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| 1 | 极高强度他汀治疗对冠状动脉粥样硬化消退的影响——ASTEROID试验显示文摘背景:以前的血管内超声(intravascular ultrasound,IVUS)试验证实,他汀治疗可减缓或阻止动脉粥样硬化的进展,但是迄今尚无应用动脉粥样斑块体积百分比(percent atheroma volume,PAV)证实粥样硬化消退的确切证据。PAV是最严格的评价病变进展和消退的IVUS测量指标。
目标:评价极高强度他汀治疗是否能逆转IVUS确定的冠状动脉粥样硬化。
设计和地点:于美国、加拿大、欧洲和澳大利亚53个社区和3级保健中心进行前瞻性开标盲法终点试验(A Study to Evaluate the Effect of Rosuvastatin on Intravascular Ultrasound-Derived Coronary Atheroma Burden,ASTEROID)。应用马达驱动回撤IVUS评价基线和治疗24个月时冠状动脉粥样斑块负荷。每对基线和随访IVUS测量结果均进行盲法分析。
病例:从2002年11月到2003年10月,507例患者有基线IVUS检查结果,并接受至少1个剂量的研究药物。在24个月后,349例患者具有可用于评估的系列IVUS检查结果。
干预:所有患者均接受瑞舒伐他汀40ms/d强化治疗。
主要观测指标:预先设定了两个一级疗效指标:PAV变化和基线最严重病变10min节段动脉粥样斑块体积变化。二级疗效指标为整个动脉标准化总斑块体积的变化。结果:平均(SD)LDL—C水平由基线时的130.4(34.3)ms/dL降至60.8(20.0)ms/扎,平均下降了53.2%(P〈0.001)。平均(SD)HDL-C水平从基线时的43.1(11.1)ms/dL升至49.0(12.6)ms/dL,平均增加了14.7%(P〈0.001)。整个血管PAV平均(SD)变化为-0.98%(3.15%),中位数为-0.79%(97.5%CI,-1.21%~-0.53%)(与基线比较,P〈0.001)。最严重病变10min节段斑块体积平均(SD)变化为-6.1(10.1)mm^3,中位数为-5.6mm^3(97.5%CI,-6.8~-4.0mm^3)(与基线比较,P〈0.001)。总斑块体积变化中位数降低了6.8%,平均减少了-14.7(25.7)mm^3,中位数为-12.5mm^3(95%CI,-15.1~-10.5mm^3)(与基线比较,P〈0.001)。不良事件少见,与其他他汀试验相似。
结论:应用瑞舒伐他汀40ms/d进行极高强度他汀治疗可使LDL-C平均水平达到60.8ms/dL,使HDL—C增加14.7%。这导致所有3个预先设定的IVUS斑块负荷指标均显示动脉粥样硬化消退。因此,将LDL-C降至低于目前指南规定的水平,同时显著提高HDL-C,可以使冠心病患者动脉粥样硬化斑块消退。这些变化对临床预后的影响尚需进一步研究确定。 | Steven E. Nissen Stephen J. Nicholls Ilks Sipahi Peter Libby Joel S. Raichlen Christie M. Ballantyne Jean Davignon Raimund Erbel Jean Charles Fruchart Jean-Claude Tardif Paul Schoenhagen Tim Crowe Valerie Cain Kathy Wolski Marlene Coormastic E. Murat Tuzcu 仝其广(译) 王淑敏(译) 胡大一(校) | 2006 | 美国医学会杂志(中文版)2006，25，4： | 341 |
| 2 | 他汀、高密度脂蛋白胆固醇与冠状动脉粥样硬化消退显示文摘背景:他汀类药物可以降低低密度脂蛋白胆固醇(low—density lipoprotein cholesterol,LDL—C)水平并减缓冠状动脉粥样硬化的进展。然而,对于他汀类药物所致高密度脂蛋白胆固醇(high—density lipoprotein cholesterol,HDL—C)变化与疾病进展的关系,目前仍无相关数据描述。目的:了解LDL—C和HDL—C水平变化与动脉粥样硬化的相互关系。设计、地点及患者:对4项前瞻性随机试验(1999~2005年在美国、北美、欧洲和澳大利亚进行)的原始数据进行事后分析。其中1455例经血管造影证实的冠心病患者在接受他汀治疗(18个月或24个月)时进行了系列血管内超声扫描。所有超声分析均在相同的核心实验室中进行。主要观测指标:脂蛋白水平变化与冠状动脉粥样斑块体积的相互关系。结果:他汀治疗期间,LDL—C平均(SD)水平从124.0(38.3)mg,/dL(3.2[0.99]mmol/L)降至87.5(28.8)mg,/dL(2.3[0.75]mmol/L)(下降23.5%;P〈0.001),HDL—C水平从42.5(11.0)mg/dL(1.1[0.28]mmol/L)升至45.1(11.4)mg/dL(1.2[0.29]mmol/L)(上升7.5%;P〈0.001)。LDL—C与HDL—C比值从平均(SD)3.0(1.1)降至2.1(0.9)(下降26.7%;P〈0.001)。这些变化同时伴随平均(SD)百分粥样斑块体积的增加(从39.7%[9.8%]增至40.1%[9.7%])(增加0.5%[3.9%];P=0.001)以及平均(SD)总粥样斑块体积的减小(2.4[23.6]mm^3;P〈0.001)。在单变量分析中,LDL—C、总胆固醇、非HDL胆固醇、载脂蛋白B以及载脂蛋白B与载脂蛋白A-1比值平均水平和治疗引起的变化与动脉粥样硬化进展速率显著相关,而治疗所致HDL—C变化则与动脉粥样斑块体积负相关。在多变量分析中,平均LDL—C水平(β系数,0.11[95%可信区间,0.07~0.15])以及HDL—C升高(β系数,-0.26[95%可信区间,-0.41--0.10])依然为动脉粥样硬化消退的独立预测因子。动脉硬化显著消退(动脉粥样斑块体积减少≥5%)见于治疗期间LDL—C水平低于均值(87.5mg/dL)和HDL—C升高百分比大于均值(7.5%;P〈0.001)的患者。临床事件的发生未见显著差异。结论:在LDL—C显著降低以及HDL上升〉7.5%时,他汀治疗与冠状动脉粥样硬化消退相关。这些结果提示他汀治疗的获益源自致动脉粥样硬化脂蛋白的降低以及HDL.C的升高。尽管血脂水平的这些变化与动脉粥样硬化消退相关,但是后者是否可以转化为临床事件的显著减少,并改善临床预后仍有待进一步研究确定。 | Stephen J. Nicholls, MBBS, PhD E. Murat Tuzcu, MD IIke Sipahi, MD Adam W. Grasso, MD Paul Schoenhagen, MD Tingfei Hu, MS Kathy Wolski, MPH Tim Crowe, BS Milind Y. Desai, MD Stanley L. Hazen, MD, PhD Samir R. Kapadia, MD Steven E. Nissen, MD 李呈亿(译) | 2007 | 美国医学会杂志(中文版)2007，26，3： | 48 |
