|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 中国燃煤汞排放清单的初步建立显示文摘建立中国分省燃煤汞排放清单 ,对于研究汞的大气化学转化、迁移和沉降 ,制定中国汞污染控制对策具有重要意义 .本研究按经济部门、燃料类型、燃烧方式和污染控制技术将排放源划分为 6 5种不同类型 ,根据各类型的煤炭消费量、燃料汞含量和汞排放因子计算汞排放量 ,最终建立了分省燃煤汞排放清单 .用 2组原煤汞含量数据资料计算的 2 0 0 0年中国燃煤大气汞排放量分别为 16 .1 6t和 2 .19 5t,其中绝大部分汞排放来自工业、电力和生活消费 ,分别占 4 6 %、35 %和 14 % .Hg0 、Hg2 + 和Hgp在中国燃煤大气汞排放中所占的比例分别为 16 %、6 .1%和 2 3% .中国燃煤汞排放在各地区间有较大差异 ,排放量较大的省份有河南、山西、河北、辽宁和江苏 ,均超过 10t/a . | 蒋靖坤 郝吉明 吴烨 David G. Streets 段雷 田贺忠 | 2005 | 环境科学2005，26，2： | 129 |
| 2 | 长江三角洲地区大气O3和PM10的区域污染特征模拟显示文摘以TRACE-P污染源资料及上海市地方排放清单为基础,采用Models-3/CMAQ环境空气质量模型和中尺度气象模式MM5,模拟研究了2001-01和2001-07长三角近地面二次污染物O3及PM10的浓度分布及输送状况,并以上海市国控点2001年冬、夏季各10 d的小时监测数据对模型进行了验证.验证结果显示,Models-3/CMAQ对O3和PM10的模拟结果与监测值的相关系数分别为0.77和0.52;一致性指数分别达到0.81和0.99.模型对O3小时最高浓度的估算偏低27%,标准偏差为-3.1%;对PM10小时平均浓度的估算偏低10%,标准偏差为46%.模型已具备再现和模拟长三角大气污染输送过程的能力,且误差落在可接受的范围之内.模拟结果显示,2001-07长三角区域16个主要城市中,有14个城市O3小时最大浓度超过国家二级标准,高浓度O3可覆盖苏南和浙北广大区域.2001-01泰州、扬州、南京、镇江、常州等城市受本地排放源和北部大气污染输送的影响显著,大气PM10日均浓度超过PM10国家二级标准.长三角地区环境空气质量与污染类型受大气污染传输与化学转化的影响十分明显.夏季太阳辐射较强时,南部城市排放的污染物常以二次污染物的形式影响下风向城市;太阳辐射较弱的情况下,则以一次污染物输送为主的形式影响周边地区.冬季长三角区域颗粒物污染总体水平较高,这与我国北方地区排放的颗粒物在西北风作用下向长三角输送造成的影响密切相关.长三角地区的大气污染已逐渐从局地转为区域问题. | 李莉 陈长虹 黄成 黄海英 李作攀 Joshua S. Fu Carey J. Jang David G. Streets | 2008 | 环境科学2008，29，1： | 91 |
| 3 | CHA2007年患者安全目标暨主要措施显示文摘1 提高医务人员对患者识别的准确性,严格执行三查七对制度
(1)健全与完善患者识别制度,至少在抽血、给药或输血时,必须严格执行三查七对制度,应至少同时使用二种患者识别的方法(不得仅以床号作为识别的依据)。 | Chinese Hospital Association, Heping Street, Chaoyang District, Beijing, 100013, PRC | 2007 | 中国医院2007，11，1： | 54 |
| 4 | Epigenetic regulation: methylation of histone and non-histone proteins显示文摘Histone methylation is believed to play important roles in epigenetic memory in various biological processes. However, questions like whether the methylation marks themselves are faithfully transmit- ted into daughter cells and through what mechanisms are currently under active investigation. Previ- ously, methylation was considered to be irreversible, but the recent discovery of histone lysine de- methylases revealed a dynamic nature of histone methylation regulation on four of the main sites of methylation on histone H3 and H4 tails (H3K4, H3K9, H3K27 and H3K36). Even so, it is still unclear whether demethylases specific for the remaining two sites, H3K79 and H4K20, exist. Furthermore, be- sides histone proteins, the lysine methylation and demethylation also occur on non-histone proteins, which are probably subjected to similar regulation as histones. This review discusses recent pro- gresses in protein lysine methylation regulation focusing on the above topics, while referring readers to a number of recent reviews for the biochemistry and biology of these enzymes. | LAN Fei1 & SHI Yang 2 1 Department of Biology, Constellation Pharmaceuticals, 148 Sidney Street, Cambridge, MA 02139, USA 2 Department of Pathology, Harvard Medical School, 77 Ave Louise Pasteur, Boston MA, 02115, USA | 2009 | Science China(Life Sciences)2009，52，4： | 27 |
| 5 | Signal transduction mediated by Bid,a pro-death Bcl-2 family proteins, connects the death receptor and mitochondria apoptosis pathways显示文摘Two major apoptosis pathways have been defined in mammalian cells, the Fas/TNF-R1 death receptor pathway and the mitochondria pathway. The Bcl-2 family proteins consist of both anti-apoptosis and pro- apoptosis members that regulate apoptosis, mainly by controlling the release of cytochrome c and other mitochondrial apoptotic events. However, death signals mediated by Fas/TNF-R1 receptors can usually activate caspases directly, bypassing the need for mitochondria and escaping the regulation by Bcl-2 family proteins. Bid is a novel pro-apoptosis Bcl-2 family protein that is activated by caspase 8 in response to Fas/TNF-R1 death receptor signals. Activated Bid is translocated to mitochondria and induces cytochrome c release, which in turn activates downstream caspases. Such a connection between the two apoptosis pathways could be important for induction of apoptosis in certain types of cells and responsible for the pathogenesis of a number of human diseases. | YIN XIAO-MING (Department of Pathology, University of Pittsburgh School of Medicine, 3550 Terrace Street, Pittsburgh, PA 15261, USA) | 2000 | Cell Research2000，10，3： | 25 |
