|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Understanding cancer stem cell heterogeneity and plasticity显示文摘异质是在 vitro 并且在 vivo 的哺乳动物的房间的一个无所不在的特征。甚至在最好的文化条件下面的老鼠和人的胚胎的干细胞是异构的象部分承诺的房间一样包含 pluripotent,这最近被认识到。在成年器官的体的干细胞也是异构的,包含有不同再生能力的自我更新的细胞的许多 subpopulations。成年干细胞的区分的子孙也保留能被许多试验性的途径导致的重要发展粘性。象正常干细胞一样,最近的数据建议癌症干细胞(CSC ) 同样显示重要 phenotypic 和功能的异质,并且 CSC 子孙能表明多样的粘性。这里,我在肿瘤开发和前进的上下文讨论 CSC 异质和粘性,并且由与正常干细胞开发作比较。对癌症房间粘性的欣赏必要到在肿瘤的仅仅 tumorigenic 子集需要到的更早的概念的修订被指向。由理解在 CSC 和他们的区分的子孙之间的相互关系,我们能希望开发能阻止能成立一个新肿瘤和远转移的肿瘤房间变体的出现的更好治疗学的政体。 | Dean G Tang | 2012 | Cell Research2012，22，3： | 37 |
| 2 | Covalently closed-circular hepatitis B virus DNA reduction with entecavir or lamivudine显示文摘AIM: To investigate the reduction in hepatitis B virus(HBV) covalently closed-circular DNA(ccc DNA) with entecavir(ETV) or lamivudine(LAM). METHODS: This analysis included patients who had participated in the randomized Phase Ⅲ study ETV-022 comparing ETV vs LAM in nucleos(t)ide-naive, HBe Agpositive patients. Patients received ETV(0.5 mg daily) or LAM(100 mg daily) for a minimum of 52 wk. Patients were eligible to participate in this sub-study if they had paired biopsies at baseline and week 48 with evaluable measurements for hepatic HBV ccc DNA and total hepatic HBV DNA. The main objective was to compare changes in hepatic HBV ccc DNA and total hepatic HBV DNA at week 48 of ETV or LAM treatment, which was a secondary endpoint of study ETV-022. Additional post hoc analyses included linear regression analyses to assess associations of baseline levels and on-treatment changes of ccc DNA with other baseline factors [sex,age, serum HBV DNA, alanine aminotransferase(ALT), Knodell necroinflammatory score, Ishak fibrosis score, total hepatic HBV DNA, and HBV genotype], or ontreatment factors(changes from baseline at week 48 in serum HBV DNA, ALT, Knodell necroinflammatory score, Ishak fibrosis score, total hepatic HBV DNA, and HBe Ag loss at week 48).RESULTS: Overall, 305 patients(ETV = 159; LAM = 146) of ETV-022 had paired baseline and week 48 liver biopsies with evaluable measurements for hepatic HBV ccc DNA and total hepatic HBV DNA, and were included in this analysis. Baseline demographics and disease characteristics were comparable between the two arms. After 48 wk, ETV resulted in significantly greater reductions in hepatic HBV ccc DNA [-0.9 log10 copies/human genome equivalent(HGEq) vs-0.7 log10 copies/HGEq; P = 0.0033] and total hepatic DNA levels(-2.1 log10 copies/HGEq vs-1.6 log10 copies/HGEq; P < 0.0001) than LAM. Virologic, biochemical, and histologic response rates at week 48 were also greater with ETV than with LAM. Baseline HBV ccc DNA levels were positively associated with baseline levels of serum HBV DNA and total hepatic HBV DNA, and negatively associated with HBV genotype F. On-treatment changes in HBV ccc DNA levels were negatively associated with baseline levels of serum HBV DNA and baseline ALT, and were positively associated with on-treatment changes in the levels of serum HBV DNA, total hepatic HBV DNA levels, and ALT, change in Knodell necroinflammatory score, and HBe Ag loss.CONCLUSION: Forty-eight weeks of ETV resulted in greater reductions in ccc DNA and total hepatic HBV DNA than LAM, but long-term therapy may be needed for ccc DNA elimination. | Scott Bowden Stephen Locarnini Ting-Tsung Chang You-Chen Chao Kwang-Hyub Han Robert G Gish Robert A de Man Miao Yu Cyril Llamoso Hong Tang | 2015 | World Journal of Gastroenterology2015，21，15： | 11 |
| 3 | Spatial-temporal dynamics of desert vegetation and its responses to climatic variations over the last three decades:a case study of Hexi region in Northwest China显示文摘Analysis of spatial-temporal variations of desert vegetation under the background of climate changes can provide references for ecological restoration in arid and semi-arid areas.In this study,we used the Global Inventory Modeling and Mapping Studies(GIMMS)NDVI data from 1982 to 2006 and Moderate Resolution Imaging Spectroradiometer(MODIS)NDVI data from 2000 to 2013 to reveal the dynamics of desert vegetation in Hexi region of Northwest China over the past three decades.We also used the annual temperature and precipitation