| 3 | CFD investigation of dense phase pneumatic conveying at a pipeline enlargement显示文摘The practice of stepping a conveying line is not new and there are many examples in industry; however, the details of the flow behaviour at the step have not been extensively studied. Three step geometries were modelled: an 'abrupt' step and two 'gradual' step-up geometries from a pipe bore of 75-100 mm. The flow behaviour of a single plug of material passing through these geometries was investigated using the 'Eulerian' CFD model from Fluent. Solids volume fractions were recorded at 0.01 s time steps at several point locations, and visualised throughout the pipe. | Don McGlinchey Andrew Cowell Ryan Crowe | 2012 | Particuology2012，10，2： | 10 |
| 4 | Johanson-Blizzard syndrome with mild phenotypic features confirmed by UBR1 gene testing显示文摘Johanson-Blizzard syndrome (JBS) is a rare autosomal recessive condition associated with exocrine pancreatic insufficiency,and is characterized by hypoplastic nasal alae,mental retardation,sensorineural hearing loss,short stature,scalp defects,dental abnormalities and abnormal hair patterns. Growth hormone deficiency,hypopituitarism,and impaired glucagon secretion response to insulin-induced hypoglycemia have been reported. Congenital heart defects have also been described in this condition. Mental retardation is typically moderate to severe in patients with JBS; however,normal intelligence can occur. In the pancreas,there is a selective defect of acinar tissue,whereas the islets of Langerhans and ducts are preserved. Diabetes has been reported in older children,suggesting the progressive nature of pancreatic disease. The molecular basis of JBS has recently been mapped to chromosome 15q15-q21 with identified mutations in the UBR1 gene. We report the case of a 7-year-old female with pancreatic insufficiency and mild phenotypic features,in whom the diagnosis of JBS was established using recently described molecular testing for the UBR1 gene. | Naim Alkhouri Barbara Kaplan Marsha Kay Amy Shealy Carol Crowe Susanne Bauhuber Martin Zenker | 2008 | World Journal of Gastroenterology2008，14，44： | 4 |
| 5 | TH17 Cells in Asthma and COPD显示文摘 | John F. Alcorn Christopher R. Crowe Jay K. Kolls | 2010 | Annual Review of Physiology2010，，： | 3 |
| 6 | How to deal with real estate booms: Lessons from country experiences显示文摘 | Christopher Crowe Giovanni Dell’Ariccia Deniz Igan Pau Rabanal | 2013 | Journal of Financial Stability2013，，3： | 2 |