| 6 | 统一认识 正确定位 加速临床药师制的建立——临床药师培训试点基地工作调研报告显示文摘从试点基地及专业培训分布情况、学员基本情况、培训组织工作、试点基地的培训管理制度、培训师资情况、专业培训方向设计、培训计划的制定、带教模式、临床药师在职培训工作的定位等方面介绍了第一批临床药师培训试点工作基本情况,指出必须坚持《卫生部临床药师培训试点方案》的基本原则,坚持招收学员的标准,调整专科化临床药师的培训方向,制订《专科临床药师培训标准》,强化培训计划的制定与实施,加强培训的带教工作,规范培训用技术性文件,加强法律法规教育。 | Drug Management Committee, Clinical Pharmacist Training Committee of Chinese Hospital Association Drug Management Committee, Clinical Pharmacist Training Committee of Chinese Hospital Association, No, 2, South Xizhimen Street, Beijing, 100044, PRC | 2007 | 中国医院2007，11，1： | 21 |
| 7 | Molecular signal transduction in vascular cell apoptosis显示文摘Apoptosis is a form of genetically programmed cell death, which plays a key role in regulation of cellularity in a variety of tissue and cell types including the cardiovascular tissues. Under both physiological and pathophysiological conditions, various biophysiological and biochemical factors, including mechanical forces, reactive oxygen and nitrogen species, cytokines, growth factors, oxidized lipoproteins, etc., ma influence apoptosis of vascular cells. The Fas/Fas ligand/caspase death-signaling pathway, Bcl-2 protein family/mitochondria, the tumor suppressive gene p53, and the proto-oncogene c-myc may be activated in atherosclerotic lesions, and mediates vascular apoptosis during the development of atherosclerosis. Abnormal expression and dysfunction of these apoptosis-regulating genes may attenuate or accelerate vascular cell apoptosis and affect the integrity and stability of atherosclerotic plaques. Clarification of the molecular mechanism that regulates apoptosis may help design a new strategy for treatment of atherosclerosis and ii major complication, the acute vascular syndromes. | GENG YONG JIAN Center for Cardiovascular Biology and Atherosclerosis Research, Division of Cardiology, Department of Internal Medicine, University of Texas Houston Health Science Center Medical School, 6431 Fannin Street, MSB 6.045, Houston, TX 77030, USA | 2001 | Cell Research2001，11，4： | 20 |
| 8 | A Study on Solid/Melt Interfaces and the Formation of<100> Texture in Solidified FCC Metals显示文摘The (100) texture of solidified fcc metals, caused by the preferential (100) dendrite growth, could be closeIy related to solid/melt interfaces which behave differently along different crystallographic orientation. The stability and roughness of {111} and {100} solid/melt interfaces of fcc metals were investigated using a modified Temkin multi-layer model. It is demonstrated that {100}crystal/melt interface is more unstable and rougher than {111} interface. The effect of the stability of crystal/melt interface on the (100) texture formation in solidified fcc metals has been analysed and discussed. | D.Y.Li(Dept. of Mater. Sci & Eng., The Pennsylvania State University, University Park, PA 16802, USA )B.Debray and J.A.Szpunar(Dept. of Metall. Eng., McGill University, 3450 Uuiversity Street, Molitreal, PQ, Canada H3A 2A7) | 1997 | Journal of Materials Science & Technology1997，13，6： | 20 |
| 9 | The common language of space:a way of looking at the social,economic and environmental functioning of cities on a common basis显示文摘This paper proposes that in addition to urban research which seeks to provide answers to policy questions, there is also a need for research which directly addresses the physical and spatial complexity of the built environment itself, and explores any effects it may in itself have on the functioning of the urban system. This type of research reflects the questions architects and urban designers typically ask, rather than those that preoccupy planners. For such research to be effective, the