data acquired from the Chinese meteorological stations to analyze the response of desert vegetation to climatic variations.The average value of NDVImax(the maximum NDVI during the growing season)for desert vegetation in Hexi region increased at the rate of 0.65×10–3/a(P<0.05)from 1982 to 2013,and the significant increases of NDVImax mainly appeared in the typical desert vegetation areas.Vegetation was significantly improved in the lower reaches of Shule and Shiyang river basins,and the weighted mean center of desert vegetation mainly shifted toward the lower reaches of the two basins.Almost 95.32% of the total desert vegetation area showed positive correlation between NDVImax and annual precipitation,indicating that precipitation is the key factor for desert vegetation growth in the entire study area.Moreover,the areas with non-significant positive correlation between NDVImax and annual precipitation mainly located in the lower reaches of Shiyang and Shule river basins,this may be due to human activities.Only 7.64% of the desert vegetation showed significant positive correlation between NDVImax and annual precipitation in the Shule River Basin(an extremely arid area),indicating that precipitation is not the most important factor for vegetation growth in this basin,and further studies are needed to investigate the mechanism for this phenomenon. | YANG Xuemei LIU Shizeng YANG Taibao XU Xianying KANG Caizhou TANG Jinnian WEI Huaidong Mihretab G GHEBREZGABHER LI Zhiqi | 2016 | Journal of Arid Land2016，8，4： | 10 |
| 4 | Genetic Diversity Based on Allozyme Alleles of Chinese Cultivated Rice显示文摘Genetic diversity was analyzed with 6632 core rice cultivars selected from 60 282 Chinese rice accessions on the basis of 12 allozyme loci, Pgi1, Pgi2, Amp1, Amp2, Amp3, Amp4, Sdh1, Adh1, Est1, Est2, Est5 and Est9, by starch gel electrophoresis. Among the materials examined, 52 alleles at 12 polymorphic loci were identified, which occupied 96.3% of 54 alleles found in cultivated germplasm of O. sativa L. The number of alleles per locus ranged from 2 to 7 with an average of 4.33. The gene diversity (He) each locus varied considerably from 0.017 for Amp4 to 0.583 for Est2 with an average gene diversity (Ht) 0.271, and Shannon-Wiener index from 0.055 to 0.946 with an average of 0.468. The degree of polymorphism (DP) was in a range from 0.9 to 46.9% with an average of 21.4%. It was found that the genetic diversity in japonica (Keng) subspecies was lower in terms of allele's number, Ht and S-W index, being 91.8, 66.2 and 75.7% of indica (Hsien) one, respectively. Significant genetic differentiation between indica and japonica rice has been appeared in the loci Pgi1, Amp2, Pgi2, and Est2, with higher average coefficient of genetic differentiation (Gst) 0.635, 0.626, 0.322 and 0.282, respectively. Except less allele number per locus (3.33) for modern cultivars, being 76.9% of landraces, the Ht and S-W index showed in similar between the modern cultivars and the landraces detected. In terms of allozyme, the rice cultivars in the Southwest Plateau and Central China have richer genetic diversity. The present study reveals again that Chinese cultivated rice germplasm has rich genetic diversity, showed by the allozyme allele variation. | TANG Sheng-xiang WEI Xing-hua JIANG Yun-zhu D S Brar G SKhush | 2007 | Agricultural Sciences in China2007，6，6： | 3 |
| 5 | 高血压患者血清磷酸盐与新发高尿酸血症风险的关系显示文摘血清磷酸盐与新发高尿酸血症的关系仍不确定。该研究对中国脑卒中一级预防试验(China stroke primary prevention trial,CSPPT)的尿酸亚组研究进行事后分析,旨在评估血清磷酸盐与新发高血尿酸症的风险之间的关系。研究包括基线尿酸水平正常(<357μmol/L)的参与者共10612人。主要观察指标是新发高血尿酸症,其定义为男性血尿酸浓度≥417或女性≥357μmol/L。在中位数为4.4年的随访期间,1663名(15.7%)参与者发生了新发高尿酸血症。 | 刘莉(译) 叶鹏(摘、审校) Cao J Zhang J Li Q Jiang C Song Y Liu C Liu L Wang B Li J Zhang Y Cui Y Huo Y Wang X Tang G Xu X Qin X | 2019 | 中华高血压杂志2019，27，6： | 2 |