| 7 | Road transport of cattle, swine and poultry in North America and its impact on animal welfare, carcass and meat quality: A review显示文摘 | K.S. Schwartzkopf-Genswein L. Faucitano S. Dadgar P. Shand L.A. González T.G. Crowe | 2012 | Meat Science2012，，3： | 2 |
| 8 | 萍乡傩面具的表现程式显示文摘 | Crow | 2004 | 民族论坛2004，，4： | 2 |
| 9 | Helicobacter pylori in Gastric Malignancies显示文摘 | Abhishek Bhandari Sheila E. Crowe | 2012 | Current Gastroenterology Reports2012，，6： | 2 |
| 10 | 随钻声波测井新技术显示文摘工程师根据声波测井仪记录的声波资料以更高的安全系数提高钻井效率,优化完井方式。LWD声波测井仪是在上世纪90年代中期问世的,能够记录纵波资料,但不能记录所有地层的横波资料。新型LWD声波测井仪能记录以前无法得到的横渡资料,工程师正在利用横渡资料优化钻井作业,确定最佳钻进方向,识别具有更好完井特征的岩层。 | Jeff Alford Matt Blyth Ed Tollefsen John Crowe Julio Loreto Saeed Mohammed Vivian Pistre Adrian Rodriguez-Herrera | 2013 | 国外测井技术2013，，2： | 2 |
| 11 | Outcomes of Early- and Late-Identified Children at 3 Years of Age: Findings From a Prospective Population-Based Study显示文摘 | Teresa Y. C. Ching Harvey Dillon Vivienne Marnane Sanna Hou Julia Day Mark Seeto Kathryn Crowe Laura Street Jessica Thomson Patricia Van Buynder Vicky Zhang Angela Wong Lauren Burns Christopher Flynn Linda Cupples Robert S. C. Cowan Greg Leigh Jessica Sja | 2013 | Ear and Hearing2013，，5： | 2 |
| 12 | Nonlinear parameter estimation of excitation systems 显示文摘 | BHASKAR R CROW M L LUDWIG E | 2000 | IEEE Transactions on Power Systems2000，15，4： | 1 |
| 13 | Stability theory for a pair of trailing vortices 显示文摘 | Crow S C | 1970 | AIAA Journal1970，8，12： | 1 |
| 14 | Regulatory focus and strategic inclinations: Promotion and prevention in decision-making显示文摘 | Crowe E and Higgins E T | 1997 | Organizational Behavior and Human Decision Processes1997，69，2： | 1 |
| 15 | Postpartum depression screening at well-child visits:validity of a 2-question screen and the PHQ-9显示文摘 | Gjerdingen D Crow S McGovern P | 2009 | Ann Fam Med2009，7，1： | 1 |
| 16 | Vasoactive in testinal Polypepatide Levels diseasein sigm oid idiopation and diverticular显示文摘 | Milner P Crowe R Kamm M A | 1990 | Gastroenterology1990，99，3： | 1 |
| 17 | The effectiveness of EMG biofeedback in the treatment of arm function after stroke 显示文摘 | Crow JL Lincoln NB Nouri FM | 1989 | Int Disabil Stud1989，11，4： | 1 |
| 18 | The minnesota code manual of electrocardiographic findings: standards and procedures for measurement and classification 显示文摘 | Prineas RJ Crow RS Blackburn HW | 1982 | John Wright: PSG Inc1982，，： | 1 |
| 19 | Relative efficacy of intravenous immunoglobulin G in ameliorating thrombocytopenia induced by antiplatelet GP Ⅱ IbⅢa versus GPlbalpha antibodies 显示文摘 | Webster ML Sayeh E Crow M | 2006 | Blood2006，108，3： | 1 |
| 20 | The mitochondrial death pathway and cardiac myocyte apoptosis显示文摘 | CROW M T MANI K NAM Y J | 2004 | Circ Res2004，95，10： | 1 |
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