physical complexity variable must be controlled at the level at which real design decisions are made. “Space syntax” research attempts to do this by treating built environments as systems of space, analysing them “configurationally”, and trying to bring to light their underlying patterns and structures. Results from space syntax research into many aspects of urban space and how it works show a consistency which suggests that analysing spacial structure can be a general means of investigating the structure and function of cities. It may, in effect, be the common language of the city. | Bill Hillier Bartlett School of Graduate Studies, University College London, Gower Street, London WC1E 6BT, U.K. E\|mail:b.hillier@ucl.ac.uk | 1999 | Journal of Environmental Sciences1999，11，3： | 18 |
| 10 | Ozone sensitivity analysis with the MM5-CMAQ modeling system for Shanghai显示文摘Ozone has become one of the most important air pollution issues around the world. This article applied both O 3 /(NOy-NOx) and H 2 O 2 /HNO 3 indicators to analyze the ozone sensitivity in urban and rural areas of Shanghai, with implementation of the MM5-CMAQ modeling system in July, 2007. The meteorological parameters were obtained by using the MM5 model. A regional emission inventory with spatial and temporal allocation based on the statistical data has been developed to provide input emission data to the MM5-CMAQ modeling system. Results showed that the ozone concentrations in Shanghai show clear regional differences. The ozone concentration in rural areas was much higher than that in the urban area. Two indicators showed that ozone was more sensitive to VOCs in urban areas, while it tended to be NOx sensitive in rural areas of Shanghai. | Li Li Changhong Chen Cheng Huang Haiying Huang Gangfeng Zhang Yangjun Wang Minghua Chen Hongli Wang Yiran Chen D. G. Streets Jiamo Fu | 2011 | Journal of Environmental Sciences2011，23，7： | 18 |
| 11 | Bmi-1:At the crossroads of physiological and pathological biology显示文摘Bmi-1 is a member of the Polycomb repressor complex 1 that mediates gene silencing by regulating chromatin structure and is indispensable for self-renewal of both normal and cancer stem cells.Despite three decades of research that have elucidated the transcriptional regulation,post-translational modifications and functions of Bmi-1 in regulating the DNA damage response,cellular bioenergetics,and pathologies,the entire potential of a protein with such varied functions remains to be realized.This review attempts to synthesize the current knowledge on Bmi-1 with an emphasis on its role in both normal physiology and cancer.Additionally,since cancer stem cells are emerging as a new paradigm for therapy resistance,the role of Bmi-1 in this perspective is also highlighted.The wide spectrum of malignancies that implicate Bmi-1 as a signature for stemness and oncogenesis also make it a suitable candidate for therapy.Nonetheless,new approaches are vitally needed to further characterize physiological roles of Bmi-1 with the long-term goal of using Bmi-1 as a prognostic marker and a therapeutic target. | Resham Bhattacharya Soumyajit Banerjee Mustafi Mark Street Anindya Dey Shailendra Kumar Dhar Dwivedi | 2015 | Genes & Diseases2015，2，3： | 15 |
| 12 | On a class of weak Landsberg metrics显示文摘In this paper, we discuss a class of Finsler metrics defined by a Riemannian metric and a 1-form on a manifold. We characterize weak Landsberg metrics in this class and show that there exist weak Landsberg metrics which are not Landsberg metrics in dimension greater than two. | Ben-ling LI & Zhong-min SHEN Department of Mathematics, Zhejiang University, Hangzhou 310028, China Department of Mathematical Sciences, Indiana University Purdue University Indianapolis (IUPUI), 402 N. Blackford Street, Indianapolis, IN 46202-3216, USA Center of Mathematical Sciences, Zhejiang University, Hangzhou 310027, China | 2007 | Science China Mathematics2007，50，4： | 14 |
