscaletti Riccardo Casadei Carla Brindisi Giampaolo Gavelli | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，2： | 5 |
| 4 | The usefulness of spiral Computed Tomography and colour-Doppler ultrasonography to predict portal-mesenteric trunk involvement in pancreatic cancer显示文摘 | Calculli L Casadei R Amore B | 2002 | Radio Med2002，104，4： | 1 |
| 5 | The usefulness of spiral computed tomography and colour-doppler ultrasonography to predict portal- mesenteric trunk involvement in pancreatic cancer 显示文摘 | Calculli L Casadei R Amore B | 2002 | Radio Med (Torino)2002，104，： | 1 |
| 6 | Pancreatic solid - cystic pippillary tumor:clinical features, imaging finding and operative management显示文摘 | Casadei R Santini D Calculli L | 2006 | J Pancreas2006，11，1： | 1 |
| 7 | Role of Spiral Computerized Tomography in the Staging of Pancreatic Carcinoma显示文摘 | Calculli L Casadei R Diacono D | 1998 | Radiol Med1998，95，4： | 1 |
| 8 | Role of spiral computerized tomography in the staging of pancreatic carcinoma显示文摘 | Calculli L Casadei R Diacono D | 1998 | Radiol Med1998，95，4： | 1 |
| 9 | Pancreatic solid-cystic papillary tumor: clinical features, imaging findings and operative management显示文摘 | Casadei R Santini D Calculli L | 2006 | JOP2006，7，1： | 1 |
| 10 | Branch-type intraductal papillary mu-cinous neoplasm of the pancreas: clinically and patient-repor-ted outcomes 显示文摘 | Pezzilli R Calculli L | 2015 | Pancreas2015，44，2： | 1 |
| 11 | Role of spiral computerized tomography in the staging of pancreatic carcinoma 显示文摘 | Calculli L Casadei R Diacono D | 1998 | Radiol Med1998，95，4： | 1 |
| 12 | Pancreatic solid-cystic pa- pillary tumor: clinical features, imaging findings and operative management显示文摘 | Casadei R Santini D Calculli L | 2006 | JOP2006，7，1： | 1 |
| 13 | Italian consensus guidelines for chronic pancreatitis显示文摘 | Luca Frulloni Massimo Falconi Armando Gabbrielli Ezio Gaia Rossella Graziani Raffaele Pezzilli Generoso Uomo Angelo Andriulli Gianpaolo Balzano Luigi Benini Lucia Calculli Donata Campra Gabriele Capurso Giulia Martina Cavestro Claudio De Angelis Luigi Ghe | 2010 | Digestive and Liver Disease2010，，： | 1 |
| 14 | Role of spiral computerized tomography in the staging og pancreatic carcinoma显示文摘 | Calculli L Casadei R Diacono D | 1998 | Radiol Med (Torino)1998，95，4： | 1 |
| 15 | Therapeutic management and clinical outcome of autoimmune pancreatitis显示文摘 | Raffaele Pezzilli Giulio Cariani Donatella Santini Lucia Calculli Riccardo Casadei Antonio Maria Morselli-Labate Roberto Corinaldesi | 2011 | Scandinavian Journal of Gastroenterology2011，，9： | 1 |
| 16 | Three-Dimensional Contrast-Enhanced Ultrasonography of Intraductal Papillary Mucinous Neoplasms of the Pancreas: A Comparison With Magnetic Resonance Imaging显示文摘 | Raffaele Pezzilli Carla Serra Lucia Calculli Fabio Ferroni Maria Teresa Iammarino Riccardo Casadei | 2013 | Pancreas2013，，： | 1 |
| 17 | Italian consensus guidelines for chronic pancreatitis显示文摘 | Luca Frulloni Massimo Falconi Armando Gabbrielli Ezio Gaia Rossella Graziani Raffaele Pezzilli Generoso Uomo Angelo Andriulli Gianpaolo Balzano Luigi Benini Lucia Calculli Donata Campra Gabriele Capurso Giulia Martina Cavestro Claudio De Angelis Luigi Ghe | 2010 | Digestive and Liver Disease2010，，： | 1 |
| 18 | Pancreatic solid-cystic papillary tumor:clinical features,imaging findings and operative management显示文摘 | Casadei R Santini D Calculli L | 2006 | JOP2006，7，1： | 1 |
| 19 | Cystic dystrophy of the duodenal wall is not always associated with chronic pancreatitis显示文摘Cystic dystrophy of the duodenal wall is a rare form of the disease which was described in 1970 by French authors who reported the presence of focal pancreatic disease localized in an area comprising the C-loop of the duodenum and the head of the pancreas.Ger-man authors have defined this area as a'groove'.We report our recent experience on cystic dystrophy of the paraduodenal space and systematically review the data in the literature regarding the alterations of this space.A MEDLINE search of papers published between 1966 and 2010 was carried out and 59 paperswere considered for the present study;there were 19 cohort studies and 40 case reports.The majority of patients having groove pancreatitis were middle aged.Mean age was significantly higher in patients having groove carcinoma.The diagnosis of cystic dystrophy of the duodenal wall can now be assessed by multi-detector computer tomography,magnetic resonance imaging and endoscopic ultrasonography.These latter two techniques may also add more information on the involvement of the remaining pancreatic gland not involved by the duodenal malformation and they may help in differentiating'groove pancreatitis'from 'groove adenocarcinoma'.In conclusion,chronic pan-creatitis involving the entire pancreatic gland was present in half of the patients with cystic dystrophy of the duodenal wall and,in the majority of them,the pan-creatitis had calcifications. | Raffaele Pezzilli Donatella Santini Lucia Calculli Riccardo Casadei Antonio Maria Morselli-Labate Andrea Imbrogno Dario Fabbri Giovanni Taffurelli Claudio Ricci Roberto Corinaldesi | 2011 | World Journal of Gastroenterology2011，17，39： | 1 |
| 20 | The usefulness of spiral computed tomography and colour-doppler ultrasonography to predict portal-mesenteric trunk involvement in pancreatic cancer显示文摘 | Calculli L Casadei R Amore B | 2002 | Radio Med(Torino)2002，104，4： | 1 |
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