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| 1 | USP3 inhibits type I interferon signaling by deubiquitinating RIG-I-like receptors显示文摘(K63 ) 离氨酸 63 连接了 RIG-I 戏的 ubiquitination 在类型的激活的一个关键角色我干扰素小径,然而,为它的 deubiquitination 负责的分子的机制仍然糟糕被理解。这里,我们报导 deubiquitination 酶 ubiquitin 特定的朊酶(USP3 ) 3 否定地调整类型的激活我干扰素由指向 RIG-I 发信号。USP3 击倒 RIG-I 的明确地提高的连接 K63 的 ubiquitination, upregulated IRF3 的 phosphorylation 并且扩充了类型的生产我干扰素 cytokines 和抗病毒的免疫。我们进一步证明在 unstimulated 或 uninfected 房间在 USP3 和 RIG-I-like 受体( RLR )之间没有相互作用,但是在病毒的感染或 ligand 刺激之上, USP3 绑在 RLR 的 caspase 激活招募领域然后通过它的锌手指的合作劈开 polyubiquitin 链Ub有约束力的领域和 USP 催化领域。变化分析表明到 RIG-I 上的 polyubiquitin 链的 USP3 的那绑定是为它 polyubiquitin 链的劈开的前提步。我们的调查结果在 RIG-I 激活识别 USP3 的一个以前未被认出的角色并且提供卓见进 USP3 由禁止 RIG-I 发信号和抗病毒的免疫的机制。 | Jun Cui Yanxia Song Yinyin Li Qingyuan Zhu Peng Tan Yunfei Qin Helen Y Wang Rong-Fu Wang | 2014 | Cell Research2014，24，4： | 20 |
| 2 | Curcumin protects PC12 cells against 1-methyl-4-phenylpyridinium ion-induced apoptosis by bcl-2-mitochondria-ROS-iNOS pathway.显示文摘 | Chert J Tang XQ Zhi JL Cui Y Yu HM Tang EH Sun SN Feng JQ Chen PX Chen J | 2006 | 中国生物学文摘2006，20，10： | 16 |
| 3 | Enhanced TLR-induced NF-KB signaling and type I interferon responses in NLRC5 deficient mice显示文摘 | Yanzheng Tong Jun Cui Qingtian Li Jia Zou Helen Y Wang Rong-Fu Wang | 2012 | Cell Research2012，22，5： | 14 |
| 4 | Ex vivo expansion of hematopoietic stem cells derived from umbilical cord blood in rotating wall vessel显示文摘 | Liu Y Liu T Fan X Ma X Cui Z | 2006 | 中国生物学文摘2006，20，5： | 11 |
| 5 | Association between adiponectin concentrations and diabetic retinopathy in patients with type 2 diabetes: a meta analysis显示文摘 | Fan XH Wu QH Hao YH Ning N Kang Z Cui Y Liu RH | 2014 | Chinese Medical Journal2014，，4： | 8 |
| 6 | Patterns of nestin expression in human skin显示文摘 | Wang Y Zhang Y Zeng Y Zheng Y Fu G Cui Z Yang T | 2006 | 中国生物学文摘2006，20，5： | 7 |
| 7 | Distribution of pericellular matrix molecules in the temporomandibular joint and their chondroprotective effects against inflammation显示文摘The objectives of this study were to(1) determine the distribution and synthesis of pericellular matrix(PCM) molecules(collagen VI, collagen IV and laminin) in rat temporomandibular joint(TMJ) and(2) investigate the effects of PCM molecules on chondrocytes against inflammation in osteoarthritis. Four zones(fibrous, proliferating, mature and hypertrophic) of condylar cartilage and three bands(anterior, intermediate and posterior) of disc were analysed by immunohistochemistry for the presence of PCM molecules in rat TMJs. Isolated chondrocytes were pre-treated with PCM molecules before being subjected to interleukin(IL)-1β treatment to stimulate inflammation. The responses of the chondrocytes were analysed using gene expression, nitric oxide release and matrix metalloproteinase(MMP)-13 production measures. Histomorphometric analyses revealed that the highest areal deposition of collagen VI(67.4%), collagen IV(45.7%) and laminin(52.4%) was in the proliferating zone of TMJ condylar cartilage. No significant difference in the distribution of PCM molecules was noted among the three bands of the TMJ disc. All three PCM molecules were expressed intracellularly by chondrocytes cultured in the monolayer. Among the PCM molecules, pre-treatment with collagen VI enhanced cellular proliferation, ameliorated IL-1β-induced MMP-3, MMP-9, MMP-13 and inducible nitric oxide synthase gene expression, and attenuated the downregulation of cartilage matrix genes, including collagen I, aggrecan and cartilage oligomeric matrix protein(COMP). Concurrently, collagen VI pretreatment inhibited nitric oxide and MMP-13 production. Our study demonstrates for the first time the distribution and role of PCM molecules, particularly collagen VI, in the protection of chondrocytes against inflammation. | Wern Cui Chu Shipin Zhang Timothy J Sng Yu Jie Ong Wen-Li Tan Vivien Y Ang Casper B Foldager Wei Seong Toh | 2017 | International Journal of Oral Science2017，9，1： | 5 |