| 13 | Differential mercury volatilization by tobacco organs expressing a modi-fied bacterial merA gene显示文摘Mercury pollution is a major environmental problem accompanying industrial activities. Most of the mercury released ends up and retained in the soil as complexes of the toxic ionic mercury (Hg2+), which then can be converted by microbes into the even more toxic methylmercury which tends to bioaccumulate. Mercury detoxification of the soil can also occur by microbes converting the ionic mercury into the least toxic metallic mercury (Hg0) form, which then evaporates. The remediation potentia1 of transgenic plants carrying the MerA gene from E. coLi encoding mercuric ion reductase could be evaluated. A modified version of the gene, optimized for plant codon preferences (merApe9, Rugh et al. 1996), was introduced into tobacco by Agrobacterium-mediated leaf disk transformation. Transgenic seeds were resistant to HgCl2 at 50 μM and some of them (10-20% ) could germinate on media containing as much as 350 μM HgCl2, while the control plants were fully inhibited or died on 50 μM HgCl2. The rate of elemental mercury evolution from Hg2+ (added as HgCl2) was 5-8 times higher for transgenic plants than the control. Mercury volatilization by isolated organs standardized for fresh weight was higher (up to 5 times) in the roots than in shoots or the leaves. The data suggest that it is the root system of the transgenic plants that volatilizes most of the reduced mercury (Hg0). It also suggests that much of the mercury need not enter the vascular system to be transported to the leaves for volatilization. Thansgenic plants with the merApe9 gene may be used to mercury detoxification for environmental improvement in mercury-- contaminated regions more efficiently than it had been predicted based on data on volatilization of whole plants via the upper parts only (Rugh et al. 1996). | HE YU KE, JIAN GE SUN, XIAN ZHONG FENG, MIHALY CZAKU, LASZLO MARTON Depariment of Biological Sciences, University of South Carolina, 700 Sumter Street, Columbia, SC29208, USA National Laboratory of Plant Molecular Genetics, Shanghai Institute of Plant Phy | 2001 | Cell Research2001，11，3： | 14 |
| 14 | Valuing water quality in China:purpose,approach and policy显示文摘The economic valuation of water quality in a rapidly developing country such as China should be undertaken to determine when the benefits from rapid growth begin to exceed the costs from the same. The best approach is to ascertain the total economic valuation of the environmental resource. This includes all of the various uses of the resource, and even those values that are unconnected to individual use (e.g. natural and aesthetic values). A method known as contingent valuation (CV) is used to ascertain these forms of value. This approach is demonstrated here in an application to river water quality in the Beijing area. A CV study is reported in which Beijing area citizens reported an average willingness to pay about 1.3% of annual income in order to prevent further deterioration of river water quality. Aggregation over the representative population indicates that the perceived cost of further river quality deterioration is in the neighbourhood of USD 60 million. Such a measure provides some indication of the socially desired “stopping point”—— in the pursuit of economic growth at the expense of environmental quality. | Timothy Swanson,Brett Day,Susana Mourato Centre for Social and Economic Research on the Global Environment, Department of Economics, and School of Public Policy, University College London, Gower Street, London WC1E 6BT, United Kingdom | 1999 | Journal of Environmental Sciences1999，11，3： | 12 |