| 6 | Preparation of stable micropatterns of gold on cell-adhesion-resistant hydrogels assisted by a hetero-bifunctional macromonomer linker显示文摘Surface patterning is very useful in biomaterial studies, yet it is not easy to prepare a micropattern with cell-adhesion contrast that is stable in a wet environment. Recently, a platform technique of transfer photolithography was invented to fabricate stable metal microarrays on the surface of a cell-adhesion resistant and mechanically biomimetic poly(ethylene glycol) hydrogel; the linker is the key chemical in such a transfer strategy. This article reports the design and synthesis of a hetero-bifunctional macromonomer linker with a thiol group at one end and an acryloyl group at the other end. The bifunctional linker was characterized by GPC and 1H NMR, and the average number of thiol groups in the bifunctional linker was detected by Ellman's reagent. The regent stability under wet conditions was also confirmed by the model reactants. The resultant micropatterned surfaces are meaningful for future studies of cell behaviors on mechanically biomimetic matrixes. | SUN JianGuo GRAETER Stefan V TANG Jian HUANG JingHuan LIU Peng LAI YuXiao YU Lin MAJER Günter SPATZ Joachim P DING JianDong | 2014 | Science China Chemistry2014，57，4： | 2 |
| 7 | Variable-Notch One-Size Test Method for Fracture Energy and Process Zone Length显示文摘 | Tang T Bazant Z P Yang S Zollinger D G | 1996 | Engineering Fracture Mechanics1996，55，3： | 2 |
| 8 | Enhanced Offset Averaging Technique for Flash ADC Design显示文摘This paper presents a new combined AC/DC-coupled output averaging technique for input amplifier design of flash analog-to-digital converters (ADC). The new offset averaging design technique takes full advantage of traditional DC-coupled resistance averaging and AC-coupled capacitance averaging techniques to minimize offset-induced ADC nonlinearities. Circuit analysis allows selection of optimum resistance and capacitance averaging factors to achieve maximum offset reduction in ADC designs. The new averaging method is verified in designing a 4 bit 1 Gs/s flash ADC that is implemented in foundry 0.13 μm CMOS technology. | Siqiang FAN He TANG Hui ZHAO Xin WANG Albert WANG Bin ZHAO Gary G ZHANG | 2011 | Tsinghua Science and Technology2011，16，3： | 2 |
| 9 | Toughening modification of PS with n-BA/MMA/styrene coreshell structured copolymer from emulsifier-free emulsion polymerization 显示文摘 | Guo T Y Tang G L Hao G J | 2003 | Journal of Applied Science2003，90，： | 1 |
| 10 | Hybrid Transient Stability Analysis显示文摘 | Mafia G A Tang C Kim J | 1990 | IEEE Trans on Power Systems1990，5，2： | 1 |
| 11 | The role of autoregressive conditional skewness and kurtosis in the estimation of conditional var 显示文摘 | Turan G Bali Hengyong Mo Yi Tang | 2007 | Journal of Banking & Finance2007，，3： | 1 |
| 12 | Ultraviolet spontaneous and stimulated emissions from ZnO microcrystallite thin films at room temperature 显示文摘 | Zu P Tang Z K Wong G K L | 1997 | Solid State Commun1997，，103： | 1 |
| 13 | Truncated hepatitis B virus RNA in human hepatocellular carcinoma: Its representation in patients with advancing age 显示文摘 | Beerheide W Zhou G Tang Y Edler L Schroeder CH | 1999 | Intervirology1999，42，： | 1 |
| 14 | siRNA and miRNA:An insight into RISCs显示文摘 | | 2005 | Trends Biochem Sci2005，30，2： | 1 |
| 15 | A fundamental understanding to the failure of cement concrete pavement based on the concept of fracture mechanics显示文摘 | YI Z J YANG Q G TANG B M | 2002 | International Journal of Road Material and Pavement Design2002，3，3： | 1 |
| 16 | Controllable formation and electrochemical properties of one - dimensional nanostructured spinel Li4Ti5 O12 显示文摘 | Li J R Tang Z L Zhang Z G | 2005 | Electrochemistry Communications2005，7，： | 1 |
| 17 | Binding of puerarin to human serum albumin:a spectroscopic analysis and molecular docking显示文摘 | HE Y WANG Y W TANG L F LIU H CHEN W ZHENG Z L ZOU G L | 2008 | J Fluoresc2008，18，2： | 1 |
| 18 | New Directions for Low-Dimensional Thermoelectric Materials 显示文摘 | DRESSELHAUS MS CHEN G TANG MY | 2007 | Advanced Materials2007，19，： | 1 |
| 19 | MDR1, the blood-brain barrier transporter, is associated with Parkinson's disease in ethnic Chinese 显示文摘 | LEE C G TANG K CHEUNG Y B | 2004 | J Med Genet2004，41，5： | 1 |
| 20 | Effect of electmpuls- ing treatment on nficrostructure and tensile fracture be- havior of aged Mg - 9A1 - 1Zn alloy strip 显示文摘 | Jiang Y Tang G Shek C Zhu Y | 2009 | Applied Physics A: Materials Science & Processing2009，97，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员