| 8 | Association of polymorphisms in the vascular endothelial growth factor gene and its serum levels with diabetic retinopathy in Chinese patients with type 2 diabetes: A cross-sectional study显示文摘 | Fan XH Wu QH Li Y Hao YH Ning N Kang Z Cui Y Liu RH | 2014 | Chinese Medical Journal2014，，4： | 4 |
| 9 | Improved cryopreservation of human embryonic stem cells with trehalose显示文摘 | Wu CF Tsung HC Zhang W J Wang Y Lu JH Tang ZY Kuang YP Jin W Cui L Liu W Cao YL | 2006 | 中国生物学文摘2006，20，7： | 2 |
| 10 | 高血压患者血清磷酸盐与新发高尿酸血症风险的关系显示文摘血清磷酸盐与新发高尿酸血症的关系仍不确定。该研究对中国脑卒中一级预防试验(China stroke primary prevention trial,CSPPT)的尿酸亚组研究进行事后分析,旨在评估血清磷酸盐与新发高血尿酸症的风险之间的关系。研究包括基线尿酸水平正常(<357μmol/L)的参与者共10612人。主要观察指标是新发高血尿酸症,其定义为男性血尿酸浓度≥417或女性≥357μmol/L。在中位数为4.4年的随访期间,1663名(15.7%)参与者发生了新发高尿酸血症。 | 刘莉(译) 叶鹏(摘、审校) Cao J Zhang J Li Q Jiang C Song Y Liu C Liu L Wang B Li J Zhang Y Cui Y Huo Y Wang X Tang G Xu X Qin X | 2019 | 中华高血压杂志2019，27，6： | 2 |
| 11 | 中国女性孕期抑郁孕晚期发生率与影响因素显示文摘采用横截面研究分析了中国人群中孕晚期的抑郁发生率与影响因素。本研究通过一间妇女儿童健康医院登记记录募集研究对象。测量量表包括中文版抑郁自评量表,艾森克人格问卷,社会支持评定量表和简化版应对策略问卷。292名研究对象中,抑郁症状检出率为28.5%。 | Zeng Y Cui Y Li J 张继 | 2017 | 中华预防医学杂志2017，51，2： | 2 |
| 12 | The ASIC Design for Synthesizing Dual Channel Gauss White Noise显示文摘 | Cui W Han Y Q Long T | 2002 | Chinese Journal of Electronics2002，11，3： | 2 |
| 13 | Doping and electrical transport in silicon nanowires显示文摘 | Cui Y Duan X F Hu J T | 2000 | J Phys Chem B2000，104，22： | 2 |
| 14 | The prevalence of dementia in urban and rural areas of China显示文摘 | Jianping Jia Fen Wang Cuibai Wei Aihong Zhou Xiangfei Jia Fang Li Muni Tang Lan Chu Youlong Zhou Chunkui Zhou Yong Cui Qi Wang Weishan Wang Peng Yin Nan Hu Xiumei Zuo Haiqing Song Wei Qin Liyong Wu Dan Li Longfei Jia Juexian Song Ying Han Yi Xing Peijie Y | 2013 | Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association2013，，： | 2 |
| 15 | Effect of ultrasonic vibration on unmixed zone formation 显示文摘 | Cui Y Xu C L Han Q | 2006 | Scripta Materialia2006，55，11： | 1 |
| 16 | Investigation of flow in a steam turbine exhaust hood with/without turbine exit conditions simulated显示文摘 | LIU J J CUI Y Q JIANG H D | 2003 | Journal of Engineering for Gas Turbines and Power2003，125，1： | 1 |
| 17 | Transfer hydrogenation of activatied C=C bonds catalyzed by ruthenium amido complexes: Reaction scope, limitation, and enantioselectivity 显示文摘 | Xue D Chen Y C Cui X | 2005 | Journal of Organic Chemistry2005，70，9： | 1 |
| 18 | Effect of matrix composition on the microstructure of in-situ synthesized TiC particulate reinforced ironbased composites 显示文摘 | Mei Z Yan Y W Cui K | 2003 | Materials Letters2003，57，3： | 1 |
| 19 | Effect of a feeding stimulant on feeding adaptation of gibel carp Carassius auratus gibelio (Bloch),fed diets with replacement of fish meal by meat and bone meal显示文摘 | Xue M Xie S Q Cui Y B | 2004 | Aquaculture Research2004，35，： | 1 |
| 20 | Dynamic motion planning for mobile robots using potential field method显示文摘 | CUI Y J | 2002 | Autonomous Robots2002，13，3： | 1 |
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