| 15 | 应用Models-3/CMAQ研究长三角区域大气污染及输送显示文摘选用美国国家环保局第3代空气质量模式(Models-3,/CMAQ),配合中尺度气象模式(MM5)进行研究,模拟了2001年1、7月份长江三角洲区域冬夏季典型天气条件下大气层二次污染物臭氧及颗粒物的浓度分布及输送状况。采用2001年冬.夏季各10d的小时监测数据对模式验证。结果表明,Models-3/CMAQ对O3、PM10的模拟相关系数分别为0.77和052;一致性指数分别达到081和0.99。模型对于O3略微低估,标准偏差为-31%,而对于PM10则有所高估,标准偏差为46%。对长三角7月份O3浓度及1月份PM10的模拟结果显示,7月份长三角区域16个主要城市O3日均浓度集中在0.043~0.086mg/m^3之间,其中,泰州、扬州.湖州、镇江O3月日均浓度相对较高,均超过0.064mg/m3o模拟时段内O3最高小时浓度达0.276mg/m^3。1月份整个模拟区域PM10月日均浓度为O056mg/m^3,其中,南京市PM10日均浓度最高,达0.080mg/m^3模拟时段内PM10最高小时浓度达0.432mg/m^3研究表明,长三角地区存在明显的污染物输送现象,大气污染已经从局地污染转化为区域污染。 | 李莉 陈长虹 黄海英 黄成 李作攀 Joshua S Fu Carey J Jang David G Streets | 2007 | 上海环境科学2007，26，4： | 11 |
| 16 | Nitric Oxide:from a mysterious labile factor to the molecule of the Nobel Prize Recent progress in nitric oxide research显示文摘NO is now known to be an important messenger molecule in biology.It regulates a variety of functions within cells and tissues including vasodilation, neurotransmission and immunological process. This review will focus on the nitric oxide synthase gene family and recent progress on molecular genetic analysis of NOS1, NOS2 and N0S3 genes. | XU WEI MING LI ZHI LIU (The Wolfson Institute for Biomedical Research, The Rayne Institute, University College London, 5 University Street,London WC1E 6JJ) | 1998 | Cell Research1998，8，4： | 11 |
| 17 | Multifractal Simulation of GeochemicalMap Patterns显示文摘Using a simple multifractal model based on the model De Wijs, various geochemical map patterns for element concentration values are being simulated. Each pattern is self-similar on the average in that a similar pattern can be derived by application of the multiplicative cascade model used to any small subarea on the pattern. In other experiments, the original, self-similar pattern is distorted by superimposing a 2-dimensional trend pattern and by mixing it with a constant concentration value model. It is investigated how such distortions change the multifractal spectrum estimated by means of the 3-step method of moments. Discrete and continuous frequency distribution models are derived for patterns that satisfy the model of De Wijs. These simulated patterns satisfy a discrete frequency distribution model that as upper bound has a continuous frequency distribution to which it approaches in form when the subdivisions of the multiplicative cascade model are repeated indefinitely. This limiting distribution is lognormal in the center and has Pareto tails. Potentially, this approach has important implications in mineral and oil resource evaluation. | Agterberg Frederik P Geological Survey of Canada, 601 Booth Street, Ottawa, K1A 0E8, Canada | 2001 | Journal of China University of Geosciences2001，12，1： | 10 |
| 18 | Transarterial embolization ablation of hepatocellular carcinoma with a lipiodol-ethanol mixture显示文摘AIM: To determine the safety and effectiveness of transarterial embolization ablation (TEA) of hepatocellular carcinoma (HCC) with a lipiodol-ethanol mixture. METHODS: Between January 1 and December 31, 2009, 15 patients with HCC (13 men/two women, aged 38-75 years) accepted TEA treatment and were enrolled in this study, including five newly diagnosed patients and 10 with refractory disease. Two months after TEA, angiography and contrast computed tomography (CT) were performed, and responses were assessed using a modified version of Response Evaluation Criteria in Solid Tumors (RECIST version 1.1). The follow-up period was to June 30, 2010. RESULTS: Every new case was treated once. Angiography was performed immediately after TEA, and showed that the tumor-feeding vessels were completely embolized and that lipiodol was densely deposited inside tumors. Two months after treatment, contrast CT showed no enhanced lesions. Alpha fetoprotein levels returned to normal in four patients and markedly decreased in another. mean ± SD survival after treatment was 10.8 ± 4.5 mo. All five patients survived during the follow-up period. Ten patients with refractory disease were treated a total of 14 times. Angiography immediately after TEA showed that blood flow to the tumors was obviously decreased in all cases, and contrast CT showed obvious depositions of lipiodol. Two months after treatment, the tumors had shrunk (6/10) or were stable (3/10). One had progressed after 2 mo and died of tumor rupture 3 mo after TEA. mean ± SD survival after treatment was 8.6 ± 4.3 mo; two patients survived during the follow-up period. Adverse effects included reversible hepatic decompensation, upper abdominal pain, and fever. CONCLUSION: TEA is an effective therapy for patients with HCC and might be more effective than transcather arterial chemoembolization for treating refractory disease. | Yang-Kui Gu, Rong-Guang Luo, Jin-Hua Huang, Qi-Jiao Si Tu, Xiao-Xia Li, Fei Gao,State Key Laboratory of Oncology in Southern China,Department of Medical Imaging and Interventional Radiology,Cancer Center,Sun Yat-sen University,Guangzhou510060,Guangdong Province,China Department of Medical Imaging and Interventional Radiology, the First Affiliated Hospital of Nan-Chang University, 17 Yongwaizheng Street, Nanchang 330006, Jiangxi Province, China | 2010 | World Journal of Gastroenterology2010，16，45： | 9 |
| 19 | 绍兴仓桥直街历史街区保护显示文摘绍兴仓桥直街历史街区是绍兴历史文化名城的重要组成部分。本文详细叙述了该街区的现状及存在问题 ,保护原则、目标、具体方法以及相应制定的有关政策。 | The Historic Street Preservation\|management Office of Shaoxing,Shaoxing,Zhejiang 312000 | 2001 | 城市发展研究2001，8，5： | 9 |
| 20 | Multifractal modelling and spectrum analysis: Methods and applications to gamma ray spectrometer data from southwestern Nova Scotia, Canada显示文摘Multifractal spectrum, autocorrelation/semivariogram and power spectrum are three dif- ferent functions characterizing a field or measure from different aspects. These functions are interre- lated in such that the autocorrelation/semivariogram and power spectrum are related to the low order statistical moments (0 to 2 nd) which may determine the local multifractality (τ ″(1)) of a multifractal measure. A better understanding of the interrelationships among these three functions is important because, on one hand, the multifractal modelling characterizes a multifractal measure in a more de- tailed manner since it involves moments of all orders. On the other hand, the commonly used semivariogram and power spectrum functions can be used as alternatives to study the dominant mul- tifractal properties around the mean measure. Moreover, semivariogram and power-spectrum func- tions provide spatial and spectral information, which is highly valued in geological applications. A new fractal relation found between area and power-spectrum will be useful for investigation of new meth- ods of spatial-spectral analysis for pattern recognition, anomaly separation, classification, etc. These results have been demonstrated with the case study of modelling gamma ray spectrometer data from the mineral district, southwestern Nova Scotia, Canada. The results have shown that the values of uranium (U), thorium (Th) and potassium (K) may possess monofractal properties whereas the ratios of these values show high multifractality. The values of the ratios U/K and U/Th show relatively large variances and may provide more information for distinguishing the distinct phases of the granites, country rocks as well as possible gold mineralization-associated regional hydrothermal alteration zones. In addition, the power spectra for U, Th, K, U/Th and U/K consistently show two distinct power-law relationships for two ranges of wave number 12≤ω ≤160 km and 0≤ω ≤12 km. These properties might provide useful thresholds for separating the power-spectrum values into two types of patterns to reflect different influences of possible geological processes such as hydrothermal altera- tion in the study area. | CHENG Qiuming1,2 1. State Key Lab of Geological Processes and Mineral Resources, China University of Geosciences, Wuhan 430074, China 2. Department of Earth and Space Science and Engineering, Department of Geography, York University, 4700 Keele Street, Toronto, Ontario, M3J 1P3, Canada | 2006 | Science China Earth Sciences2006，49，3： | 8 |
您所在的机构暂未开通此部分的功能，请联系管理员